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Article

Long non-coding RNA TCF7 predicts the progression and facilitates the growth and metastasis of colorectal cancer

  • Authors:
    • Fu‑Shu Jin
    • Hong‑Mei Wang
    • Xiao‑Yan Song
  • View Affiliations / Copyright

    Affiliations: Anorectal Section, Yantai City Hospital of Traditional Chinese Medicine, Yantai, Shandong 264000, P.R. China, Department of Obstetrics and Gynecology, Yantai City Hospital of Traditional Chinese Medicine, Yantai, Shandong 264000, P.R. China, Department of Emergency, Yantai City Hospital of Traditional Chinese Medicine, Yantai, Shandong 264000, P.R. China
  • Pages: 6902-6908
    |
    Published online on: March 9, 2018
       https://doi.org/10.3892/mmr.2018.8708
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Abstract

Long non-coding RNA (lnc)TCF7 has been reported to promote the self‑renewal of human cancer stem cells, and enhance the aggressiveness of human non‑small cell lung cancer and hepatocellular carcinoma cells. However, the effect of lncTCF7 on colorectal cancer (CRC) tumorigenesis and progression is currently unclear. In the present study, reverse transcription‑quantitative polymerase chain reaction results demonstrated that lncTCF7 expression was higher in CRC tissues compared with adjacent normal tissues and was significantly associated with tumor size, differentiation degree, tumor‑node‑metastasis grade, lymph node metastasis and invasion depth. In addition, lncTCF7 demonstrated a high sensitivity and specificity for diagnosing CRC, as determined by receiver operating characteristic curve analysis. Furthermore, lncTCF7 silencing in SW‑620 and HT29 CRC cell lines inhibited the proliferation, cell cycle, migration and invasion of cells, as determined by Cell Counting Kit‑8 assays, propidium iodide (PI) staining and flow cytometry, wound healing assays and Transwell invasion assays, respectively; however, Annexin V/PI double staining and flow cytometry indicated that lncTCF7 silencing did not significantly affect the apoptosis of CRC cells. These results indicate that lncTCF7 may predict the progression, and promote the growth and metastasis, of CRC, and may therefore be a novel diagnostic marker and therapeutic target for CRC treatment.
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1 

Torre LA, Bray F, Siegel RL, Ferlay J, Lortet-Tieulent J and Jemal A: Global cancer statistics, 2012. CA Cancer J Clin. 65:87–108. 2015. View Article : Google Scholar : PubMed/NCBI

2 

Chen W, Zheng R, Zeng H, Zhang S and He J: Annual report on status of cancer in China, 2011. Chin J Cancer Res. 27:2–12. 2015. View Article : Google Scholar : PubMed/NCBI

3 

Fleshman JW and Smallwood N: Current concepts in rectal cancer. Clin Colon Rectal Surg. 28:5–11. 2015. View Article : Google Scholar : PubMed/NCBI

4 

Rao AKDM, Rajkumar T and Mani S: Perspectives of long non-coding RNAs in cancer. Mol Biol Rep. 44:203–218. 2017. View Article : Google Scholar : PubMed/NCBI

5 

Li M, Wang Y, Cheng L, Niu W, Zhao G, Raju JK, Huo J, Wu B, Yin B, Song Y and Bu R: Long non-coding RNAs in renal cell carcinoma: A systematic review and clinical implications. Oncotarget. 8:48424–48435. 2017.PubMed/NCBI

6 

Klingenberg M, Matsuda A, Diederichs S and Patel T: Non-coding RNA in hepatocellular carcinoma: Mechanisms, biomarkers and therapeutic targets. J Hepatol. 67:603–618. 2017. View Article : Google Scholar : PubMed/NCBI

7 

Richtig G, Ehall B, Richtig E, Aigelsreiter A, Gutschner T and Pichler M: Function and clinical implications of long non-coding RNAs in melanoma. Int J Mol Sci. 18:pii: E715. 2017. View Article : Google Scholar : PubMed/NCBI

8 

Yang Y, Zhao L, Lei L, Lau WB, Lau B, Yang Q, Le X, Yang H, Wang C, Luo Z, et al: LncRNAs: The bridge linking RNA and colorectal cancer. Oncotarget. 8:12517–12532. 2017.PubMed/NCBI

9 

Wang Y, He L, Du Y, Zhu P, Huang G, Luo J, Yan X, Ye B, Li C, Xia P, et al: The long noncoding RNA lncTCF7 promotes self-renewal of human liver cancer stem cells through activation of Wnt signaling. Cell Stem Cell. 16:413–425. 2015. View Article : Google Scholar : PubMed/NCBI

10 

Weber BN, Chi AW, Chavez A, Yashiro-Ohtani Y, Yang Q, Shestova O and Bhandoola A: A critical role for TCF-1 in T-lineage specification and differentiation. Nature. 476:63–68. 2011. View Article : Google Scholar : PubMed/NCBI

11 

Cui L, Guan Y, Qu Z, Zhang J, Liao B, Ma B, Qian J, Li D, Li W, Xu GT and Jin Y: WNT signaling determines tumorigenicity and function of ESC-derived retinal progenitors. J Clin Invest. 123:1647–1661. 2013. View Article : Google Scholar : PubMed/NCBI

12 

Nikuseva-Martic T, Serman L, Zeljko M, Vidas Z, Gašparov S, Zeljko HM, Kosović M and Pećina-Šlaus N: Expression of secreted frizzled-related protein 1 and 3, T-cell factor 1 and lymphoid enhancer factor 1 in clear cell renal cell carcinoma. Pathol Oncol Res. 19:545–551. 2013. View Article : Google Scholar : PubMed/NCBI

13 

Siu MK, Chen WY, Tsai HY, Chen HY, Yin JJ, Chen CL, Tsai YC and Liu YN: TCF7 is suppressed by the androgen receptor via microRNA-1-mediated downregulation and is involved in the development of resistance to androgen deprivation in prostate cancer. Prostate Cancer Prostatic Dis. 20:172–178. 2017. View Article : Google Scholar : PubMed/NCBI

14 

Chen WY, Liu SY, Chang YS, Yin JJ, Yeh HL, Mouhieddine TH, Hadadeh O, Abou-Kheir W and Liu YN: MicroRNA-34a regulates WNT/TCF7 signaling and inhibits bone metastasis in Ras-activated prostate cancer. Oncotarget. 6:441–457. 2015.PubMed/NCBI

15 

Wang Y, Zhang S, Xu Y, Zhang Y, Guan H, Li X, Li Y and Wang Y: Upregulation of miR-192 inhibits cell growth and invasion and induces cell apoptosis by targeting TCF7 in human osteosarcoma. Tumour Biol. 37:15211–15220. 2016. View Article : Google Scholar : PubMed/NCBI

16 

Wu J and Wang D: Long noncoding RNA TCF7 promotes invasiveness and self-renewal of human non-small cell lung cancer cells. Hum Cell. 30:23–29. 2017. View Article : Google Scholar : PubMed/NCBI

17 

Wu J, Zhang J, Shen B, Yin K, Xu J, Gao W and Zhang L: Long noncoding RNA lncTCF7, induced by IL-6/STAT3 transactivation, promotes hepatocellular carcinoma aggressiveness through epithelial-mesenchymal transition. J Exp Clin Cancer Res. 34:1162015. View Article : Google Scholar : PubMed/NCBI

18 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

19 

Li C, Liang G, Yang S, Sui J, Yao W, Shen X, Zhang Y, Peng H, Hong W, Xu S, et al: Dysregulated lncRNA-UCA1 contributes to the progression of gastric cancer through regulation of the PI3K-Akt-mTOR signaling pathway. Oncotarget. 8:93476–93491. 2017.PubMed/NCBI

20 

Xu C, Sun L, Jiang C, Zhou H, Gu L, Liu Y and Xu Q: SPP1, analyzed by bioinformatics methods, promotes the metastasis in colorectal cancer by activating EMT pathway. Biomed Pharmacother. 91:1167–1177. 2017. View Article : Google Scholar : PubMed/NCBI

21 

Pan Y, Jiao G, Wang C, Yang J and Yang W: MicroRNA-421 inhibits breast cancer metastasis by targeting metastasis associated 1. Biomed Pharmacother. 83:1398–1406. 2016. View Article : Google Scholar : PubMed/NCBI

22 

Romagnoli P, Filipponi F, Bandettini L and Brugnola D: Increase of mitotic activity in the colonic mucosa of patients with colorectal cancer. Dis Colon Rectum. 27:305–308. 1984. View Article : Google Scholar : PubMed/NCBI

23 

Paganelli GM, Biasco G, Santucci R, Brandi G, Lalli AA, Miglioli M and Barbara L: Rectal cell proliferation and colorectal cancer risk level in patients with nonfamilial adenomatous polyps of the large bowel. Cancer. 68:2451–2454. 1991. View Article : Google Scholar : PubMed/NCBI

24 

Yao M, Lam EC, Kelly CR, Zhou W and Wolfe MM: Cyclooxygenase-2 selective inhibition with NS-398 suppresses proliferation and invasiveness and delays liver metastasis in colorectal cancer. Br J Cancer. 90:712–719. 2004. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Jin FS, Wang HM and Song XY: Long non-coding RNA TCF7 predicts the progression and facilitates the growth and metastasis of colorectal cancer. Mol Med Rep 17: 6902-6908, 2018.
APA
Jin, F., Wang, H., & Song, X. (2018). Long non-coding RNA TCF7 predicts the progression and facilitates the growth and metastasis of colorectal cancer. Molecular Medicine Reports, 17, 6902-6908. https://doi.org/10.3892/mmr.2018.8708
MLA
Jin, F., Wang, H., Song, X."Long non-coding RNA TCF7 predicts the progression and facilitates the growth and metastasis of colorectal cancer". Molecular Medicine Reports 17.5 (2018): 6902-6908.
Chicago
Jin, F., Wang, H., Song, X."Long non-coding RNA TCF7 predicts the progression and facilitates the growth and metastasis of colorectal cancer". Molecular Medicine Reports 17, no. 5 (2018): 6902-6908. https://doi.org/10.3892/mmr.2018.8708
Copy and paste a formatted citation
x
Spandidos Publications style
Jin FS, Wang HM and Song XY: Long non-coding RNA TCF7 predicts the progression and facilitates the growth and metastasis of colorectal cancer. Mol Med Rep 17: 6902-6908, 2018.
APA
Jin, F., Wang, H., & Song, X. (2018). Long non-coding RNA TCF7 predicts the progression and facilitates the growth and metastasis of colorectal cancer. Molecular Medicine Reports, 17, 6902-6908. https://doi.org/10.3892/mmr.2018.8708
MLA
Jin, F., Wang, H., Song, X."Long non-coding RNA TCF7 predicts the progression and facilitates the growth and metastasis of colorectal cancer". Molecular Medicine Reports 17.5 (2018): 6902-6908.
Chicago
Jin, F., Wang, H., Song, X."Long non-coding RNA TCF7 predicts the progression and facilitates the growth and metastasis of colorectal cancer". Molecular Medicine Reports 17, no. 5 (2018): 6902-6908. https://doi.org/10.3892/mmr.2018.8708
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