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Article

Induction of Th1 chemokine secretion in dermal fibroblasts by vanadium pentoxide

  • Authors:
    • P. Fallahi
    • R. Foddis
    • G. Elia
    • F. Ragusa
    • A. Patrizio
    • G. Guglielmi
    • G. Frenzilli
    • S. Benvenga
    • A. Cristaudo
    • A. Antonelli
    • S. M. Ferrari
  • View Affiliations / Copyright

    Affiliations: Department of Clinical and Experimental Medicine, University of Pisa, I‑56126 Pisa, Italy, Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, I‑56126 Pisa, Italy, U.O. Medicina Preventiva del Lavoro, Azienda Ospedaliero‑Universitaria Pisana, I‑56124 Pisa, Italy, Department of Clinical and Experimental Medicine, University of Messina, I‑98125 Messina, Italy
  • Pages: 6914-6918
    |
    Published online on: March 9, 2018
       https://doi.org/10.3892/mmr.2018.8712
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Abstract

Vanadium is a soft, silvery‑grey metal with a number of different oxidation states. The most common commercial form of vanadium is vanadium pentoxide (V2O5). All vanadium compounds are considered toxic. An increase in skin rashes has been observed in certain vanadium workers, including the development of atopic dermatitis. However, to the best of our knowledge, no prior in vivo or in vitro studies have evaluated the effect of vanadium exposure in human dermal fibroblasts. The present study evaluated the effect of V2O5 on proliferation and chemokine secretion in dermal fibroblasts. The results revealed that V2O5 had no significant effect on the viability or proliferation of fibroblasts, however it was able to induce the secretion of T‑helper (Th)1 chemokines from dermal fibroblasts, synergistically increasing the effect of important Th1 cytokines, including interferon‑γ and tumor necrosis factor‑α. Through these processes, V2O5 may lead to the induction and perpetuation of an inflammatory reaction in dermal tissue. The induction and perpetuation of inflammation in the dermis and the variety of involved candidate genes may be at the base of V2O5‑induced effects following occupational and environmental exposures. Further studies are necessary to evaluate dermal integrity and manifestations in subjects who are occupationally exposed, or living in polluted areas.
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1 

Ingram JL, Antao-Menezes A, Turpin EA, Wallace DG, Mangum JB, Pluta LJ, Thomas RS and Bonner JC: Genomic analysis of human lung fibroblasts exposed to vanadium pentoxide to identify candidate genes for occupational bronchitis. Respir Res. 8:342007. View Article : Google Scholar : PubMed/NCBI

2 

Occupational Safety and Health Administration (OSHA): Occupational safety and health guideline for vanadium pentoxide dust. OSHA; Washington, DC: 2007

3 

Sax NI: Dangerous Properties of Industrial Materials. 6th. Van Nostrand Reinhold Company; New York, NY: pp. 2717–2720. 1984

4 

Ress NB, Chou BJ, Renne RA, Dill JA, Miller RA, Roycroft JH, Hailey JR, Haseman JK and Bucher JR: Carcinogenicity of inhaled vanadium pentoxide in F344/N rats and B6C3F1 mice. Toxicol Sci. 74:287–296. 2003. View Article : Google Scholar : PubMed/NCBI

5 

Wörle-Knirsch JM, Kern K, Schleh C, Adelhelm C, Feldmann C and Krug HF: Nanoparticulate vanadium oxide potentiated vanadium toxicity in human lung cells. Environ Sci Technol. 41:331–336. 2007. View Article : Google Scholar : PubMed/NCBI

6 

Scibior A, Zaporowska H and Ostrowski J: Selected haematological and biochemical parameters of blood in rats after subchronic administration of vanadium and/or magnesium in drinking water. Arch Environ Contam Toxicol. 51:287–295. 2006. View Article : Google Scholar : PubMed/NCBI

7 

González-Villalva A, Fortoul T, Avila-Costa MR, Piñón-Zarate G, Rodriguez-Laraa V, Martínez-Levy G, Rojas-Lemus M, Bizarro-Nevarez P, Díaz-Bech P, Mussali-Galante P and Colin-Barenque L: Thrombocytosis induced in mice after subacute and subchronic V2O5 inhalation. Toxicol Ind Health. 22:113–116. 2006. View Article : Google Scholar : PubMed/NCBI

8 

Soazo M and Garcia GB: Vanadium exposure through lactation produces behavioral alterations and CNS myelin deficit in neonatal rats. Neurotoxicol Teratol. 29:503–510. 2007. View Article : Google Scholar : PubMed/NCBI

9 

Kobayashi K, Himeno S, Satoh M, Kuroda J, Shibata N, Seko Y and Hasegawa T: Pentavalent vanadium induces hepatic metallothionein through interleukin-6-dependent and -independent mechanisms. Toxicology. 228:162–170. 2006. View Article : Google Scholar : PubMed/NCBI

10 

Barceloux DG: Vanadium. J Toxicol Clin Toxicol. 37:265–278. 1999. View Article : Google Scholar : PubMed/NCBI

11 

Antonelli A, Ferri C, Fallahi P, Ferrari SM, Frascerra S, Sebastiani M, Franzoni F, Galetta F and Ferrannini E: High values of CXCL10 serum levels in patients with hepatitis C associated mixed cryoglobulinemia in presence or absence of autoimmune thyroiditis. Cytokine. 42:137–143. 2008. View Article : Google Scholar : PubMed/NCBI

12 

Valyasevi RW, Harteneck DA, Dutton CM and Bahn RS: Stimulation of adipogenesis, peroxisome proliferator-activated receptor-gamma (PPARgamma), and thyrotropin receptor by PPARgamma agonist in human orbital preadipocyte fibroblasts. J Clin Endocrinol Metab. 87:2352–2358. 2002. View Article : Google Scholar : PubMed/NCBI

13 

Antonelli A, Rotondi M, Fallahi P, Romagnani P, Ferrari SM, Buonamano A, Ferrannini E and Serio M: High levels of circulating CXC chemokine ligand 10 are associated with chronic autoimmune thyroiditis and hypothyroidism. J Clin Endocrinol Metab. 89:5496–5499. 2004. View Article : Google Scholar : PubMed/NCBI

14 

Kemp EH, Metcalfe RA, Smith KA, Woodroofe MN, Watson PF and Weetman AP: Detection and localization of chemokine gene expression in autoimmune thyroid disease. Clin Endocrinol (Oxf). 59:207–213. 2003. View Article : Google Scholar : PubMed/NCBI

15 

Antonelli A, Ferrari SM, Fallahi P, Frascerra S, Santini E, Franceschini SS and Ferrannini E: Monokine induced by interferon gamma (IFNgamma) (CXCL9) and IFNgamma inducible T-cell alpha-chemoattractant (CXCL11) involvement in Graves' disease and ophthalmopathy: Modulation by peroxisome proliferator-activated receptor-gamma agonists. J Clin Endocrinol Metab. 94:1803–1809. 2009. View Article : Google Scholar : PubMed/NCBI

16 

Antonelli A, Ferrari SM, Frascerra S, Pupilli C, Mancusi C, Metelli MR, Orlando C, Ferrannini E and Fallahi P: CXCL9 and CXCL11 chemokines modulation by peroxisome proliferator-activated receptor-alpha agonists secretion in Graves' and normal thyrocytes. J Clin Endocrinol Metab. 95:E413–E420. 2010. View Article : Google Scholar : PubMed/NCBI

17 

Garcià-Lòpez MA, Sancho D, Sànchez-Madrid F and Marazuela M: Thyrocytes from autoimmune thyroid disorders produce the chemokines IP-10 and Mig and attract CXCR3v lymphocytes. J Clin Endocrinol Metab. 86:5008–5016. 2001. View Article : Google Scholar : PubMed/NCBI

18 

Antonelli A, Ferrari SM, Corrado A, Ferrannini E and Fallahi P: CXCR3, CXCL10 and type 1 diabetes. Cytokine Growth Factor Rev. 25:57–65. 2014. View Article : Google Scholar : PubMed/NCBI

19 

Antonelli A, Ferrari SM, Giuggioli D, Ferrannini E, Ferri C and Fallahi P: Chemokine (C-X-C motif) ligand (CXCL)10 in autoimmune diseases. Autoimmun Rev. 13:272–280. 2014. View Article : Google Scholar : PubMed/NCBI

20 

Antonelli A, Fallahi P, Delle Sedie A, Ferrari SM, Maccheroni M, Bombardieri S, Riente L and Ferrannini E: High values of Th1 (CXCL10) and Th2 (CCL2) chemokines in patients with psoriatic arthtritis. Clin Exp Rheumatol. 27:22–27. 2009.PubMed/NCBI

21 

Fallahi P, Ferrari SM, Ruffilli I, Elia G, Biricotti M, Vita R, Benvenga S and Antonelli A: The association of other autoimmune diseases in patients with autoimmune thyroiditis: Review of the literature and report of a large series of patients. Autoimmun Rev. 15:1125–1128. 2016. View Article : Google Scholar : PubMed/NCBI

22 

Antao-Menezes A, Turpin EA, Bost PC, Ryman-Rasmussen JP and Bonner JC: STAT-1 signaling in human lung fibroblasts is induced by vanadium pentoxide through an IFN-beta autocrine loop. J Immunol. 180:4200–4207. 2008. View Article : Google Scholar : PubMed/NCBI

23 

Sabbioni E, Kuèera J, Pietra R and Vesterberg O: A critical review on normal concentrations of vanadium in human blood, serum, and urine. Sci Total Environ. 188:49–58. 1996. View Article : Google Scholar : PubMed/NCBI

24 

Ivancsits S, Pilger A, Diem E, Schaffer A and Rüdiger HW: Vanadate induces DNA strand breaks in cultured human fibroblasts at doses relevant to occupational exposure. Mutat Res. 519:25–35. 2002. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Fallahi P, Foddis R, Elia G, Ragusa F, Patrizio A, Guglielmi G, Frenzilli G, Benvenga S, Cristaudo A, Antonelli A, Antonelli A, et al: Induction of Th1 chemokine secretion in dermal fibroblasts by vanadium pentoxide. Mol Med Rep 17: 6914-6918, 2018.
APA
Fallahi, P., Foddis, R., Elia, G., Ragusa, F., Patrizio, A., Guglielmi, G. ... Ferrari, S.M. (2018). Induction of Th1 chemokine secretion in dermal fibroblasts by vanadium pentoxide. Molecular Medicine Reports, 17, 6914-6918. https://doi.org/10.3892/mmr.2018.8712
MLA
Fallahi, P., Foddis, R., Elia, G., Ragusa, F., Patrizio, A., Guglielmi, G., Frenzilli, G., Benvenga, S., Cristaudo, A., Antonelli, A., Ferrari, S. M."Induction of Th1 chemokine secretion in dermal fibroblasts by vanadium pentoxide". Molecular Medicine Reports 17.5 (2018): 6914-6918.
Chicago
Fallahi, P., Foddis, R., Elia, G., Ragusa, F., Patrizio, A., Guglielmi, G., Frenzilli, G., Benvenga, S., Cristaudo, A., Antonelli, A., Ferrari, S. M."Induction of Th1 chemokine secretion in dermal fibroblasts by vanadium pentoxide". Molecular Medicine Reports 17, no. 5 (2018): 6914-6918. https://doi.org/10.3892/mmr.2018.8712
Copy and paste a formatted citation
x
Spandidos Publications style
Fallahi P, Foddis R, Elia G, Ragusa F, Patrizio A, Guglielmi G, Frenzilli G, Benvenga S, Cristaudo A, Antonelli A, Antonelli A, et al: Induction of Th1 chemokine secretion in dermal fibroblasts by vanadium pentoxide. Mol Med Rep 17: 6914-6918, 2018.
APA
Fallahi, P., Foddis, R., Elia, G., Ragusa, F., Patrizio, A., Guglielmi, G. ... Ferrari, S.M. (2018). Induction of Th1 chemokine secretion in dermal fibroblasts by vanadium pentoxide. Molecular Medicine Reports, 17, 6914-6918. https://doi.org/10.3892/mmr.2018.8712
MLA
Fallahi, P., Foddis, R., Elia, G., Ragusa, F., Patrizio, A., Guglielmi, G., Frenzilli, G., Benvenga, S., Cristaudo, A., Antonelli, A., Ferrari, S. M."Induction of Th1 chemokine secretion in dermal fibroblasts by vanadium pentoxide". Molecular Medicine Reports 17.5 (2018): 6914-6918.
Chicago
Fallahi, P., Foddis, R., Elia, G., Ragusa, F., Patrizio, A., Guglielmi, G., Frenzilli, G., Benvenga, S., Cristaudo, A., Antonelli, A., Ferrari, S. M."Induction of Th1 chemokine secretion in dermal fibroblasts by vanadium pentoxide". Molecular Medicine Reports 17, no. 5 (2018): 6914-6918. https://doi.org/10.3892/mmr.2018.8712
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