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Article

Protective effects of icariin on human vascular endothelial cells induced by oxidized low-density lipoprotein via modulating caspase-3 and Bcl-2

  • Authors:
    • Yanwu Hu
    • Haitao Li
    • Kai Liu
    • Yang Zhang
    • Liqun Ren
    • Zhimin Fan
  • View Affiliations / Copyright

    Affiliations: Department of Breast Surgery, The First Hospital, Jilin University, Changchun, Jilin 130021, P.R. China, Department of Pharmacy, The Affiliated Hospital of Changchun University of Chinese Medicine, Changchun, Jilin 130021, P.R. China, Department of Experimental Pharmacology and Toxicology, School of Pharmaceutical Science, Jilin University, Changchun, Jilin 130021, P.R. China
  • Pages: 6835-6839
    |
    Published online on: March 9, 2018
       https://doi.org/10.3892/mmr.2018.8717
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Abstract

Icariin belongs to the family of flavonoids that is extracted from Epimedium brevicornum Maxim, and exhibits antioxidative, antitumorigenic, antiosteoporotic, immunoregulatory and antiatherosclerotic properties. To understand the mechanisms underlying the antiatherosclerotic properties of icariin, the present study investigated the effects of icariin on human vascular endothelial cells (HUVECs) following treatment with oxidized low‑density lipoprotein (ox‑LDL). Thus, following pretreatment with icariin at four various concentrations (0, 10, 20 and 40 µM), HUVECs were stimulated with ox‑LDL (100 µg/ml). The viability of cells was evaluated via an MTT assay and flow cytometry was performed to assess apoptosis. Additionally, the protein and mRNA expression levels of apoptosis regulator Bcl‑2 (Bcl‑2) and caspase‑3 were determined by western blotting and reverse transcription‑quantitative polymerase chain reaction. The findings of the present study indicated that icariin prevented injury and apoptosis in HUVECs following ox‑LDL treatment, in particular via the regulation of protein and mRNA expression levels of Bcl-2 and caspase-3.
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1 

Grundtman C and Wick G: The autoimmune concept of atherosclerosis. Curr Opin Lipidol. 22:327–334. 2011. View Article : Google Scholar : PubMed/NCBI

2 

Dell'omo G, Penno G, Pucci L, Lucchesi D, Fotino C, Del Prato S and Pedrinelli R: ACE gene insertion/deletion polymorphism modulates capillary permeability in hypertension. Clin Sci (Lond). 111:357–364. 2006. View Article : Google Scholar : PubMed/NCBI

3 

Zhu F, Li C, Jin XP, Weng SX, Fan LL, Zheng Z, Li WL, Wang F, Wang WF, Hu XF, et al: Celastrol may have an anti-atherosclerosis effect in a rabbit experimental carotid atherosclerosis model. Int J Clin Exp Med. 7:1684–1691. 2014.PubMed/NCBI

4 

Hansson GK: Inflammation, atherosclerosis, and coronary artery disease. N Engl J Med. 352:1685–1695. 2005. View Article : Google Scholar : PubMed/NCBI

5 

Yang H, Yan L, Qian P, Duan H, Wu J, Li B and Wang S: Icariin inhibits foam cell formation by down-regulating the expression of CD36 and up-regulating the expression of SR-BI. J Cell Biochem. 116:580–588. 2015. View Article : Google Scholar : PubMed/NCBI

6 

Bruyndonckx L, Hoymans VY, Van Craenenbroeck AH, Vissers DK, Vrints CJ, Ramet J and Conraads VM: Assessment of endothelial dysfunction in childhood obesity and clinical use. Oxid Med Cell Longev. 2013:1747822013. View Article : Google Scholar : PubMed/NCBI

7 

Liu YR, Chen JJ and Dai M: Paeonol protects rat vascular endothelial cells from ox-LDL-induced injury in vitro via downregulating microRNA-21 expression and TNF-α release. Acta Pharmacol Sin. 35:483–488. 2014. View Article : Google Scholar : PubMed/NCBI

8 

Xie F, Wu CF, Lai WP, Yang XJ, Cheung PY, Yao XS, Leung PC and Wong MS: The osteoprotective effect of Herba epimedii (HEP) extract in vivo and in vitro. Evid Based Complement Alternat Med. 2:353–361. 2005. View Article : Google Scholar : PubMed/NCBI

9 

Hidaka S, Okamoto Y, Yamada Y, Kon Y and Kimura T: A Japanese herbal medicine, Chujo-to, has a beneficial effect on osteoporosis in rats. Phytother Res. 13:14–19. 1999. View Article : Google Scholar : PubMed/NCBI

10 

Sakamoto S, Sassa S, Kudo H, Suzuki S, Mitamura T and Shinoda H: Preventive effects of a herbal medicine on bone loss in rats treated with a GnRH agonist. Eur J Endocrinol. 143:139–142. 2000. View Article : Google Scholar : PubMed/NCBI

11 

Xiao-Hong D, Chang-Qin X, Jian-Hua H, Wen-Jiang Z and Bing S: Icariin delays homocysteine-induced endothelial cellular senescence involving activation of the PI3K/AKT-eNOS signaling pathway. Pharm Biol. 51:433–440. 2013. View Article : Google Scholar : PubMed/NCBI

12 

Zeng KW, Fu H, Liu GX and Wang XM: Icariin attenuates lipopolysaccharide-induced microglial activation and resultant death of neurons by inhibiting TAK1/IKK/NF-kappaB and JNK/p38 MAPK pathways. Int Immunopharmacol. 10:668–678. 2010. View Article : Google Scholar : PubMed/NCBI

13 

Zhang G, Qin L, Sheng H, Yeung KW, Yeung HY, Cheung WH, Griffith J, Chan CW, Lee KM and Leung KS: Epimedium-derived phytoestrogen exert beneficial effect on preventing steroid-associated osteonecrosis in rabbits with inhibition of both thrombosis and lipid-deposition. Bone. 40:685–692. 2007. View Article : Google Scholar : PubMed/NCBI

14 

Zhang DC, Liu JL, Ding YB, Xia JG and Chen GY: Icariin potentiates the antitumor activity of gemcitabine in gallbladder cancer by suppressing NF-κB. Acta Pharmacol Sin. 34:301–308. 2013. View Article : Google Scholar : PubMed/NCBI

15 

Yap SP, Shen P, Li J, Lee LS and Yong EL: Molecular and pharmacodynamic properties of estrogenic extracts from the traditional Chinese medicinal herb, Epimedium. J Ethnopharmacol. 113:218–224. 2007. View Article : Google Scholar : PubMed/NCBI

16 

Chen Y, Huang JH, Ning Y and Shen ZY: Icariin and its pharmaceutical efficacy: Research progress of molecular mechanism. Zhong Xi Yi Jie He Xue Bao. 9:1179–1184. 2011.(In Chinese). View Article : Google Scholar : PubMed/NCBI

17 

Hu Y, Liu K, Yan M, Zhang Y, Wang Y and Ren L: Effects and mechanisms of icariin on atherosclerosis. Int J Clin Exp Med. 8:3585–3589. 2015.PubMed/NCBI

18 

Hu Y, Liu K, Yan M, Zhang Y, Wang Y and Ren L: Icariin inhibits oxidized low-density lipoprotein-induced proliferation of vascular smooth muscle cells by suppressing activation of extracellular signal-regulated kinase 1/2 and expression of proliferating cell nuclear antigen. Mol Med Rep. 13:2899–2903. 2016. View Article : Google Scholar : PubMed/NCBI

19 

Hu Y, Sun B, Liu K, Yan M, Zhang Y, Miao C and Ren L: Icariin attenuates high-cholesterol diet induced atherosclerosis in rats by inhibition of inflammatory response and p38 MAPK signaling pathway. Inflammation. 39:228–236. 2016. View Article : Google Scholar : PubMed/NCBI

20 

Xu CQ, Liu BJ, Wu JF, Xu YC, Duan XH, Cao YX and Dong JC: Icariin attenuates LPS-induced acute inflammatory responses: Involvement of PI3K/Akt and NF-kappaB signaling pathway. Eur J Pharmacol. 642:146–153. 2010. View Article : Google Scholar : PubMed/NCBI

21 

Xu HB and Huang ZQ: Vasorelaxant effects of icariin on isolated canine coronary artery. J Cardiovasc Pharmacol. 49:207–213. 2007. View Article : Google Scholar : PubMed/NCBI

22 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

23 

Chen J, Mehta JL, Haider N, Zhang X, Narula J and Li D: Role of caspases in Ox-LDL-induced apoptotic cascade in human coronary artery endothelial cells. Circ Res. 94:370–376. 2004. View Article : Google Scholar : PubMed/NCBI

24 

Ehara S, Ueda M, Naruko T, Haze K, Itoh A, Otsuka M, Komatsu R, Matsuo T, Itabe H, Takano T, et al: Elevated levels of oxidized low density lipoprotein show a positive relationship with the severity of acute coronary syndromes. Circulation. 103:1955–1960. 2001. View Article : Google Scholar : PubMed/NCBI

25 

Li D, Yang B and Mehta JL: Ox-LDL induces apoptosis in human coronary artery endothelial cells: Role of PKC, PTK, bcl-2, and Fas. Am J Physiol. 275:H568–H576. 1998. View Article : Google Scholar : PubMed/NCBI

26 

Giovannini C, Matarrese P, Scazzocchio B, Sanchez M, Masella R and Malorni W: Mitochondria hyperpolarization is an early event in oxidized low-density lipoprotein-induced apoptosis in Caco-2 intestinal cells. FEBS Lett. 523:200–206. 2002. View Article : Google Scholar : PubMed/NCBI

27 

Imanishi T, Hano T, Sawamura T, Takarada S and Nishio I: Oxidized low density lipoprotein potentiation of Fas-induced apoptosis through lectin-like oxidized-low density lipoprotein receptor-1 in human umbilical vascular endothelial cells. Circ J. 66:1060–1064. 2002. View Article : Google Scholar : PubMed/NCBI

28 

Salvayre R, Auge N, Benoist H and Negre-Salvayre A: Oxidized low-density lipoprotein-induced apoptosis. Biochim Biophys Acta. 1585:213–221. 2002. View Article : Google Scholar : PubMed/NCBI

29 

Suo J, Zhao L, Wang J, Zhu Z, Zhang H and Gao R: Influenza virus aggravates the ox-LDL-induced apoptosis of human endothelial cells via promoting p53 signaling. J Med Virol. 87:1113–1123. 2015. View Article : Google Scholar : PubMed/NCBI

30 

Cominacini L, Pasini AF, Garbin U, Davoli A, Tosetti ML, Campagnola M, Rigoni A, Pastorino AM, Lo Cascio V and Sawamura T: Oxidized low density lipoprotein (ox-LDL) binding to ox-LDL receptor-1 in endothelial cells induces the activation of NF-kappaB through an increased production of intracellular reactive oxygen species. J Biol Chem. 275:12633–12638. 2000. View Article : Google Scholar : PubMed/NCBI

31 

Cominacini L, Rigoni A, Pasini AF, Garbin U, Davoli A, Campagnola M, Pastorino AM, Lo Cascio V and Sawamura T: The binding of oxidized low density lipoprotein (ox-LDL) to ox-LDL receptor-1 reduces the intracellular concentration of nitric oxide in endothelial cells through an increased production of superoxide. J Biol Chem. 276:13750–13755. 2001. View Article : Google Scholar : PubMed/NCBI

32 

Li D and Mehta JL: Antisense to LOX-1 inhibits oxidized LDL-mediated upregulation of monocyte chemoattractant protein-1 and monocyte adhesion to human coronary artery endothelial cells. Circulation. 101:2889–2895. 2000. View Article : Google Scholar : PubMed/NCBI

33 

Li D and Mehta JL: Upregulation of endothelial receptor for oxidized LDL (LOX-1) by oxidized LDL and implications in apoptosis of human coronary artery endothelial cells: Evidence from use of antisense LOX-1 mRNA and chemical inhibitors. Arterioscler Thromb Vasc Biol. 20:1116–1122. 2000. View Article : Google Scholar : PubMed/NCBI

34 

Morishima N, Nakanishi K, Takenouchi H, Shibata T and Yasuhiko Y: An endoplasmic reticulum stress-specific caspase cascade in apoptosis. Cytochrome c-independent activation of caspase-9 by caspase-12. J Biol Chem. 277:34287–34294. 2002. View Article : Google Scholar : PubMed/NCBI

35 

Luo Y, Lu S, Dong X, Xu L, Sun G and Sun X: Dihydromyricetin protects human umbilical vein endothelial cells from injury through ERK and Akt mediated Nrf2/HO-1 signaling pathway. Apoptosis. 22:1013–1024. 2017. View Article : Google Scholar : PubMed/NCBI

36 

Yin H, Zhou Y, Zhu M, Hou S, Li Z, Zhong H, Lu J, Meng T, Wang J, Xia L, et al: Role of mitochondria in programmed cell death mediated by arachidonic acid-derived eicosanoids. Mitochondrion. 13:209–224. 2013. View Article : Google Scholar : PubMed/NCBI

37 

Yu Y, Liu Q, Guo S, Zhang Q, Tang J, Liu G, Kong D, Li J, Yan S, Wang R, et al: 2, 3, 7, 8-Tetrachlorodibenzo-p-dioxin promotes endothelial cell apoptosis through activation of EP3/p38MAPK/Bcl-2 pathway. J Cell Mol Med. 21:3540–3551. 2017. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Hu Y, Li H, Liu K, Zhang Y, Ren L and Fan Z: Protective effects of icariin on human vascular endothelial cells induced by oxidized low-density lipoprotein via modulating caspase-3 and Bcl-2. Mol Med Rep 17: 6835-6839, 2018.
APA
Hu, Y., Li, H., Liu, K., Zhang, Y., Ren, L., & Fan, Z. (2018). Protective effects of icariin on human vascular endothelial cells induced by oxidized low-density lipoprotein via modulating caspase-3 and Bcl-2. Molecular Medicine Reports, 17, 6835-6839. https://doi.org/10.3892/mmr.2018.8717
MLA
Hu, Y., Li, H., Liu, K., Zhang, Y., Ren, L., Fan, Z."Protective effects of icariin on human vascular endothelial cells induced by oxidized low-density lipoprotein via modulating caspase-3 and Bcl-2". Molecular Medicine Reports 17.5 (2018): 6835-6839.
Chicago
Hu, Y., Li, H., Liu, K., Zhang, Y., Ren, L., Fan, Z."Protective effects of icariin on human vascular endothelial cells induced by oxidized low-density lipoprotein via modulating caspase-3 and Bcl-2". Molecular Medicine Reports 17, no. 5 (2018): 6835-6839. https://doi.org/10.3892/mmr.2018.8717
Copy and paste a formatted citation
x
Spandidos Publications style
Hu Y, Li H, Liu K, Zhang Y, Ren L and Fan Z: Protective effects of icariin on human vascular endothelial cells induced by oxidized low-density lipoprotein via modulating caspase-3 and Bcl-2. Mol Med Rep 17: 6835-6839, 2018.
APA
Hu, Y., Li, H., Liu, K., Zhang, Y., Ren, L., & Fan, Z. (2018). Protective effects of icariin on human vascular endothelial cells induced by oxidized low-density lipoprotein via modulating caspase-3 and Bcl-2. Molecular Medicine Reports, 17, 6835-6839. https://doi.org/10.3892/mmr.2018.8717
MLA
Hu, Y., Li, H., Liu, K., Zhang, Y., Ren, L., Fan, Z."Protective effects of icariin on human vascular endothelial cells induced by oxidized low-density lipoprotein via modulating caspase-3 and Bcl-2". Molecular Medicine Reports 17.5 (2018): 6835-6839.
Chicago
Hu, Y., Li, H., Liu, K., Zhang, Y., Ren, L., Fan, Z."Protective effects of icariin on human vascular endothelial cells induced by oxidized low-density lipoprotein via modulating caspase-3 and Bcl-2". Molecular Medicine Reports 17, no. 5 (2018): 6835-6839. https://doi.org/10.3892/mmr.2018.8717
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