Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Molecular Medicine Reports
Join Editorial Board Propose a Special Issue
Print ISSN: 1791-2997 Online ISSN: 1791-3004
Journal Cover
May-2018 Volume 17 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
May-2018 Volume 17 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

Benzoxazole derivatives suppress lipopolysaccharide-induced mast cell activation

  • Authors:
    • Kyung‑Ah Cho
    • Minhwa Park
    • Yu‑Hee Kim
    • Hea‑Young Park Choo
    • Kyung Ho Lee
  • View Affiliations / Copyright

    Affiliations: Department of Microbiology, School of Medicine, Ewha Womans University, Seoul 07985, Republic of Korea, College of Pharmacy and Graduate School of Pharmaceutical Sciences, Ewha Womans University, Seoul 03760, Republic of Korea, Department of Dermatology, Bucheon St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Bucheon‑si 14647, Republic of Korea
  • Pages: 6723-6730
    |
    Published online on: March 9, 2018
       https://doi.org/10.3892/mmr.2018.8719
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Mast cells are central regulators of allergic inflammation that function by releasing various proallergic inflammatory mediators, including histamine, eicosanoids and proinflammatory cytokines. Occasionally, bacterial infections may initiate or worsen allergic inflammation. A number of studies have indicated that activation of lipoxygenase in mast cells positive regulates allergic inflammatory responses by generating leukotrienes and proinflammatory cytokines. In the present study, the effects of benzoxazole derivatives on the lipopolysaccharide (LPS)‑induced expression of proinflammatory cytokines, production of histamine and surface expression of co‑stimulatory molecules on bone marrow-derived mast cells (BMMCs) were studied. The benzoxazole derivatives significantly reduced the expression of interleukin (IL)‑1β, IL‑6, IL‑13, tumor necrosis factor‑α, perilipin (PLIN) 2, and PLIN3 in BMMCs treated with LPS. Furthermore, histamine production was suppressed in BMMCs treated with LPS, or treated with phorbol-12-myristate-13-acetate/ionomycin. Benzoxazole derivatives marginally affected the surface expression of cluster of differentiation (CD)80 and CD86 on BMMCs in the presence of LPS, although LPS alone did not increase the expression of those proteins. Therefore, benzoxazole derivatives inhibited the secretion of proinflammatory cytokines in mast cells and may be potential candidate anti‑allergic agents to suppress mast cell activation.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

View References

1 

Sismanopoulos N, Delivanis DA, Alysandratos KD, Angelidou A, Therianou A, Kalogeromitros D and Theoharides TC: Mast cells in allergic and inflammatory diseases. Curr Pharm Des. 18:2261–2277. 2012. View Article : Google Scholar : PubMed/NCBI

2 

Wernersson S and Pejler G: Mast cell secretory granules: Armed for battle. Nat Rev Immunol. 14:478–494. 2014. View Article : Google Scholar : PubMed/NCBI

3 

Yamashita M and Nakayama T: Progress in allergy signal research on mast cells: Regulation of allergic airway inflammation through toll-like receptor 4-mediated modification of mast cell function. J Pharmacol Sci. 106:332–335. 2008. View Article : Google Scholar : PubMed/NCBI

4 

Masuda A, Yoshikai Y, Aiba K and Matsuguchi T: Th2 cytokine production from mast cells is directly induced by lipopolysaccharide and distinctly regulated by c-Jun N-terminal kinase and p38 pathways. J Immunol. 169:3801–3810. 2002. View Article : Google Scholar : PubMed/NCBI

5 

Murakami D, Yamada H, Yajima T, Masuda A, Komune S and Yoshikai Y: Lipopolysaccharide inhalation exacerbates allergic airway inflammation by activating mast cells and promoting Th2 responses. Clin Exp Allergy. 37:339–347. 2007. View Article : Google Scholar : PubMed/NCBI

6 

Nigo YI, Yamashita M, Hirahara K, Shinnakasu R, Inami M, Kimura M, Hasegawa A, Kohno Y and Nakayama T: Regulation of allergic airway inflammation through Toll-like receptor 4-mediated modification of mast cell function. Proc Natl Acad Sci USA. 103:pp. 2286–2291. 2006; View Article : Google Scholar : PubMed/NCBI

7 

Shiba E, Izawa K, Kaitani A, Isobe M, Maehara A, Uchida K, Maeda K, Nakano N, Ogawa H, Okumura K, et al: Ceramide-CD300f binding inhibits lipopolysaccharide-induced skin inflammation. J Biol Chem. 292:2924–2932. 2017. View Article : Google Scholar : PubMed/NCBI

8 

Kuhn H and O'Donnell VB: Inflammation and immune regulation by 12/15-lipoxygenases. Prog Lipid Res. 45:334–356. 2006. View Article : Google Scholar : PubMed/NCBI

9 

Han H, Liang X, Ekberg M, Kritikou JS, Brunnström Å, Pelcman B, Matl M, Miao X, Andersson M, Yuan X, et al: Human 15-lipoxygenase-1 is a regulator of dendritic-cell spreading and podosome formation. FASEB J. 31:491–504. 2017. View Article : Google Scholar : PubMed/NCBI

10 

Claesson HE: On the biosynthesis and biological role of eoxins and 15-lipoxygenase-1 in airway inflammation and Hodgkin lymphoma. Prostaglandins Other Lipid Mediat. 89:120–125. 2009. View Article : Google Scholar : PubMed/NCBI

11 

Ro M, Lee AJ and Kim JH: 5-/12-lipoxygenase-linked cascade contributes to the IL-33-induced synthesis of IL-13 in mast cells, thus promoting asthma development. Allergy. 73:350–360. 2018. View Article : Google Scholar : PubMed/NCBI

12 

Mashima R and Okuyama T: The role of lipoxygenases in pathophysiology; new insights and future perspectives. Redox Biol. 6:297–310. 2015. View Article : Google Scholar : PubMed/NCBI

13 

Song H, Oh SR, Lee HK, Han G, Kim JH, Chang HW, Doh KE, Rhee HK and Choo HY: Synthesis and evaluation of benzoxazole derivatives as 5-lipoxygenase inhibitors. Bioorg Med Chem. 18:7580–7585. 2010. View Article : Google Scholar : PubMed/NCBI

14 

Lee JH, An MH, Choi EH, Choo HYP and Han G: A facile synthesis of 2-acyl and 2-alkylaminobenzimidazoles for 5-lipoxygenase inhibitors. Heterocycles. 70:571–580. 2006. View Article : Google Scholar

15 

Yoon JH, Song H, Kim SW, Han G and Choo HYP: A facile synthesis of 2-aminothiazolo [5,4-b]pyridines and 2-aminobenzoxazoles via cyclization of thioureas. Heterocycles. 65:2729–2740. 2005. View Article : Google Scholar

16 

Kim D, Won HY, Hwang ES, Kim YK and Choo HP: Synthesis of benzoxazole derivatives as interleukin-6 antagonists. Bioorg Med Chem. 25:3127–3134. 2017. View Article : Google Scholar : PubMed/NCBI

17 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

18 

Chiba N, Masuda A, Yoshikai Y and Matsuguchi T: Ceramide inhibits LPS-induced production of IL-5, IL-10, and IL-13 from mast cells. J Cell Physiol. 213:126–136. 2007. View Article : Google Scholar : PubMed/NCBI

19 

Hochdörfer T, Tiedje C, Stumpo DJ, Blackshear PJ, Gaestel M and Huber M: LPS-induced production of TNF-α and IL-6 in mast cells is dependent on p38 but independent of TTP. Cell Signal. 25:1339–1347. 2013. View Article : Google Scholar : PubMed/NCBI

20 

Sandig H and Bulfone-Paus S: TLR signaling in mast cells: Common and unique features. Front Immunol. 3:1852012. View Article : Google Scholar : PubMed/NCBI

21 

Lopes DEM, Jabr CL, Dejani NN, Saraiva AC, de Aquino SG, Medeiros AI and Junior CR: Inhibition of 5-lipoxygenase (5-Lo) attenuates inflammation and bone resorption in lipopolysaccharide (Lps)-induced periodontal disease. J Periodontol. 1–18. 2017.(Epub ahead of print). View Article : Google Scholar : PubMed/NCBI

22 

Rossaint J, Nadler JL, Ley K and Zarbock A: Eliminating or blocking 12/15-lipoxygenase reduces neutrophil recruitment in mouse models of acute lung injury. Crit Care. 16:R1662012. View Article : Google Scholar : PubMed/NCBI

23 

Lee SJ, Seo KW and Kim CD: LPS increases 5-LO expression on monocytes via an activation of Akt-Sp1/NF-αB pathways. Korean J Physiol Pharmacol. 19:263–268. 2015. View Article : Google Scholar : PubMed/NCBI

24 

D'Avila H, Maya-Monteiro CM and Bozza PT: Lipid bodies in innate immune response to bacterial and parasite infections. Int Immunopharmacol. 8:1308–1315. 2008. View Article : Google Scholar : PubMed/NCBI

25 

Bozza PT, Bakker-Abreu I, Navarro-Xavier RA and Bandeira-Melo C: Lipid body function in eicosanoid synthesis: An update. Prostaglandins Leukot Essent Fatty Acids. 85:205–213. 2011. View Article : Google Scholar : PubMed/NCBI

26 

Dichlberger A, Schlager S, Lappalainen J, Käkelä R, Hattula K, Butcher SJ, Schneider WJ and Kovanen PT: Lipid body formation during maturation of human mast cells. J Lipid Res. 52:2198–2208. 2011. View Article : Google Scholar : PubMed/NCBI

27 

Nakamura Y, Franchi L, Kambe N, Meng G, Strober W and Núñez G: Critical role for mast cells in interleukin-1β-driven skin inflammation associated with an activating mutation in the nlrp3 protein. Immunity. 37:85–95. 2012. View Article : Google Scholar : PubMed/NCBI

28 

Shoji N, Yoshida A, Yu Z, Endo Y and Sasano T: Lipopolysaccharide stimulates histamine-forming enzyme (histidine decarboxylase) activity in murine dental pulp and gingiva. Arch Oral Biol. 51:856–860. 2006. View Article : Google Scholar : PubMed/NCBI

29 

Hershko AY and Rivera J: Mast cell and T cell communication; amplification and control of adaptive immunity. Immunol Lett. 128:98–104. 2010. View Article : Google Scholar : PubMed/NCBI

30 

Kambayashi T, Allenspach EJ, Chang JT, Zou T, Shoag JE, Reiner SL, Caton AJ and Koretzky GA: Inducible MHC class II expression by mast cells supports effector and regulatory T cell activation. J Immunol. 182:4686–4695. 2009. View Article : Google Scholar : PubMed/NCBI

31 

Espinosa E and Valitutti S: New roles and controls of mast cells. Curr Opin Immunol. 50:39–47. 2017. View Article : Google Scholar : PubMed/NCBI

32 

Nakamura Y and Kambe N: Linkage of bacterial colonization of skin and the urticaria-like rash of NLRP3-mediated autoinflammatory syndromes through mast cell-derived TNF-α. J Dermatol Sci. 71:83–88. 2013. View Article : Google Scholar : PubMed/NCBI

33 

Cho KA and Kang PB: PLIN2 inhibits insulin-induced glucose uptake in myoblasts through the activation of the NLRP3 inflammasome. Int J Mol Med. 36:839–844. 2015. View Article : Google Scholar : PubMed/NCBI

34 

Wisastra R and Dekker FJ: Inflammation, cancer and oxidative lipoxygenase activity are intimately linked. Cancers (Basel). 6:1500–1521. 2014. View Article : Google Scholar : PubMed/NCBI

35 

Werz O: Inhibition of 5-lipoxygenase product synthesis by natural compounds of plant origin. Planta Med. 73:1331–1357. 2007. View Article : Google Scholar : PubMed/NCBI

36 

Pettersen D, Davidsson Ö and Whatling C: Recent advances for FLAP inhibitors. Bioorg Med Chem Lett. 25:2607–2612. 2015. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Cho KA, Park M, Kim YH, Choo HYP and Lee KH: Benzoxazole derivatives suppress lipopolysaccharide-induced mast cell activation. Mol Med Rep 17: 6723-6730, 2018.
APA
Cho, K., Park, M., Kim, Y., Choo, H.P., & Lee, K.H. (2018). Benzoxazole derivatives suppress lipopolysaccharide-induced mast cell activation. Molecular Medicine Reports, 17, 6723-6730. https://doi.org/10.3892/mmr.2018.8719
MLA
Cho, K., Park, M., Kim, Y., Choo, H. P., Lee, K. H."Benzoxazole derivatives suppress lipopolysaccharide-induced mast cell activation". Molecular Medicine Reports 17.5 (2018): 6723-6730.
Chicago
Cho, K., Park, M., Kim, Y., Choo, H. P., Lee, K. H."Benzoxazole derivatives suppress lipopolysaccharide-induced mast cell activation". Molecular Medicine Reports 17, no. 5 (2018): 6723-6730. https://doi.org/10.3892/mmr.2018.8719
Copy and paste a formatted citation
x
Spandidos Publications style
Cho KA, Park M, Kim YH, Choo HYP and Lee KH: Benzoxazole derivatives suppress lipopolysaccharide-induced mast cell activation. Mol Med Rep 17: 6723-6730, 2018.
APA
Cho, K., Park, M., Kim, Y., Choo, H.P., & Lee, K.H. (2018). Benzoxazole derivatives suppress lipopolysaccharide-induced mast cell activation. Molecular Medicine Reports, 17, 6723-6730. https://doi.org/10.3892/mmr.2018.8719
MLA
Cho, K., Park, M., Kim, Y., Choo, H. P., Lee, K. H."Benzoxazole derivatives suppress lipopolysaccharide-induced mast cell activation". Molecular Medicine Reports 17.5 (2018): 6723-6730.
Chicago
Cho, K., Park, M., Kim, Y., Choo, H. P., Lee, K. H."Benzoxazole derivatives suppress lipopolysaccharide-induced mast cell activation". Molecular Medicine Reports 17, no. 5 (2018): 6723-6730. https://doi.org/10.3892/mmr.2018.8719
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team