Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Molecular Medicine Reports
Join Editorial Board Propose a Special Issue
Print ISSN: 1791-2997 Online ISSN: 1791-3004
Journal Cover
May-2018 Volume 17 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
May-2018 Volume 17 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

Pathway- and clinical-factor-based risk model predicts the prognosis of patients with gastric cancer

  • Authors:
    • Junchi Yang
    • Lumin Bo
    • Ting Han
    • Dan Ding
    • Mingming Nie
    • Kai Yin
  • View Affiliations / Copyright

    Affiliations: Department of Gastrointestinal Surgery, Changhai Hospital, Shanghai 200433, P.R. China, Department of Gastroenterology, Changhai Hospital, Shanghai 200433, P.R. China
    Copyright: © Yang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 6345-6356
    |
    Published online on: March 9, 2018
       https://doi.org/10.3892/mmr.2018.8722
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Gastric cancer (GC) has a high incidence and mortality rate. If discovered late, GC tends to have a poor prognosis. Improvements in the prognostic accuracy of GC through combined analysis of multiple relevant genes and clinical factors may solve this problem. In the present study, GSE62254 (including 300 GC tissues), obtained from the Gene Expression Omnibus database, was used as a training set, and the mRNA‑sequencing data of GC (including 384 GC tissues) downloaded from the Cancer Genome Atlas database served as a validation set. Based on the t‑test and Wilcoxon test, the significantly differentially expressed genes (DEGs) were obtained by screening the intersecting DEGs. The prognosis-associated genes and clinical factors were identified using Cox regression analysis in the R survival package. The optimal prognosis‑associated pathways were examined using the Cox‑proportional hazards (Cox‑PH) model in the R penalized package. Finally, risk prediction models were constructed and validated using the Cox‑PH model and the Kaplan‑Meier method, respectively. There were a total of 382 significant DEGs, including 268 upregulated genes and 114 downregulated genes. A total of 50 prognosis‑associated genes were identified, 16 optimal prognosis‑associated pathways (including mitochondrial pathway and the tyrosine‑protein kinase JAK‑signal transducer and activator of transcription signaling pathway, which involve caspase 7, phosphoinositide‑3‑kinase regulatory subunit 3, peroxisome proliferator‑activated receptor γ and collagen triple helix repeat containing 1) and four prognosis‑associated clinical factors [including Pathologic_N, Pathologic_stage, mutL homolog 1 (MLH1) mutation and recurrence]. The pathway‑ and clinical‑factor‑based risk prediction model exhibited marked prognostic accuracy. The clinical‑factor‑based risk prediction model with improved P‑values for prognosis prediction may be superior to the pathway‑based risk prediction model in predicting the prognosis of GC patients.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

Figure 6

Figure 7

Figure 8

View References

1 

Hartgrink HH, Jansen EP, van Grieken NC and van de Velde CJ: Gastric cancer. Lancet. 374:477–490. 2009. View Article : Google Scholar : PubMed/NCBI

2 

Sim F and Mckee M: Issues in Public Health. Open University Press; 2011, View Article : Google Scholar

3 

World Health Organization: World Cancer Report. 2014.

4 

Chang AH and Parsonnet J: Role of bacteria in oncogenesis. Clin Microbiol Rev. 23:837–857. 2010. View Article : Google Scholar : PubMed/NCBI

5 

Choi YY, An JY, Kim HI, Cheong JH, Hyung WJ and Noh SH: Current practice of gastric cancer treatment. Chin Med J. 127:547–553. 2014.PubMed/NCBI

6 

Raymond W and Ruddon RW: Cancer Biology. 4th. Oxford University Press; Oxford: pp. 7912007

7 

Orditura M, Galizia G, Sforza V, Gambardella V, Fabozzi A, Laterza MM, Andreozzi F, Ventriglia J, Savastano B, Mabilia A, et al: Treatment of gastric cancer. World J Gastroenterol. 20:1635–1649. 2014. View Article : Google Scholar : PubMed/NCBI

8 

Jian-bo X, Hui W, Yu-long H, Chang-hua Z, Long-juan Z, Shi-rong C and Wen-hua Z: Astrocyte-elevated gene-1 overexpression is associated with poor prognosis in gastric cancer. Med Oncol. 28:455–462. 2011. View Article : Google Scholar : PubMed/NCBI

9 

Liang L, Li L, Tian J, Lee SO, Dang Q, Huang CK, Yeh S, Erturk E, Bushinsky D, Chang LS, et al: Androgen receptor enhances kidney stone-CaOx crystal formation via modulation of oxalate biosynthesis & oxidative stress. Mol Endocrinol. 28:1291–1303. 2014. View Article : Google Scholar : PubMed/NCBI

10 

Gomez-Martin C, Plaza JC, Pazo-Cid R, Salud A, Pons F, Fonseca P, Leon A, Alsina M, Visa L, Rivera F, et al: Level of HER2 gene amplification predicts response and overall survival in HER2-positive advanced gastric cancer treated with trastuzumab. J Clin Oncol. 31:4445–4452. 2013. View Article : Google Scholar : PubMed/NCBI

11 

Wang DD, Chen YB, Pan K, Wang W, Chen SP, Chen JG, Zhao JJ, Lv L, Pan QZ, Li YQ, et al: Decreased expression of the ARID1A gene is associated with poor prognosis in primary gastric cancer. PLoS One. 7:e403642012. View Article : Google Scholar : PubMed/NCBI

12 

Yan HB, Wang XF, Zhang Q, Tang ZQ, Jiang YH, Fan HZ, Sun YH, Yang PY and Liu F: Reduced expression of the chromatin remodeling gene ARID1A enhances gastric cancer cell migration and invasion via downregulation of E-cadherin transcription. Carcinogenesis. 35:867–876. 2014. View Article : Google Scholar : PubMed/NCBI

13 

Okugawa Y, Tanaka K, Inoue Y, Kawamura M, Kawamoto A, Hiro J, Saigusa S, Toiyama Y, Ohi M, Uchida K, et al: Brain-derived neurotrophic factor/tropomyosin-related kinase B pathway in gastric cancer. Br J Cancer. 108:121–130. 2013. View Article : Google Scholar : PubMed/NCBI

14 

Santoro R, Carboni F, Lepiane P, Ettorre GM and Santoro E: Clinicopathological features and prognosis of gastric cancer in young European adults. Br J Surg. 94:737–742. 2007. View Article : Google Scholar : PubMed/NCBI

15 

Shimada H, Noie T, Ohashi M, Oba K and Takahashi Y: Clinical significance of serum tumor markers for gastric cancer: A systematic review of literature by the Task Force of the Japanese Gastric Cancer Association. Gastric Cancer. 17:26–33. 2014. View Article : Google Scholar : PubMed/NCBI

16 

Huang S, Yee C, Ching T, Yu H and Garmire LX: A novel model to combine clinical and pathway-based transcriptomic information for the prognosis prediction of breast cancer. PLoS Comput Biol. 10:e10038512014. View Article : Google Scholar : PubMed/NCBI

17 

Huang S, Chong N, Lewis NE, Jia W, Xie G and Garmire LX: Novel personalized pathway-based metabolomics models reveal key metabolic pathways for breast cancer diagnosis. Genome Med. 8:342016. View Article : Google Scholar : PubMed/NCBI

18 

Cristescu R, Lee J, Nebozhyn M, Kim KM, Ting JC, Wong SS, Liu J, Yue YG, Wang J, Yu K, et al: Molecular analysis of gastric cancer identifies subtypes associated with distinct clinical outcomes. Nat Med. 21:449–456. 2015. View Article : Google Scholar : PubMed/NCBI

19 

Woo HG, Park ES, Cheon JH, Kim JH, Lee JS, Park BJ, Kim W, Park SC, Chung YJ, Kim BG, et al: Gene expression-based recurrence prediction of hepatitis B virus-related human hepatocellular carcinoma. Clin Cancer Res. 14:2056–2064. 2008. View Article : Google Scholar : PubMed/NCBI

20 

Irizarry RA, Bolstad BM, Collin F, Cope LM, Hobbs B and Speed TP: Summaries of Affymetrix GeneChip probe level data. Nucleic Acids Res. 31:e152003. View Article : Google Scholar : PubMed/NCBI

21 

R Core Team: R: A language and environment for statistical computing. Vienna, Austria: The R Foundation for Statistical Computing. http://www.R-project.org/2017.

22 

Kruschke JK: Bayesian estimation supersedes the t test. J Exp Psychol Gen. 142:573–603. 2013. View Article : Google Scholar : PubMed/NCBI

23 

Nagarajan N and Keich U: Reliability and efficiency of algorithms for computing the significance of the Mann-Whitney test. Comput Stat. 24:6052009. View Article : Google Scholar

24 

Therneau T: A package for survival analysis in S. R package version. 2:37. 2014.

25 

Farinelli A, Bicego M, Bistaffa F and Ramchurn SD: A hierarchical clustering approach to large-scale near-optimal coalition formation with quality guarantees. Eng Appl Art Intell. 59:170–185. 2017. View Article : Google Scholar

26 

Kolde R: Pheatmap: Pretty Heatmaps [Software]. 2015.

27 

Subramanian A, Tamayo P, Mootha VK, Mukherjee S, Ebert BL, Gillette MA, Paulovich A, Pomeroy SL, Golub TR, Lander ES and Mesirov JP: Gene set enrichment analysis: A knowledge-based approach for interpreting genome-wide expression profiles. Proc Natl Acad Sci USA. 102:pp. 15545–15550. 2005; View Article : Google Scholar : PubMed/NCBI

28 

Drier Y, Sheffer M and Domany E: Pathway-based personalized analysis of cancer. Proc Natl Acad Sci USA. 110:pp. 6388–6393. 2013; View Article : Google Scholar : PubMed/NCBI

29 

Goeman JJ: L1 penalized estimation in the Cox proportional hazards model. Biom J. 52:70–84. 2010.PubMed/NCBI

30 

Bachoc F: Cross validation and maximum likelihood estimations of hyper-parameters of Gaussian processes with model misspecification. Comput Stat Data Anal. 66:55–69. 2013. View Article : Google Scholar

31 

Yoo NJ, Lee JW, Kim YJ, Soung YH, Kim SY, Nam SW, Park WS, Lee JY and Lee SH: Loss of caspase-2, −6 and −7 expression in gastric cancers. APMIS. 112:330–335. 2004. View Article : Google Scholar : PubMed/NCBI

32 

Wang MY, Zhu ML, He J, Shi TY, Li QX, Wang YN, Li J, Zhou XY, Sun MH, Wang XF, et al: Potentially functional polymorphisms in the CASP7 gene contribute to gastric adenocarcinoma susceptibility in an eastern Chinese population. PLoS One. 8:e740412013. View Article : Google Scholar : PubMed/NCBI

33 

Zhou J, Chen GB, Tang YC, Sinha RA, Wu Y, Yap CS, Wang G, Hu J, Xia X, Tan P, et al: Genetic and bioinformatic analyses of the expression and function of PI3K regulatory subunit PIK3R3 in an Asian patient gastric cancer library. BMC Med Genomics. 5:342012. View Article : Google Scholar : PubMed/NCBI

34 

Fang WL, Huang KH, Lan YT, Lin CH, Chang SC, Chen MH, Chao Y, Lin WC, Lo SS, Li AF, et al: Mutations in PI3K/AKT pathway genes and amplifications of PIK3CA are associated with patterns of recurrence in gastric cancers. Oncotarget. 7:6201–6220. 2016. View Article : Google Scholar : PubMed/NCBI

35 

Matsuoka T and Yashiro M: The role of PI3K/Akt/mTOR signaling in gastric carcinoma. Cancers. 6:1441–1463. 2014. View Article : Google Scholar : PubMed/NCBI

36 

Konturek PC, Kania J, Kukharsky V, Raithel M, Ocker M, Rembiasz K, Hahn EG and Konturek SJ: Implication of peroxisome proliferator-activated receptor gamma and proinflammatory cytokines in gastric carcinogenesis: Link to Helicobacter pylori-infection. J Pharmacol Sci. 96:134–143. 2004. View Article : Google Scholar : PubMed/NCBI

37 

Konturek PC, Kania J, Konturek JW, Nikiforuk A, Konturek SJ and Hahn EG: H. pylori infection, atrophic gastritis, cytokines, gastrin, COX-2, PPAR gamma and impaired apoptosis in gastric carcinogenesis. Med Sci Monit. 9:SR53–SR66. 2003.PubMed/NCBI

38 

Guo F, Ren X, Dong Y, Hu X, Xu D, Zhou H, Meng F, Tian W and Zhao Y: Constitutive expression of PPARγ inhibits proliferation and migration of gastric cancer cells and down-regulates Wnt/β-Catenin signaling pathway downstream target genes TERT and ENAH. Gene. 584:31–37. 2016. View Article : Google Scholar : PubMed/NCBI

39 

Wang P, Wang YC, Chen XY, Shen ZY, Cao H, Zhang YJ, Yu J, Zhu JD, Lu YY and Fang JY: CTHRC1 is upregulated by promoter demethylation and transforming growth factor-β1 and may be associated with metastasis in human gastric cancer. Cancer Sci. 103:1327–1333. 2012. View Article : Google Scholar : PubMed/NCBI

40 

Yu J, Feng J, Zhi X, Tang J, Li Z, Xu Y, Yang L, Hu Z and Xu Z: Let-7b inhibits cell proliferation, migration, and invasion through targeting Cthrc1 in gastric cancer. Tumour Biol. 36:3221–3229. 2015. View Article : Google Scholar : PubMed/NCBI

41 

Gu L, Liu L, Zhong L, Bai Y, Sui H, Wei X, Zhang W, Huang P, Gao D, Kong Y and Lou G: Cthrc1 overexpression is an independent prognostic marker in gastric cancer. Hum Pathol. 45:1031–1038. 2014. View Article : Google Scholar : PubMed/NCBI

42 

Ji YB, Qu ZY and Zou X: Juglone-induced apoptosis in human gastric cancer SGC-7901 cells via the mitochondrial pathway. Exp Toxicol Pathol. 63:69–78. 2011. View Article : Google Scholar : PubMed/NCBI

43 

Zhang H, Fang DC, Lan CH and Luo YH: Helicobacter pylori infection induces apoptosis in gastric cancer cells through the mitochondrial pathway. J Gastroenterol Hepatol. 22:1051–1056. 2007. View Article : Google Scholar : PubMed/NCBI

44 

Yu RX, Hu XM, Xu SQ, Jiang ZJ and Yang W: Effects of fucoxanthin on proliferation and apoptosis in human gastric adenocarcinoma MGC-803 cells via JAK/STAT signal pathway. Eur J Pharmacol. 657:10–19. 2011. View Article : Google Scholar : PubMed/NCBI

45 

Shigeyasu K, Nagasaka T, Mori Y, Yokomichi N, Kawai T, Fuji T, Kimura K, Umeda Y, Kagawa S, Goel A and Fujiwara T: Clinical significance of MLH1 methylation and CpG island methylator phenotype as prognostic markers in patients with gastric cancer. PLoS One. 10:e01304092015. View Article : Google Scholar : PubMed/NCBI

46 

Li Y, Yang Y, Lu Y, Herman JG, Brock MV, Zhao P and Guo M: Predictive value of CHFR and MLH1 methylation in human gastric cancer. Gastric Cancer. 18:280–287. 2015. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Yang J, Bo L, Han T, Ding D, Nie M and Yin K: Pathway- and clinical-factor-based risk model predicts the prognosis of patients with gastric cancer. Mol Med Rep 17: 6345-6356, 2018.
APA
Yang, J., Bo, L., Han, T., Ding, D., Nie, M., & Yin, K. (2018). Pathway- and clinical-factor-based risk model predicts the prognosis of patients with gastric cancer. Molecular Medicine Reports, 17, 6345-6356. https://doi.org/10.3892/mmr.2018.8722
MLA
Yang, J., Bo, L., Han, T., Ding, D., Nie, M., Yin, K."Pathway- and clinical-factor-based risk model predicts the prognosis of patients with gastric cancer". Molecular Medicine Reports 17.5 (2018): 6345-6356.
Chicago
Yang, J., Bo, L., Han, T., Ding, D., Nie, M., Yin, K."Pathway- and clinical-factor-based risk model predicts the prognosis of patients with gastric cancer". Molecular Medicine Reports 17, no. 5 (2018): 6345-6356. https://doi.org/10.3892/mmr.2018.8722
Copy and paste a formatted citation
x
Spandidos Publications style
Yang J, Bo L, Han T, Ding D, Nie M and Yin K: Pathway- and clinical-factor-based risk model predicts the prognosis of patients with gastric cancer. Mol Med Rep 17: 6345-6356, 2018.
APA
Yang, J., Bo, L., Han, T., Ding, D., Nie, M., & Yin, K. (2018). Pathway- and clinical-factor-based risk model predicts the prognosis of patients with gastric cancer. Molecular Medicine Reports, 17, 6345-6356. https://doi.org/10.3892/mmr.2018.8722
MLA
Yang, J., Bo, L., Han, T., Ding, D., Nie, M., Yin, K."Pathway- and clinical-factor-based risk model predicts the prognosis of patients with gastric cancer". Molecular Medicine Reports 17.5 (2018): 6345-6356.
Chicago
Yang, J., Bo, L., Han, T., Ding, D., Nie, M., Yin, K."Pathway- and clinical-factor-based risk model predicts the prognosis of patients with gastric cancer". Molecular Medicine Reports 17, no. 5 (2018): 6345-6356. https://doi.org/10.3892/mmr.2018.8722
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team