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Article Open Access

miR-25 enhances cell migration and invasion in non-small-cell lung cancer cells via ERK signaling pathway by inhibiting KLF4

  • Authors:
    • Xiaoli Ding
    • Tianyu Zhong
    • Lixia Jiang
    • Junyun Huang
    • Yu Xia
    • Rong Hu
  • View Affiliations / Copyright

    Affiliations: Department of Laboratory Medicine, First Affiliated Hospital of Gannan Medical University, Ganzhou, Jiangxi 341000, P.R. China , Graduate Student Major of Laboratory Medicine of Gannan Medical University, Ganzhou, Jiangxi 341000, P.R. China
    Copyright: © Ding et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 7005-7016
    |
    Published online on: March 16, 2018
       https://doi.org/10.3892/mmr.2018.8772
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Abstract

In recent years, microRNAs (miRNAs/miRs) have gained increasing interest in cancer research. Increasing evidences demonstrated that miRNAs are important for tumor early detection and prognosis. The present study aimed to explore the function of miR‑25 in non‑small‑cell lung cancer (NSCLC) and its underlying mechanisms. The expression levels of miR‑25 and Krüppel-like factor 4 (KLF4) were assessed in 31 pairs of tissue from patients with NSCLC. In addition, the biological roles of miR‑25 in NSCLC were analyzed via a cell wound healing assay, Transwell invasion and migration assays. Target genes of miR‑25 were predicted using TargetScan and verified via a dual luciferase activity assay, western blotting and reverse transcription‑quantitative polymerase chain reaction. The downstream signaling pathway was confirmed by western blot analysis. In the present study, miR‑25 was overexpressed in 31 NSCLC samples compared with in corresponding normal tissues. Overexpression of miR‑25 using miR‑25 mimics markedly promoted NSCLC cell migration and invasion, while inhibition of miR‑25 exerted the opposite effect. KLF4 was suggested to be a novel target gene of miR‑25 in NSCLC cells. Knockdown of KLF4 promoted the migration and invasion of NSCLC cells, whereas rescue of KLF4 expression reduced cell motion ability in miR‑25‑overexpressing NSCLC cells. Furthermore, it was demonstrated that miR‑25 activated the extracellular signal‑regulated kinase (ERK) signaling pathway, which eventually led to increased vimentin, matrix metalloproteinase 11 and N‑cadherin levels, and the downregulation of E‑cadherin expression by inhibiting the expression of KLF4. In conclusion, miR‑25 was demonstrated to activate the ERK signaling pathway by directly targeting KLF4, promoting cell migration and invasion. The findings of the present study indicated that miR‑25 or KLF4 may serve as a therapeutic target for the treatment of NSCLC.
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1 

Torre LA, Bray F, Siegel RL, Ferlay J, Lortet-Tieulent J and Jemal A: Global cancer statistics, 2012. CA Cancer J Clin. 65:87–108. 2015. View Article : Google Scholar : PubMed/NCBI

2 

Torre LA, Siegel RL and Jemal A: Lung cancer statistics. Adv Exp Med Biol. 893:1–19. 2016. View Article : Google Scholar : PubMed/NCBI

3 

Chen Z, Fillmore CM, Hammerman PS, Kim CF and Wong KK: Non-small-cell lung cancers: A heterogeneous set of diseases. Nat Rev Cancer. 14:535–546. 2014. View Article : Google Scholar : PubMed/NCBI

4 

Moreira AL and Eng J: Personalized therapy for lung cancer. Chest. 146:1649–1657. 2014. View Article : Google Scholar : PubMed/NCBI

5 

Preiss A, Rosenberg UB, Kienlin A, Seifert E and Jäckle H: Molecular genetics of Kruppel, a gene required for segmentation of the drosophila embryo. Nature. 313:27–32. 1985. View Article : Google Scholar : PubMed/NCBI

6 

Shields JM, Christy RJ and Yang VW: Identification and characterization of a gene encoding a gut-enriched Kruppel-like factor expressed during growth arrest. J Biol Chem. 271:20009–20017. 1996. View Article : Google Scholar : PubMed/NCBI

7 

Pandya AY, Talley LI, Frost AR, Fitzgerald TJ, Trivedi V, Chakravarthy M, Chhieng DC, Grizzle WE, Engler JA, Krontiras H, et al: Nuclear localization of KLF4 is associated with an aggressive phenotype in early-stage breast cancer. Clin Cancer Res. 10:2709–2719. 2004. View Article : Google Scholar : PubMed/NCBI

8 

Chen YJ, Wu CY, Chang CC, Ma CJ, Li MC and Chen CM: Nuclear Kruppel-like factor 4 expression is associated with human skin squamous cell carcinoma progression and metastasis. Cancer Biol Ther. 7:777–782. 2008. View Article : Google Scholar : PubMed/NCBI

9 

Wang N, Liu ZH, Ding F, Wang XQ, Zhou CN and Wu M: Down-regulation of gut-enriched Kruppel-like factor expression in esophageal cancer. World J Gastroenterol. 8:966–970. 2002. View Article : Google Scholar : PubMed/NCBI

10 

Wei D, Gong W, Kanai M, Schlunk C, Wang L, Yao JC, Wu TT, Huang S and Xie K: Drastic down-regulation of Kruppel-like factor 4 expression is critical in human gastric cancer development and progression. Cancer Res. 65:2746–2754. 2005. View Article : Google Scholar : PubMed/NCBI

11 

Wei D, Kanai M, Huang S and Xie K: Emerging role of KLF4 in human gastrointestinal cancer. Carcinogenesis. 27:23–31. 2006. View Article : Google Scholar : PubMed/NCBI

12 

Bartel DP: MicroRNAs: Genomics, biogenesis, mechanism, and function. Cell. 116:281–297. 2004. View Article : Google Scholar : PubMed/NCBI

13 

Friedman RC, Farh KK, Burge CB and Bartel DP: Most mammalian mRNAs are conserved targets of microRNAs. Genome Res. 19:92–105. 2009. View Article : Google Scholar : PubMed/NCBI

14 

Li X, Li H, Zhang R and Liu J and Liu J: MicroRNA-449a inhibits proliferation and induces apoptosis by directly repressing E2F3 in gastric cancer. Cell Physiol Biochem. 35:2033–2042. 2015. View Article : Google Scholar : PubMed/NCBI

15 

Yang C, Ning S, Li Z, Qin X and Xu W: miR-22 is down-regulated in esophageal squamous cell carcinoma and inhibits cell migration and invasion. Cancer Cell Int. 14:1382014. View Article : Google Scholar : PubMed/NCBI

16 

Wang D, Qiu C, Zhang H, Wang J, Cui Q and Yin Y: Human microRNA oncogenes and tumor suppressors show significantly different biological patterns: From functions to targets. PLoS One. 5:pii: e13067. 2010. View Article : Google Scholar

17 

Xiao P, Liu W and Zhou H: miR-429 promotes the proliferation of non-small cell lung cancer cells via targeting DLC-1. Oncol Lett. 12:2163–2168. 2016. View Article : Google Scholar : PubMed/NCBI

18 

Hu W, Jin P, Ding C and Liu W: miR-19a/b modulates lung cancer cells metastasis through suppression of MXD1 expression. Oncol Lett. 12:1901–1905. 2016. View Article : Google Scholar : PubMed/NCBI

19 

Wang WM and Liu JC: Effect and molecular mechanism of mir-146a on proliferation of lung cancer cells by targeting and regulating MIF gene. Asian Pac J Trop Med. 9:806–811. 2016. View Article : Google Scholar : PubMed/NCBI

20 

Zhang HB, Sun LC, Ling L, Cong LH and Lian R: miR-143 suppresses the proliferation of NSCLC cells by inhibiting the epidermal growth factor receptor. Exp Ther Med. 12:1795–1802. 2016. View Article : Google Scholar : PubMed/NCBI

21 

Shi H, Ji Y, Zhang D, Liu Y and Fang P: MicroRNA-3666-induced suppression of SIRT7 inhibits the growth of non-small cell lung cancer cells. Oncol Rep. 36:3051–3057. 2016. View Article : Google Scholar : PubMed/NCBI

22 

Perepelyuk M, Maher C, Lakshmikuttyamma A and Shoyele SA: Aptamer-hybrid nanoparticle bioconjugate efficiently delivers miRNA-29b to non-small-cell lung cancer cells and inhibits growth by downregulating essential oncoproteins. Int J Nanomedicine. 11:3533–3544. 2016. View Article : Google Scholar : PubMed/NCBI

23 

Petrocca F, Vecchione A and Croce CM: Emerging role of miR-106b-25/miR-17-92 clusters in the control of transforming growth factor beta signaling. Cancer Res. 68:8191–8194. 2008. View Article : Google Scholar : PubMed/NCBI

24 

Savita U and Karunagaran D: MicroRNA-106b-25 cluster targets β-TRCP2, increases the expression of Snail and enhances cell migration and invasion in H1299 (non small cell lung cancer) cells. Biochem Biophys Res Commun. 434:841–847. 2013. View Article : Google Scholar : PubMed/NCBI

25 

Su ZX, Zhao J, Rong ZH, Geng WM, Wu YG and Qin CK: Upregulation of microRNA-25 associates with prognosis in hepatocellular carcinoma. Diagn Pathol. 9:472014. View Article : Google Scholar : PubMed/NCBI

26 

Li BS, Zuo QF, Zhao YL, Xiao B, Zhuang Y, Mao XH, Wu C, Yang SM, Zeng H, Zou QM and Guo G: MicroRNA-25 promotes gastric cancer migration, invasion and proliferation by directly targeting transducer of ERBB2, 1 and correlates with poor survival. Oncogene. 34:2556–2565. 2015. View Article : Google Scholar : PubMed/NCBI

27 

Zhou J, Wang J, Wu S, Zhu S, Wang S, Zhou H, Tian X, Tang N and Nie S: Angiopoietin-like protein 2 negatively regulated by microRNA-25 contributes to the malignant progression of colorectal cancer. Int J Mol Med. 34:1286–1292. 2014. View Article : Google Scholar : PubMed/NCBI

28 

Wu T, Chen W, Kong D, Li X, Lu H, Liu S, Wang J, Du L, Kong Q, Huang X and Lu Z: miR-25 targets the modulator of apoptosis 1 gene in lung cancer. Carcinogenesis. 36:925–935. 2015. View Article : Google Scholar : PubMed/NCBI

29 

Xiang J, Hang JB, Che JM and Li HC: MiR-25 is up-regulated in non-small cell lung cancer and promotes cell proliferation and motility by targeting FBXW7. Int J Clin Exp Pathol. 8:9147–9153. 2015.PubMed/NCBI

30 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

31 

Wang Z, Wang J, Yang Y, Hao B, Wang R, Li Y and Wu Q: Loss of has-miR-337-3p expression is associated with lymph node metastasis of human gastric cancer. J Exp Clin Cancer Res. 32:762013. View Article : Google Scholar : PubMed/NCBI

32 

Chen X, Zhai Y, Yu D, Cui J, Hu JF and Li W: Valproic acid enhances iPSC induction from human bone marrow-derived cells through the suppression of reprogramming-induced senescence. J Cell Physiol. 231:1719–1727. 2016. View Article : Google Scholar : PubMed/NCBI

33 

Zhai Y, Chen X, Yu D, Li T, Cui J, Wang G, Hu JF and Li W: Histone deacetylase inhibitor valproic acid promotes the induction of pluripotency in mouse fibroblasts by suppressing reprogramming-induced senescence stress. Exp Cell Res. 337:61–67. 2015. View Article : Google Scholar : PubMed/NCBI

34 

Patel RS, Carter G, El Bassit G, Patel AA, Cooper DR, Murr M and Patel NA: Adipose-derived stem cells from lean and obese humans show depot specific differences in their stem cell markers, exosome contents and senescence: Role of protein kinase C delta (PKCδ) in adipose stem cell niche. Stem Cell Investig. 3:22016.PubMed/NCBI

35 

Xu Q, Liu M, Zhang J, Xue L, Zhang G, Hu C, Wang Z, He S, Chen L, Ma K, et al: Overexpression of KLF4 promotes cell senescence through microRNA-203-survivin-p21 pathway. Oncotarget. 7:60290–60302. 2016.PubMed/NCBI

36 

Yu T, Chen X, Zhang W, Liu J, Avdiushko R, Napier DL, Liu AX, Neltner JM, Wang C, Cohen D and Liu C: KLF4 regulates adult lung tumor-initiating cells and represses K-Ras-mediated lung cancer. Cell Death Differ. 23:207–215. 2016. View Article : Google Scholar : PubMed/NCBI

37 

Hu W, Jia Y, Xiao X, Lv K, Chen Y, Wang L, Luo X, Liu T, Li W, Li Y, et al: KLF4 downregulates hTERT expression and telomerase activity to inhibit lung carcinoma growth. Oncotarget. 7:52870–52887. 2016.PubMed/NCBI

38 

Hu W, Hofstetter WL, Li H, Zhou Y, He Y, Pataer A, Wang L, Xie K, Swisher SG and Fang B: Putative tumor-suppressive function of Kruppel-like factor 4 in primary lung carcinoma. Clin Cancer Res. 15:5688–5695. 2009. View Article : Google Scholar : PubMed/NCBI

39 

Zheng B, Han M, Bernier M, Zhang XH, Meng F, Miao SB, He M, Zhao XM and Wen JK: Kruppel-like factor 4 inhibits proliferation by platelet-derived growth factor receptor beta-mediated, not by retinoic acid receptor alpha-mediated, phosphatidylinositol 3-kinase and ERK signaling in vascular smooth muscle cells. J Biol Chem. 284:22773–22785. 2009. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Ding X, Zhong T, Jiang L, Huang J, Xia Y and Hu R: miR-25 enhances cell migration and invasion in non-small-cell lung cancer cells via ERK signaling pathway by inhibiting KLF4. Mol Med Rep 17: 7005-7016, 2018.
APA
Ding, X., Zhong, T., Jiang, L., Huang, J., Xia, Y., & Hu, R. (2018). miR-25 enhances cell migration and invasion in non-small-cell lung cancer cells via ERK signaling pathway by inhibiting KLF4. Molecular Medicine Reports, 17, 7005-7016. https://doi.org/10.3892/mmr.2018.8772
MLA
Ding, X., Zhong, T., Jiang, L., Huang, J., Xia, Y., Hu, R."miR-25 enhances cell migration and invasion in non-small-cell lung cancer cells via ERK signaling pathway by inhibiting KLF4". Molecular Medicine Reports 17.5 (2018): 7005-7016.
Chicago
Ding, X., Zhong, T., Jiang, L., Huang, J., Xia, Y., Hu, R."miR-25 enhances cell migration and invasion in non-small-cell lung cancer cells via ERK signaling pathway by inhibiting KLF4". Molecular Medicine Reports 17, no. 5 (2018): 7005-7016. https://doi.org/10.3892/mmr.2018.8772
Copy and paste a formatted citation
x
Spandidos Publications style
Ding X, Zhong T, Jiang L, Huang J, Xia Y and Hu R: miR-25 enhances cell migration and invasion in non-small-cell lung cancer cells via ERK signaling pathway by inhibiting KLF4. Mol Med Rep 17: 7005-7016, 2018.
APA
Ding, X., Zhong, T., Jiang, L., Huang, J., Xia, Y., & Hu, R. (2018). miR-25 enhances cell migration and invasion in non-small-cell lung cancer cells via ERK signaling pathway by inhibiting KLF4. Molecular Medicine Reports, 17, 7005-7016. https://doi.org/10.3892/mmr.2018.8772
MLA
Ding, X., Zhong, T., Jiang, L., Huang, J., Xia, Y., Hu, R."miR-25 enhances cell migration and invasion in non-small-cell lung cancer cells via ERK signaling pathway by inhibiting KLF4". Molecular Medicine Reports 17.5 (2018): 7005-7016.
Chicago
Ding, X., Zhong, T., Jiang, L., Huang, J., Xia, Y., Hu, R."miR-25 enhances cell migration and invasion in non-small-cell lung cancer cells via ERK signaling pathway by inhibiting KLF4". Molecular Medicine Reports 17, no. 5 (2018): 7005-7016. https://doi.org/10.3892/mmr.2018.8772
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