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Intensity‑dependent effect of treadmill running on differentiation of rat bone marrow stromal cells

  • Authors:
    • Sheng‑Yao Liu
    • Zhe Li
    • Shao‑Yong Xu
    • Lei Xu
    • Mo Yang
    • Guo‑Xin Ni
  • View Affiliations / Copyright

    Affiliations: Department of Orthopedics and Traumatology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong 510515, P.R. China, Department of Hematology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong 510515, P.R. China
    Copyright: © Liu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 7746-7756
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    Published online on: March 28, 2018
       https://doi.org/10.3892/mmr.2018.8797
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Abstract

The effect of running on bone mass depends on its intensity. However, the underlying molecular mechanism that associates running intensity with bone mass is unclear. The current study examined the effects of treadmill running at different intensities on bone mass and osteogenic differentiation of bone marrow stromal cells (BMSCs) in a rat model. A total of 24 male Wistar rats were randomly divided into groups and subjected to no running (Con group), low‑intensity running (LIR group), moderate‑intensity running (MIR group), and high‑intensity running (HIR group). Histological, immunohistochemistry and micro‑CT examinations were performed on the femora harvested after 8 weeks of treadmill running. The study demonstrated that treadmill running affected trabecular bone mass in an intensity‑dependent manner. In addition, such an intensity‑dependent effect was also demonstrated on the osteogenic and adipogenic differentiation and proliferation of BMSCs. Furthermore, the Wnt/β‑catenin signaling pathway may be involved in the running‑induced increase in bone mass in rats in the MIR group. There appears to be a biomechanical ‘window’, in which running‑induced strain signals can increase the number of BMSCs and progenitor cells (specific to the osteoblast lineage) causing upregulation of osteogenesis and downregulation of adipogenesis of BMSCs. This finding may provide insight into the molecular and cellular mechanisms responsible for bone homeostasis.
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1 

Williams PT: Lower prevalence of hypertension, hypercholesterolemia, and diabetes in marathoners. Med Sci Sports Exerc. 41:523–529. 2009. View Article : Google Scholar : PubMed/NCBI

2 

Schneider S, Askew CD, Diehl J, Mierau A, Kleinert J, Abel T, Carnahan H and Strüder HK: EEG activity and mood in health orientated runners after different exercise intensities. Physiol Behav. 96:709–716. 2009. View Article : Google Scholar : PubMed/NCBI

3 

Iwamoto J, Takeda T and Sato Y: Effect of treadmill exercise on bone mass in female rats. Exp Anim. 54:1–6. 2005. View Article : Google Scholar : PubMed/NCBI

4 

Bourrin S, Genty C, Palle S, Gharib C and Alexandre C: Adverse effects of strenuous exercise: a densitometric and histomorphometric study in the rat. J Appl Physiol (1985). 76:1999–2005. 1994. View Article : Google Scholar : PubMed/NCBI

5 

Hind K, Truscott JG and Evans JA: Low lumbar spine bone mineral density in both male and female endurance runners. Bone. 39:880–885. 2006. View Article : Google Scholar : PubMed/NCBI

6 

Lappe J, Cullen D, Haynatzki G, Recker R, Ahlf R and Thompson K: Calcium and vitamin d supplementation decreases incidence of stress fractures in female navy recruits. J Bone Miner Res. 23:741–749. 2008. View Article : Google Scholar : PubMed/NCBI

7 

Frost HM: Bone's mechanostat: A 2003 update. Anat Rec A Discov Mol Cell Evol Biol. 275:1081–1101. 2003. View Article : Google Scholar : PubMed/NCBI

8 

Ozcivici E, Luu YK, Adler B, Qin YX, Rubin J, Judex S and Rubin CT: Mechanical signals as anabolic agents in bone. Nat Rev Rheumatol. 6:50–59. 2010. View Article : Google Scholar : PubMed/NCBI

9 

Rubin CT and Lanyon LE: Regulation of bone mass by mechanical strain magnitude. Calcif Tissue Int. 37:411–417. 1985. View Article : Google Scholar : PubMed/NCBI

10 

Scott A, Khan KM, Duronio V and Hart DA: Mechanotransduction in human bone: In vitro cellular physiology that underpins bone changes with exercise. Sports Med. 38:139–160. 2008. View Article : Google Scholar : PubMed/NCBI

11 

Klein-Nulend J, Bacabac RG and Bakker AD: Mechanical loading and how it affects bone cells: The role of the osteocyte cytoskeleton in maintaining our skeleton. Eur Cell Mater. 24:278–291. 2012. View Article : Google Scholar : PubMed/NCBI

12 

Georgiou KR, Scherer MA, Fan CM, Cool JC, King TJ, Foster BK and Xian CJ: Methotrexate chemotherapy reduces osteogenesis but increases adipogenic potential in the bone marrow. J Cell Physiol. 227:909–918. 2012. View Article : Google Scholar : PubMed/NCBI

13 

Bianco P and Robey Gehron P: Marrow stromal stem cells. J Clin Invest. 105:1663–1668. 2000. View Article : Google Scholar : PubMed/NCBI

14 

Kajkenova O, Lecka-Czernik B, Gubrij I, Hauser SP, Takahashi K, Parfitt AM, Jilka RL, Manolagas SC and Lipschitz DA: Increased adipogenesis and myelopoiesis in the bone marrow of SAMP6, a murine model of defective osteoblastogenesis and low turnover osteopenia. J Bone Miner Res. 12:1772–1779. 1997. View Article : Google Scholar : PubMed/NCBI

15 

Nuttall ME and Gimble JM: Is there a therapeutic opportunity to either prevent or treat osteopenic disorders by inhibiting marrow adipogenesis? Bone. 27:177–184. 2000. View Article : Google Scholar : PubMed/NCBI

16 

Nuttall ME and Gimble JM: Controlling the balance between osteoblastogenesis and adipogenesis and the consequent therapeutic implications. Curr Opin Pharmacol. 4:290–294. 2004. View Article : Google Scholar : PubMed/NCBI

17 

Tsai MY, Shyr CR, Kang HY, Chang YC, Weng PL, Wang SY, Huang KE and Chang C: The reduced trabecular bone mass of adult ARKO male mice results from the decreased osteogenic differentiation of bone marrow stroma cells. Biochem Biophys Res Commun. 411:477–482. 2011. View Article : Google Scholar : PubMed/NCBI

18 

Mauney JR, Sjostorm S, Blumberg J, Horan R, O'Leary JP, Vunjak-Novakovic G, Volloch V and Kaplan DL: Mechanical stimulation promotes osteogenic differentiation of human bone marrow stromal cells on 3-D partially demineralized bone scaffolds in vitro. Calcif Tissue Int. 74:458–468. 2004. View Article : Google Scholar : PubMed/NCBI

19 

Sakata T, Sakai A, Tsurukami H, Okimoto N, Okazaki Y, Ikeda S, Norimura T and Nakamura T: Trabecular bone turnover and bone marrow cell development in tail-suspended mice. J Bone Miner Res. 14:1596–1604. 1999. View Article : Google Scholar : PubMed/NCBI

20 

Ahdjoudj S, Kaabeche K, Holy X, Fromigué O, Modrowski D, Zérath E and Marie PJ: Transforming growth factor-beta inhibits CCAAT/enhancer-binding protein expression and PPARgamma activity in unloaded bone marrow stromal cells. Exp Cell Res. 303:138–147. 2005. View Article : Google Scholar : PubMed/NCBI

21 

David V, Martin A, Lafage-Proust MH, Malaval L, Peyroche S, Jones DB, Vico L and Guignandon A: Mechanical loading down-regulates peroxisome proliferator-activated receptor gamma in bone marrow stromal cells and favors osteoblastogenesis at the expense of adipogenesis. Endocrinology. 148:2553–2562. 2007. View Article : Google Scholar : PubMed/NCBI

22 

Mori T, Okimoto N, Sakai A, Okazaki Y, Nakura N, Notomi T and Nakamura T: Climbing exercise increases bone mass and trabecular bone turnover through transient regulation of marrow osteogenic and osteoclastogenic potentials in mice. J Bone Miner Res. 18:2002–2009. 2003. View Article : Google Scholar : PubMed/NCBI

23 

Yokota H, Leong DJ and Sun HB: Mechanical loading: Bone remodeling and cartilage maintenance. Curr Osteoporos Rep. 9:237–242. 2011. View Article : Google Scholar : PubMed/NCBI

24 

Ni GX, Liu SY, Lei L, Li Z, Zhou YZ and Zhan LQ: Intensity-dependent effect of treadmill running on knee articular cartilage in a rat model. Biomed Res Int. 2013:1723922013. View Article : Google Scholar : PubMed/NCBI

25 

Bu S, Chen Y, Wang S, Zhang F and Ji G: Treadmill training regulates β-catenin signaling through phosphorylation of GSK-3β in lumbar vertebrae of ovariectomized rats. Eur J Appl Physiol. 112:3295–3304. 2012. View Article : Google Scholar : PubMed/NCBI

26 

Su N, Sun Q, Li C, Lu X, Qi H, Chen S, Yang J, Du X, Zhao L, He Q, et al: Gain-of-function mutation in FGFR3 in mice leads to decreased bone mass by affecting both osteoblastogenesis and osteoclastogenesis. Hum Mol Genet. 19:1199–1210. 2010. View Article : Google Scholar : PubMed/NCBI

27 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta DeltaC(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

28 

Chen Y, Wang S, Bu S, Wang Y, Duan Y and Yang S: Treadmill training prevents bone loss by inhibition of PPARγ expression but not promoting of Runx2 expression in ovariectomized rats. Eur J Appl Physiol. 111:1759–1767. 2011. View Article : Google Scholar : PubMed/NCBI

29 

Kiuchi A, Shimegi S, Tanaka I, Izumo N, Fukuyama R, Nakamuta H and Koida M: Dose-response effects of exercise intensity on bone in ovariectomized rats. Int J Sports Health Sci. 4:10–18. 2006. View Article : Google Scholar

30 

Huang TH, Lin SC, Chang FL, Hsieh SS, Liu SH and Yang RS: Effects of different exercise modes on mineralization, structure, and biomechanical properties of growing bone. J Appl Physiol (1985). 95:300–307. 2003. View Article : Google Scholar : PubMed/NCBI

31 

Sööt T, Jürimäe T, Jürimäe J, Gapeyeva H and Pääsuke M: Relationship between leg bone mineral values and muscle strength in women with different physical activity. J Bone Miner Metab. 23:401–406. 2005. View Article : Google Scholar : PubMed/NCBI

32 

Turner CH, Forwood MR, Rho JY and Yoshikawa T: Mechanical loading thresholds for lamellar and woven bone formation. J Bone Miner Res. 9:87–97. 1994. View Article : Google Scholar : PubMed/NCBI

33 

Chow JW, Jagger CJ and Chambers TJ: Characterization of osteogenic response to mechanical stimulation in cancellous bone of rat caudal vertebrae. Am J Physiol. 265:E340–E347. 1993.PubMed/NCBI

34 

Bacabac RG, Van Loon JJ, Smit TH and Klein-Nulend J: Noise enhances the rapid nitric oxide production by bone cells in response to fluid shear stress. Technol Health Care. 17:57–65. 2009.PubMed/NCBI

35 

Li YJ, Batra NN, You L, Meier SC, Coe IA, Yellowley CE and Jacobs CR: Oscillatory fluid flow affects human marrow stromal cell proliferation and differentiation. J Orthop Res. 22:1283–1289. 2004. View Article : Google Scholar : PubMed/NCBI

36 

Jagodzinski M, Drescher M, Zeichen J, Hankemeier S, Krettek C, Bosch U and van Griensven M: Effects of cyclic longitudinal mechanical strain and dexamethasone on osteogenic differentiation of human bone marrow stromal cells. Eur Cell Mater. 7:35–41. 2004. View Article : Google Scholar : PubMed/NCBI

37 

Verborgt O, Gibson GJ and Schaffler MB: Loss of osteocyte integrity in association with microdamage and bone remodeling after fatigue in vivo. J Bone Miner Res. 15:60–67. 2000. View Article : Google Scholar : PubMed/NCBI

38 

Stanford CM, Welsch F, Kastner N, Thomas G, Zaharias R, Holtman K and Brand RA: Primary human bone cultures from older patients do not respond at continuum levels of in vivo strain magnitudes. J Biomech. 33:63–71. 2000. View Article : Google Scholar : PubMed/NCBI

39 

Basso N, Jia Y, Bellows CG and Heersche JN: The effect of reloading on bone volume, osteoblast number, and osteoprogenitor characteristics: Studies in hind limb unloaded rats. Bone. 37:370–378. 2005. View Article : Google Scholar : PubMed/NCBI

40 

Cao Y, Zhou Z, de Crombrugghe B, Nakashima K, Guan H, Duan X, Jia SF and Kleinerman ES: Osterix, a transcription factor for osteoblast differentiation, mediates antitumor activity in murine osteosarcoma. Cancer Res. 65:1124–1128. 2005. View Article : Google Scholar : PubMed/NCBI

41 

Jikko A, Harris SE, Chen D, Mendrick DL and Damsky CH: Collagen integrin receptors regulate early osteoblast differentiation induced by BMP-2. J Bone Miner Res. 14:1075–1083. 1999. View Article : Google Scholar : PubMed/NCBI

42 

Pockwinse SM, Wilming LG, Conlon DM, Stein GS and Lian JB: Expression of cell growth and bone specific genes at single cell resolution during development of bone tissue-like organization in primary osteoblast cultures. J Cell Biochem. 49:310–323. 1992. View Article : Google Scholar : PubMed/NCBI

43 

Shockley KR, Lazarenko OP, Czernik PJ, Rosen CJ, Churchill GA and Lecka-Czernik B: PPARgamma2 nuclear receptor controls multiple regulatory pathways of osteoblast differentiation from marrow mesenchymal stem cells. J Cell Biochem. 106:232–246. 2009. View Article : Google Scholar : PubMed/NCBI

44 

Bruedigam C, Koedam M, Chiba H, Eijken M and van Leeuwen JP: Evidence for multiple peroxisome proliferator-activated receptor gamma transcripts in bone: Fine-tuning by hormonal regulation and mRNA stability. FEBS Lett. 582:1618–1624. 2008. View Article : Google Scholar : PubMed/NCBI

45 

Armstrong VJ, Muzylak M, Sunters A, Zaman G, Saxon LK, Price JS and Lanyon LE: Wnt/beta-catenin signaling is a component of osteoblastic bone cell early responses to load-bearing and requires estrogen receptor alpha. J Biol Chem. 282:20715–20727. 2007. View Article : Google Scholar : PubMed/NCBI

46 

Bonewald LF and Johnson ML: Osteocytes, mechanosensing and Wnt signaling. Bone. 42:606–615. 2008. View Article : Google Scholar : PubMed/NCBI

47 

Robinson JA, Chatterjee-Kishore M, Yaworsky PJ, Cullen DM, Zhao W, Li C, Kharode Y, Sauter L, Babij P, Brown EL, et al: Wnt/beta-catenin signaling is a normal physiological response to mechanical loading in bone. J Biol Chem. 281:31720–31728. 2006. View Article : Google Scholar : PubMed/NCBI

48 

Takada I, Kouzmenko AP and Kato S: Wnt and PPARgamma signaling in osteoblastogenesis and adipogenesis. Nat Rev Rheumatol. 5:442–447. 2009. View Article : Google Scholar : PubMed/NCBI

49 

Sen B, Xie Z, Case N, Ma M, Rubin C and Rubin J: Mechanical strain inhibits adipogenesis in mesenchymal stem cells by stimulating a durable beta-catenin signal. Endocrinology. 149:6065–6075. 2008. View Article : Google Scholar : PubMed/NCBI

50 

Case N, Ma M, Sen B, Xie Z, Gross TS and Rubin J: Beta-catenin levels influence rapid mechanical responses in osteoblasts. J Biol Chem. 283:29196–29205. 2008. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Liu SY, Li Z, Xu SY, Xu L, Yang M and Ni GX: Intensity‑dependent effect of treadmill running on differentiation of rat bone marrow stromal cells. Mol Med Rep 17: 7746-7756, 2018.
APA
Liu, S., Li, Z., Xu, S., Xu, L., Yang, M., & Ni, G. (2018). Intensity‑dependent effect of treadmill running on differentiation of rat bone marrow stromal cells. Molecular Medicine Reports, 17, 7746-7756. https://doi.org/10.3892/mmr.2018.8797
MLA
Liu, S., Li, Z., Xu, S., Xu, L., Yang, M., Ni, G."Intensity‑dependent effect of treadmill running on differentiation of rat bone marrow stromal cells". Molecular Medicine Reports 17.6 (2018): 7746-7756.
Chicago
Liu, S., Li, Z., Xu, S., Xu, L., Yang, M., Ni, G."Intensity‑dependent effect of treadmill running on differentiation of rat bone marrow stromal cells". Molecular Medicine Reports 17, no. 6 (2018): 7746-7756. https://doi.org/10.3892/mmr.2018.8797
Copy and paste a formatted citation
x
Spandidos Publications style
Liu SY, Li Z, Xu SY, Xu L, Yang M and Ni GX: Intensity‑dependent effect of treadmill running on differentiation of rat bone marrow stromal cells. Mol Med Rep 17: 7746-7756, 2018.
APA
Liu, S., Li, Z., Xu, S., Xu, L., Yang, M., & Ni, G. (2018). Intensity‑dependent effect of treadmill running on differentiation of rat bone marrow stromal cells. Molecular Medicine Reports, 17, 7746-7756. https://doi.org/10.3892/mmr.2018.8797
MLA
Liu, S., Li, Z., Xu, S., Xu, L., Yang, M., Ni, G."Intensity‑dependent effect of treadmill running on differentiation of rat bone marrow stromal cells". Molecular Medicine Reports 17.6 (2018): 7746-7756.
Chicago
Liu, S., Li, Z., Xu, S., Xu, L., Yang, M., Ni, G."Intensity‑dependent effect of treadmill running on differentiation of rat bone marrow stromal cells". Molecular Medicine Reports 17, no. 6 (2018): 7746-7756. https://doi.org/10.3892/mmr.2018.8797
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