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Article

β2‑adrenergic receptor functionality and genotype in two different models of chronic inflammatory disease: Liver cirrhosis and osteoarthritis

  • Authors:
    • Reyes Roca
    • Pablo Esteban
    • Pedro Zapater
    • María‑Del‑Mar Inda
    • Anna Lucia Conte
    • Laura Gómez‑Escolar
    • Helena Martínez
    • José F. Horga
    • José M. Palazon
    • Ana M. Peiró
  • View Affiliations / Copyright

    Affiliations: Occupational Observatory, Miguel Hernández University (UMH) of Elche, 03202 Elche, Spain, CIBERehd, Carlos III Health Institute, 28029 Madrid, Spain, Neuropharmacology on Pain (NED) Research Group, ISABIAL‑FISABIO, General Hospital of Alicante, 03010 Alicante, Spain, Liver Unit, General Hospital of Alicante, 03010 Alicante, Spain, Clinical R&D Area, Bioiberica S.A., 08029 Barcelona, Spain, Clinical Pharmacology, General Hospital of Alicante, 03010 Alicante, Spain
  • Pages: 7987-7995
    |
    Published online on: March 29, 2018
       https://doi.org/10.3892/mmr.2018.8820
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Abstract

The present study was designed to investigate the functional status of β2 adrenoceptors (β2AR) in two models of chronic inflammatory disease: liver cirrhosis (LC) and osteoarthritis (OA). The β2AR gene contains three single nucleotide polymorphisms at amino acid positions 16, 27 and 164. The aim of the present study was to investigate the potential influence of lymphocyte β2AR receptor functionality and genotype in LC and OA patients. Blood samples from cirrhotic patients (n=52, hepatic venous pressure gradient 13±4 mmHg, CHILD 7±2 and MELD 11±4 scores), OA patients (n=30, 84% Kellgren‑Lawrence severity 4 grade, 14% knee replacement joint) and healthy volunteers as control group (n=26) were analyzed. Peripheral blood mononuclear cells (PBMC) were isolated from whole blood and basal and isoproterenol induced adenylate cyclase activity (isoproterenol stimulus from 10‑9 to 10‑4 mM), and β2AR allelic variants (rs1042713, rs1042714, rs1800888) were determined. β2AR functionality was decreased in the two different models of chronic inflammatory disease studied, OA (50% vs. control) and LC (85% vs. control). In these patients, the strength of the β2AR response to adrenergic stimulation was very limited. Adrenergic modulation of PBMC function through the β2AR stimulus is decreased in chronic inflammatory processes including LC and OA, suggesting that the adrenergic system may be important in the development of these processes.
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1 

Baerwald CG, Burmester GR and Krause A: Interactions of autonomic nervous, neuroendocrine, and immune systems in rheumatoid arthritis. Rheum Dis Clin North Am. 26:841–857. 2000. View Article : Google Scholar : PubMed/NCBI

2 

Bergquist J, Tarkowski A, Ekman R and Ewing A: Discovery of endogenous catecholamines in lymphocytes and evidence for catecholamine regulation of lymphocyte function via an autocrine loop. Proc Natl Acad Sci USA. 91:12912–12916. 1994. View Article : Google Scholar : PubMed/NCBI

3 

Lorton D, Lubahn C and Bellinger DL: Potential use of drugs that target neural-immune pathways in the treatment of rheumatoid arthritis and other autoimmune diseases. Curr Drug Targets Inflamm Allergy. 2:1–30. 2003. View Article : Google Scholar : PubMed/NCBI

4 

Felsner P, Hofer D, Rinner I, Mangge H, Gruber M, Korsatko W and Schauenstein K: Continuous in vivo treatment with catecholamines suppresses in vitro reactivity of rat peripheral blood T-lymphocytes via alpha-mediated mechanisms. J Neuroimmunol. 37:47–57. 1992. View Article : Google Scholar : PubMed/NCBI

5 

Elenkov IJ, Papanicolaou DA, Wilder RL and Chrousos GP: Modulatory effects of glucocorticoids and catecholamines on human interleukin-12 and interleukin-10 production: Clinical implications. Proc Assoc Am Physicians. 108:374–381. 1996.PubMed/NCBI

6 

Panina-Bordignon P, Mazzeo D, Lucia PD, D'Ambrosio D, Lang R, Fabbri L, Self C and Sinigaglia F: Beta2-agonists prevent Th1 development by selective inhibition of interleukin 12. J Clin Invest. 100:1513–1519. 1997. View Article : Google Scholar : PubMed/NCBI

7 

Hernández FT, Zapater P, De-Madaria E, Palazón JM, Pascual S, Irurzun J, Such J, Perez-Mateo M and Horga JF: Functional status of beta-2-adrenoceptor in isolated membranes of mature erythrocytes from patients with cirrhosis and oesophageal varices. Vascul Pharmacol. 44:464–468. 2006. View Article : Google Scholar : PubMed/NCBI

8 

Brodde OE, Zerkowski HR, Doetsch N, Motomura S, Khamssi M and Michel MC: Myocardial beta-adrenoceptor changes in heart failure: Concomitant reduction in beta 1- and beta 2-adrenoceptor function related to the degree of heart failure in patients with mitral valve disease. J Am Coll Cardiol. 14:323–331. 1989. View Article : Google Scholar : PubMed/NCBI

9 

Yu XY, Lin SG, Wang XM, Liu Y, Zhang B, Lin QX, Yang M and Zhou SF: Evidence for coexistence of three beta-adrenoceptor subtypes in human peripheral lymphocytes. Clin Pharmacol Ther. 81:654–658. 2007. View Article : Google Scholar : PubMed/NCBI

10 

Xu B, Yi Q, Pirskanen R, Matell G, Eng H and Lefvert AK: Decreased beta2-adrenergic receptor density on peripheral blood mononuclear cells in myasthenia gravis. J Autoimmun. 10:401–406. 1997. View Article : Google Scholar : PubMed/NCBI

11 

Levine JD, Goetzl EJ and Basbaum AI: Contribution of the nervous system to the pathophysiology of rheumatoid arthritis and other polyarthritides. Rheum Dis Clin North Am. 13:369–383. 1987.PubMed/NCBI

12 

Härle P, Möbius D, Carr DJ, Schölmerich J and Straub RH: An opposing time-dependent immune-modulating effect of the sympathetic nervous system conferred by altering the cytokine profile in the local lymph nodes and spleen of mice with type II collagen-induced arthritis. Arthritis Rheum. 52:1305–1313. 2005. View Article : Google Scholar : PubMed/NCBI

13 

Härle P, Pongratz G, Albrecht J, Tarner IH and Straub RH: An early sympathetic nervous system influence exacerbates collagen-induced arthritis via CD4+CD25+ cells. Arthritis Rheum. 58:2347–2355. 2008. View Article : Google Scholar : PubMed/NCBI

14 

Malfait AM, Malik AS, Marinova-Mutafchieva L, Butler DM, Maini RN and Feldmann M: The beta2-adrenergic agonist salbutamol is a potent suppressor of established collagen-induced arthritis: Mechanisms of action. J Immunol. 162:6278–6283. 1999.PubMed/NCBI

15 

Lorton D, Bellinger DL, Schaller JA, Shewmaker E, Osredkar T and Lubahn C: Altered sympathetic-to-immune cell signaling via β2-adrenergic receptors in adjuvant arthritis. Clin Dev Immunol. 2013:7643952013. View Article : Google Scholar : PubMed/NCBI

16 

Neuhuber WL and Tiegs G: Innervation of immune cells: Evidence for neuroimmunomodulation in the liver. Anat Rec A Discov Mol Cell Evol Biol. 280:884–892. 2004. View Article : Google Scholar : PubMed/NCBI

17 

Tiegs G, Bang R and Neuhuber WL: Requirement of peptidergic sensory innervation for disease activity in murine models of immune hepatitis and protection by beta-adrenergic stimulation. J Neuroimmunol. 96:131–143. 1999. View Article : Google Scholar : PubMed/NCBI

18 

Grässel SG: The role of peripheral nerve fibers and their neurotransmitters in cartilage and bone physiology and pathophysiology. Arthritis Res Ther. 16:4852014. View Article : Google Scholar : PubMed/NCBI

19 

Eitner A, Pester J, Nietzsche S, Hofmann GO and Schaible HG: The innervation of synovium of human osteoarthritic joints in comparison with normal rat and sheep synovium. Osteoarthritis Cartilage. 21:1383–1391. 2013. View Article : Google Scholar : PubMed/NCBI

20 

Najafipour H and Niazmand S: Alteration in alpha- and beta- adrenoceptor profile of rabbit-knee-joint blood vessels due to chronic inflammation. Pflugers Arch. 453:23–32. 2006. View Article : Google Scholar : PubMed/NCBI

21 

Beckmann J, Knödl M, Bauser E, Tingart M, Grifka J and Straub RH: Loss of sympathetic nerve fibers in vital intertrochanteric bone cylinders lateral to osteonecrosis of the femoral head. Joint Bone Spine. 80:188–194. 2013. View Article : Google Scholar : PubMed/NCBI

22 

Fernandes JC, Martel-Pelletier J and Pelletier JP: The role of cytokines in osteoarthritis pathophysiology. Biorheology. 39:237–246. 2002.PubMed/NCBI

23 

Malemud CJ: Anticytokine therapy for osteoarthritis: Evidence to date. Drugs Aging. 27:95–115. 2010. View Article : Google Scholar : PubMed/NCBI

24 

D'Amico G and Luca A: Natural history. Clinical-haemodynamic correlations. Prediction of the risk of bleeding. Baillieres Clin Gastroenterol. 11:243–256. 1997. View Article : Google Scholar : PubMed/NCBI

25 

Sanders VM: The beta2-adrenergic receptor on T and B lymphocytes: Do we understand it yet? Brain Behav Immun. 26:195–200. 2012. View Article : Google Scholar : PubMed/NCBI

26 

Biecker E: Portal hypertension and gastrointestinal bleeding: Diagnosis, prevention and management. World J Gastroenterol. 19:5035–5050. 2013. View Article : Google Scholar : PubMed/NCBI

27 

Pateron D, Tazi KA, Sogni P, Heller J, Chagneau C, Poirel O, Philippe M, Moreau R and Lebrec D: Role of aortic nitric oxide synthase 3 (eNOS) in the systemic vasodilation of portal hypertension. Gastroenterology. 119:196–200. 2000. View Article : Google Scholar : PubMed/NCBI

28 

Tazi KA, Barrière E, Moreau R, Heller J, Sogni P, Pateron D, Poirel O and Lebrec D: Role of shear stress in aortic eNOS up-regulation in rats with biliary cirrhosis. Gastroenterology. 122:1869–1877. 2002. View Article : Google Scholar : PubMed/NCBI

29 

Karadsheh Z and Allison H: Primary prevention of variceal bleeding: Pharmacological therapy versus endoscopic banding. N Am J Med Sci. 5:573–579. 2013. View Article : Google Scholar : PubMed/NCBI

30 

Lemaitre RN, Heckbert SR, Sotoodehnia N, Bis JC, Smith NL, Marciante KD, Hindorff LA, Lange LA, Lumley TS, Rice KM, et al: beta1- and beta2-adrenergic receptor gene variation, beta-blocker use and risk of myocardial infarction and stroke. Am J Hypertens. 21:290–296. 2008. View Article : Google Scholar : PubMed/NCBI

31 

Heckbert SR, Hindorff LA, Edwards KL, Psaty BM, Lumley T, Siscovick DS, Tang Z, Durda JP, Kronmal RA and Tracy RP: Beta2-adrenergic receptor polymorphisms and risk of incident cardiovascular events in the elderly. Circulation. 107:2021–2024. 2003. View Article : Google Scholar : PubMed/NCBI

32 

Sotoodehnia N, Siscovick DS, Vatta M, Psaty BM, Tracy RP, Towbin JA, Lemaitre RN, Rea TD, Durda JP, Chang JM, et al: Beta2-adrenergic receptor genetic variants and risk of sudden cardiac death. Circulation. 113:1842–1848. 2006. View Article : Google Scholar : PubMed/NCBI

33 

Stanzione R, Di Angelantonio E, Evangelista A, Barbato D, Marchitti S, Zanda B, Pirisi A, Quarta G, Volpe M and Rubattu S: Beta2-adrenergic receptor gene polymorphisms and risk of ischemic stroke. Am J Hypertens. 20:657–662. 2007. View Article : Google Scholar : PubMed/NCBI

34 

Lanfear DE, Jones PG, Marsh S, Cresci S, McLeod HL and Spertus JA: Beta2-adrenergic receptor genotype and survival among patients receiving beta-blocker therapy after an acute coronary syndrome. JAMA. 294:1526–1533. 2005. View Article : Google Scholar : PubMed/NCBI

35 

Tan S, Hall IP, Dewar J, Dow E and Lipworth B: Association between beta 2-adrenoceptor polymorphism and susceptibility to bronchodilator desensitisation in moderately severe stable asthmatics. Lancet. 350:995–999. 1997. View Article : Google Scholar : PubMed/NCBI

36 

Gianfagna F, Cugino D, Ahrens W, Bailey ME, Bammann K, Herrmann D, Koni AC, Kourides Y, Marild S, Molnár D, et al: Understanding the links among neuromedin U gene, beta2-adrenoceptor gene and bone health: An observational study in European children. PLoS One. 8:e706322013. View Article : Google Scholar : PubMed/NCBI

37 

Malysheva O, Pierer M, Wagner U, Wahle M, Wagner U and Baerwald CG: Association between beta2 adrenergic receptor polymorphisms and rheumatoid arthritis in conjunction with human leukocyte antigen (HLA)-DRB1 shared epitope. Ann Rheum Dis. 67:1759–1764. 2008. View Article : Google Scholar : PubMed/NCBI

38 

Xu B, Arlehag L, Rantapää-Dahlquist SB and Lefvert AK: Beta2-adrenergic receptor gene single-nucleotide polymorphisms are associated with rheumatoid arthritis in northern Sweden. Scand J Rheumatol. 33:395–398. 2004. View Article : Google Scholar : PubMed/NCBI

39 

Kushnir VM, Cassell B, Gyawali CP, Newberry RD, Kibe P, Nix BD, Sabzpoushan A, Kanuri ND and Sayuk GS: Genetic variation in the beta-2 adrenergic receptor (ADRB2) predicts functional gastrointestinal diagnoses and poorer health-related quality of life. Aliment Pharmacol Ther. 38:313–323. 2013. View Article : Google Scholar : PubMed/NCBI

40 

Kellgren JH and Lawrence JS: Radiological assessment of osteo-arthrosis. Ann Rheum Dis. 16:494–502. 1957. View Article : Google Scholar : PubMed/NCBI

41 

Bosch J, Abraldes JG, Albillos A, Aracil C, Bañares R, Berzigotti A, Calleja JL, de la Peña J, Escorsell A, García-Pagán JC, et al: Portal hypertension: Recommendations for evaluation and treatment: Consensus document sponsored by the Spanish association for the study of the liver (AEEH) and the biomedical research network center for liver and digestive diseases (CIBERehd). Gastroenterol Hepatol. 35:421–450. 2012.(In Spanish). View Article : Google Scholar : PubMed/NCBI

42 

Sondergaard SB, Knudsen JH and Christensen NJ: Regulation of cAMP in a lymphocyte preparation isolated from peripheral venous blood in human subjects: The significance of residual thrombocytes, noradrenaline and prostaglandins. Clin Sci (Lond). 95:377–383. 1998. View Article : Google Scholar : PubMed/NCBI

43 

Drysdale CM, McGraw DW, Stack CB, Stephens JC, Judson RS, Nandabalan K, Arnold K, Ruano G and Liggett SB: Complex promoter and coding region beta 2-adrenergic receptor haplotypes alter receptor expression and predict in vivo responsiveness. Proc Natl Acad Sci USA. 97:10483–10488. 2000. View Article : Google Scholar : PubMed/NCBI

44 

Belfer I, Buzas B, Hipp H, Phillips G, Taubman J, Lorincz I, Evans C, Lipsky RH, Enoch MA, Max MB and Goldman D: Haplotype-based analysis of alpha 2A, 2B, and 2C adrenergic receptor genes captures information on common functional loci at each gene. J Hum Genet. 50:12–20. 2005. View Article : Google Scholar : PubMed/NCBI

45 

Campello L, Esteve-Rudd J, Bru-Martinez R, Herrero MT, Fernández-Villalba E, Cuenca N and Martín-Nieto J: Alterations in energy metabolism, neuroprotection and visual signal transduction in the retina of Parkinsonian, MPTP-treated monkeys. PLoS One. 8:e744392013. View Article : Google Scholar : PubMed/NCBI

46 

Garcia-Tsao G, Sanyal AJ, Grace ND and Carey W: Practice Guidelines Committee of the American Association for the Study of Liver Diseases; Practice Parameters Committee of the American College of Gastroenterology: Prevention and management of gastroesophageal varices and variceal hemorrhage in cirrhosis. Hepatology. 46:922–938. 2007. View Article : Google Scholar : PubMed/NCBI

47 

Jeanningros R, Mazzola P, Azorin JM, Samuelian-Massa C and Tissot R: Beta-adrenoceptor density of intact mononuclear leukocytes in subgroups of depressive disorders. Biol Psychiatry. 29:789–798. 1991. View Article : Google Scholar : PubMed/NCBI

48 

Maekawa K, Twe C, Lotaif A, Chiappelli F and Clark GT: Function of beta-adrenergic receptors on mononuclear cells in female patients with fibromyalgia. J Rheumatol. 30:364–368. 2003.PubMed/NCBI

49 

Leineweber K, Rohe P, Beilfuss A, Wolf C, Sporkmann H, Bruck H, Jakob HG, Heusch G, Philipp T and Brodde OE: G-protein-coupled receptor kinase activity in human heart failure: Effects of beta-adrenoceptor blockade. Cardiovasc Res. 66:512–519. 2005. View Article : Google Scholar : PubMed/NCBI

50 

Scarpace PJ, Tumer N and Mader SL: Beta-adrenergic function in aging. Basic mechanisms and clinical implications. Drugs Aging. 1:116–129. 1991.PubMed/NCBI

51 

Krause A, Henrich A, Beckh KH, Von Wichert P and Baerwald C: Correlation between density of beta 2-adrenergic receptors on peripheral blood mononuclear cells and serum levels of soluble interleukin-2 receptors in patients with chronic inflammatory diseases. Eur J Clin Invest. 22 Suppl 1:S47–S51. 1992.

52 

Baerwald C, Graefe C, Muhl C, Von Wichert P and Krause A: Beta 2-adrenergic receptors on peripheral blood mononuclear cells in patients with rheumatic diseases. Eur J Clin Invest. 22 Suppl 1:S42–S46. 1992.

53 

Wahle M, Kölker S, Krause A, Burmester GR and Baerwald CG: Impaired catecholaminergic signalling of B lymphocytes in patients with chronic rheumatic diseases. Ann Rheum Dis. 60:505–510. 2001. View Article : Google Scholar : PubMed/NCBI

54 

Maekawa K, Kuboki T, Inoue E, Inoue-Minakuchi M, Suzuki K, Yatani H and Clark GT: Function of beta 2-adrenergic receptors in chronic localized myalgia. J Orofac Pain. 17:140–144. 2003.PubMed/NCBI

55 

Maekawa K, Clark GT and Kuboki T: Intramuscular hypoperfusion, adrenergic receptors, and chronic muscle pain. J Pain. 3:251–260. 2002. View Article : Google Scholar : PubMed/NCBI

56 

Lefkowitz RJ, Caron MG and Stiles GL: Mechanisms of membrane-receptor regulation. Biochemical, physiological, and clinical insights derived from studies of the adrenergic receptors. N Engl J Med. 310:1570–1579. 1984. View Article : Google Scholar : PubMed/NCBI

57 

de Galan BE, Rietjens SJ, Tack CJ, van der Werf SP, Sweep CG, Lenders JW and Smits P: Antecedent adrenaline attenuates the responsiveness to but not the release of counterregulatory hormones during subsequent hypoglycemia. J Clin Endocrinol Metab. 88:5462–5467. 2003. View Article : Google Scholar : PubMed/NCBI

58 

Baerwald CG, Laufenberg M, Specht T, von Wichert P, Burmester GR and Krause A: Impaired sympathetic influence on the immune response in patients with rheumatoid arthritis due to lymphocyte subset-specific modulation of beta 2-adrenergic receptors. Br J Rheumatol. 36:1262–1269. 1997. View Article : Google Scholar : PubMed/NCBI

59 

Ader R, Cohen N and Felten D: Psychoneuroimmunology: Interactions between the nervous system and the immune system. Lancet. 345:99–103. 1995. View Article : Google Scholar : PubMed/NCBI

60 

Capellino S, Cosentino M, Wolff C, Schmidt M, Grifka J and Straub RH: Catecholamine-producing cells in the synovial tissue during arthritis: Modulation of sympathetic neurotransmitters as new therapeutic target. Ann Rheum Dis. 69:1853–1860. 2010. View Article : Google Scholar : PubMed/NCBI

61 

Straub RH, Grum F, Strauch U, Capellino S, Bataille F, Bleich A, Falk W, Schölmerich J and Obermeier F: Anti-inflammatory role of sympathetic nerves in chronic intestinal inflammation. Gut. 57:911–921. 2008. View Article : Google Scholar : PubMed/NCBI

62 

Brodde OE, Bruck H and Leineweber K: Cardiac adrenoceptors: Physiological and pathophysiological relevance. J Pharmacol Sci. 100:323–337. 2006. View Article : Google Scholar : PubMed/NCBI

63 

Kirstein SL and Insel PA: Autonomic nervous system pharmacogenomics: A progress report. Pharmacol Rev. 56:31–52. 2004. View Article : Google Scholar : PubMed/NCBI

64 

Diatchenko L, Anderson AD, Slade GD, Fillingim RB, Shabalina SA, Higgins TJ, Sama S, Belfer I, Goldman D, Max MB, et al: Three major haplotypes of the beta2 adrenergic receptor define psychological profile, blood pressure, and the risk for development of a common musculoskeletal pain disorder. Am J Med Genet B Neuropsychiatr Genet. 141B:449–462. 2006. View Article : Google Scholar : PubMed/NCBI

65 

Small KM, McGraw DW and Liggett SB: Pharmacology and physiology of human adrenergic receptor polymorphisms. Annu Rev Pharmacol Toxicol. 43:381–411. 2003. View Article : Google Scholar : PubMed/NCBI

66 

Zuurhout MJ, Vijverberg SJ, Raaijmakers JA, Koenderman L, Postma DS, Koppelman GH and Maitland-van der Zee AH: Arg16 ADRB2 genotype increases the risk of asthma exacerbation in children with a reported use of long-acting β2-agonists: Results of the PACMAN cohort. Pharmacogenomics. 14:1965–1971. 2013. View Article : Google Scholar : PubMed/NCBI

67 

Bengtsson K, Orho-Melander M, Melander O, Lindblad U, Ranstam J, Råstam L and Groop L: Beta(2)-adrenergic receptor gene variation and hypertension in subjects with type 2 diabetes. Hypertension. 37:1303–1308. 2001. View Article : Google Scholar : PubMed/NCBI

68 

Martinez FD, Graves PE, Baldini M, Solomon S and Erickson R: Association between genetic polymorphisms of the beta2-adrenoceptor and response to albuterol in children with and without a history of wheezing. J Clin Invest. 100:3184–3188. 1997. View Article : Google Scholar : PubMed/NCBI

69 

Gjesing AP, Andersen G, Burgdorf KS, Borch-Johnsen K, Jørgensen T, Hansen T and Pedersen O: Studies of the associations between functional beta2-adrenergic receptor variants and obesity, hypertension and type 2 diabetes in 7,808 white subjects. Diabetologia. 50:563–568. 2007. View Article : Google Scholar : PubMed/NCBI

70 

Qing F, Rahman SU, Hayes MJ, Rhodes CG, Ind PW, Jones T and Hughes JM: Effect of long-term beta2-agonist dosing on human cardiac beta-adrenoceptor expression in vivo: Comparison with changes in lung and mononuclear leukocyte beta-receptors. J Nucl Cardiol. 4:532–538. 1997. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Roca R, Esteban P, Zapater P, Inda MDM, Conte AL, Gómez‑Escolar L, Martínez H, Horga JF, Palazon JM, Peiró AM, Peiró AM, et al: β2‑adrenergic receptor functionality and genotype in two different models of chronic inflammatory disease: Liver cirrhosis and osteoarthritis. Mol Med Rep 17: 7987-7995, 2018.
APA
Roca, R., Esteban, P., Zapater, P., Inda, M., Conte, A.L., Gómez‑Escolar, L. ... Peiró, A.M. (2018). β2‑adrenergic receptor functionality and genotype in two different models of chronic inflammatory disease: Liver cirrhosis and osteoarthritis. Molecular Medicine Reports, 17, 7987-7995. https://doi.org/10.3892/mmr.2018.8820
MLA
Roca, R., Esteban, P., Zapater, P., Inda, M., Conte, A. L., Gómez‑Escolar, L., Martínez, H., Horga, J. F., Palazon, J. M., Peiró, A. M."β2‑adrenergic receptor functionality and genotype in two different models of chronic inflammatory disease: Liver cirrhosis and osteoarthritis". Molecular Medicine Reports 17.6 (2018): 7987-7995.
Chicago
Roca, R., Esteban, P., Zapater, P., Inda, M., Conte, A. L., Gómez‑Escolar, L., Martínez, H., Horga, J. F., Palazon, J. M., Peiró, A. M."β2‑adrenergic receptor functionality and genotype in two different models of chronic inflammatory disease: Liver cirrhosis and osteoarthritis". Molecular Medicine Reports 17, no. 6 (2018): 7987-7995. https://doi.org/10.3892/mmr.2018.8820
Copy and paste a formatted citation
x
Spandidos Publications style
Roca R, Esteban P, Zapater P, Inda MDM, Conte AL, Gómez‑Escolar L, Martínez H, Horga JF, Palazon JM, Peiró AM, Peiró AM, et al: β2‑adrenergic receptor functionality and genotype in two different models of chronic inflammatory disease: Liver cirrhosis and osteoarthritis. Mol Med Rep 17: 7987-7995, 2018.
APA
Roca, R., Esteban, P., Zapater, P., Inda, M., Conte, A.L., Gómez‑Escolar, L. ... Peiró, A.M. (2018). β2‑adrenergic receptor functionality and genotype in two different models of chronic inflammatory disease: Liver cirrhosis and osteoarthritis. Molecular Medicine Reports, 17, 7987-7995. https://doi.org/10.3892/mmr.2018.8820
MLA
Roca, R., Esteban, P., Zapater, P., Inda, M., Conte, A. L., Gómez‑Escolar, L., Martínez, H., Horga, J. F., Palazon, J. M., Peiró, A. M."β2‑adrenergic receptor functionality and genotype in two different models of chronic inflammatory disease: Liver cirrhosis and osteoarthritis". Molecular Medicine Reports 17.6 (2018): 7987-7995.
Chicago
Roca, R., Esteban, P., Zapater, P., Inda, M., Conte, A. L., Gómez‑Escolar, L., Martínez, H., Horga, J. F., Palazon, J. M., Peiró, A. M."β2‑adrenergic receptor functionality and genotype in two different models of chronic inflammatory disease: Liver cirrhosis and osteoarthritis". Molecular Medicine Reports 17, no. 6 (2018): 7987-7995. https://doi.org/10.3892/mmr.2018.8820
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