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Article Open Access

Involvement of dysregulated coding and long non‑coding RNAs in the pathogenesis of strabismus

  • Authors:
    • Wen‑Xiu Ma
    • Xiao‑Gang Huang
    • Tian‑Ke Yang
    • Jing‑Yan Yao
  • View Affiliations / Copyright

    Affiliations: Department of Ophthalmology, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu 215000, P.R. China
    Copyright: © Ma et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 7737-7745
    |
    Published online on: March 29, 2018
       https://doi.org/10.3892/mmr.2018.8832
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Abstract

Strabismus is a common ocular disorder in children and may result in exterior abnormalities and impaired visual functions. However, the detailed pathogenesis of strabismus unclear. The present study assessed the comprehensive analyses on the roles of RNAs in the development of strabismus. The public datasets of strabismus and the corresponding control tissues were downloaded from the Gene Expression Omnibus (GEO). Reannotations of the dysregulated coding and long non‑coding RNAs (lncRNAs) and functional enrichments of the differently expressed genes (DEGs) were conducted. A total of 790 DEGs were screened (648 upregulated and 142 downregulated) in the present study. Among the DEGs, a total of 32 differently expressed lncRNAs were detected (14 upregulated and 18 downregulated). When the Gene Ontology (GO) enrichment was considered, it was identified that a total of 143 GO terms (82 for biological process, 31 for cellular component and 30 for molecular function) were identified. Among all the 57 detected Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways, the phagosome pathway, which was labeled as hsa004145, demonstrated the most bioinformatics importance. However, most lncRNAs, except LINC01279 and LOC643733, indicated <3 target mRNAs and were not suitable for advanced bioinformatics analyses. Bioinformatics analyses demonstrated that there was a GO term for each lncRNA (proteinaceous extracellular for LINC01279 and cell surface for LOC643733). In conclusion, a set of coding RNA as well as lncRNAs differentially expressed in strabismus EOM samples were indicated. Notably, the present findings important information for advanced pathogenesis research and biomarkers detection.
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1 

Lambert SR: Population-based incidence of strabismus: Why is it important? JAMA Ophthalmol. 135:1053–1054. 2017. View Article : Google Scholar : PubMed/NCBI

2 

Shapira Y, Machluf Y, Mimouni M, Chaiter Y and Mezer E: Amblyopia and strabismus: Trends in prevalence and risk factors among young adults in Israel. Br J Ophthalmol. 2017.doi: 10.1136/bjophthalmol-2017-310364. PubMed/NCBI

3 

Nelson LB: Macular changes following strabismus surgery confirmed by the use of optical coherence tomography. J Pediatr Ophthalmol Strabismus. 53:102016. View Article : Google Scholar : PubMed/NCBI

4 

Lindstrom M, Tjust AE and Domellof Pedrosa F: Pax7-positive cells/satellite cells in human extraocular muscles. Invest Ophthalmol Vis Sci. 56:6132–6143. 2015. View Article : Google Scholar : PubMed/NCBI

5 

Gong HM, Wang J, Xu J, Zhou ZY, Li JW and Chen SF: Identification of rare paired box 3 variant in strabismus by whole exome sequencing. Int J Ophthalmol. 10:1223–1228. 2017.PubMed/NCBI

6 

Altick AL, Feng CY, Schlauch K, Johnson LA and von Bartheld CS: Differences in gene expression between strabismic and normal human extraocular muscles. Invest Ophthalmol Vis Sci. 53:5168–5177. 2012. View Article : Google Scholar : PubMed/NCBI

7 

Wang H, Huo X, Yang XR, He J, Cheng L, Wang N, Deng X, Jin H, Wang N, Wang C, et al: STAT3-mediated upregulation of lncRNA HOXD-AS1 as a ceRNA facilitates liver cancer metastasis by regulating SOX4. Mol Cancer. 16:1362017. View Article : Google Scholar : PubMed/NCBI

8 

Akhade VS, Pal D and Kanduri C: Long noncoding RNA: Genome organization and mechanism of action. Adv Exp Med Biol. 1008:47–74. 2017. View Article : Google Scholar : PubMed/NCBI

9 

Aubert G, Strauss KA, Lansdorp PM and Rider NL: Defects in lymphocyte telomere homeostasis contribute to cellular immune phenotype in patients with cartilage-hair hypoplasia. J Allergy Clin Immunol. 140:1120–1129.e1. 2017. View Article : Google Scholar : PubMed/NCBI

10 

Li Y, Xu F, Xiao H and Han F: Long noncoding RNA BDNF-AS inversely regulated BDNF and modulated high-glucose induced apoptosis in human retinal pigment epithelial cells. J Cell Biochem. 119:817–823. 2018. View Article : Google Scholar : PubMed/NCBI

11 

Zhu W, Meng YF, Xing Q, Tao JJ, Lu J and Wu Y: Identification of lncRNAs involved in biological regulation in early age-related macular degeneration. Int J Nanomedicine. 12:7589–7602. 2017. View Article : Google Scholar : PubMed/NCBI

12 

Ye Z, Li Z and He S: Long noncoding RNA associated competing endogenous RNAs are induced by clusterin in retinal pigment epithelial cells. Mol Med Rep. 16:8399–8405. 2017. View Article : Google Scholar : PubMed/NCBI

13 

Dennis G Jr, Sherman BT, Hosack DA, Yang J, Gao W, Lane HC and Lempicki RA: DAVID: Database for annotation, visualization and integrated discovery. Genome Biol. 4:P32003. View Article : Google Scholar : PubMed/NCBI

14 

Kanehisa M, Sato Y, Kawashima M, Furumichi M and Tanabe M: KEGG as a reference resource for gene and protein annotation. Nucleic Acids Res. 44:D457–D462. 2016. View Article : Google Scholar : PubMed/NCBI

15 

von Mering C, Huynen M, Jaeggi D, Schmidt S, Bork P and Snel B: STRING: A database of predicted functional associations between proteins. Nucleic Acids Res. 31:258–261. 2003. View Article : Google Scholar : PubMed/NCBI

16 

Franz M, Lopes CT, Huck G, Dong Y, Sumer O and Bader GD: Cytoscape.js: A graph theory library for visualisation and analysis. Bioinformatics. 32:309–311. 2016.PubMed/NCBI

17 

Langfelder P and Horvath S: WGCNA: An R package for weighted correlation network analysis. BMC Bioinformatics. 9:5592008. View Article : Google Scholar : PubMed/NCBI

18 

Ye XC, Pegado V, Patel MS and Wasserman WW: Strabismus genetics across a spectrum of eye misalignment disorders. Clin Genet. 86:103–111. 2014. View Article : Google Scholar : PubMed/NCBI

19 

Lueder GT: Orbital causes of incomitant strabismus. Middle East Afr J Ophthalmol. 22:286–291. 2015. View Article : Google Scholar : PubMed/NCBI

20 

Min X, Fan H, Zhao G and Liu G: Identification of 2 potentially relevant gene mutations involved in strabismus using whole-exome sequencing. Med Sci Monit. 23:1719–1724. 2017. View Article : Google Scholar : PubMed/NCBI

21 

Rajab GZ, Suh SY and Demer JL: Magnetic resonance imaging in dissociated strabismus complex demonstrates generalized hypertrophy of rectus extraocular muscles. J AAPOS. 21:205–209. 2017. View Article : Google Scholar : PubMed/NCBI

22 

Haider AS: Unilateral internuclear ophthalmoplegia, strabismus and transient torsional nystagmus in focal pontine infarction. BMJ Case Rep. 2016:bcr20162165032016. View Article : Google Scholar : PubMed/NCBI

23 

Agarwal AB, Feng CY, Altick AL, Quilici DR, Wen D, Johnson LA and von Bartheld CS: Altered protein composition and gene expression in strabismic human extraocular muscles and tendons. Invest Ophthalmol Vis Sci. 57:5576–5585. 2016. View Article : Google Scholar : PubMed/NCBI

24 

Schwalm S, Beyer S, Frey H, Haceni R, Grammatikos G, Thomas D, Geisslinger G, Schaefer L, Huwiler A and Pfeilschifter J: Sphingosine kinase-2 deficiency ameliorates kidney fibrosis by up-regulating Smad7 in a mouse model of unilateral ureteral obstruction. Am J Pathol. 187:2413–2429. 2017. View Article : Google Scholar : PubMed/NCBI

25 

Saika S, Yamanaka O, Okada Y, Tanaka S, Miyamoto T, Sumioka T, Kitano A, Shirai K and Ikeda K: TGF beta in fibroproliferative diseases in the eye. Front Biosci (Schol Ed). 1:376–390. 2009. View Article : Google Scholar : PubMed/NCBI

26 

Choi SU, Kim KW and Moon NJ: Effective treatment for prevention of post-operative adhesion after strabismus surgery in experimental rabbit model: 0.5% tranilast ophthalmic solution. BMC Ophthalmol. 16:1662016. View Article : Google Scholar : PubMed/NCBI

27 

Mahan M and Engel JM: The resurgence of botulinum toxin injection for strabismus in children. Curr Opin Ophthalmol. 28:460–464. 2017. View Article : Google Scholar : PubMed/NCBI

28 

McLoon LK, Christiansen SP, Ghose GM, Das VE and Mustari MJ: Improvement of eye alignment in adult strabismic monkeys by sustained IGF-1 treatment. Invest Ophthalmol Vis Sci. 57:6070–6078. 2016. View Article : Google Scholar : PubMed/NCBI

29 

Levin R, Grinstein S and Canton J: The life cycle of phagosomes: Formation, maturation and resolution. Immunol Rev. 273:156–179. 2016. View Article : Google Scholar : PubMed/NCBI

30 

Steinhauser C, Dallenga T, Tchikov V, Schaible UE, Schutze S and Reiling N: Immunomagnetic isolation of pathogen-containing phagosomes and apoptotic blebs from primary phagocytes. Curr Protoc Immunol. 105:14.36.1–26. 2014. View Article : Google Scholar

31 

Russell DG: Phagosomes, fatty acids and tuberculosis. Nat Cell Biol. 5:776–778. 2003. View Article : Google Scholar : PubMed/NCBI

32 

Jiang M, Esteve-Rudd J, Lopes VS, Diemer T, Lillo C, Rump A and Williams DS: Microtubule motors transport phagosomes in the RPE and lack of KLC1 leads to AMD-like pathogenesis. J Cell Biol. 210:595–611. 2015. View Article : Google Scholar : PubMed/NCBI

33 

Chen YG, Satpathy AT and Chang HY: Gene regulation in the immune system by long noncoding RNAs. Nat Immunol. 18:962–972. 2017. View Article : Google Scholar : PubMed/NCBI

34 

Zheng Y, Liu L and Shukla GC: A comprehensive review of web-based non-coding RNA resources for cancer research. Cancer Lett. 407:1–5. 2017. View Article : Google Scholar : PubMed/NCBI

35 

Jarroux J, Morillon A and Pinskaya M: History, discovery and classification of lncRNAs. Adv Exp Med Biol. 1008:1–46. 2017. View Article : Google Scholar : PubMed/NCBI

36 

Wan P, Su W and Zhuo Y: Precise long non-coding RNA modulation in visual maintenance and impairment. J Med Genet. 54:450–459. 2017. View Article : Google Scholar : PubMed/NCBI

37 

Liu J, Ding X, Yuan L and Zhang X: Identification of pterygium-related long non-coding RNAs and expression profiling by microarray analysis. Int J Mol Med. 38:529–536. 2016. View Article : Google Scholar : PubMed/NCBI

38 

Li F, Wen X, Zhang H and Fan X: Novel insights into the role of long noncoding RNA in ocular diseases. Int J Mol Sci. 17:4782016. View Article : Google Scholar : PubMed/NCBI

39 

Gong C, Li Z, Ramanujan K, Clay I, Zhang Y, Lemire-Brachat S and Glass DJ: A long non-coding RNA, LncMyoD, regulates skeletal muscle differentiation by blocking IMP2-mediated mRNA translation. Dev Cell. 34:181–191. 2015. View Article : Google Scholar : PubMed/NCBI

40 

Antunes-Foschini RS, Miyashita D, Bicas HE and McLoon LK: Activated satellite cells in medial rectus muscles of patients with strabismus. Invest Ophthalmol Vis Sci. 49:215–220. 2008. View Article : Google Scholar : PubMed/NCBI

41 

Jin CF, Li Y, Ding XB, Li X, Zhang LL, Liu XF and Guo H: lnc133b, a novel, long non-coding RNA, regulates bovine skeletal muscle satellite cell proliferation and differentiation by mediating miR-133b. Gene. 630:35–43. 2017. View Article : Google Scholar : PubMed/NCBI

42 

Tang R, Zhang G, Wang YC, Mei X and Chen SY: The long non-coding RNA GAS5 regulates transforming growth factor beta (TGF-beta)-induced smooth muscle cell differentiation via RNA Smad-binding elements. J Biol Chem. 292:14270–14278. 2017. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Ma WX, Huang XG, Yang TK and Yao JY: Involvement of dysregulated coding and long non‑coding RNAs in the pathogenesis of strabismus. Mol Med Rep 17: 7737-7745, 2018.
APA
Ma, W., Huang, X., Yang, T., & Yao, J. (2018). Involvement of dysregulated coding and long non‑coding RNAs in the pathogenesis of strabismus. Molecular Medicine Reports, 17, 7737-7745. https://doi.org/10.3892/mmr.2018.8832
MLA
Ma, W., Huang, X., Yang, T., Yao, J."Involvement of dysregulated coding and long non‑coding RNAs in the pathogenesis of strabismus". Molecular Medicine Reports 17.6 (2018): 7737-7745.
Chicago
Ma, W., Huang, X., Yang, T., Yao, J."Involvement of dysregulated coding and long non‑coding RNAs in the pathogenesis of strabismus". Molecular Medicine Reports 17, no. 6 (2018): 7737-7745. https://doi.org/10.3892/mmr.2018.8832
Copy and paste a formatted citation
x
Spandidos Publications style
Ma WX, Huang XG, Yang TK and Yao JY: Involvement of dysregulated coding and long non‑coding RNAs in the pathogenesis of strabismus. Mol Med Rep 17: 7737-7745, 2018.
APA
Ma, W., Huang, X., Yang, T., & Yao, J. (2018). Involvement of dysregulated coding and long non‑coding RNAs in the pathogenesis of strabismus. Molecular Medicine Reports, 17, 7737-7745. https://doi.org/10.3892/mmr.2018.8832
MLA
Ma, W., Huang, X., Yang, T., Yao, J."Involvement of dysregulated coding and long non‑coding RNAs in the pathogenesis of strabismus". Molecular Medicine Reports 17.6 (2018): 7737-7745.
Chicago
Ma, W., Huang, X., Yang, T., Yao, J."Involvement of dysregulated coding and long non‑coding RNAs in the pathogenesis of strabismus". Molecular Medicine Reports 17, no. 6 (2018): 7737-7745. https://doi.org/10.3892/mmr.2018.8832
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