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(‑)‑Epicatechin protects against myocardial ischemia‑induced cardiac injury via activation of the PTEN/PI3K/AKT pathway

  • Authors:
    • Jia‑Wen Li
    • Xiao‑Yun Wang
    • Xin Zhang
    • Lei Gao
    • Li‑Feng Wang
    • Xin‑Hua Yin
  • View Affiliations / Copyright

    Affiliations: Department of Cardiology, First Affiliated Hospital, Harbin Medical University, Harbin, Heilongjiang 150001, P.R. China, Department of Cardiology, Fourth Affiliated Hospital, Harbin Medical University, Harbin, Heilongjiang 150001, P.R. China
    Copyright: © Li et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 8300-8308
    |
    Published online on: April 12, 2018
       https://doi.org/10.3892/mmr.2018.8870
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Abstract

Flavonol (‑)‑epicatechin (EPI) is primarily contained in green tea (Camellia sinensis) and cocoa beans (Theobroma cacao), and has been demonstrated to be beneficial for the health of the cardiovascular system. However, the effect and the underlying mechanism of EPI on myocardial ischemia induced cardiac injury has not yet been determined. Therefore, the present study aimed to detect whether EPI inhibited myocardial ischemia injury. An in vivo mouse myocardial ischemia model was induced by the ligation of left descending coronary artery for 7 days. EPI (1 mg/kg/day) was administrated 10 days prior to myocardial ischemia operation. The in vitro mouse myocardial ischemia model was induced by cultivating neonatal mouse cardiomyocytes under anoxia condition for 12 h. Cardiomyocytes were treated with EPI (5 µM) for 1 h and then incubated under anoxia conditions. Mouse hearts and cultured cardiomyocytes were used for hematoxylin‑eosin, masson, ultrasonography, terminal dUTP nick end‑labeling, immunofluorescence, western blotting and MTT assays. Results revealed that myocardial ischemia‑induced mouse cardiac injury was significantly inhibited by EPI, as evidenced by decreased myocardial apoptosis, cardiac fibrosis and myocardial hypertrophy and improved cardiac function. In addition, it was confirmed that EPI serves a protective effect against myocardial ischemia via the phosphatase and tensin homolog (PTEN)/phosphoinositide 3‑kinase (PI3K)/protein kinase B (AKT) signaling pathway, which was reversed by the PI3K inhibitor, LY294002. The protective role of EPI in myocardial apoptosis was further confirmed on mouse cardiomyocytes following anoxia treatment in vitro. In conclusion, the data suggested that EPI protects against myocardial ischemia induced cardiac injury through the PTEN/PI3K/AKT signaling pathway in vivo and in vitro, which may provide clinical therapeutic approaches and targets for cardiac ischemia injury.
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View References

1 

Steg PG, Greenlaw N, Tendera M, Tardif JC, Ferrari R, Al-Zaibag M, Dorian P, Hu D, Shalnova S, Sokn FJ, et al: Prevalence of anginal symptoms and myocardial ischemia and their effect on clinical outcomes in outpatients with stable coronary artery disease: Data from the international observational CLARIFY registry. JAMA Intern Med. 174:1651–1659. 2014. View Article : Google Scholar : PubMed/NCBI

2 

Cheng D, Zhu C, Cao J and Jiang W: The protective effects of polyphenols from jujube peel (Ziziphus Jujube Mill) on isoproterenol-induced myocardial ischemia and aluminum-induced oxidative damage in rats. Food Chem Toxicol. 50:1302–1308. 2012. View Article : Google Scholar : PubMed/NCBI

3 

Misumida N, Kobayashi A, Saeed M, Fox JT and Kanei Y: Electrocardiographic left ventricular hypertrophy as a predictor for nonsignificant coronary artery disease in patients with non-ST-segment elevation myocardial infarction. Angiology. 67:27–33. 2016. View Article : Google Scholar : PubMed/NCBI

4 

Sung HK, Chan YK, Han M, Jahng JWS, Song E, Danielson E, Berger T, Mak TW and Sweeney G: Lipocalin-2 (NGAL) attenuates autophagy to exacerbate cardiac apoptosis induced by myocardial ischemia. J Cell Physiol. 232:2125–2134. 2017. View Article : Google Scholar : PubMed/NCBI

5 

Panza JA, Holly TA, Asch FM, She L, Pellikka PA, Velazquez EJ, Lee KL, Borges-Neto S, Farsky PS, Jones RH, et al: Inducible myocardial ischemia and outcomes in patients with coronary artery disease and left ventricular dysfunction. J Am Coll Cardiol. 61:1860–1870. 2013. View Article : Google Scholar : PubMed/NCBI

6 

Patel RD and Saver JL: Evolution of reperfusion therapies for acute brain and acute myocardial ischemia: A systematic, comparative analysis. Stroke. 44:94–98. 2013. View Article : Google Scholar : PubMed/NCBI

7 

Shay J, Elbaz HA, Lee I, Zielske SP, Malek MH and Huttemann M: Molecular mechanisms and therapeutic effects of (−)-epicatechin and other polyphenols in cancer, inflammation, diabetes, and neurodegeneration. Oxidat Med Cell Longev. 2015:1812602015. View Article : Google Scholar

8 

Quine SD and Raghu PS: Effects of (−)-epicatechin, a flavonoid on lipid peroxidation and antioxidants in streptozotocin-induced diabetic liver, kidney and heart. Pharmacol Rep. 57:610–615. 2005.PubMed/NCBI

9 

Yamazaki KG, Romero-Perez D, Barraza-Hidalgo M, Cruz M, Rivas M, Cortez-Gomez B, Ceballos G and Villarreal F: Short- and long-term effects of (−)-epicatechin on myocardial ischemia-reperfusion injury. Am J Physiol Heart Circulat Physiol. 295:H761–H767. 2008. View Article : Google Scholar

10 

Yamazaki KG, Taub PR, Barraza-Hidalgo M, Rivas MM, Zambon AC, Ceballos G and Villarreal FJ: Effects of (−)-epicatechin on myocardial infarct size and left ventricular remodeling after permanent coronary occlusion. J Am Coll Cardiol. 55:2869–2876. 2010. View Article : Google Scholar : PubMed/NCBI

11 

Sheng R, Gu ZL and Xie ML: Epigallocatechin gallate, the major component of polyphenols in green tea, inhibits telomere attrition mediated cardiomyocyte apoptosis in cardiac hypertrophy. Int J Cardiol. 162:199–209. 2013. View Article : Google Scholar : PubMed/NCBI

12 

Suzuki J, Ogawa M, Maejima Y, Isobe K, Tanaka H, Sagesaka YM and Isobe M: Tea catechins attenuate chronic ventricular remodeling after myocardial ischemia in rats. J Mol Cell Cardiol. 42:432–440. 2007. View Article : Google Scholar : PubMed/NCBI

13 

Ke Z, Wang G, Yang L, Qiu H, Wu H, Du M, Chen J, Song J, Jia X and Feng L: Crude terpene glycoside component from Radix paeoniae rubra protects against isoproterenol-induced myocardial ischemic injury via activation of the PI3K/AKT/mTOR signaling pathway. J Ethnopharmacol. 206:160–169. 2017. View Article : Google Scholar : PubMed/NCBI

14 

Cui G, Shan L, Hung M, Lei S, Choi I, Zhang Z, Yu P, Hoi P, Wang Y and Lee SM: A novel Danshensu derivative confers cardioprotection via PI3K/Akt and Nrf2 pathways. Int J Cardiol. 168:1349–1359. 2013. View Article : Google Scholar : PubMed/NCBI

15 

Zhang J, Yu XH, Yan YG, Wang C and Wang WJ: PI3K/Akt signaling in osteosarcoma. Clin Chim Acta. 444:182–192. 2015. View Article : Google Scholar : PubMed/NCBI

16 

Ouyang ZH, Wang WJ, Yan YG, Wang B and Lv GH: The PI3K/Akt pathway: A critical player in intervertebral disc degeneration. Oncotarget. 8:57870–57881. 2017. View Article : Google Scholar : PubMed/NCBI

17 

De Los Santos S, García-Pérez V, Hernández-Reséndiz S, Palma-Flores C, González-Gutiérrez CJ, Zazueta C, Canto P and Coral-Vázquez RM: (−)-Epicatechin induces physiological cardiac growth by activation of the PI3K/Akt pathway in mice. Mol Nutri Food Res. 61:2017.

18 

Li C, Li X, Gao X, Zhang R, Zhang Y, Liang H, Xu C, Du W, Zhang Y, Liu X, et al: MicroRNA-328 as a regulator of cardiac hypertrophy. Int J Cardiol. 173:268–276. 2014. View Article : Google Scholar : PubMed/NCBI

19 

Pan Z, Sun X, Shan H, Wang N, Wang J, Ren J, Feng S, Xie L, Lu C, Yuan Y, et al: MicroRNA-101 inhibited postinfarct cardiac fibrosis and improved left ventricular compliance via the FBJ osteosarcoma oncogene/transforming growth factor-β1 pathway. Circulation. 126:840–850. 2012. View Article : Google Scholar : PubMed/NCBI

20 

Abbate A, Salloum FN, Van Tassell BW, Vecile E, Toldo S, Seropian I, Mezzaroma E and Dobrina A: Alterations in the interleukin-1/interleukin-1 receptor antagonist balance modulate cardiac remodeling following myocardial infarction in the mouse. PLoS One. 6:e279232011. View Article : Google Scholar : PubMed/NCBI

21 

Panneerselvam M, Tsutsumi YM, Bonds JA, Horikawa YT, Saldana M, Dalton ND, Head BP, Patel PM, Roth DM and Patel HH: Dark chocolate receptors: Epicatechin-induced cardiac protection is dependent on delta-opioid receptor stimulation. Am J Physiol Heart Circ Physiol. 299:H1604–H1609. 2010. View Article : Google Scholar : PubMed/NCBI

22 

Wu AZ, Loh SH, Cheng TH, Lu HH and Lin CI: Antiarrhythmic effects of (−)-epicatechin-3-gallate, a novel sodium channel agonist in cultured neonatal rat ventricular myocytes. Biochem Pharmacol. 85:69–80. 2013. View Article : Google Scholar : PubMed/NCBI

23 

Feng W, Hwang HS, Kryshtal DO, Yang T, Padilla IT, Tiwary AK, Puschner B, Pessah IN and Knollmann BC: Coordinated regulation of murine cardiomyocyte contractility by nanomolar (−)-epigallocatechin-3-gallate, the major green tea catechin. Mol Pharmacol. 82:993–1000. 2012. View Article : Google Scholar : PubMed/NCBI

24 

Siddall HK, Warrell CE, Yellon DM and Mocanu MM: Ischemia-reperfusion injury and cardioprotection: Investigating PTEN, the phosphatase that negatively regulates PI3K, using a congenital model of PTEN haploinsufficiency. Basic Res Cardiol. 103:560–568. 2008. View Article : Google Scholar : PubMed/NCBI

25 

Ounzain S, Crippa S and Pedrazzini T: Small and long non-coding RNAs in cardiac homeostasis and regeneration. Biochim Biophys Acta. 1833:923–933. 2013. View Article : Google Scholar : PubMed/NCBI

26 

Wang JX, Zhang XJ, Li Q, Wang K, Wang Y, Jiao JQ, Feng C, Teng S, Zhou LY, Gong Y, et al: MicroRNA-103/107 regulate programmed necrosis and myocardial ischemia/reperfusion injury through targeting FADD. Circ Res. 117:352–363. 2015. View Article : Google Scholar : PubMed/NCBI

27 

Rein D, Lotito S, Holt RR, Keen CL, Schmitz HH and Fraga CG: Epicatechin in human plasma: In vivo determination and effect of chocolate consumption on plasma oxidation status. J Nutri. 130 8S Suppl:S2109–S2114. 2000. View Article : Google Scholar

28 

Del Rio D, Rodriguez-Mateos A, Spencer JP, Tognolini M, Borges G and Crozier A: Dietary (poly)phenolics in human health: Structures, bioavailability, and evidence of protective effects against chronic diseases. Antioxidants Redox Signal. 18:1818–1892. 2013. View Article : Google Scholar

29 

Cremonini E, Bettaieb A, Haj FG, Fraga CG and Oteiza PI: (−)-Epicatechin improves insulin sensitivity in high fat diet-fed mice. Arch Biochem Biophys. 599:13–21. 2016. View Article : Google Scholar : PubMed/NCBI

30 

Drouin A, Bolduc V, Thorin-Trescases N, Bélanger É, Fernandes P, Baraghis E, Lesage F, Gillis MA, Villeneuve L, Hamel E, et al: Catechin treatment improves cerebrovascular flow-mediated dilation and learning abilities in atherosclerotic mice. Am J Physiol Heart Circ Physiol. 300:H1032–H1043. 2011. View Article : Google Scholar : PubMed/NCBI

31 

Lotito SB and Frei B: Consumption of flavonoid-rich foods and increased plasma antioxidant capacity in humans: Cause, consequence, or epiphenomenon? Free Radic Biol Med. 41:1727–1746. 2006. View Article : Google Scholar : PubMed/NCBI

32 

Chen DD, Dong YG, Liu D and He JG: Epigallocatechin-3-gallate attenuates cardiac hypertrophy in hypertensive rats in part by modulation of mitogen-activated protein kinase signals. Clin Exp Pharmacol Physiol. 36:925–932. 2009. View Article : Google Scholar : PubMed/NCBI

33 

Hao J, Kim CH, Ha TS and Ahn HY: Epigallocatechin-3 gallate prevents cardiac hypertrophy induced by pressure overload in rats. J Vet Sci. 8:121–129. 2007. View Article : Google Scholar : PubMed/NCBI

34 

Lau E: Complex disease: Piecing together the puzzle of coronary artery disease. Nat Rev Genet. 15:572–573. 2014. View Article : Google Scholar : PubMed/NCBI

35 

Atif F, Yousuf S and Stein DG: Anti-tumor effects of progesterone in human glioblastoma multiforme: Role of PI3K/Akt/mTOR signaling. J Steroid Biochem Mol Biol. 146:62–73. 2015. View Article : Google Scholar : PubMed/NCBI

36 

Ji H, Ding Z, Hawke D, Xing D, Jiang BH, Mills GB and Lu Z: AKT-dependent phosphorylation of Niban regulates nucleophosmin- and MDM2-mediated p53 stability and cell apoptosis. EMBO Rep. 13:554–560. 2012. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Li JW, Wang XY, Zhang X, Gao L, Wang LF and Yin XH: (‑)‑Epicatechin protects against myocardial ischemia‑induced cardiac injury via activation of the PTEN/PI3K/AKT pathway. Mol Med Rep 17: 8300-8308, 2018.
APA
Li, J., Wang, X., Zhang, X., Gao, L., Wang, L., & Yin, X. (2018). (‑)‑Epicatechin protects against myocardial ischemia‑induced cardiac injury via activation of the PTEN/PI3K/AKT pathway. Molecular Medicine Reports, 17, 8300-8308. https://doi.org/10.3892/mmr.2018.8870
MLA
Li, J., Wang, X., Zhang, X., Gao, L., Wang, L., Yin, X."(‑)‑Epicatechin protects against myocardial ischemia‑induced cardiac injury via activation of the PTEN/PI3K/AKT pathway". Molecular Medicine Reports 17.6 (2018): 8300-8308.
Chicago
Li, J., Wang, X., Zhang, X., Gao, L., Wang, L., Yin, X."(‑)‑Epicatechin protects against myocardial ischemia‑induced cardiac injury via activation of the PTEN/PI3K/AKT pathway". Molecular Medicine Reports 17, no. 6 (2018): 8300-8308. https://doi.org/10.3892/mmr.2018.8870
Copy and paste a formatted citation
x
Spandidos Publications style
Li JW, Wang XY, Zhang X, Gao L, Wang LF and Yin XH: (‑)‑Epicatechin protects against myocardial ischemia‑induced cardiac injury via activation of the PTEN/PI3K/AKT pathway. Mol Med Rep 17: 8300-8308, 2018.
APA
Li, J., Wang, X., Zhang, X., Gao, L., Wang, L., & Yin, X. (2018). (‑)‑Epicatechin protects against myocardial ischemia‑induced cardiac injury via activation of the PTEN/PI3K/AKT pathway. Molecular Medicine Reports, 17, 8300-8308. https://doi.org/10.3892/mmr.2018.8870
MLA
Li, J., Wang, X., Zhang, X., Gao, L., Wang, L., Yin, X."(‑)‑Epicatechin protects against myocardial ischemia‑induced cardiac injury via activation of the PTEN/PI3K/AKT pathway". Molecular Medicine Reports 17.6 (2018): 8300-8308.
Chicago
Li, J., Wang, X., Zhang, X., Gao, L., Wang, L., Yin, X."(‑)‑Epicatechin protects against myocardial ischemia‑induced cardiac injury via activation of the PTEN/PI3K/AKT pathway". Molecular Medicine Reports 17, no. 6 (2018): 8300-8308. https://doi.org/10.3892/mmr.2018.8870
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