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Article Open Access

LncSOX4 serves an oncogenic role in the tumorigenesis of epithelial ovarian cancer by promoting cell proliferation and inhibiting apoptosis

  • Authors:
    • Yulan Liu
    • Yan Wang
    • Dongmei Yao
    • Diansheng Cui
  • View Affiliations / Copyright

    Affiliations: Gynecology Department, Hubei Women and Children's Hospital, Wuhan, Hubei 430070, P.R. China, Urology Department, Hubei Cancer Hospital, Wuhan, Hubei 430079, P.R. China
    Copyright: © Liu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 8282-8288
    |
    Published online on: April 18, 2018
       https://doi.org/10.3892/mmr.2018.8892
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Abstract

Epithelial ovarian cancer is one of the primary causes of gynecological cancer mortality. Increasing evidence has suggested that long non‑coding RNAs (lncRNAs) may serve a pivotal role in cancer development. To determine whether Lnc SRY‑box 4 (SOX4), an lncRNA, promotes the self‑renewal of liver tumor cells and contributes to the development of epithelial ovarian cancer, the present study investigated the expression of LncSOX4 in clinical epithelial ovarian cancer tissues and non‑cancer controls by reverse transcription‑quantitative polymerase chain reaction analysis. In addition, siRNA targeting LncSOX4 was designed and transfected into epithelial ovarian cancer cells to further assess the effect of knocking out LncSOX4 on cellular apoptosis, cell viability, proliferation and the cell cycle. The results demonstrated that the LncSOX4 expression level was significantly upregulated in epithelial ovarian cancer tissues (3.98 vs. 1.71, P<0.001). Silencing LncSOX4 in the SKOV3 and OVCAR3 cell lines significantly impaired cell proliferation (P<0.001). Cell cycle assays revealed that the proportion of cells in the G0/G1 phase increased significantly, whereas those in the S phase and G2/M phase decreased. Apoptosis rate additionally increased following knockdown of LncSOX4 in the two cell lines. Furthermore, it was observed that an increased LncSOX4 expression level was positively associated with larger tumor sizes, more advanced tumor grade and more distant metastases.
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Copy and paste a formatted citation
Spandidos Publications style
Liu Y, Wang Y, Yao D and Cui D: LncSOX4 serves an oncogenic role in the tumorigenesis of epithelial ovarian cancer by promoting cell proliferation and inhibiting apoptosis. Mol Med Rep 17: 8282-8288, 2018.
APA
Liu, Y., Wang, Y., Yao, D., & Cui, D. (2018). LncSOX4 serves an oncogenic role in the tumorigenesis of epithelial ovarian cancer by promoting cell proliferation and inhibiting apoptosis. Molecular Medicine Reports, 17, 8282-8288. https://doi.org/10.3892/mmr.2018.8892
MLA
Liu, Y., Wang, Y., Yao, D., Cui, D."LncSOX4 serves an oncogenic role in the tumorigenesis of epithelial ovarian cancer by promoting cell proliferation and inhibiting apoptosis". Molecular Medicine Reports 17.6 (2018): 8282-8288.
Chicago
Liu, Y., Wang, Y., Yao, D., Cui, D."LncSOX4 serves an oncogenic role in the tumorigenesis of epithelial ovarian cancer by promoting cell proliferation and inhibiting apoptosis". Molecular Medicine Reports 17, no. 6 (2018): 8282-8288. https://doi.org/10.3892/mmr.2018.8892
Copy and paste a formatted citation
x
Spandidos Publications style
Liu Y, Wang Y, Yao D and Cui D: LncSOX4 serves an oncogenic role in the tumorigenesis of epithelial ovarian cancer by promoting cell proliferation and inhibiting apoptosis. Mol Med Rep 17: 8282-8288, 2018.
APA
Liu, Y., Wang, Y., Yao, D., & Cui, D. (2018). LncSOX4 serves an oncogenic role in the tumorigenesis of epithelial ovarian cancer by promoting cell proliferation and inhibiting apoptosis. Molecular Medicine Reports, 17, 8282-8288. https://doi.org/10.3892/mmr.2018.8892
MLA
Liu, Y., Wang, Y., Yao, D., Cui, D."LncSOX4 serves an oncogenic role in the tumorigenesis of epithelial ovarian cancer by promoting cell proliferation and inhibiting apoptosis". Molecular Medicine Reports 17.6 (2018): 8282-8288.
Chicago
Liu, Y., Wang, Y., Yao, D., Cui, D."LncSOX4 serves an oncogenic role in the tumorigenesis of epithelial ovarian cancer by promoting cell proliferation and inhibiting apoptosis". Molecular Medicine Reports 17, no. 6 (2018): 8282-8288. https://doi.org/10.3892/mmr.2018.8892
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