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Article

MicroRNA‑29a is involved lipid metabolism dysfunction and insulin resistance in C2C12 myotubes by targeting PPARδ

  • Authors:
    • Peng Wu
    • Qianyi Wang
    • Cuilian Jiang
    • Chen Chen
    • Yun Liu
    • Yajun Chen
    • Yu Zeng
  • View Affiliations / Copyright

    Affiliations: Clinical Medical College, Jiangsu Health Vocational College, Nanjing, Jiangsu 211800, P.R. China, High School Affiliated to Nanjing Normal University, Nanjing, Jiangsu 210003, P.R. China, Department of Clinical Laboratory, Nanjing Maternity and Child Health Care Hospital, Obstetrics and Gynecology Hospital Affiliated to Nanjing Medical University, Nanjing, Jiangsu 210029, P.R. China
  • Pages: 8493-8501
    |
    Published online on: April 19, 2018
       https://doi.org/10.3892/mmr.2018.8902
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Abstract

MicroRNA‑29a (miR‑29a) expression has been reported to be closely associated with skeletal muscle insulin resistance and type 2 diabetes. The present study investigated the effect of miR‑29a on palmitic acid (PA)‑induced lipid metabolism dysfunction and insulin resistance in C2C12 myotubes via overexpressing or silencing of miR‑29a expression. Mouse C2C12 myoblasts were cultured, differentiated and transfected with miR‑29a or miR‑29a inhibitor lentiviral with or without subsequent palmitic acid (PA) treatment. Reverse transcription‑quantitative polymerase chain reaction (RT‑qPCR) and western blot analysis were performed to assess the mRNA and protein levels of related genes, respectively. PA treatment increased the expression of miR‑29a in a time‑ and dose‑ dependent manner. miR‑29a silencing improved insulin‑induced glucose uptake and increased glucose transporter‑4 (GLUT4) transportation to the plasma membrane by upregulating its target peroxisome proliferator‑activated receptor δ (PPARδ). Furthermore, it was observed that miR‑29a regulated the expression of genes associated with lipid metabolism, including pyruvate dehydrogenase kinase isoform, mitochondrial uncoupling protein (UCP)2, UCP3, long chain specific acyl‑CoA dehydrogenase, mitochondrial and fatty acid transport protein 2. The results confirmed that silencing miR‑29a induced a decrease in glucose transport and affected lipid metabolism in PA‑treated C2C12 cells, and therefore may be involved in insulin resistance by targeting PPARδ in skeletal muscle. Therefore, the inhibition of miR‑29a may be a potential novel strategy for treating insulin resistance and type 2 diabetes.
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1 

Phillips DI, Barker DJ, Hales CN, Hirst S and Osmond C: Thinness at birth and insulin resistance in adult life. Diabetologia. 37:150–154. 1994. View Article : Google Scholar : PubMed/NCBI

2 

Bouzakri K, Koistinen HA and Zierath JR: Molecular mechanisms of skeletal muscle insulin resistance in type 2 diabetes. Curr Diabet Rev. 1:167–174. 2005. View Article : Google Scholar

3 

Goodpaster BH and Wolf D: Skeletal muscle lipid accumulation in obesity, insulin resistance, and type 2 diabetes. Pediatr Diabetes. 5:219–226. 2004. View Article : Google Scholar : PubMed/NCBI

4 

Morino K, Petersen KF and Shulman GI: Molecular mechanisms of insulin resistance in humans and their potential links with mitochondrial dysfunction. Diabetes. 55 Suppl 2:S9–S15. 2006. View Article : Google Scholar : PubMed/NCBI

5 

Di Meo S, Iossa S and Venditti P: Skeletal muscle insulin resistance: Role of mitochondria and other ROS sources. J Endocrinol. 233:R15–R42. 2017. View Article : Google Scholar : PubMed/NCBI

6 

Morales PE, Bucarey JL and Espinosa A: Muscle lipid metabolism: Role of lipid droplets and perilipins. J Diabetes Res. 2017:17893952017. View Article : Google Scholar : PubMed/NCBI

7 

Ambros V: The functions of animal microRNAs. Nature. 431:350–355. 2004. View Article : Google Scholar : PubMed/NCBI

8 

Bartel DP: MicroRNAs: Genomics, biogenesis, mechanism, and function. Cell. 116:281–297. 2004. View Article : Google Scholar : PubMed/NCBI

9 

Quinn JJ and Chang HY: Unique features of long non-coding RNA biogenesis and function. Nat Rev Genet. 17:47–62. 2016. View Article : Google Scholar : PubMed/NCBI

10 

McClelland AD and Kantharidis P: microRNA in the development of diabetic complications. Clin Sci (Lond). 126:95–110. 2014. View Article : Google Scholar : PubMed/NCBI

11 

Zhou T, Meng X, Che H, Shen N, Xiao D, Song X, Liang M, Fu X, Ju J, Li Y, et al: Regulation of insulin resistance by multiple MiRNAs via targeting the GLUT4 signalling pathway. Cell Physiol Biochem. 38:2063–2078. 2016. View Article : Google Scholar : PubMed/NCBI

12 

Fde Frias T, de Mendonça M, Martins AR, Gindro AF, Cogliati B, Curi R and Rodrigues AC: MyomiRs as markers of insulin resistance and decreased myogenesis in skeletal muscle of diet-induced obese mice. Front Endocrinol (Lausanne). 7:762016.PubMed/NCBI

13 

He A, Zhu L, Gupta N, Chang Y and Fang F: Overexpression of micro ribonucleic acid 29, highly up-regulated in diabetic rats, leads to insulin resistance in 3T3-L1 adipocytes. Mol Endocrinol. 21:2785–2794. 2007. View Article : Google Scholar : PubMed/NCBI

14 

Zhou Y, Gu P, Shi W, Li J, Hao Q, Cao X, Lu Q and Zeng Y: MicroRNA-29a induces insulin resistance by targeting PPARδ in skeletal muscle cells. Int J Mol Med. 37:931–938. 2016. View Article : Google Scholar : PubMed/NCBI

15 

Kong L, Zhu J, Han W, Jiang X, Xu M, Zhao Y, Dong Q, Pang Z, Guan Q, Gao L, et al: Significance of serum microRNAs in pre-diabetes and newly diagnosed type 2 diabetes: A clinical study. Acta Diabetol. 48:61–69. 2011. View Article : Google Scholar : PubMed/NCBI

16 

Peng H, Zhong M, Zhao W, Wang C, Zhang J, Liu X, Li Y, Paudel SD, Wang Q and Lou T: Urinary miR-29 correlates with albuminuria and carotid intima-media thickness in type 2 diabetes patients. PloS One. 8:e826072013. View Article : Google Scholar : PubMed/NCBI

17 

Tao W, Dong X, Kong G, Fang P, Huang X and Bo P: Elevated circulating hsa-miR-106b, hsa-miR-26a, and hsa-miR-29b in type 2 diabetes mellitus with diarrhea-predominant irritable bowel syndrome. Gastroenterol Res Pract. 2016:92562092016. View Article : Google Scholar : PubMed/NCBI

18 

Doktorova M, Zwarts I, Zutphen TV, Dijk TH, Bloks VW, Harkema L, Bruin A, Downes M, Evans RM, Verkade HJ and Jonker JW: Intestinal PPARδ protects against diet-induced obesity, insulin resistance and dyslipidemia. Sci Rep. 7:8462017. View Article : Google Scholar : PubMed/NCBI

19 

Sprecher DL: Lipids, lipoproteins, and peroxisome proliferator activated receptor-delta. Am J Cardiol. 100:n20–n24. 2007. View Article : Google Scholar : PubMed/NCBI

20 

Cox RL: Rationally designed PPARδ-specific agonists and their therapeutic potential for metabolic syndrome. Proc Natl Acad Sci USA. 114:3284–3285. 2017. View Article : Google Scholar : PubMed/NCBI

21 

Zhang Y, Zhao YP, Gao YF, Fan ZM, Liu MY, Cai XY, Xia ZK and Gao CL: Silencing miR-106b improves palmitic acid-induced mitochondrial dysfunction and insulin resistance in skeletal myocytes. Mol Med Rep. 11:3834–3841. 2015. View Article : Google Scholar : PubMed/NCBI

22 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

23 

Dooley J, Garcia-Perez JE, Sreenivasan J, Schlenner SM, Vangoitsenhoven R, Papadopoulou AS, Tian L, Schonefeldt S, Serneels L, Deroose C, et al: The microRNA-29 family dictates the balance between homeostatic and pathological glucose handling in diabetes and obesity. Diabetes. 65:53–61. 2016. View Article : Google Scholar : PubMed/NCBI

24 

Bagge A, Clausen TR, Larsen S, Ladefoged M, Rosenstierne MW, Larsen L, Vang O, Nielsen JH and Dalgaard LT: MicroRNA-29a is up-regulated in beta-cells by glucose and decreases glucose-stimulated insulin secretion. Biochem Biophys Res Commun. 426:266–272. 2012. View Article : Google Scholar : PubMed/NCBI

25 

Roggli E, Gattesco S, Caille D, Briet C, Boitard C, Meda P and Regazzi R: Changes in microRNA expression contribute to pancreatic beta-cell dysfunction in prediabetic NOD mice. Diabetes. 61:1742–1751. 2012. View Article : Google Scholar : PubMed/NCBI

26 

Wang YX, Zhang CL, Yu RT, Cho HK, Nelson MC, Bayuga-Ocampo CR, Ham J, Kang H and Evans RM: Regulation of muscle fiber type and running endurance by PPARdelta. PLoS Biol. 2:e2942004. View Article : Google Scholar : PubMed/NCBI

27 

Yang WM, Min KH and Lee W: MiR-1271 upregulated by saturated fatty acid palmitate provokes impaired insulin signaling by repressing INSR and IRS-1 expression in HepG2 cells. Biochem Biophys Res Commun. 478:1786–1791. 2016. View Article : Google Scholar : PubMed/NCBI

28 

Ye M, Qiu H, Cao Y, Zhang M, Mi Y, Yu J and Wang C: Curcumin improves palmitate-induced insulin resistance in human umbilical vein endothelial cells by maintaining proteostasis in endoplasmic reticulum. Front Pharmacol. 8:1482017. View Article : Google Scholar : PubMed/NCBI

29 

Simon-Szabó L, Kokas M, Mandl J, Kéri G and Csala M: Metformin attenuates palmitate-induced endoplasmic reticulum stress, serine phosphorylation of IRS-1 and apoptosis in rat insulinoma cells. PloS One. 9:e978682014. View Article : Google Scholar : PubMed/NCBI

30 

Bakar Abu MH and Tan JS: Improvement of mitochondrial function by celastrol in palmitate-treated C2C12 myotubes via activation of PI3K-Akt signaling pathway. Biomed Pharmacother. 93:903–912. 2017. View Article : Google Scholar : PubMed/NCBI

31 

Yang WM, Jeong HJ, Park SY and Lee W: Induction of miR-29a by saturated fatty acids impairs insulin signaling and glucose uptake through translational repression of IRS-1 in myocytes. FEBS Lett. 588:2170–2176. 2014. View Article : Google Scholar : PubMed/NCBI

32 

Krämer DK, Al-Khalili L, Perrini S, Skogsberg J, Wretenberg P, Kannisto K, Wallberg-Henriksson H, Ehrenborg E, Zierath JR and Krook A: Direct activation of glucose transport in primary human myotubes after activation of peroxisome proliferator-activated receptor delta. Diabetes. 54:1157–1163. 2005. View Article : Google Scholar : PubMed/NCBI

33 

Krämer DK, Al-Khalili L, Guigas B, Leng Y, Garcia-Roves PM and Krook A: Role of AMP kinase and PPARdelta in the regulation of lipid and glucose metabolism in human skeletal muscle. J Biol Chem. 282:19313–19320. 2007. View Article : Google Scholar : PubMed/NCBI

34 

Perry RJ, Samuel VT, Petersen KF and Shulman GI: The role of hepatic lipids in hepatic insulin resistance and type 2 diabetes. Nature. 510:84–91. 2014. View Article : Google Scholar : PubMed/NCBI

35 

Kong Q, Zhang H, Zhao T, Zhang W, Yan M, Dong X and Li P: Tangshen formula attenuates hepatic steatosis by inhibiting hepatic lipogenesis and augmenting fatty acid oxidation in db/db mice. Int J Mol Med. 38:1715–1726. 2016. View Article : Google Scholar : PubMed/NCBI

36 

Liston A, Papadopoulou AS, Danso-Abeam D and Dooley J: MicroRNA-29 in the adaptive immune system: Setting the threshold. Cell Mol Life Sci. 69:3533–3541. 2012. View Article : Google Scholar : PubMed/NCBI

37 

Bouvy-Liivrand M, Heinäniemi M, John E, Schneider JG, Sauter T and Sinkkonen L: Combinatorial regulation of lipoprotein lipase by microRNAs during mouse adipogenesis. RNA Biol. 11:76–91. 2014. View Article : Google Scholar : PubMed/NCBI

38 

Wang YX, Lee CH, Tiep S, Yu RT, Ham J, Kang H and Evans RM: Peroxisome-proliferator-activated receptor delta activates fat metabolism to prevent obesity. Cell. 113:159–170. 2003. View Article : Google Scholar : PubMed/NCBI

39 

Abbot EL, McCormack JG, Reynet C, Hassall DG, Buchan KW and Yeaman SJ: Diverging regulation of pyruvate dehydrogenase kinase isoform gene expression in cultured human muscle cells. FEBS J. 272:3004–3014. 2005. View Article : Google Scholar : PubMed/NCBI

40 

MacLellan JD, Gerrits MF, Gowing A, Smith PJ, Wheeler MB and Harper ME: Physiological increases in uncoupling protein 3 augment fatty acid oxidation and decrease reactive oxygen species production without uncoupling respiration in muscle cells. Diabetes. 54:2343–2350. 2005. View Article : Google Scholar : PubMed/NCBI

41 

Nakamura MT, Yudell BE and Loor JJ: Regulation of energy metabolism by long-chain fatty acids. Prog Lipid Res. 53:124–144. 2014. View Article : Google Scholar : PubMed/NCBI

42 

Zhu H and Leung SW: Identification of microRNA biomarkers in type 2 diabetes: A meta-analysis of controlled profiling studies. Diabetologia. 58:900–911. 2015. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Wu P, Wang Q, Jiang C, Chen C, Liu Y, Chen Y and Zeng Y: MicroRNA‑29a is involved lipid metabolism dysfunction and insulin resistance in C2C12 myotubes by targeting PPARδ. Mol Med Rep 17: 8493-8501, 2018.
APA
Wu, P., Wang, Q., Jiang, C., Chen, C., Liu, Y., Chen, Y., & Zeng, Y. (2018). MicroRNA‑29a is involved lipid metabolism dysfunction and insulin resistance in C2C12 myotubes by targeting PPARδ. Molecular Medicine Reports, 17, 8493-8501. https://doi.org/10.3892/mmr.2018.8902
MLA
Wu, P., Wang, Q., Jiang, C., Chen, C., Liu, Y., Chen, Y., Zeng, Y."MicroRNA‑29a is involved lipid metabolism dysfunction and insulin resistance in C2C12 myotubes by targeting PPARδ". Molecular Medicine Reports 17.6 (2018): 8493-8501.
Chicago
Wu, P., Wang, Q., Jiang, C., Chen, C., Liu, Y., Chen, Y., Zeng, Y."MicroRNA‑29a is involved lipid metabolism dysfunction and insulin resistance in C2C12 myotubes by targeting PPARδ". Molecular Medicine Reports 17, no. 6 (2018): 8493-8501. https://doi.org/10.3892/mmr.2018.8902
Copy and paste a formatted citation
x
Spandidos Publications style
Wu P, Wang Q, Jiang C, Chen C, Liu Y, Chen Y and Zeng Y: MicroRNA‑29a is involved lipid metabolism dysfunction and insulin resistance in C2C12 myotubes by targeting PPARδ. Mol Med Rep 17: 8493-8501, 2018.
APA
Wu, P., Wang, Q., Jiang, C., Chen, C., Liu, Y., Chen, Y., & Zeng, Y. (2018). MicroRNA‑29a is involved lipid metabolism dysfunction and insulin resistance in C2C12 myotubes by targeting PPARδ. Molecular Medicine Reports, 17, 8493-8501. https://doi.org/10.3892/mmr.2018.8902
MLA
Wu, P., Wang, Q., Jiang, C., Chen, C., Liu, Y., Chen, Y., Zeng, Y."MicroRNA‑29a is involved lipid metabolism dysfunction and insulin resistance in C2C12 myotubes by targeting PPARδ". Molecular Medicine Reports 17.6 (2018): 8493-8501.
Chicago
Wu, P., Wang, Q., Jiang, C., Chen, C., Liu, Y., Chen, Y., Zeng, Y."MicroRNA‑29a is involved lipid metabolism dysfunction and insulin resistance in C2C12 myotubes by targeting PPARδ". Molecular Medicine Reports 17, no. 6 (2018): 8493-8501. https://doi.org/10.3892/mmr.2018.8902
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