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Article

Parthenolide inhibits hydrogen peroxide‑induced osteoblast apoptosis

  • Authors:
    • Weihuan Mao
    • Ziguan Zhu
  • View Affiliations / Copyright

    Affiliations: Department of Orthopedics, The Fifth People's Hospital of Yuhang District, Hangzhou, Zhejiang 311100, P.R. China, Department of Hand and Reconstructive Surgery, Zhejiang Provincial People's Hospital, People's Hospital of Hangzhou Medical College, Hangzhou, Zhejiang 310014, P.R. China
  • Pages: 8369-8376
    |
    Published online on: April 20, 2018
       https://doi.org/10.3892/mmr.2018.8908
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Abstract

Parthenolide is a natural product from the shoots of Tanacetum parthenium that has been demonstrated to have immunomodulatory effects in a number of diseases. The present study aimed to determine the effect and mechanism of parthenolide on the apoptotic ability of H2O2‑induced osteoblasts. Cell viability was analyzed with a MTT assay and the apoptotic rate was subsequently measured using flow cytometry. The activity of the antioxidative enzymes superoxide dismutase (SOD) and glutathione peroxidase (GPX), and the serum marker enzymes alkaline phosphatase (ALP), malondialdehyde (MDA) and lactate dehydrogenase (LDH) was measured. Reverse transcription‑quantitative polymerase chain reaction and western blot analyses were performed to analyze the expression levels of osteogenesis and oxidative stress‑associated genes. The results indicated that parthenolide increased cell viability and inhibited the apoptosis of H2O2‑induced osteoblasts. Parthenolide decreased the levels of reactive oxygen species, MDA, LDH and ALP. SOD and GPX levels were increased by parthenolide in H2O2‑induced osteoblasts. This suggested that parthenolide may break the equilibrium state of oxidative stress and inhibit cellular apoptosis. Parthenolide additionally increased the expression levels of oxidative stress‑associated genes, including nuclear factor erythroid 2 like 2, hemeoxygenase‑1 and quinone oxidoreductase 1 in H2O2‑induced osteoblasts. Furthermore, parthenolide increased the expression of osteogenesis‑associated genes, including runt‑related transcription factor 2, osteopontin, osteocalcin and collagen 1 in H2O2‑inducedosteoblasts. Therefore, it was concluded that parthenolide may be used in the treatment of osteoporosis.
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1 

Marengoni A, Rizzuto D, Wang HX, Winblad B and Fratiglioni L: Patterns of chronic multimorbidity in the elderly population. J Am Geriatr Soc. 57:225–230. 2009. View Article : Google Scholar : PubMed/NCBI

2 

Carmeliet G, Dermauw V and Bouillon R: Vitamin D signaling in calcium and bone homeostasis: A delicate balance. Best Pract Res Clin Endocrinol Metab. 29:621–631. 2015. View Article : Google Scholar : PubMed/NCBI

3 

Reid IR, Bristow SM and Bolland MJ: Calcium supplements: Benefits and risks. J Int Med. 278:354–368. 2015. View Article : Google Scholar

4 

Ströhle A, Hadji P and Hahn A: Calcium and bone health-goodbye, calcium supplements? Climacteric. 18:702–714. 2015. View Article : Google Scholar : PubMed/NCBI

5 

Davidovich P, Kearney CJ and Martin SJ: Inflammatory outcomes of apoptosis, necrosis and necroptosis. Biol Chem. 395:1163–1171. 2014. View Article : Google Scholar : PubMed/NCBI

6 

Elmore S: Apoptosis: A review of programmed cell death. Toxicol Pathol. 35:495–516. 2007. View Article : Google Scholar : PubMed/NCBI

7 

Kamogashira T, Fujimoto C and Yamasoba T: Reactive oxygen species, apoptosis and mitochondrial dysfunction in hearing loss. Biomed Res Int. 2015:6172072015. View Article : Google Scholar : PubMed/NCBI

8 

Baek KH, Oh KW, Lee WY, Lee SS, Kim MK, Kwon HS, Rhee EJ, Han JH, Song KH, Cha BY, et al: Association of oxidative stress with postmenopausal osteoporosis and the effects of hydrogen peroxide on osteoclast formation in human bone marrow cell cultures. Calcif Tissue Int. 87:226–235. 2010. View Article : Google Scholar : PubMed/NCBI

9 

Mackinnon ES, Rao AV and Rao LG: Dietary restriction of lycopene for a period of one month resulted in significantly increased biomarkers of oxidative stress and bone resorption in postmenopausal women. J Nutr Health Aging. 15:133–138. 2011. View Article : Google Scholar : PubMed/NCBI

10 

Callaway DA and Jiang JX: Reactive oxygen species and oxidative stress in osteoclastogenesis, skeletal aging and bone diseases. J Bone Miner Metab. 33:359–370. 2015. View Article : Google Scholar : PubMed/NCBI

11 

Hamada Y, Fujii H and Fukagawa M: Role of oxidative stress in diabetic bone disorder. Bone. 45 Suppl 1:S35–S38. View Article : Google Scholar : PubMed/NCBI

12 

Vela L, Contel M, Palomera L, Azaceta G and Marzo I: Iminophosphorane-organogold (III) complexes induce cell death through mitochondrial ROS production. J Inorg Biochem. 105:1306–1313. 2011. View Article : Google Scholar : PubMed/NCBI

13 

D'Amico E, Factor-Litvak P, Santella RM and Mitsumoto H: Clinical perspective on oxidative stress in sporadic amyotrophic lateral sclerosis. Free Radic Biol Med. 65:509–527. 2013. View Article : Google Scholar : PubMed/NCBI

14 

Ling F, Niu R, Hatakeyama H, Goto Y, Shibata T and Yoshida M: Reactive oxygen species stimulate mitochondrial allele segregation toward homoplasmy in human cells. Mol Biol Cell. 27:1684–1693. 2016. View Article : Google Scholar : PubMed/NCBI

15 

Majid AS, Yin ZQ and Ji D: Sulphur antioxidants inhibit oxidative stress induced retinal ganglion cell death by scavenging reactive oxygen species but influence nuclear factor (erythroid-derived 2)-like 2 signalling pathway differently. Biol Pharm Bull. 36:1095–1110. 2013. View Article : Google Scholar : PubMed/NCBI

16 

Romiszewska A and Nowak-Stępniowska A: Photodynamic reaction and oxidative stress-influence of the photodynamic effect on the activity antioxidant enzymes. Postepy Biochemii. 60:355–364. 2014.PubMed/NCBI

17 

She C, Zhu LQ, Zhen YF, Wang XD and Dong QR: Activation of AMPK protects against hydrogen peroxide-induced osteoblast apoptosis through autophagy induction and NADPH maintenance: New implications for osteonecrosis treatment? Cell Signal. 26:1–8. 2014. View Article : Google Scholar : PubMed/NCBI

18 

Harachikuma M, Watanabe S and Satooka H: Involvement of aquaporin-3 in epidermal growth factor receptor signaling via H2O2 transport in cancer cells. Biochem Biophys Res Commun. 471:603–609. 2016. View Article : Google Scholar : PubMed/NCBI

19 

Holmström KM and Finkel T: Cellular mechanisms and physiological consequences of redox-dependent signalling. Nat Rev Mol Cell Biol. 15:411–421. 2014. View Article : Google Scholar : PubMed/NCBI

20 

Yue Q, Gao G, Zou G, Yu H and Zheng X: Natural products as adjunctive treatment for pancreatic cancer: Recent trends and advancements. Biomed Res Int. 2017:84125082017. View Article : Google Scholar : PubMed/NCBI

21 

Sun J, Zhang C, Bao YL, Wu Y, Chen ZL, Yu CL, Huang YX, Sun Y, Zheng LH, Wang X and Li YX: Parthenolide-induced apoptosis, autophagy and suppression of proliferation in HepG2 cells. Asian Pac J Cancer Prev. 15:4897–4902. 2014. View Article : Google Scholar : PubMed/NCBI

22 

Uchibori R, Tsukahara T, Ohmine K and Ozawa K: Cancer gene therapy using mesenchymal stem cells. Int J Hematol. 99:377–382. 2014. View Article : Google Scholar : PubMed/NCBI

23 

Zhou J, Zhang H, Gu P, Bai J, Margolick JB and Zhang Y: NF-kappaB pathway inhibitors preferentially inhibit breast cancer stem-like cells. Breast Cancer Res Treat. 111:419–427. 2008. View Article : Google Scholar : PubMed/NCBI

24 

Diamanti P, Cox CV, Moppett JP and Blair A: Parthenolide eliminates leukemia-initiating cell populations and improves survival in xenografts of childhood acute lymphoblastic leukemia. Blood. 121:1384–1393. 2013. View Article : Google Scholar : PubMed/NCBI

25 

Al Fatlawi AA, Al-Fatlawi AA, Irshad M, Rahisuddin and Ahmad A: Effect of parthenolide on growth and apoptosis regulatory genes of human cancer cell lines. Pharm Biol. 53:104–109. 2015. View Article : Google Scholar : PubMed/NCBI

26 

Sang WK, Park ES and Lee CS: Parthenolide induces apoptosis by activating the mitochondrial and death receptor pathways and inhibits FAK-mediated cell invasion. Mol Cell Biochem. 385:133–144. 2013.PubMed/NCBI

27 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

28 

Shen Y, Guo W, Wang Z, Zhang Y, Zhong L and Zhu Y: Protective Effects of hydrogen sulfide in hypoxic human umbilical vein endothelial cells: A possible mitochondria-dependent pathway. Int J Mol Sci. 14:13093–13108. 2013. View Article : Google Scholar : PubMed/NCBI

29 

Mccord JM and Fridovich I: Superoxide dismutase. An enzymic function for erythrocuprein (hemocuprein). J Biol Chem. 244:6049–6055. 1969.PubMed/NCBI

30 

Cabaud PG and Wroblewski F: Colorimetric measurement of lactic dehydrogenase activity of body fluids. Am J Clin Pathol. 30:234–236. 1958. View Article : Google Scholar : PubMed/NCBI

31 

Maseko T, Howell K, Dunshea FR and Ng K: Selenium-enriched Agaricus bisporus increases expression and activity of glutathione peroxidase-1 and expression of glutathione peroxidase-2 in rat colon. Food Chem. 146:327–333. 2014. View Article : Google Scholar : PubMed/NCBI

32 

Can M, Guven B, Bektas S and Arikan I: Oxidative stress and apoptosis in preeclampsia. Tissue Cell. 46:477–481. 2014. View Article : Google Scholar : PubMed/NCBI

33 

Jain S, Webster TJ, Sharma A and Basu B: Intracellular reactive oxidative stress, cell proliferation and apoptosis of Schwann cells on carbon nanofibrous substrates. Biomaterials. 34:4891–4901. 2013. View Article : Google Scholar : PubMed/NCBI

34 

Vaz CV, Marques R, Maia CJ and Socorro S: Aging-associated changes in oxidative stress, cell proliferation and apoptosis are prevented in the prostate of transgenic rats overexpressing regucalcin. Transl Res. 166:693–705. 2015. View Article : Google Scholar : PubMed/NCBI

35 

Yen YH, Farooqi AA, Li KT, Butt G, Tang JY, Wu CY, Cheng YB, Hou MF and Chang HW: Methanolic extracts of solieria robusta inhibits proliferation of oral cancer ca9-22 cells via apoptosis and oxidative stress. Molecules. 19:18721–18732. 2014. View Article : Google Scholar : PubMed/NCBI

36 

Simon HU, Hajyehia A and Levischaffer F: Role of reactive oxygen species (ROS) in apoptosis induction. Apoptosis. 5:415–418. 2000. View Article : Google Scholar : PubMed/NCBI

37 

Yee C, Yang W and Hekimi S: The intrinsic apoptosis pathway mediates the pro-longevity response to mitochondrial ROS in C. elegans. Cell. 157:8972014. View Article : Google Scholar : PubMed/NCBI

38 

Sharma SS and Dietz KJ: The relationship between metal toxicity and cellular redox imbalance. Trends Plant Sci. 14:43–50. 2009. View Article : Google Scholar : PubMed/NCBI

39 

Sivaramakrishnan V, Shilpa PN, Kumar VR and Devaraj SN: Attenuation of N-nitrosodiethylamine-induced hepatocellular carcinogenesis by a novel flavonol-Morin. Chem Biol Interact. 171:79–88. 2008. View Article : Google Scholar : PubMed/NCBI

40 

Wang Z, Feng Z, Wu G, Bai S, Yan D and Zhao Y: In vitro studies on human periodontal ligament stem cell sheets enhanced by enamel matrix derivative. Colloids Surf B Biointerfaces. 141:102–111. 2016. View Article : Google Scholar : PubMed/NCBI

41 

Rosen CJ and Bouxsein ML: Mechanisms of Disease: is osteoporosis the obesity of bone? Nat Clin Pract Rheumatol. 2:35–43. 2006. View Article : Google Scholar : PubMed/NCBI

42 

Xie G, Schepetkin IA and Quinn MT: Immunomodulatory activity of acidic polysaccharides isolated from Tanacetum vulgare L. Int Immunopharmacol. 7:1639–1650. 2007. View Article : Google Scholar : PubMed/NCBI

43 

Tiuman TS, Uedanakamura T, DA Cortez Garcia, Filho Dias BP, Morgado-Díaz JA, de Souza W and Nakamura CV: Antileishmanial activity of parthenolide, a sesquiterpene lactone isolated from tanacetum parthenium. Antimicrob Agents Chemother. 49:176–182. 2005. View Article : Google Scholar : PubMed/NCBI

44 

Mathema VB, Koh YS, Thakuri BC and Sillanpää M: Parthenolide, a sesquiterpene lactone, expresses multiple anti-cancer and anti-inflammatory activities. Inflammation. 35:560–565. 2012. View Article : Google Scholar : PubMed/NCBI

45 

Valko M, Morris H and Cronin MT: Metals, toxicity and oxidative stress. Curr Med Chem. 12:1161–1208. 2005. View Article : Google Scholar : PubMed/NCBI

46 

Szegezdi E, Logue SE, Gorman AM and Samali A: Mediators of endoplasmic reticulum stress-induced apoptosis. EMBO Rep. 7:880–885. 2006. View Article : Google Scholar : PubMed/NCBI

47 

Manna SK, Sarkar S, Barr J, Wise K, Barrera EV, Jejelowo O, Rice-Ficht AC and Ramesh GT: Single-walled carbon nanotube induces oxidative stress and activates nuclear transcription factor-κB in human keratinocytes. Nano Lett. 5:1676–1684. 2005. View Article : Google Scholar : PubMed/NCBI

48 

Manolagas SC: From estrogen-centric to aging and oxidative stress: A revised perspective of the pathogenesis of osteoporosis. Endocr Rev. 31:266–300. 2010. View Article : Google Scholar : PubMed/NCBI

49 

Doshi SB and Agarwal A: The role of oxidative stress in menopause. J Midlife Health. 4:140–146. 2013.PubMed/NCBI

50 

Kim Y, You Y, Yoon HG, Lee YH, Kim K, Lee J, Kim MS, Kim JC and Jun W: Hepatoprotective effects of fermented Curcuma longa L. on carbon tetrachloride-induced oxidative stress in rats. Food Chem. 151:148–153. 2014. View Article : Google Scholar : PubMed/NCBI

51 

Pajak B, Gajkowska B and Orzechowski A: Molecular basis of parthenolide-dependent proapoptotic activity in cancer cells. Folia Histochem Cytobiol. 46:129–135. 2008. View Article : Google Scholar : PubMed/NCBI

52 

Wyrębska A, Gach K and Janecka A: Combined effect of parthenolide and various anti-cancer drugs or anticancer candidate substances on malignant cells in vitro and in vivo. Mini Rev Med Chem. 14:222–228. 2014. View Article : Google Scholar : PubMed/NCBI

53 

Kim JH, Liu L, Lee SO, Kim YT, You KR and Kim DG: Susceptibility of cholangiocarcinoma cells to parthenolide-induced apoptosis. Cancer Res. 65:6312–6320. 2005. View Article : Google Scholar : PubMed/NCBI

54 

Fang LJ, Shao XT, Wang S, Lu GH, Tao X and Zhou JY: Sesquiterpene lactone parthenolide markedly enhances sensitivity of human A549 cells to low-dose oxaliplatin via inhibition of NF-κB activation and induction of apoptosis. Planta Med. 76:258–264. 2010. View Article : Google Scholar : PubMed/NCBI

55 

Kim SL, Liu YC, Park YR, Seo SY, Kim SH, Kim IH, Lee SO, Lee ST, Kim DG and Kim SW: Parthenolide enhances sensitivity of colorectal cancer cells to TRAIL by inducing death receptor 5 and promotes TRAIL-induced apoptosis. Int J Oncol. 46:1121–1130. 2015. View Article : Google Scholar : PubMed/NCBI

56 

Michaeloudes C, Mercado N, Clarke C, Bhavsar PK, Adcock IM, Barnes PJ and Chung KF: Bromodomain and extraterminal proteins suppress NF-E2-related factor 2-mediated antioxidant gene expression. J Immunol. 192:4913–4920. 2014. View Article : Google Scholar : PubMed/NCBI

57 

Paul MK, Bisht B, Darmawan DO, Chiou R, Ha VL, Wallace WD, Chon AT, Hegab AE, Grogan T, Elashoff DA, et al: Dynamic changes in intracellular ROS levels regulate airway basal stem cell homeostasis through Nrf2-dependent Notch signaling. Cell Stem Cell. 15:199–214. 2014. View Article : Google Scholar : PubMed/NCBI

58 

Ma Q: Role of nrf2 in oxidative stress and toxicity. Annu Rev Pharmacol Toxicol. 53:401–426. 2013. View Article : Google Scholar : PubMed/NCBI

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Spandidos Publications style
Mao W and Zhu Z: Parthenolide inhibits hydrogen peroxide‑induced osteoblast apoptosis. Mol Med Rep 17: 8369-8376, 2018.
APA
Mao, W., & Zhu, Z. (2018). Parthenolide inhibits hydrogen peroxide‑induced osteoblast apoptosis. Molecular Medicine Reports, 17, 8369-8376. https://doi.org/10.3892/mmr.2018.8908
MLA
Mao, W., Zhu, Z."Parthenolide inhibits hydrogen peroxide‑induced osteoblast apoptosis". Molecular Medicine Reports 17.6 (2018): 8369-8376.
Chicago
Mao, W., Zhu, Z."Parthenolide inhibits hydrogen peroxide‑induced osteoblast apoptosis". Molecular Medicine Reports 17, no. 6 (2018): 8369-8376. https://doi.org/10.3892/mmr.2018.8908
Copy and paste a formatted citation
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Spandidos Publications style
Mao W and Zhu Z: Parthenolide inhibits hydrogen peroxide‑induced osteoblast apoptosis. Mol Med Rep 17: 8369-8376, 2018.
APA
Mao, W., & Zhu, Z. (2018). Parthenolide inhibits hydrogen peroxide‑induced osteoblast apoptosis. Molecular Medicine Reports, 17, 8369-8376. https://doi.org/10.3892/mmr.2018.8908
MLA
Mao, W., Zhu, Z."Parthenolide inhibits hydrogen peroxide‑induced osteoblast apoptosis". Molecular Medicine Reports 17.6 (2018): 8369-8376.
Chicago
Mao, W., Zhu, Z."Parthenolide inhibits hydrogen peroxide‑induced osteoblast apoptosis". Molecular Medicine Reports 17, no. 6 (2018): 8369-8376. https://doi.org/10.3892/mmr.2018.8908
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