Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Molecular Medicine Reports
Join Editorial Board Propose a Special Issue
Print ISSN: 1791-2997 Online ISSN: 1791-3004
Journal Cover
June-2018 Volume 17 Issue 6

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
June-2018 Volume 17 Issue 6

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

microRNA‑145 modulates migration and invasion of bladder cancer cells by targeting N‑cadherin

  • Authors:
    • Xue‑Feng Zhang
    • Xue‑Qi Zhang
    • Zhe‑Xing Chang
    • Cui‑Cui Wu
    • Hang Guo
  • View Affiliations / Copyright

    Affiliations: Department of Nuclear Medicine, Affiliated Hospital of BeiHua University, Jilin, Jilin 132011, P.R. China, Department of Oncology, Affiliated Hospital of BeiHua University, Jilin, Jilin 132011, P.R. China, Department of Laboratory Medicine, Affiliated Hospital of BeiHua University, Jilin, Jilin 132011, P.R. China
  • Pages: 8450-8456
    |
    Published online on: April 20, 2018
       https://doi.org/10.3892/mmr.2018.8910
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

MicroRNA (miRNA)‑145 has been demonstrated to serve a role in several types of tumors, however, the potential molecular mechanism of action of miRNA‑145 in bladder cancer metastasis remains to be elucidated. This study aimed to investigate the potential modulation of miRNA‑145 in bladder carcinoma and elucidate the underlying molecular mechanism. The expression of miRNA‑145 in bladder adenocarcinoma tissues and bladder cancer cells was measured by reverse transcription‑quantitative polymerase chain reaction. miRNA‑145 mimics and inhibitor were transfected into bladder cancer (BC) cells to determine the role of miRNA‑145 on cell motility and invasion measured by wound healing and transwell assays. Luciferase assay was performed to confirm whether N‑cadherin was the direct target of miRNA‑145. Subsequently, expression of N‑cadherin and matrix metalloproteinase‑9 (MMP9) in BC cells were detected by western blot analysis. miRNA‑145 was significantly downregulated cells and tissues from patients with BC, compared with healthy controls. miRNA‑145 markedly inhibited the ability of BC cells to migrate and invade. Furthermore, N‑cadherin was identified as a target of miRNA‑145 in BC cells. MMP9, acting downstream of N‑cadherin, was downregulated in BC cells by miRNA‑145. In the present study, miRNA‑145 suppressed the migration and invasion of BC cells by regulating N‑cadherin. The results of the present study indicated that miRNA‑145 may function as a tumor suppressor and may have a potential to be a diagnostic and predictive biomarker, and a therapeutic target for treatment of BC.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

View References

1 

Chen W, Zheng R, Zhang S, Zeng H, Xia C, Zuo T, Yang Z, Zou X and He J: Cancer incidence and mortality in China, 2013. Cancer Lett. 401:63–71. 2017. View Article : Google Scholar : PubMed/NCBI

2 

Chen W, Zheng R, Baade PD, Zhang S, Zeng H, Bray F, Jemal A, Yu XQ and He J: Cancer statistics in China, 2015. CA Cancer J Clin. 66:115–132. 2016. View Article : Google Scholar : PubMed/NCBI

3 

Choe J, Braschi-Amirfarzan M, Tirumani SH, Shinagare AB, Kim KW, Ramaiya NH and Krajewski KM: Updates for the radiologist in non-muscle-invasive, muscle-invasive, and metastatic bladder cancer. Abdom Radiol (NY). 42:2710–2724. 2017. View Article : Google Scholar : PubMed/NCBI

4 

Lobo N, Mount C, Omar K, Nair R, Thurairaja R and Khan MS: Landmarks in the treatment of muscle-invasive bladder cancer. Nat Rev Urol. 14:565–574. 2017. View Article : Google Scholar : PubMed/NCBI

5 

Hermans TJN, Voskuilen CS, van der Heijden MS, Schmitz-Dräger BJ, Kassouf W, Seiler R, Kamat AM, Grivas P, Kiltie AE, Black PC and van Rhijn BWG: Neoadjuvant treatment for muscle-invasive bladder cancer: The past, the present, and the future. Urol Oncol. Nov 8–2017.(Epub ahead of print). View Article : Google Scholar : PubMed/NCBI

6 

Korpics MC, Block AM, Martin B, Hentz C, Gaynor ER, Henry E, Harkenrider MM and Solanki AA: Concurrent chemotherapy is associated with improved survival in elderly patients with bladder cancer undergoing radiotherapy. Cancer. 123:3524–3531. 2017. View Article : Google Scholar : PubMed/NCBI

7 

Kang Z, Li Y, Yu Y and Guo Z: Research progress on bladder cancer molecular genetics. J Cancer Res Ther. 10 Suppl:C89–C94. 2014. View Article : Google Scholar : PubMed/NCBI

8 

Na SW, Yu SH, Kim KH, Hwang EC, Jung SI, Kwon DD and Kang TW: The prognosis of patients less than 40 years with bladder cancer. J Cancer Res Ther. 10:710–714. 2014.PubMed/NCBI

9 

Bartel DP: MicroRNAs: Genomics, biogenesis, mechanism, and function. Cell. 116:281–297. 2004. View Article : Google Scholar : PubMed/NCBI

10 

Bartel DP: MicroRNA Target recognition and regulatory functions. Cell. 136:215–233. 2009. View Article : Google Scholar : PubMed/NCBI

11 

Zhang H, Liu A, Feng X, Tian L, Bo W, Wang H and Hu Y: MiR-132 promotes the proliferation, invasion and migration of human pancreatic carcinoma by inhibition of the tumor suppressor gene PTEN. Prog Biophys Mol Biol. Sep 20–2017.(Epub ahead of print). View Article : Google Scholar :

12 

Slabakova E, Culig Z, Remsik J and Soucek K: Alternative mechanisms of miR-34a regulation in cancer. Cell Death Dis. 8:e31002017. View Article : Google Scholar : PubMed/NCBI

13 

Zhou Q, Huang SX, Zhang F, Li SJ, Liu C, Xi YY, Wang L, Wang X, He QQ, Sun CC and Li DJ: MicroRNAs: A novel potential biomarker for diagnosis and therapy in patients with non-small cell lung cancer. Cell Prolif. 50:2017.doi: 10.1111/cpr.12394. View Article : Google Scholar

14 

Jena MK: MicroRNAs in the development and neoplasia of the mammary gland. Version 2. F1000Res. 6:10182017. View Article : Google Scholar : PubMed/NCBI

15 

Celano M, Rosignolo F, Maggisano V, Pecce V, Iannone M, Russo D and Bulotta S: MicroRNAs as biomarkers in thyroid carcinoma. Int J Genomics. 2017:64965702017. View Article : Google Scholar : PubMed/NCBI

16 

Masuda T, Hayashi N, Kuroda Y, Ito S, Eguchi H and Mimori K: MicroRNAs as biomarkers in colorectal cancer. Cancers (Basel). 9:1242017. View Article : Google Scholar :

17 

Sathyanarayanan A, Chandrasekaran KS and Karunagaran D: microRNA-145 downregulates SIP1-expression but differentially regulates proliferation, migration, invasion and Wnt signaling in SW480 and SW620 cells. J Cell Biochem. 119:2022–2035. 2018. View Article : Google Scholar : PubMed/NCBI

18 

Chen GM, Zheng AJ, Cai J and Han P: microRNA-145-3p inhibits non-small cell lung cancer cell migration and invasion by targeting PDK1 via the mTOR signaling pathway. J Cellular Biochem. 119:885–895. 2018. View Article : Google Scholar

19 

Setua S, Khan S, Doxtater K, Yallapu MM, Jaggi M and Chauhan SC: miR-145: Revival of a dragon in pancreatic cancer. J Nat Sci. 3:pii:e3322017.

20 

Moon S, Kim DK and Kim J: Apoptosis-related microRNA-145-5p enhances the effects of pheophorbide a-based photodynamic therapy in oral cancer. Oncotarget. 8:35184–35192. 2017. View Article : Google Scholar : PubMed/NCBI

21 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

22 

Chou CH, Chang NW, Shrestha S, Hsu SD, Lin YL, Lee WH, Yang CD, Hong HC, Wei TY, Tu SJ, et al: miRTarBase 2016: Updates to the experimentally validated miRNA-target interactions database. Nucleic Acids Res. 44:D239–D247. 2016. View Article : Google Scholar : PubMed/NCBI

23 

Rieger-Christ KM, Lee P, Zagha R, Kosakowski M, Moinzadeh A, Stoffel J, Ben-Ze'ev A, Libertino JA and Summerhayes IC: Novel expression of N-cadherin elicits in vitro bladder cell invasion via the Akt signaling pathway. Oncogene. 23:4745–4753. 2004. View Article : Google Scholar : PubMed/NCBI

24 

Bajan S and Hutvagner G: Regulation of miRNA processing and miRNA mediated gene repression in cancer. Microrna. 3:10–17. 2014. View Article : Google Scholar : PubMed/NCBI

25 

Wozniak M, Mielczarek A and Czyz M: miRNAs in melanoma: Tumor suppressors and oncogenes with prognostic potential. Curr Med Chem. 23:3136–3153. 2016. View Article : Google Scholar : PubMed/NCBI

26 

Tutar Y, Özgur A, Tutar E, Tutar L, Pulliero A and Izzotti A: Regulation of oncogenic genes by MicroRNAs and pseudogenes in human lung cancer. Biomed Pharmacother. 83:1182–1190. 2016. View Article : Google Scholar : PubMed/NCBI

27 

Zhang Z, Zhang M, Chen Q and Zhang Q: Downregulation of microRNA-145 promotes epithelial-mesenchymal transition via regulating Snail in osteosarcoma. Cancer Gene Ther. 24:83–88. 2017. View Article : Google Scholar : PubMed/NCBI

28 

Sheng N, Tan G, You W, Chen H, Gong J, Chen D, Zhang H and Wang Z: MiR-145 inhibits human colorectal cancer cell migration and invasion via PAK4-dependent pathway. Cancer Med. 6:1331–1340. 2017. View Article : Google Scholar : PubMed/NCBI

29 

Zhou X, Yue Y, Wang R, Gong B and Duan Z: MicroRNA-145 inhibits tumorigenesis and invasion of cervical cancer stem cells. Int J Oncol. 50:853–862. 2017. View Article : Google Scholar : PubMed/NCBI

30 

Li Y, Liu J, Liu ZZ and Wei WB: MicroRNA-145 inhibits tumour growth and metastasis in osteosarcoma by targeting cyclin-dependent kinase, CDK6. Eur Rev Med Pharmacol Sci. 20:5117–5125. 2016.PubMed/NCBI

31 

Sathyanarayanan A, Chandrasekaran KS and Karunagaran D: microRNA-145 modulates epithelial-mesenchymal transition and suppresses proliferation, migration and invasion by targeting SIP1 in human cervical cancer cells. Cell Oncol (Dordr). 40:119–131. 2017. View Article : Google Scholar : PubMed/NCBI

32 

Zhang JH, Du AL, Wang L, Wang XY, Gao JH and Wang TY: Episomal lentiviral Vector-mediated miR-145 overexpression inhibits proliferation and induces apoptosis of human esophageal carcinomas cells. Recent Pat Anticancer Drug Discov. 11:453–460. 2016. View Article : Google Scholar : PubMed/NCBI

33 

Xiang Y, Zhang Y, Tang Y and Li Q: MALAT1 modulates TGF-β1-induced Endothelial-to-mesenchymal transition through downregulation of miR-145. Cell Physiol Biochem. 42:357–372. 2017. View Article : Google Scholar : PubMed/NCBI

34 

Zeng JF, Ma XQ, Wang LP and Wang W: MicroRNA-145 exerts tumor-suppressive and chemo-resistance lowering effects by targeting CD44 in gastric cancer. World J Gastroenterol. 23:2337–2345. 2017. View Article : Google Scholar : PubMed/NCBI

35 

Hecht JR: Metastasis in colorectal cancer: What makes the tumor aggressive? Eur J Surg Suppl. 104–110. 1998.PubMed/NCBI

36 

Ellenrieder V, Adler G and Gress TM: Invasion and metastasis in pancreatic cancer. Ann Oncol. 10 Suppl 4:S46–S50. 1999. View Article : Google Scholar

37 

Singh M, Darcy KM, Brady WE, Clubwala R, Weber Z, Rittenbach JV, Akalin A, Whitney CW, Zaino R, Ramirez NC and Leslie KK: Cadherins, catenins and cell cycle regulators: Impact on survival in a Gynecologic Oncology Group phase II endometrial cancer trial. Gynecol Oncol. 123:320–328. 2011. View Article : Google Scholar : PubMed/NCBI

38 

Derycke LD and Bracke ME: N-cadherin in the spotlight of cell-cell adhesion, differentiation, embryogenesis, invasion and signalling. Int J Dev Biol. 48:463–476. 2004. View Article : Google Scholar : PubMed/NCBI

39 

Mariotti A, Perotti A, Sessa C and Ruegg C: N-cadherin as a therapeutic target in cancer. Expert Opin Investig Drugs. 16:451–465. 2007. View Article : Google Scholar : PubMed/NCBI

40 

Wu HM, Huang HY, Schally AV, Chao A, Chou HH, Leung PC and Wang HS: Growth hormone-releasing hormone antagonist inhibits the invasiveness of human endometrial cancer cells by down-regulating twist and N-cadherin expression. Oncotarget. 8:4410–4421. 2017.PubMed/NCBI

41 

Da C, Wu K, Yue C, Bai P, Wang R, Wang G, Zhao M, Lv Y and Hou P: N-cadherin promotes thyroid tumorigenesis through modulating major signaling pathways. Oncotarget. 8:8131–8142. 2017. View Article : Google Scholar : PubMed/NCBI

42 

Wu X, Wang H, Lian Y, Chen L, Gu L, Wang J and Huang Y, Deng M, Gao Z and Huang Y: GTSE1 promotes cell migration and invasion by regulating EMT in hepatocellular carcinoma and is associated with poor prognosis. Sci Rep. 7:51292017. View Article : Google Scholar : PubMed/NCBI

43 

Abufaraj M, Haitel A, Moschini M, Gust K, Foerster B, Özsoy M, D'Andrea D, Karakiewicz PI, Rouprêt M, Briganti A and Shariat SF: Prognostic role of N-cadherin expression in patients with invasive bladder cancer. Clin Genitourin Cancer. Aug 15–2017.(Epub ahead of print).

44 

Mo D, Yang D, Xiao X, Sun R, Huang L and Xu J: MiRNA-145 suppresses lung adenocarcinoma cell invasion and migration by targeting N-cadherin. Biotechnol Lett. 39:701–710. 2017. View Article : Google Scholar : PubMed/NCBI

45 

Merchant N, Nagaraju GP, Rajitha B, Lammata S, Jella KK, Buchwald ZS, Lakka SS and Ali AN: Matrix metalloproteinases: Their functional role in lung cancer. Carcinogenesis. 38:766–780. 2017. View Article : Google Scholar : PubMed/NCBI

46 

Han YH, Kee JY, Kim DS, Mun JG, Park SH, Kim YJ, Um JY and Hong SH: Arctii fructus inhibits colorectal cancer cell proliferation and MMPs mediated invasion via AMPK. Am J Chin Med. 45:1309–1325. 2017. View Article : Google Scholar : PubMed/NCBI

47 

Lyu ZK, Li CL, Jin Y, Liu YZ, Zhang X, Zhang F, Ning LN, Liang ES, Ma M, Gao W, et al: Paeonol exerts potential activities to inhibit the growth, migration and invasion of human gastric cancer BGC823 cells via downregulating MMP-2 and MMP-9. Mol Med Rep. 16:7513–7519. 2017. View Article : Google Scholar : PubMed/NCBI

48 

Chen W, Zhu H, Yin L, Wang T, Wu J, Xu J, Tao H, Liu J and He X: lncRNA-PVT1 facilitates invasion through upregulation of MMP9 in nonsmall cell lung cancer cell. DNA Cell Biol. 36:787–793. 2017.PubMed/NCBI

49 

Suyama K, Shapiro I, Guttman M and Hazan RB: A signaling pathway leading to metastasis is controlled by N-cadherin and the FGF receptor. Cancer Cell. 2:301–314. 2002. View Article : Google Scholar : PubMed/NCBI

50 

Gao P, Xing AY, Zhou GY, Zhang TG, Zhang JP, Gao C, Li H and Shi DB: The molecular mechanism of microRNA-145 to suppress invasion-metastasis cascade in gastric cancer. Oncogene. 32:491–501. 2013. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Zhang XF, Zhang XQ, Chang ZX, Wu CC and Guo H: microRNA‑145 modulates migration and invasion of bladder cancer cells by targeting N‑cadherin. Mol Med Rep 17: 8450-8456, 2018.
APA
Zhang, X., Zhang, X., Chang, Z., Wu, C., & Guo, H. (2018). microRNA‑145 modulates migration and invasion of bladder cancer cells by targeting N‑cadherin. Molecular Medicine Reports, 17, 8450-8456. https://doi.org/10.3892/mmr.2018.8910
MLA
Zhang, X., Zhang, X., Chang, Z., Wu, C., Guo, H."microRNA‑145 modulates migration and invasion of bladder cancer cells by targeting N‑cadherin". Molecular Medicine Reports 17.6 (2018): 8450-8456.
Chicago
Zhang, X., Zhang, X., Chang, Z., Wu, C., Guo, H."microRNA‑145 modulates migration and invasion of bladder cancer cells by targeting N‑cadherin". Molecular Medicine Reports 17, no. 6 (2018): 8450-8456. https://doi.org/10.3892/mmr.2018.8910
Copy and paste a formatted citation
x
Spandidos Publications style
Zhang XF, Zhang XQ, Chang ZX, Wu CC and Guo H: microRNA‑145 modulates migration and invasion of bladder cancer cells by targeting N‑cadherin. Mol Med Rep 17: 8450-8456, 2018.
APA
Zhang, X., Zhang, X., Chang, Z., Wu, C., & Guo, H. (2018). microRNA‑145 modulates migration and invasion of bladder cancer cells by targeting N‑cadherin. Molecular Medicine Reports, 17, 8450-8456. https://doi.org/10.3892/mmr.2018.8910
MLA
Zhang, X., Zhang, X., Chang, Z., Wu, C., Guo, H."microRNA‑145 modulates migration and invasion of bladder cancer cells by targeting N‑cadherin". Molecular Medicine Reports 17.6 (2018): 8450-8456.
Chicago
Zhang, X., Zhang, X., Chang, Z., Wu, C., Guo, H."microRNA‑145 modulates migration and invasion of bladder cancer cells by targeting N‑cadherin". Molecular Medicine Reports 17, no. 6 (2018): 8450-8456. https://doi.org/10.3892/mmr.2018.8910
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team