Hair growth is promoted by BeauTop via expression of EGF and FGF‑7
- Chien‑Ying Lee
- Chi‑Yu Yang
- Ching‑Che Lin
- Min‑Chien Yu
- Shuenn‑Jyi Sheu
- Yu‑Hsiang Kuan
Affiliations: Department of Pharmacology, Chung Shan Medical University, Taichung 40201, Taiwan, R.O.C., Division of Animal Medicine, Animal Technology Laboratories, Agricultural Technology Research Institute, Miaoli 35053, Taiwan, R.O.C., Brion Research Institute of Taiwan, New Taipei 23143, Taiwan, R.O.C., Department of Integrated Chinese and Western Medicine, Chung Shan Medical University Hospital, Taichung 40201, Taiwan, R.O.C.
- Published online on: April 23, 2018 https://doi.org/10.3892/mmr.2018.8917
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Minoxidil and finasteride have been approved to treat hair loss by the Food and Drug Administration. However, the further elucidation of treatments for hair loss, including those using Chinese herbal medicine, remains important clinically. BeauTop (BT) is a health food supplement which contains Ginseng radix, Astragali radix, Radix Angelicae sinensis, Ligustri fructus, Rehmannia glutinosa and Eclipta prostrata (Linn). Susbsequent to oral administration of BT at 0.6 g/kg/day to wax/rosin‑induced alopecia in C57BL/6 mice, BT significantly induced hair growth at day 8 compared with control treatment (P<0.05). The expression levels of epidermal growth factor (EGF), and fibroblast growth factor (FGF)‑7 were increased compared with control animals on day 8. In contrast, levels of FGF‑5 of the BT group were reduced compared with the control on day 12. There were no effects on the expression of insulin‑like growth factor 1. The results demonstrated that the mechanism of BT improving alopecia is potentially associated with modulation of EGF and FGF‑7 levels. Taken together, it is suggested that BT may have a potential effect of the promotion of hair growth.