Open Access

Hair growth is promoted by BeauTop via expression of EGF and FGF‑7

  • Authors:
    • Chien‑Ying Lee
    • Chi‑Yu Yang
    • Ching‑Che Lin
    • Min‑Chien Yu
    • Shuenn‑Jyi Sheu
    • Yu‑Hsiang Kuan
  • View Affiliations

  • Published online on: April 23, 2018     https://doi.org/10.3892/mmr.2018.8917
  • Pages: 8047-8052
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Abstract

Minoxidil and finasteride have been approved to treat hair loss by the Food and Drug Administration. However, the further elucidation of treatments for hair loss, including those using Chinese herbal medicine, remains important clinically. BeauTop (BT) is a health food supplement which contains Ginseng radix, Astragali radix, Radix Angelicae sinensis, Ligustri fructus, Rehmannia glutinosa and Eclipta prostrata (Linn). Susbsequent to oral administration of BT at 0.6 g/kg/day to wax/rosin‑induced alopecia in C57BL/6 mice, BT significantly induced hair growth at day 8 compared with control treatment (P<0.05). The expression levels of epidermal growth factor (EGF), and fibroblast growth factor (FGF)‑7 were increased compared with control animals on day 8. In contrast, levels of FGF‑5 of the BT group were reduced compared with the control on day 12. There were no effects on the expression of insulin‑like growth factor 1. The results demonstrated that the mechanism of BT improving alopecia is potentially associated with modulation of EGF and FGF‑7 levels. Taken together, it is suggested that BT may have a potential effect of the promotion of hair growth.
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June-2018
Volume 17 Issue 6

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Spandidos Publications style
Lee CY, Yang CY, Lin CC, Yu MC, Sheu SJ and Kuan YH: Hair growth is promoted by BeauTop via expression of EGF and FGF‑7. Mol Med Rep 17: 8047-8052, 2018
APA
Lee, C., Yang, C., Lin, C., Yu, M., Sheu, S., & Kuan, Y. (2018). Hair growth is promoted by BeauTop via expression of EGF and FGF‑7. Molecular Medicine Reports, 17, 8047-8052. https://doi.org/10.3892/mmr.2018.8917
MLA
Lee, C., Yang, C., Lin, C., Yu, M., Sheu, S., Kuan, Y."Hair growth is promoted by BeauTop via expression of EGF and FGF‑7". Molecular Medicine Reports 17.6 (2018): 8047-8052.
Chicago
Lee, C., Yang, C., Lin, C., Yu, M., Sheu, S., Kuan, Y."Hair growth is promoted by BeauTop via expression of EGF and FGF‑7". Molecular Medicine Reports 17, no. 6 (2018): 8047-8052. https://doi.org/10.3892/mmr.2018.8917