Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Molecular Medicine Reports
Join Editorial Board Propose a Special Issue
Print ISSN: 1791-2997 Online ISSN: 1791-3004
Journal Cover
July-2018 Volume 18 Issue 1

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
July-2018 Volume 18 Issue 1

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

Dishevelled‑2 modulates osteogenic differentiation of human synovial fibroblasts in osteoarthritis

  • Authors:
    • Lihua Zhang
    • Luan Luan
    • Yingying Ma
  • View Affiliations / Copyright

    Affiliations: Department of Rheumatology, Jining No. 1 People's Hospital, Jining, Shandong 272000, P.R. China
    Copyright: © Zhang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 292-298
    |
    Published online on: May 4, 2018
       https://doi.org/10.3892/mmr.2018.8975
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Dishevelled (Dvl)‑2 represents one of the cytoplasmic proteins, which serves as a pivotal hub in signaling intermediates through a number of different signaling pathways associated with the Wnt family. The aim of the present study was to investigate the roles and mechanisms of Dvl‑2 on synovial fibroblasts (SFBs) in osteoarthritis (OA). A Cell Counting kit‑8 (CCK‑8) assay was used to determine cell viability. An alkaline phosphatase (ALP) test kit was used to measure the activity of ALP. Western blot and reverse transcription‑quantitative polymerase chain reaction analysis were used to evaluate the protein and mRNA expression, respectively. The results suggest that depletion of Dvl‑2 significantly decreased the expression of osteoprotegerin (OPG) and ALP (P<0.05) and significantly increased the expression of receptor activator of nuclear factor‑κB ligand (RANKL), ALP, osteonectin (ON), osteocalcin (OCN) and osterix (P<0.05). In addition, the depletion of Dvl‑2 also significantly inhibited the expression of runt‑related transcription factor 2 (Runx‑2) and β‑catenin in SFBs (P<0.05). The effect of Dvl‑2 over‑expression was opposite to the effect of Dvl‑2 silencing. The inactivation of Wnt3a reversed the effect of Dvl‑2 silencing. In conclusion, the results indicate that Dvl‑2 regulated osteogenic differentiation of SFBs in OA.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

Figure 6

View References

1 

Glyn-Jones S, Palmer AJ, Agricola R, Price AJ, Vincent TL, Weinans H and Carr AJ: Osteoarthritis. Lancet. 386:376–387. 2015. View Article : Google Scholar : PubMed/NCBI

2 

Johnson VL and Hunter DJ: The epidemiology of osteoarthritis. Best Pract Res Clin Rheumatol. 28:5–15. 2014. View Article : Google Scholar : PubMed/NCBI

3 

Benito MJ, Veale DJ, FitzGerald O, van den Berg WB and Bresnihan B: Synovial tissue inflammation in early and late osteoarthritis. Ann Rheum Dis. 64:1263–1267. 2005. View Article : Google Scholar : PubMed/NCBI

4 

Lambert C, Dubuc JE, Montell E, Vergés J, Munaut C, Noë A and Henrotin Y: Gene expression pattern of cells from inflamed and normal areas of osteoarthritis synovial membrane. Arthritis Rheumatol. 66:960–968. 2014. View Article : Google Scholar : PubMed/NCBI

5 

Iwanaga T, Shikichi M, Kitamura H, Yanase H and Nozawa-Inoue K: Morphology and functional roles of synoviocytes in the joint. Arch Histol Cytol. 63:17–31. 2000. View Article : Google Scholar : PubMed/NCBI

6 

Danks L, Komatsu N, Guerrini MM, Sawa S, Armaka M, Kollias G, Nakashima T and Takayanagi H: RANKL expressed on synovial fibroblasts is primarily responsible for bone erosions during joint inflammation. Ann Rheum Dis. 75:1187–1195. 2016. View Article : Google Scholar : PubMed/NCBI

7 

Miyashita T, Kawakami A, Nakashima T, Yamasaki S, Tamai M, Tanaka F, Kamachi M, Ida H, Migita K, Origuchi T, et al: Osteoprotegerin (OPG) acts as an endogenous decoy receptor in tumour necrosis factor-related apoptosis-inducing ligand (TRAIL)-mediated apoptosis of fibroblast-like synovial cells. Clin Exp Immunol. 137:430–436. 2004. View Article : Google Scholar : PubMed/NCBI

8 

Sharma U, Pal D and Prasad R: Alkaline phosphatase: An overview. Indian J Clin Biochem. 29:269–278. 2014. View Article : Google Scholar : PubMed/NCBI

9 

Delgado-Calle J, Sanudo C, Sánchez-Verde L, Garcia-Renedo RJ, Arozamena J and Riancho JA: Epigenetic regulation of alkaline phosphatase in human cells of the osteoblastic lineage. Bone. 49:830–838. 2011. View Article : Google Scholar : PubMed/NCBI

10 

Ek-Rylander B and Andersson G: Osteoclast migration on phosphorylated osteopontin is regulated by endogenous tartrate-resistant acid phosphatase. Exp Cell Res. 316:443–451. 2010. View Article : Google Scholar : PubMed/NCBI

11 

Prins HJ, Braat AK, Gawlitta D, Dhert WJ, Egan DA, Tijssen-Slump E, Yuan H, Coffer PJ, Rozemuller H and Martens AC: In vitro induction of alkaline phosphatase levels predicts in vivo bone forming capacity of human bone marrow stromal cells. Stem Cell Res. 12:428–440. 2014. View Article : Google Scholar : PubMed/NCBI

12 

Seo HJ, Cho YE, Kim T, Shin HI and Kwun IS: Zinc may increase bone formation through stimulating cell proliferation, alkaline phosphatase activity and collagen synthesis in osteoblastic MC3T3-E1 cells. Nutr Res Pract. 4:356–361. 2010. View Article : Google Scholar : PubMed/NCBI

13 

Sardiwal S, Magnusson P, Goldsmith DJ and Lamb EJ: Bone alkaline phosphatase in CKD-mineral bone disorder. Am J Kidney Dis. 62:810–822. 2013. View Article : Google Scholar : PubMed/NCBI

14 

Gulseren G, Yasa IC, Ustahuseyin O, Tekin ED, Tekinay AB and Guler MO: Alkaline phosphatase-mimicking peptide nanofibers for osteogenic differentiation. Biomacromolecules. 16:2198–2208. 2015. View Article : Google Scholar : PubMed/NCBI

15 

Chien AJ, Conrad WH and Moon RT: A Wnt survival guide: From flies to human disease. J Invest Dermatol. 129:1614–1627. 2009. View Article : Google Scholar : PubMed/NCBI

16 

James RG, Conrad WH and Moon RT: Beta-catenin-independent Wnt pathways: Signals, core proteins and effectors. Methods Mol Biol. 468:131–144. 2008. View Article : Google Scholar : PubMed/NCBI

17 

Baron R and Kneissel M: WNT signaling in bone homeostasis and disease: From human mutations to treatments. Nat Med. 19:179–192. 2013. View Article : Google Scholar : PubMed/NCBI

18 

Sen M: Wnt signalling in rheumatoid arthritis. Rheumatology (Oxford). 44:708–713. 2005. View Article : Google Scholar : PubMed/NCBI

19 

Gao C and Chen YG: Dishevelled: The hub of Wnt signaling. Cell Signal. 22:717–727. 2010. View Article : Google Scholar : PubMed/NCBI

20 

Blom AB, van Lent PL, van der Kraan PM and van den Berg WB: To seek shelter from the WNT in osteoarthritis? WNT-signaling as a target for osteoarthritis therapy. Curr Drug Targets. 11:620–629. 2010. View Article : Google Scholar : PubMed/NCBI

21 

Abraham DJ, Shiwen X, Black CM, Sa S, Xu Y and Leask A: Tumor necrosis factor alpha suppresses the induction of connective tissue growth factor by transforming growth factor-beta in normal and scleroderma fibroblasts. J Biol Chem. 275:15220–15225. 2000. View Article : Google Scholar : PubMed/NCBI

22 

Wallingford JB and Habas R: The developmental biology of Dishevelled: An enigmatic protein governing cell fate and cell polarity. Development. 132:4421–4436. 2005. View Article : Google Scholar : PubMed/NCBI

23 

Pulvirenti T, Van Der Heijden M, Droms LA, Huse JT, Tabar V and Hall A: Dishevelled 2 signaling promotes self-renewal and tumorigenicity in human gliomas. Cancer Res. 71:7280–7290. 2011. View Article : Google Scholar : PubMed/NCBI

24 

Yang Y, Jiao L, Hou J, Xu C, Wang L, Yu Y, Li Y, Yang C, Wang X and Sun Y: Dishevelled-2 silencing reduces androgen-dependent prostate tumor cell proliferation and migration and expression of Wnt-3a and matrix metalloproteinases. Mol Biol Rep. 40:4241–4250. 2013. View Article : Google Scholar : PubMed/NCBI

25 

Zhou G, Ye J, Sun L, Zhang Z and Feng J: Overexpression of Dishevelled-2 contributes to proliferation and migration of human esophageal squamous cell carcinoma. J Mol Histol. 47:287–295. 2016. View Article : Google Scholar : PubMed/NCBI

26 

Sadouk MB, Pelletier JP, Tardif G, Kiansa K, Cloutier JM and Martel-Pelletier J: Human synovial fibroblasts coexpress IL-1 receptor type I and type II mRNA. The increased level of the IL-1 receptor in osteoarthritic cells is related to an increased level of the type I receptor. Lab Invest. 73:347–355. 1995.PubMed/NCBI

27 

Arocho A, Chen B, Ladanyi M and Pan Q: Validation of the 2-DeltaDeltaCt calculation as an alternate method of data analysis for quantitative PCR of BCR-ABL P210 transcripts. Diagn Mol Pathol. 15:56–61. 2006. View Article : Google Scholar : PubMed/NCBI

28 

Loeser RF, Goldring SR, Scanzello CR and Goldring MB: Osteoarthritis: A disease of the joint as an organ. Arthritis Rheum. 64:1697–1707. 2012. View Article : Google Scholar : PubMed/NCBI

29 

Grenier S, Bhargava MM and Torzilli PA: An in vitro model for the pathological degradation of articular cartilage in osteoarthritis. J Biomech. 47:645–652. 2014. View Article : Google Scholar : PubMed/NCBI

30 

Anderson HC, Sipe JB, Hessle L, Dhanyamraju R, Atti E, Camacho NP, Millán JL and Dhamyamraju R: Impaired calcification around matrix vesicles of growth plate and bone in alkaline phosphatase-deficient mice. Am J Pathol. 164:841–847. 2004. View Article : Google Scholar : PubMed/NCBI

31 

Fallon MD, Whyte MP and Teitelbaum SL: Stereospecific inhibition of alkaline phosphatase by L-tetramisole prevents in vitro cartilage calcification. Lab Invest. 43:489–494. 1980.PubMed/NCBI

32 

Yadav MC, Simão AM, Narisawa S, Huesa C, McKee MD, Farquharson C and Millán JL: Loss of skeletal mineralization by the simultaneous ablation of PHOSPHO1 and alkaline phosphatase function: A unified model of the mechanisms of initiation of skeletal calcification. J Bone Miner Res. 26:286–297. 2011. View Article : Google Scholar : PubMed/NCBI

33 

Carrión M, Juarranz Y, Pérez-Garcia S, Jimeno R, Pablos JL, Gomariz RP and Gutiérrez-Cañas I: RNA sensors in human osteoarthritis and rheumatoid arthritis synovial fibroblasts: Immune regulation by vasoactive intestinal peptide. Arthritis Rheum. 63:1626–1636. 2011. View Article : Google Scholar : PubMed/NCBI

34 

Eisinger K, Bauer S, Schäffler A, Walter R, Neumann E, Buechler C, Müller-Ladner U and Frommer KW: Chemerin induces CCL2 and TLR4 in synovial fibroblasts of patients with rheumatoid arthritis and osteoarthritis. Exp Mol Pathol. 92:90–96. 2012. View Article : Google Scholar : PubMed/NCBI

35 

Haas S and Straub RH: Disruption of rhythms of molecular clocks in primary synovial fibroblasts of patients with osteoarthritis and rheumatoid arthritis, role of IL-1beta/TNF. Arthritis Res Ther. 14:R1222012. View Article : Google Scholar : PubMed/NCBI

36 

Qin Y, Chen Y, Wang W, Wang Z, Tang G, Zhang P, He Z, Liu Y, Dai SM and Shen Q: HMGB1-LPS complex promotes transformation of osteoarthritis synovial fibroblasts to a rheumatoid arthritis synovial fibroblast-like phenotype. Cell Death Dis. 5:e10772014. View Article : Google Scholar : PubMed/NCBI

37 

Galicka A, Surazynski A, Wołczyński S, Palka J, Popko J and Gindzieński A: Phenotype variability in a daughter and father with mild osteogenesis imperfecta correlated with collagen and prolidase levels in cultured skin fibroblasts. Ann Clin Biochem. 42:80–84. 2005. View Article : Google Scholar : PubMed/NCBI

38 

Bhattaram P and Chandrasekharan U: The joint synovium: A critical determinant of articular cartilage fate in inflammatory joint diseases. Semin Cell Dev Biol. 62:86–93. 2017. View Article : Google Scholar : PubMed/NCBI

39 

Gonzalez-Sancho JM, Greer YE, Abrahams CL, Takigawa Y, Baljinnyam B, Lee KH, Lee KS, Rubin JS and Brown AM: Functional consequences of Wnt-induced dishevelled 2 phosphorylation in canonical and noncanonical Wnt signaling. J Biol Chem. 288:9428–9437. 2013. View Article : Google Scholar : PubMed/NCBI

40 

Smalley MJ, Signoret N, Robertson D, Tilley A, Hann A, Ewan K, Ding Y, Paterson H and Dale TC: Dishevelled (Dvl-2) activates canonical Wnt signalling in the absence of cytoplasmic puncta. J Cell Sci. 118:5279–5289. 2005. View Article : Google Scholar : PubMed/NCBI

41 

Yokoyama N and Malbon CC: Dishevelled-2 docks and activates Src in a Wnt-dependent manner. J Cell Sci. 122:4439–4451. 2009. View Article : Google Scholar : PubMed/NCBI

42 

Kamiya N, Ye L, Kobayashi T, Mochida Y, Yamauchi M, Kronenberg HM, Feng JQ and Mishina Y: BMP signaling negatively regulates bone mass through sclerostin by inhibiting the canonical Wnt pathway. Development. 135:3801–3811. 2008. View Article : Google Scholar : PubMed/NCBI

43 

Kawaguchi H: Regulation of osteoarthritis development by Wnt-beta-catenin signaling through the endochondral ossification process. J Bone Miner Res. 24:8–11. 2009. View Article : Google Scholar : PubMed/NCBI

44 

Yu YY, Lieu S, Lu C and Colnot C: Bone morphogenetic protein 2 stimulates endochondral ossification by regulating periosteal cell fate during bone repair. Bone. 47:65–73. 2010. View Article : Google Scholar : PubMed/NCBI

45 

Tamamura Y, Otani T, Kanatani N, Koyama E, Kitagaki J, Komori T, Yamada Y, Costantini F, Wakisaka S, Pacifici M, et al: Developmental regulation of Wnt/beta-catenin signals is required for growth plate assembly, cartilage integrity, and endochondral ossification. J Biol Chem. 280:19185–19195. 2005. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Zhang L, Luan L and Ma Y: Dishevelled‑2 modulates osteogenic differentiation of human synovial fibroblasts in osteoarthritis. Mol Med Rep 18: 292-298, 2018.
APA
Zhang, L., Luan, L., & Ma, Y. (2018). Dishevelled‑2 modulates osteogenic differentiation of human synovial fibroblasts in osteoarthritis. Molecular Medicine Reports, 18, 292-298. https://doi.org/10.3892/mmr.2018.8975
MLA
Zhang, L., Luan, L., Ma, Y."Dishevelled‑2 modulates osteogenic differentiation of human synovial fibroblasts in osteoarthritis". Molecular Medicine Reports 18.1 (2018): 292-298.
Chicago
Zhang, L., Luan, L., Ma, Y."Dishevelled‑2 modulates osteogenic differentiation of human synovial fibroblasts in osteoarthritis". Molecular Medicine Reports 18, no. 1 (2018): 292-298. https://doi.org/10.3892/mmr.2018.8975
Copy and paste a formatted citation
x
Spandidos Publications style
Zhang L, Luan L and Ma Y: Dishevelled‑2 modulates osteogenic differentiation of human synovial fibroblasts in osteoarthritis. Mol Med Rep 18: 292-298, 2018.
APA
Zhang, L., Luan, L., & Ma, Y. (2018). Dishevelled‑2 modulates osteogenic differentiation of human synovial fibroblasts in osteoarthritis. Molecular Medicine Reports, 18, 292-298. https://doi.org/10.3892/mmr.2018.8975
MLA
Zhang, L., Luan, L., Ma, Y."Dishevelled‑2 modulates osteogenic differentiation of human synovial fibroblasts in osteoarthritis". Molecular Medicine Reports 18.1 (2018): 292-298.
Chicago
Zhang, L., Luan, L., Ma, Y."Dishevelled‑2 modulates osteogenic differentiation of human synovial fibroblasts in osteoarthritis". Molecular Medicine Reports 18, no. 1 (2018): 292-298. https://doi.org/10.3892/mmr.2018.8975
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team