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Porphyromonas gingivalis induced inflammatory responses and promoted apoptosis in lung epithelial cells infected with H1N1 via the Bcl‑2/Bax/Caspase‑3 signaling pathway

  • Authors:
    • Yongju Chen
    • Rui Zhou
    • Zhe Yi
    • Yonggang Li
    • Ying Fu
    • Yibo Zhang
    • Ping Li
    • Xin Li
    • Yaping Pan
  • View Affiliations / Copyright

    Affiliations: School of Stomatology, Jinzhou Medical University, Jinzhou, Liaoning 121000, P.R. China, Department of Stomatology, The Second Affiliated Hospital of Jinzhou Medical University, Jinzhou, Liaoning 121000, P.R. China, Department of Stomatology, School of Stomatology, China Medical University, Shenyang, Liaoning 110002, P.R. China, Department of Pathogeny Biology, Jinzhou Medical University, Jinzhou, Liaoning 121000, P.R. China
    Copyright: © Chen et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 97-104
    |
    Published online on: May 7, 2018
       https://doi.org/10.3892/mmr.2018.8983
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Abstract

The aim of the present study was to investigate the effects of Porphyromonas gingivalis (P. gingivalis) on inflammatory cytokine and nitic oxide (NO) production in lung epithelial cells infected with H1N1, and the underlying mechanisms. Lung epithelial cells were co‑infected with P. gingivalis and H1N1. The concentrations of tumor necrosis factor‑α (TNF‑α), interleukin (IL)‑1β and IL‑6 were detected via an ELISA, and the concentration of NO was detected by the nitrate reductive enzymatic method at 4, 8, 12 and 24 h following infection. The expression levels of inducible NO synthase (iNOS) was detected by western blotting. The apoptotic rate of lung epithelial cells was detected by flow cytometry. The relative protein expression levels of B‑cell lymphoma‑2 (Bcl‑2), Bcl‑2‑associated X protein (Bax) and caspase‑3 in lung epithelial cells were detected by western blotting. Compared with the control group, the concentration of the inflammatory cytokines TNF‑α, IL‑1β and IL‑6 exhibited a significant increase (P<0.05) in the viral‑infected, bacterial‑infected and co‑infected groups. The concentration of NO also increased significantly (P<0.05), along with the rise in the expression levels of iNOS (P<0.05) and the increase in the apoptosis rate of lung epithelial cells (P<0.05). The relative expression levels of caspase‑3 and Bax proteins were increased significantly in the viral‑ and bacterial‑infected groups when compared with the control. The relative expression levels of Bcl‑2 protein exhibited a significant decrease in lung epithelial cells following the co‑infection with P. gingivalis and H1N1 compared with the control (P<0.05). The results of the present study revealed that the combination of P. gingivalis and H1N1 infection in lung epithelial cells may promote the production of inflammatory cytokines and increase NO production, leading to increased levels of apoptosis in lung epithelial cells via the Bcl‑2/Bax/caspase‑3 signaling pathway.
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1 

Jin LJ, Armitage GC, Klinge B, Lang NP, Tonetti M and Williams RC: Global oral health inequalities: Task group-periodontal disease. Adv Dent Res. 23:221–226. 2011. View Article : Google Scholar : PubMed/NCBI

2 

Noguchi S, Toyokawa S, Miyoshi Y, Suyama Y, Inoue K and Kobayashi Y: Five-year follow-up study of the association between periodontal disease and myocardial infarction among Japanese male workers: MY Health Up study. J Public Health (Oxf). 37:605–611. 2015.PubMed/NCBI

3 

Chapple IL and Genco R: Working group 2 of the joint EFP/AAP workshop: Diabetes and periodontal diseases: Consensus report of the Joint EFP/AAP workshop on periodontitis and systemic diseases. J Periodontol. 84 4 Suppl:S106–S112. 2013. View Article : Google Scholar : PubMed/NCBI

4 

Mikuls TR, Payne JB, Yu F, Thiele GM, Reynolds RJ, Cannon GW, Markt J, McGowan D, Kerr GS, Redman RS, et al: Periodontitis and porphyromonas gingivalis in patients with rheumatoid arthritis. Arthritis Rheumatol. 66:1090–1100. 2014. View Article : Google Scholar : PubMed/NCBI

5 

Fernández-Plata R, Olmedo-Torres D, Martínez-Briseño D, García-Sancho C, Franco-Marina F and González-Cruz H: Prevalence of severe periodontal disease and its association with respiratory disease in hospitalized adult patients in a tertiary care center. Gac Med Mex. 151:608–613. 2015.(In Spanish). PubMed/NCBI

6 

Cho BH, Jung YH, Kim DJ, Woo BH, Jung JE, Lee JH, Choi YW and Park HR: Acetylshikonin suppresses invasion of Porphyromonas gingivalis-infected YD10B oral cancer cells by modulating the interleukin-8/matrix metalloproteinase axis. Mol Med Rep. 17:2327–2334. 2018.PubMed/NCBI

7 

Anand PS, Kamath KP and Anil S: Role of dental plaque, saliva and periodontal disease in Helicobacter pylori infection. World J Gastroentero. 20:5639–5653. 2014. View Article : Google Scholar

8 

Sharma N and Shamsuddin H: Association between respiratory disease in hospitalized patients and periodontal disease: A cross-sectional study. J Periodontol. 82:1155–1160. 2011. View Article : Google Scholar : PubMed/NCBI

9 

Bousbia S, Papazian L, La Scola B and Raoult D: Detection of plant DNA in the bronchoalveolar lavage of patients with ventilator-associated pneumonia. PLoS One. 5:e112982010. View Article : Google Scholar : PubMed/NCBI

10 

El-Rabbany M, Zaghlol N, Bhandari M and Azarpazhooh A: Prophylactic oral health procedures to prevent hospital-acquired and ventilator-associated pneumonia: A systematic review. Int J Nurs Stud. 52:452–464. 2015. View Article : Google Scholar : PubMed/NCBI

11 

Bansal M, Khatri M and Taneja V: Potential role of periodontal infection in respiratory diseases-a review. J Med Life. 6:244–248. 2013.PubMed/NCBI

12 

Lee SY, Bae CS, Seo JH, Cho SS, Bae MS, Oh DS and Park DH: Mycoleptodonoides aitchisonii suppresses asthma via Th2 and Th1 cell regulation in an ovalbumin-induced asthma mouse model. Mol Med Rep. 17:11–20. 2018.PubMed/NCBI

13 

Liu Y, Xie L, Yang M, Tan X, Zeng Y, Zheng G, Chen Y and Chen P: PPAR-α improves the recovery of lung function following acute respiratory distress syndrome by suppressing the level of TGF-β1. Mol Med Rep. 16:49–56. 2017. View Article : Google Scholar : PubMed/NCBI

14 

Liu B, Wang J, Cheng L and Liang J: Role of JNK and NF-κB pathways in Porphyromonas gingivalis LPS-induced vascular cell adhesion molecule-1 expression in human aortic endothelial cells. Mol Med Rep. 8:1594–1600. 2013. View Article : Google Scholar : PubMed/NCBI

15 

Chambers C, Skowronski DM, Sabaiduc S, Winter AL, Dickinson JA, De Serres G, Gubbay JB, Drews SJ, Martineau C, Eshaghi A, et al: Interim estimates of 2015/16 vaccine effectiveness against influenza A(H1N1)pdm09, Canada, February 2016. Euro Surveill. 21:301682016. View Article : Google Scholar : PubMed/NCBI

16 

Wang J and Kubes P: A reservoir of mature cavity macrophages that can rapidly invade visceral organs to affect tissue repair. Cell. 165:668–678. 2016. View Article : Google Scholar : PubMed/NCBI

17 

Shah NS, Greenberg JA, McNulty MC, Gregg KS, Riddell J IV, Mangino JE, Weber DM, Hebert CL, Marzec NS, Barron MA, et al: Bacterial and viral co-infections complicating severe influenza: Incidence and impact among 507 U.S. patients, 2013–14. J Clin Virol. 80:12–19. 2016. View Article : Google Scholar : PubMed/NCBI

18 

Alayan J, Ivanovski S, Gemmell E, Ford P, Hamlet S and Farah CS: Deficiency of iNOS contributes to Porphyromonas gingivalis-induced tissue damage. Oral Microbiol Immunol. 21:360–365. 2006. View Article : Google Scholar : PubMed/NCBI

19 

Ahamed M, Akhtar MJ, Khan MAM, Alhadlaq HA and Aldalbahi A: Nanocubes of indium oxide induce cytotoxicity and apoptosis through oxidative stress in human lung epithelial cells. Colloids Surf B Biointerfaces. 156:157–164. 2017. View Article : Google Scholar : PubMed/NCBI

20 

Gawron K, Montgomery A, Łazarz-Bartyzel K, Bereta G, Chomyszyn-Gajewska M, Venables P and Potempa J: Porphyromonas gingivalis peptidyl arginine deiminase: A Unique bacterial PAD with implications for periodontal disease and rheumatoid Arthritis. Protein Deimination Human Health Dis. 99–135. 2017. View Article : Google Scholar

21 

Olsen I and Yilmaz Ö: Modulation of inflammasome activity by Porphyromonas gingivalis in periodontitis and associated systemic diseases. J Oral Microbiol. 8:303852016. View Article : Google Scholar : PubMed/NCBI

22 

Igari K, Inoue Y and Iwai T: An experimental model of peripheral vascular disease involving the intravenous injection of oral bacteria. Ann Vasc Dis. 9:267–271. 2016. View Article : Google Scholar : PubMed/NCBI

23 

Card JW, Carey MA, Voltz JW, Bradbury JA, Ferguson CD, Cohen EA, Schwartz S, Flake GP, Morgan DL, Arbes SJ Jr, et al: Modulation of allergic airway inflammation by the oral pathogen Porphyromonas gingivalis. Infect Immun. 78:2488–2496. 2010. View Article : Google Scholar : PubMed/NCBI

24 

Okuda K, Kimizuka R, Abe S, Kato T and Ishihara K: Involvement of periodontopathic anaerobes in aspiration pneumonia. J Periodontol. 76 11 Suppl:S2154–S2160. 2005. View Article : Google Scholar

25 

Guo L, Feng K, Wang YC, Mei JJ, Ning RT, Zheng HW, Wang JJ, Worthen GS, Wang X, Song J, et al: Critical role of CXCL4 in the lung pathogenesis of influenza (H1N1) respiratory infection. Mucosal Immunol. 10:1529–1541. 2017. View Article : Google Scholar : PubMed/NCBI

26 

Porto AN, Cortelli SC, Borges AH, Matos FZ, Aquino DR, Miranda TB, Costa Oliveira F, Aranha AF and Cortelli JR: Oral and endotracheal tubes colonization by periodontal bacteria: A case-control ICU study. Eur J Clin Microbiol Infect Dis. 35:343–351. 2016. View Article : Google Scholar : PubMed/NCBI

27 

Li Q, Pan C, Teng D, Lin L, Kou Y, Haase EM, Scannapieco FA and Pan Y: Porphyromonas gingivalis modulates Pseudomonas aeruginosa-induced apoptosis of respiratory epithelial cells through the STAT3 signaling pathway. Microbes Infect. 16:17–27. 2014. View Article : Google Scholar : PubMed/NCBI

28 

Connolly E, Millhouse E, Doyle R, Culshaw S, Ramage G and Moran GP: The Porphyromonas gingivalis haemagglutinins HagB and HagC are major mediators of adhesion and biofilm formation. Mol Oral Microbiol. 32:35–47. 2017. View Article : Google Scholar : PubMed/NCBI

29 

Chuaiphichai S, Crabtree MJ, Mcneill E, Hale AB, Trelfa L, Channon KM and Douglas G: A key role for tetrahydrobiopterin-dependent endothelial NOS regulation in resistance arteries: Studies in endothelial cell tetrahydrobiopterin-deficient mice. Brit J Pharmacol. 174:657–671. 2017. View Article : Google Scholar

30 

Assis MC, Freitas C, Saliba AM, D'A Carvalho AP, Simao TA, Albano RM and Plotkowski MC: Up-regulation of Fas expression by Pseudomonas aeruginosa-infected endothelial cells depends on modulation of iNOS and enhanced production of NO induced by bacterial type III secreted proteins. Int J Mol Med. 18:355–363. 2006.PubMed/NCBI

31 

Yan M, Hou M, Liu J, Zhang S, Liu B, Wu X and Liu G: Regulation of iNOS-derived ROS generation by HSP90 and Cav-1 in porcine reproductive and respiratory syndrome virus-infected swine lung injury. Inflammation. 40:1236–1244. 2017. View Article : Google Scholar : PubMed/NCBI

32 

Ke X, Lei L, Li H, Li H and Yan F: Manipulation of necroptosis by Porphyromonas gingivalis in periodontitis development. Mol Immunol. 77:8–13. 2016. View Article : Google Scholar : PubMed/NCBI

33 

Yiemwattana I and Kaomongkolgit R: Alpha-mangostin suppresses IL-6 and IL-8 expression in P. gingivalis LPS-stimulated human gingival fibroblasts. Odontology. 103:348–355. 2015. View Article : Google Scholar : PubMed/NCBI

34 

Wu C, Guo S, Niu Y, Yang L, Liu B, Jiang N, Su M and Wang L: Heat-shock protein 60 of Porphyromonas gingivalis may induce dysfunction of human umbilical endothelial cells via regulation of endothelial-nitric oxide synthase and vascular endothelial-cadherin. Biomed Rep. 5:243–247. 2016. View Article : Google Scholar : PubMed/NCBI

35 

Issaad N, Aitlounis A and Larabadjebari F: Cytotoxicity and actin cytoskeleton damage induced in human alveolar epithelial cells by Androctonus australis hector venom. Toxin Rev. 37:67–74. 2017. View Article : Google Scholar

36 

Kaviyarasu K, Geetha N, Kanimozhi K, Magdalane Maria C, Sivaranjani S, Ayeshamariam A, Kennedy J and Maaza M: In vitro cytotoxicity effect and antibacterial performance of human lung epithelial cells A549 activity of Zinc oxide doped TiO2 nanocrystals: Investigation of bio-medical application by chemical method. Mater Sci Eng C Mater Biol Appl. 74:325–333. 2017. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Chen Y, Zhou R, Yi Z, Li Y, Fu Y, Zhang Y, Li P, Li X and Pan Y: Porphyromonas gingivalis induced inflammatory responses and promoted apoptosis in lung epithelial cells infected with H1N1 via the Bcl‑2/Bax/Caspase‑3 signaling pathway. Mol Med Rep 18: 97-104, 2018.
APA
Chen, Y., Zhou, R., Yi, Z., Li, Y., Fu, Y., Zhang, Y. ... Pan, Y. (2018). Porphyromonas gingivalis induced inflammatory responses and promoted apoptosis in lung epithelial cells infected with H1N1 via the Bcl‑2/Bax/Caspase‑3 signaling pathway. Molecular Medicine Reports, 18, 97-104. https://doi.org/10.3892/mmr.2018.8983
MLA
Chen, Y., Zhou, R., Yi, Z., Li, Y., Fu, Y., Zhang, Y., Li, P., Li, X., Pan, Y."Porphyromonas gingivalis induced inflammatory responses and promoted apoptosis in lung epithelial cells infected with H1N1 via the Bcl‑2/Bax/Caspase‑3 signaling pathway". Molecular Medicine Reports 18.1 (2018): 97-104.
Chicago
Chen, Y., Zhou, R., Yi, Z., Li, Y., Fu, Y., Zhang, Y., Li, P., Li, X., Pan, Y."Porphyromonas gingivalis induced inflammatory responses and promoted apoptosis in lung epithelial cells infected with H1N1 via the Bcl‑2/Bax/Caspase‑3 signaling pathway". Molecular Medicine Reports 18, no. 1 (2018): 97-104. https://doi.org/10.3892/mmr.2018.8983
Copy and paste a formatted citation
x
Spandidos Publications style
Chen Y, Zhou R, Yi Z, Li Y, Fu Y, Zhang Y, Li P, Li X and Pan Y: Porphyromonas gingivalis induced inflammatory responses and promoted apoptosis in lung epithelial cells infected with H1N1 via the Bcl‑2/Bax/Caspase‑3 signaling pathway. Mol Med Rep 18: 97-104, 2018.
APA
Chen, Y., Zhou, R., Yi, Z., Li, Y., Fu, Y., Zhang, Y. ... Pan, Y. (2018). Porphyromonas gingivalis induced inflammatory responses and promoted apoptosis in lung epithelial cells infected with H1N1 via the Bcl‑2/Bax/Caspase‑3 signaling pathway. Molecular Medicine Reports, 18, 97-104. https://doi.org/10.3892/mmr.2018.8983
MLA
Chen, Y., Zhou, R., Yi, Z., Li, Y., Fu, Y., Zhang, Y., Li, P., Li, X., Pan, Y."Porphyromonas gingivalis induced inflammatory responses and promoted apoptosis in lung epithelial cells infected with H1N1 via the Bcl‑2/Bax/Caspase‑3 signaling pathway". Molecular Medicine Reports 18.1 (2018): 97-104.
Chicago
Chen, Y., Zhou, R., Yi, Z., Li, Y., Fu, Y., Zhang, Y., Li, P., Li, X., Pan, Y."Porphyromonas gingivalis induced inflammatory responses and promoted apoptosis in lung epithelial cells infected with H1N1 via the Bcl‑2/Bax/Caspase‑3 signaling pathway". Molecular Medicine Reports 18, no. 1 (2018): 97-104. https://doi.org/10.3892/mmr.2018.8983
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