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Article Open Access

Gas‑filled ultrasound microbubbles enhance the immunoactivity of the HSP70‑MAGEA1 fusion protein against MAGEA1‑expressing tumours

  • Authors:
    • Xing Gao
    • Yang Nan
    • Yuan Yuan
    • Xue Gong
    • Yuanyuan Sun
    • Huihui Zhou
    • Yujin Zong
    • Lijun Zhang
    • Ming Yu
  • View Affiliations / Copyright

    Affiliations: State Key Laboratory of Cancer Biology and Department of Pathology, Xijing Hospital, The Fourth Military Medical University, Xi'an, Shaanxi 710032, P.R. China, Department of Gynecology, The First Affiliated Hospital of Xi'an Medical University, Xi'an, Shaanxi 710077, P.R. China, Department of Ultrasound, Xijing Hospital, The Fourth Military Medical University, Xi'an, Shaanxi 710032, P.R. China, Key Laboratory of Biomedical Information Engineering of Ministry of Education, Department of Biomedical Engineering, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an, Shaanxi 710049, P.R. China, Department of Clinical Diagnosis, Tangdu Hospital, The Fourth Military Medical University, Xi'an, Shaanxi 710038, P.R. China
    Copyright: © Gao et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 315-321
    |
    Published online on: May 9, 2018
       https://doi.org/10.3892/mmr.2018.9003
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Abstract

Advanced malignant melanoma is characterized by rapid development, poor prognosis and insensitivity to chemoradiotherapy. Immunotherapy has become one of the primary clinical treatments for malignant melanomas. In recent decades, identifying specific tumour antigens and the enhanced immunoactivity of tumour vaccines has become critical for engineering successful tumour vaccines. As a widely used vaccine carrier, heat shock protein 70 (HSP70) clearly increases the immunogenicity of tumour antigens, such as melanoma‑associated antigen A1 (MAGEA1). Based on previous studies, gas‑filled ultrasound microbubbles (MBs) were engineered to carry an HSP70‑MAGEA1 fusion protein (FP). Following subcutaneous injection around the lymphatic nodes the FP was directly released into the lymph nodes under ultrasonic imaging. The results indicated that the microbubbles enhanced the immunoactivity of FPs more effectively than HSP70‑MAGEA1 fusion alone. Additionally, HSP70‑MAGEA1 delivered via microbubbles clearly inhibited and delayed the growth of MAGEA1‑expressing B16 melanomas in mice and improved the survival times of these animals compared with the fusion protein alone. The results of the present study demonstrated that controlled MBs enhance the immunoactivity of FPs and also highlights novel, potential vaccine carriers and a new strategy for engineering controllable tumour vaccine designs.
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1 

Fang JB and Wang L: The function of tumor specific antigen (MAGE) in tumor immunotherapy. Sheng Li Ke Xue Jin Zhan. 36:273–275. 2005.(In Chinese). PubMed/NCBI

2 

Xiao J and Chen HS: Biological functions of melanoma-associated antigens. World J Gastroenterol. 10:1849–1853. 2004. View Article : Google Scholar : PubMed/NCBI

3 

Xiao J and Chen HS: Biological functions of melanoma-associated antigens (MAGEs) in cell activities. Ai Zheng. 24:124–128. 2005.(In Chinese). PubMed/NCBI

4 

Sudo T, Kuramoto T, Komiya S, Inoue A and Itoh K: Expression of MAGE genes in osteosarcoma. J Orthop Res. 15:128–132. 1997. View Article : Google Scholar : PubMed/NCBI

5 

van der Bruggen P, Traversari C, Chomez P, Lurquin C, De Plaen E, Van den Eynde BJ, Knuth A and Boon T: A gene encoding an antigen recognized by cytolytic T lymphocytes on a human melanoma. J Immunol. 178:2617–2621. 2007.PubMed/NCBI

6 

van Baren N, Bonnet MC, Dréno B, Khammari A, Dorval T, Piperno-Neumann S, Liénard D, Speiser D, Marchand M, Brichard VG, et al: Tumoral and immunologic response after vaccination of melanoma patients with an ALVAC virus encoding MAGE antigens recognized by T cells. J Clin Oncol. 23:9008–9021. 2005. View Article : Google Scholar : PubMed/NCBI

7 

Slingluff CL Jr, Petroni GR, Olson W, Czarkowski A, Grosh WW, Smolkin M, Chianese-Bullock KA, Neese PY, Deacon DH, Nail C, et al: Helper T-cell responses and clinical activity of a melanoma vaccine with multiple peptides from MAGE and melanocytic differentiation antigens. J Clin Oncol. 26:4973–4980. 2008. View Article : Google Scholar : PubMed/NCBI

8 

Mackensen A, Herbst B, Chen JL, Köhler G, Noppen C, Herr W, Spagnoli GC, Cerundolo V and Lindemann A: Phase I study in melanoma patients of a vaccine with peptide-pulsed dendritic cells generated in vitro from CD34(+) hematopoietic progenitor cells. Int J Cancer. 86:385–392. 2000. View Article : Google Scholar : PubMed/NCBI

9 

Chianese-Bullock KA, Pressley J, Garbee C, Hibbitts S, Murphy C, Yamshchikov G, Petroni GR, Bissonette EA, Neese PY, Grosh WW, et al: MAGE-A1-, MAGE-A10-, and gp100-derived peptides are immunogenic when combined with granulocyte-macrophage colony-stimulating factor and montanide ISA-51 adjuvant and administered as part of a multipeptide vaccine for melanoma. J Immunol. 174:3080–3086. 2005. View Article : Google Scholar : PubMed/NCBI

10 

Akiyama Y, Tanosaki R, Inoue N, Shimada M, Hotate Y, Yamamoto A, Yamazaki N, Kawashima I, Nukaya I, Takesako K, et al: Clinical response in Japanese metastatic melanoma patients treated with peptide cocktail-pulsed dendritic cells. J Transl Med. 3:42005. View Article : Google Scholar : PubMed/NCBI

11 

Ge W, Sui YF, Wu DC, Sun YJ, Chen GS, Li ZS, Si SY, Hu PZ, Huang Y and Zhang XM: MAGE-1/Heat shock protein 70/MAGE-3 fusion protein vaccine in nanoemulsion enhances cellular and humoral immune responses to MAGE-1 or MAGE-3 in vivo. Cancer Immunol Immunother. 55:841–849. 2006. View Article : Google Scholar : PubMed/NCBI

12 

Ge W, Li Y, Li ZS, Zhang SH, Sun YJ, Hu PZ, Wang XM, Huang Y, Si SY, Zhang XM and Sui YF: The antitumor immune responses induced by nanoemulsion-encapsulated MAGE1-HSP70/SEA complex protein vaccine following peroral administration route. Cancer Immunol Immunother. 58:201–208. 2009. View Article : Google Scholar : PubMed/NCBI

13 

Ge W, Hu PZ, Huang Y, Wang XM, Zhang XM, Sun YJ, Li ZS, Si SY and Sui YF: The antitumor immune responses induced by nanoemulsion-encapsulated MAGE1-HSP70/SEA complex protein vaccine following different administration routes. Oncol Rep. 22:915–920. 2009.PubMed/NCBI

14 

Gkegkes ID and Iavazzo C: Contrast Enhanced Ultrasound (CEU) using microbubbles for sentinel lymph node biopsy in breast cancer: A systematic review. Acta Chir Belg. 115:212–218. 2015. View Article : Google Scholar : PubMed/NCBI

15 

Stride E: Physical principles of microbubbles for ultrasound imaging and therapy. Front Neurol Neurosci. 36:11–22. 2015. View Article : Google Scholar : PubMed/NCBI

16 

Wilson SR and Burns PN: Microbubble-enhanced US in body imaging: What role? Radiology. 257:24–39. 2010. View Article : Google Scholar : PubMed/NCBI

17 

Wan C, Li F and Li H: Gene therapy for ocular diseases meditated by ultrasound and microbubbles (Review). Mol Med Rep. 12:4803–4814. 2015. View Article : Google Scholar : PubMed/NCBI

18 

Suzuki R, Oda Y, Utoguchi N, Namai E, Taira Y, Okada N, Kadowaki N, Kodama T, Tachibana K and Maruyama K: A novel strategy utilizing ultrasound for antigen delivery in dendritic cell-based cancer immunotherapy. J Control Release. 133:198–205. 2009. View Article : Google Scholar : PubMed/NCBI

19 

Lemmon JC, McFarland RJ, Rybicka JM, Balce DR, McKeown KR, Krohn RM, Matsunaga TO and Yates RM: In vitro and in vivo transfection of primary phagocytes via microbubble-mediated intraphagosomal sonoporation. J Immunol Methods. 371:152–158. 2011. View Article : Google Scholar : PubMed/NCBI

20 

Bioley G, Lassus A, Bussat P, Terrettaz J, Tranquart F and Corthésy B: Gas-filled microbubble-mediated delivery of antigen and the induction of immune responses. Biomaterials. 33:5935–5946. 2012. View Article : Google Scholar : PubMed/NCBI

21 

Bioley G, Bussat P, Lassus A, Schneider M, Terrettaz J and Corthésy B: The phagocytosis of gas-filled microbubbles by human and murine antigen-presenting cells. Biomaterials. 33:333–342. 2012. View Article : Google Scholar : PubMed/NCBI

22 

Ye J, Chen GS, Song HP, Li ZS, Huang YY, Qu P, Sun YJ, Zhang XM and Sui YF: Heat shock protein 70/MAGE-1 tumor vaccine can enhance the potency of MAGE-1-specific cellular immune responses in vivo. Cancer Immunol Immunother. 53:825–834. 2004. View Article : Google Scholar : PubMed/NCBI

23 

Li S, Zhu C, Fang S, Zhang W, He N, Xu W, Kong R and Shang X: Ultrasound microbubbles enhance human β-defensin 3 against biofilms. J Surg Res. 199:458–469. 2015. View Article : Google Scholar : PubMed/NCBI

24 

Ma JH, Sui YF, Ye J, Huang YY, Li ZS, Chen GS, Qu P, Song HP and Zhang XM: Heat shock protein 70/MAGE-3 fusion protein vaccine can enhance cellular and humoral immune responses to MAGE-3 in vivo. Cancer Immunol Immunother. 54:907–914. 2005. View Article : Google Scholar : PubMed/NCBI

25 

Suzue K and Young RA: Adjuvant-free hsp70 fusion protein system elicits humoral and cellular immune responses to HIV-1 p24. J Immunol. 156:873–879. 1996.PubMed/NCBI

26 

Mizukami S, Kajiwara C, Ishikawa H, Katayama I, Yui K and Udono H: Both CD4+ and CD8+ T cell epitopes fused to heat shock cognate protein 70 (hsc70) can function to eradicate tumors. Cancer Sci. 99:1008–1015. 2008. View Article : Google Scholar : PubMed/NCBI

27 

Shen ZY, Wu MF, Zhang YX, Shen K and Xia GL: Treatment of hepatic carcinoma by low-frequency ultrasound and microbubbles: A case report. Oncol Lett. 9:1249–1253. 2015. View Article : Google Scholar : PubMed/NCBI

28 

Wallace N and Wrenn SP: Ultrasound triggered drug delivery with liposomal nested microbubbles. Ultrasonics. 63:31–38. 2015. View Article : Google Scholar : PubMed/NCBI

29 

Song S, Guo H, Jiang Z, Jin Y, Wu Y, An X, Zhang Z, Sun K and Dou H: Self-assembled microbubbles as contrast agents for ultrasound/magnetic resonance dual-modality imaging. Acta Biomater. 24:266–278. 2015. View Article : Google Scholar : PubMed/NCBI

30 

Lin T, Cai XZ, Shi MM, Ying ZM, Hu B, Zhou CH, Wang W, Shi ZL and Yan SG: In vitro and in vivo evaluation of vancomycin-loaded PMMA cement in combination with ultrasound and microbubbles-mediated ultrasound. Biomed Res Int. 2015:3097392015. View Article : Google Scholar : PubMed/NCBI

31 

Kato S, Shirai Y, Kanzaki H, Sakamoto M, Mori S and Kodama T: Delivery of molecules to the lymph node via lymphatic vessels using ultrasound and nano/microbubbles. Ultrasound Med Biol. 41:1411–1421. 2015. View Article : Google Scholar : PubMed/NCBI

32 

Palekar-Shanbhag P, Chogale MM, Jog SV and Gaikwad SS: Microbubbles and their applications in pharmaceutical targeting. Curr Drug Deliv. 10:363–373. 2013. View Article : Google Scholar : PubMed/NCBI

33 

Castle J and Feinstein SB: Ultrasound-directed, site-specific gene delivery. Methods Mol Biol. 1141:67–76. 2014. View Article : Google Scholar : PubMed/NCBI

34 

Byrn SR and Stowell JG: Drug targeting using conjugates: The importance of pharmaceutical chemistry. J Drug Target. 3:239–241. 1995. View Article : Google Scholar : PubMed/NCBI

35 

Jiang J, Xie D, Zhang W, Xiao G and Wen J: Fusion of Hsp70 to Mage-a1 enhances the potency of vaccine-specific immune responses. J Transl Med. 11:3002013. View Article : Google Scholar : PubMed/NCBI

36 

Yang FY, Fu WM, Chen WS, Yeh WL and Lin WL: Quantitative evaluation of the use of microbubbles with transcranial focused ultrasound on blood-brain-barrier disruption. Ultrason Sonochem. 15:636–643. 2008. View Article : Google Scholar : PubMed/NCBI

37 

Hernot S and Klibanov AL: Microbubbles in ultrasound-triggered drug and gene delivery. Adv Drug Deliv Rev. 60:1153–1166. 2008. View Article : Google Scholar : PubMed/NCBI

38 

Tung YS, Vlachos F, Feshitan JA, Borden MA and Konofagou EE: The mechanism of interaction between focused ultrasound and microbubbles in blood-brain barrier opening in mice. J Acoust Soc Am. 130:3059–3067. 2011. View Article : Google Scholar : PubMed/NCBI

39 

Bai M, Shen M, Teng Y, Sun Y, Li F, Zhang X, Xu Y, Duan Y and Du L: Enhanced therapeutic effect of Adriamycin on multidrug resistant breast cancer by the ABCG2-siRNA loaded polymeric nanoparticles assisted with ultrasound. Oncotarget. 6:43779–43790. 2015. View Article : Google Scholar : PubMed/NCBI

40 

Wang X, Gkanatsas Y, Palasubramaniam J, Hohmann JD, Chen YC, Lim B, Hagemeyer CE and Peter K: Thrombus-targeted theranostic microbubbles: A new technology towards concurrent rapid ultrasound diagnosis and bleeding-free fibrinolytic treatment of thrombosis. Theranostics. 6:726–738. 2016. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Gao X, Nan Y, Yuan Y, Gong X, Sun Y, Zhou H, Zong Y, Zhang L and Yu M: Gas‑filled ultrasound microbubbles enhance the immunoactivity of the HSP70‑MAGEA1 fusion protein against MAGEA1‑expressing tumours. Mol Med Rep 18: 315-321, 2018.
APA
Gao, X., Nan, Y., Yuan, Y., Gong, X., Sun, Y., Zhou, H. ... Yu, M. (2018). Gas‑filled ultrasound microbubbles enhance the immunoactivity of the HSP70‑MAGEA1 fusion protein against MAGEA1‑expressing tumours. Molecular Medicine Reports, 18, 315-321. https://doi.org/10.3892/mmr.2018.9003
MLA
Gao, X., Nan, Y., Yuan, Y., Gong, X., Sun, Y., Zhou, H., Zong, Y., Zhang, L., Yu, M."Gas‑filled ultrasound microbubbles enhance the immunoactivity of the HSP70‑MAGEA1 fusion protein against MAGEA1‑expressing tumours". Molecular Medicine Reports 18.1 (2018): 315-321.
Chicago
Gao, X., Nan, Y., Yuan, Y., Gong, X., Sun, Y., Zhou, H., Zong, Y., Zhang, L., Yu, M."Gas‑filled ultrasound microbubbles enhance the immunoactivity of the HSP70‑MAGEA1 fusion protein against MAGEA1‑expressing tumours". Molecular Medicine Reports 18, no. 1 (2018): 315-321. https://doi.org/10.3892/mmr.2018.9003
Copy and paste a formatted citation
x
Spandidos Publications style
Gao X, Nan Y, Yuan Y, Gong X, Sun Y, Zhou H, Zong Y, Zhang L and Yu M: Gas‑filled ultrasound microbubbles enhance the immunoactivity of the HSP70‑MAGEA1 fusion protein against MAGEA1‑expressing tumours. Mol Med Rep 18: 315-321, 2018.
APA
Gao, X., Nan, Y., Yuan, Y., Gong, X., Sun, Y., Zhou, H. ... Yu, M. (2018). Gas‑filled ultrasound microbubbles enhance the immunoactivity of the HSP70‑MAGEA1 fusion protein against MAGEA1‑expressing tumours. Molecular Medicine Reports, 18, 315-321. https://doi.org/10.3892/mmr.2018.9003
MLA
Gao, X., Nan, Y., Yuan, Y., Gong, X., Sun, Y., Zhou, H., Zong, Y., Zhang, L., Yu, M."Gas‑filled ultrasound microbubbles enhance the immunoactivity of the HSP70‑MAGEA1 fusion protein against MAGEA1‑expressing tumours". Molecular Medicine Reports 18.1 (2018): 315-321.
Chicago
Gao, X., Nan, Y., Yuan, Y., Gong, X., Sun, Y., Zhou, H., Zong, Y., Zhang, L., Yu, M."Gas‑filled ultrasound microbubbles enhance the immunoactivity of the HSP70‑MAGEA1 fusion protein against MAGEA1‑expressing tumours". Molecular Medicine Reports 18, no. 1 (2018): 315-321. https://doi.org/10.3892/mmr.2018.9003
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