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Article

Inhibitory roles of miR‑9 on papillary thyroid cancer through targeting BRAF

  • Authors:
    • Yi Gu
    • Nan Yang
    • Leping Yin
    • Chao Feng
    • Tong Liu
  • View Affiliations / Copyright

    Affiliations: Sichuan Academy of Medical Sciences, Sichuan Provincial People's Hospital, Chengdu, Sichuan 610072, P.R. China, College of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan 611137, P.R. China
  • Pages: 965-972
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    Published online on: May 11, 2018
       https://doi.org/10.3892/mmr.2018.9010
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Abstract

MicroRNA‑9 (miR‑9) is reported to be underexpressed in papillary thyroid carcinoma (PTC) tissues; however, the molecular mechanisms underlying the implication of miR‑9 in PTC have yet to be elucidated. The present study aimed to explore the potential roles of miR‑9 in PTC. PTC tissue samples and paired non‑cancerous adjacent tissues were collected from 60 patients with PTC. The human TPC‑1 thyroid gland papillary carcinoma cell line was used to investigate the molecular mechanisms underlying the roles of miR‑9 in PTC. The levels of miR‑9 and its downstream target gene BRAF were detected through reverse transcription‑quantitative polymerase chain reaction. MTT assay and flow cytometry were performed to evaluate cell viability and apoptosis, respectively. A mouse xenograft tumor model was established to observe the effects of miR‑9 on thyroid gland tumorigenesis in vivo. The present study revealed that the expression of miR‑9 was significantly reduced in PTC tissues compared with paired normal tissues. In addition, miR‑9 upregulation suppressed the expression of BRAF in TPC‑1 cells in vitro. Luciferase reporter assay demonstrated that BRAF may be a direct target gene of miR‑9 in TPC‑1 cells. In addition, following transfection with miR‑9 mimics, the viability of TPC‑1 cells was suppressed and their apoptosis was enhanced; conversely, transfection with miR‑9 inhibitor exerted the opposite effects in vitro. miR‑9 overexpression or downregulation also affected in vivo PTC tumorigenesis in athymic mice. The present findings suggested that miR‑9 may suppress the viability of PTC cells and inhibit tumor growth through directly targeting the expression of BRAF in PTC.
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View References

1 

Pacini F: Thyroid microcarcinoma. Best Pract Res Clin Endocrinol Metab. 26:381–389. 2012. View Article : Google Scholar : PubMed/NCBI

2 

Pellegriti G, Frasca F, Regalbuto C, Squatrito S and Vigneri R: Worldwide increasing incidence of thyroid cancer: Update on epidemiology and risk factors. J Cancer Epidemiol. 2013:9652122013. View Article : Google Scholar : PubMed/NCBI

3 

Hanley JP, Jackson E, Morrissey LA, Rizzo DM, Sprague BL, Sarkar IN and Carr FE: Geospatial and temporal analysis of thyroid cancer incidence in a rural population. Thyroid. 25:812–822. 2015. View Article : Google Scholar : PubMed/NCBI

4 

Magreni A, Bann DV, Schubart JR and Goldenberg D: The effects of race and ethnicity on thyroid cancer incidence. JAMA Otolaryngol Head Neck Surg. 141:319–323. 2015. View Article : Google Scholar : PubMed/NCBI

5 

Zolotov S: Genetic testing in differentiated thyroid carcinoma: Indications and clinical implications. Rambam Maimonides Med J. 7:28–Jan;2016.doi: 10.5041/RMMJ.10236. View Article : Google Scholar : PubMed/NCBI

6 

Griniatsos J, Tsigris C, Kanakis M, Kaltsas G, Michail O, Dimitriou N, Argyrakopoulou G, Delladetsima I, Kyriakou V, Syriou V, et al: Increased incidence of papillary thyroid cancer detection among thyroidectomies in Greece between 1991 and 2006. Anticancer Res. 29:5163–5169. 2009.PubMed/NCBI

7 

Hakala T, Kellokumpu-Lehtinen P, Kholová I, Holli K, Huhtala H and Sand J: Rising incidence of small size papillary thyroid cancers with no change in disease-specific survival in finnish thyroid cancer patients. Scand J Surg. 101:301–306. 2012. View Article : Google Scholar : PubMed/NCBI

8 

Kuo EJ, Goffredo P, Sosa JA and Roman SA: Aggressive variants of papillary thyroid microcarcinoma are associated with extrathyroidal spread and lymph-node metastases: A population-level analysis. Thyroid. 23:1305–1311. 2013. View Article : Google Scholar : PubMed/NCBI

9 

Ghossein R, Ganly I, Biagini A, Robenshtok E, Rivera M and Tuttle RM: Prognostic factors in papillary microcarcinoma with emphasis on histologic subtyping: A clinicopathologic study of 148 cases. Thyroid. 24:245–253. 2014. View Article : Google Scholar : PubMed/NCBI

10 

Grant CS: Recurrence of papillary thyroid cancer after optimized surgery. Gland Surg. 4:52–62. 2015.PubMed/NCBI

11 

Byeon HK, Ban MJ, Lee JM, Ha JG, Kim ES, Koh YW and Choi EC: Robot-assisted Sistrunk's operation, total thyroidectomy, and neck dissection via a transaxillary and retroauricular (TARA) approach in papillary carcinoma arising in thyroglossal duct cyst and thyroid gland. Ann Surg Oncol. 19:4259–4261. 2012. View Article : Google Scholar : PubMed/NCBI

12 

Lang BH, Ng SH, Lau LL, Cowling BJ, Wong KP and Wan KY: A systematic review and meta-analysis of prophylactic central neck dissection on short-term locoregional recurrence in papillary thyroid carcinoma after total thyroidectomy. Thyroid. 23:1087–1098. 2013. View Article : Google Scholar : PubMed/NCBI

13 

Macedo FI and Mittal VK: Total thyroidectomy versus lobectomy as initial operation for small unilateral papillary thyroid carcinoma: A meta-analysis. Surg Oncol. 24:117–122. 2015. View Article : Google Scholar : PubMed/NCBI

14 

Matsuzu K, Sugino K, Masudo K, Nagahama M, Kitagawa W, Shibuya H, Ohkuwa K, Uruno T, Suzuki A, Magoshi S, et al: Thyroid lobectomy for papillary thyroid cancer: Long-term follow-up study of 1,088 cases. World J Surg. 38:68–79. 2014. View Article : Google Scholar : PubMed/NCBI

15 

He Y, Lin J, Kong D, Huang M, Xu C, Kim TK, Etheridge A, Luo Y, Ding Y and Wang K: Current state of circulating MicroRNAs as cancer biomarkers. Clin Chem. 61:1138–1155. 2015. View Article : Google Scholar : PubMed/NCBI

16 

Zhou X, Du YL, Jin P and Ma F: Bioinformatic analysis of cancer-related microRNAs and their target genes. Yi Chuan. 37:855–864. 2015.PubMed/NCBI

17 

Yoruker EE, Terzioglu D, Teksoz S, Uslu FE, Gezer U and Dalay N: MicroRNA expression profiles in papillary thyroid carcinoma, benign thyroid nodules and healthy Controls. J Cancer. 7:803–809. 2016. View Article : Google Scholar : PubMed/NCBI

18 

Damanakis AI, Eckhardt S, Wunderlich A, Roth S, Wissniowski TT, Bartsch DK and Di Fazio P: MicroRNAs let7 expression in thyroid cancer: Correlation with their deputed targets HMGA2 and SLC5A5. J Cancer Res Clin Oncol. 142:1213–1220. 2016. View Article : Google Scholar : PubMed/NCBI

19 

Czajka AA, Wójcicka A, Kubiak A, Kotlarek M, Bakuła-Zalewska E, Koperski Ł, Wiechno W and Jażdżewski K: Family of microRNA-146 regulates RARβ in papillary thyroid carcinoma. PLoS One. 11:e01519682016. View Article : Google Scholar : PubMed/NCBI

20 

Cong D, He M, Chen S, Liu X and Sun H: Expression profiles of pivotal microRNAs and targets in thyroid papillary carcinoma: An analysis of the cancer genome atlas. Onco Targets Ther. 8:2271–2277. 2015.PubMed/NCBI

21 

Lima CR, Geraldo MV, Fuziwara CS, Kimura ET and Santos MF: MiRNA-146b-5p upregulates migration and invasion of different papillary thyroid carcinoma cells. BMC Cancer. 16:1082016. View Article : Google Scholar : PubMed/NCBI

22 

Minna E, Romeo P, Dugo M, De Cecco L, Todoerti K, Pilotti S, Perrone F, Seregni E, Agnelli L, Neri A, et al: miR-451a is underexpressed and targets AKT/mTOR pathway in papillary thyroid carcinoma. Oncotarget. 7:12731–12747. 2016. View Article : Google Scholar : PubMed/NCBI

23 

Salajegheh A, Vosgha H, Rahman Md A, Amin M, Smith RA and Lam AK: Modulatory role of miR-205 in angiogenesis and progression of thyroid cancer. J Mol Endocrinol. 55:183–196. 2015. View Article : Google Scholar : PubMed/NCBI

24 

Sondermann A, Andreghetto FM, Moulatlet AC, da Silva Victor E, de Castro MG, Nunes FD, Brandão LG and Severino P: MiR-9 and miR-21 as prognostic biomarkers for recurrence in papillary thyroid cancer. Clin Exp Metastasis. 32:521–530. 2015. View Article : Google Scholar : PubMed/NCBI

25 

Gundara JS, Zhao J, Gill AJ, Lee JC, Delbridge L, Robinson BG, McLean C, Serpell J and Sidhu SB: Noncoding RNA blockade of autophagy is therapeutic in medullary thyroid cancer. Cancer Med. 4:174–182. 2015. View Article : Google Scholar : PubMed/NCBI

26 

Ma B, Shi R, Yang S, Zhou L, Qu N, Liao T, Wang Y, Wang Y and Ji Q: DUSP4/MKP2 overexpression is associated with BRAF(V600E) mutation and aggressive behavior of papillary thyroid cancer. Onco Targets Ther. 9:2255–2263. 2016.PubMed/NCBI

27 

Gao Q, Zhang W, Wang N, Duan H, Zhou Y, Zhang W and Zhao D: Study on the correlation between BRAF(V600E) mutation and lymphatic metastases in papillary thyroid cancer staged preoperativelv as N0. Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 29:2048–2052. 2015.(In Chinese). PubMed/NCBI

28 

Cordioli MI, Moraes L, Carvalheira G, Sisdelli L, Alves MT, Delcelo R, Monte O, Longui CA, Cury AN and Cerutti JM: AGK-BRAF gene fusion is a recurrent event in sporadic pediatric thyroid carcinoma. Cancer Med. 5:1535–1541. 2016. View Article : Google Scholar : PubMed/NCBI

29 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

30 

Zhuang G, Wu X, Jiang Z, Kasman I, Yao J, Guan Y, Oeh J, Modrusan Z, Bais C, Sampath D and Ferrara N: Tumour-secreted miR-9 promotes endothelial cell migration and angiogenesis by activating the JAK-STAT pathway. EMBO J. 31:3513–3523. 2012. View Article : Google Scholar : PubMed/NCBI

31 

Agarwal V, Bell GW, Nam JW and Bartel DP: Predicting effective microRNA target sites in mammalian mRNAs. Elife. 4:12–Aug;2015.doi: 10.7554/eLife.05005. View Article : Google Scholar

32 

John B, Enright AJ, Aravin A, Tuschl T, Sander C and Marks DS: Human MicroRNA targets. PLoS Biol. 2:e3632004. View Article : Google Scholar : PubMed/NCBI

33 

Conzo G, Tartaglia E, Avenia N, Calò PG, de Bellis A, Esposito K, Gambardella C, Iorio S, Pasquali D, Santini L, et al: Role of prophylactic central compartment lymph node dissection in clinically N0 differentiated thyroid cancer patients: Analysis of risk factors and review of modern trends. World J Surg Oncol. 14:1492016. View Article : Google Scholar : PubMed/NCBI

34 

Chruścik A and Lam AK: Clinical pathological impacts of microRNAs in papillary thyroid carcinoma: A crucial review. Exp Mol Pathol. 99:393–398. 2015. View Article : Google Scholar : PubMed/NCBI

35 

Min XS, Huang P, Liu X, Dong C, Jiang XL, Yuan ZT, Mao LF and Chang S: Bioinformatics analyses of significant prognostic risk markers for thyroid papillary carcinoma. Tumour Biol. 36:7457–7463. 2015. View Article : Google Scholar : PubMed/NCBI

36 

Forte S, La Rosa C, Pecce V, Rosignolo F and Memeo L: The role of microRNAs in thyroid carcinomas. Anticancer Res. 35:2037–2047. 2015.PubMed/NCBI

37 

Roberts PJ and Der CJ: Targeting the Raf-MEK-ERK mitogen-activated protein kinase cascade for the treatment of cancer. Oncogene. 26:3291–3310. 2007. View Article : Google Scholar : PubMed/NCBI

38 

Schlumberger M and Sherman SI: Approach to the patient with advanced differentiated thyroid cancer. Eur J Endocrinol. 166:5–11. 2012. View Article : Google Scholar : PubMed/NCBI

39 

Zawistowski JS, Nakamura K, Parker JS, Granger DA, Golitz BT and Johnson GL: MicroRNA 9-3p targets β1 integrin to sensitize claudin-low breast cancer cells to MEK inhibition. Mol Cell Biol. 33:2260–2274. 2013. View Article : Google Scholar : PubMed/NCBI

40 

Ito T, Seyama T, Hayashi Y, Dohi K and Akiyama M: Unique association of p53 mutations with undifferentiated carcinoma of the thyroid. Nihon Rinsho. 52:1069–1074. 1994.(In Japanese). PubMed/NCBI

41 

Falchook GS, Millward M, Hong D, Naing A, Piha-Paul S, Waguespack SG, Cabanillas ME, Sherman SI, Ma B, Curtis M, et al: BRAF inhibitor dabrafenib in patients with metastatic BRAF-mutant thyroid cancer. Thyroid. 25:71–77. 2015. View Article : Google Scholar : PubMed/NCBI

42 

Rothenberg SM, McFadden DG, Palmer EL, Daniels GH and Wirth LJ: Redifferentiation of iodine-refractory BRAF V600E-mutant metastatic papillary thyroid cancer with dabrafenib. Clin Cancer Res. 21:1028–1035. 2015. View Article : Google Scholar : PubMed/NCBI

43 

Fnais N, Soobiah C, Al-Qahtani K, Hamid JS, Perrier L, Straus SE and Tricco AC: Diagnostic value of fine needle aspiration BRAF(V600E) mutation analysis in papillary thyroid cancer: A systematic review and meta-analysis. Hum Pathol. 46:1443–1454. 2015. View Article : Google Scholar : PubMed/NCBI

44 

Yi W, Zhong D and Zou Q: Expression of BRAF and its extracellular signal-regulated kinase 1/2 signal pathway in papillary thyroid cancer. Zhong Nan Da Xue Xue Bao Yi Xue Ban. 37:889–894. 2012.(In Chinese). PubMed/NCBI

45 

Kandil E, Tsumagari K, Ma J, Elmageed Abd ZY, Li X, Slakey D, Mondal D and Abdel-Mageed AB: Synergistic inhibition of thyroid cancer by suppressing MAPK/PI3K/AKT pathways. J Surg Res. 184:898–906. 2013. View Article : Google Scholar : PubMed/NCBI

46 

McCarty SK, Saji M, Zhang X, Knippler CM, Kirschner LS, Fernandez S and Ringel MD: BRAF activates and physically interacts with PAK to regulate cell motility. Endocr Relat Cancer. 21:865–877. 2014. View Article : Google Scholar : PubMed/NCBI

47 

Zhang ZX, Liu ZQ, Jiang B, Lu XY, Ning XF, Yuan CT and Wang AL: BRAF activated non-coding RNA (BANCR) promoting gastric cancer cells proliferation via regulation of NF-κB1. Biochem Biophys Res Commun. 465:225–231. 2015. View Article : Google Scholar : PubMed/NCBI

48 

Hu Y, Mintz A, Shah SR, Quinones-Hinojosa A and Hsu W: The FGFR/MEK/ERK/brachyury pathway is critical for chordoma cell growth and survival. Carcinogenesis. 35:1491–1499. 2014. View Article : Google Scholar : PubMed/NCBI

49 

Wellbrock C and Arozarena I: The Complexity of the ERK/MAP-kinase pathway and the treatment of melanoma skin cancer. Front Cell Dev Biol. 4:332016. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Gu Y, Yang N, Yin L, Feng C and Liu T: Inhibitory roles of miR‑9 on papillary thyroid cancer through targeting BRAF. Mol Med Rep 18: 965-972, 2018.
APA
Gu, Y., Yang, N., Yin, L., Feng, C., & Liu, T. (2018). Inhibitory roles of miR‑9 on papillary thyroid cancer through targeting BRAF. Molecular Medicine Reports, 18, 965-972. https://doi.org/10.3892/mmr.2018.9010
MLA
Gu, Y., Yang, N., Yin, L., Feng, C., Liu, T."Inhibitory roles of miR‑9 on papillary thyroid cancer through targeting BRAF". Molecular Medicine Reports 18.1 (2018): 965-972.
Chicago
Gu, Y., Yang, N., Yin, L., Feng, C., Liu, T."Inhibitory roles of miR‑9 on papillary thyroid cancer through targeting BRAF". Molecular Medicine Reports 18, no. 1 (2018): 965-972. https://doi.org/10.3892/mmr.2018.9010
Copy and paste a formatted citation
x
Spandidos Publications style
Gu Y, Yang N, Yin L, Feng C and Liu T: Inhibitory roles of miR‑9 on papillary thyroid cancer through targeting BRAF. Mol Med Rep 18: 965-972, 2018.
APA
Gu, Y., Yang, N., Yin, L., Feng, C., & Liu, T. (2018). Inhibitory roles of miR‑9 on papillary thyroid cancer through targeting BRAF. Molecular Medicine Reports, 18, 965-972. https://doi.org/10.3892/mmr.2018.9010
MLA
Gu, Y., Yang, N., Yin, L., Feng, C., Liu, T."Inhibitory roles of miR‑9 on papillary thyroid cancer through targeting BRAF". Molecular Medicine Reports 18.1 (2018): 965-972.
Chicago
Gu, Y., Yang, N., Yin, L., Feng, C., Liu, T."Inhibitory roles of miR‑9 on papillary thyroid cancer through targeting BRAF". Molecular Medicine Reports 18, no. 1 (2018): 965-972. https://doi.org/10.3892/mmr.2018.9010
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