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Matrine inhibits the invasive and migratory properties of human hepatocellular carcinoma by regulating epithelial‑mesenchymal transition

  • Authors:
    • Yuwen Wang
    • Shujun Zhang
    • Jia Liu
    • Biaobiao Fang
    • Jie Yao
    • Binglin Cheng
  • View Affiliations / Copyright

    Affiliations: Shenzhen Longhua District Central Hospital, Shenzhen, Guangdong 518110, P.R. China, Department of Pathology, The Fourth Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang 150001, P.R. China, Department of Traditional Chinese Medicine, The First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang 150000, P.R. China
    Copyright: © Wang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 911-919
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    Published online on: May 16, 2018
       https://doi.org/10.3892/mmr.2018.9023
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Abstract

Matrine has been reported to be an effective anti‑tumor therapy; however, the anti-metastatic effects of matrine on hepatocellular carcinoma (HCC) and the molecular mechanism(s) involved remain unclear. Therefore, the aims of the present study were to evaluate the effects of matrine on hepatoma and to determine the associated mechanism(s) involved. In the present study, matrine was confirmed to prevent the proliferation of HCC cells and it was observed that matrine also inhibited the migratory, and invasive capabilities of HCC at non‑toxic concentrations. Additionally, matrine increased epithelial‑cadherin expression and decreased the expression levels of vimentin, matrix metalloproteinase (MMP)2, MMP9, zinc finger protein SNAI1 and zinc finger protein SNAI2. These results indicate that the anti‑metastatic effect of matrine may be associated with epithelial‑mesenchymal transition (EMT). Furthermore, matrine can increase phosphatidylinositol 3,4,5‑trisphosphate 3‑phosphatase and dual‑specificity protein phosphatase PTEN (PTEN) expression and reduce phosphorylated‑protein kinase B (Akt) levels. In conclusion, these results suggested that matrine is a potential therapeutic agent that can suppress cancer‑associated invasion and migration via PTEN/Akt‑dependent inhibition of EMT.
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Copy and paste a formatted citation
Spandidos Publications style
Wang Y, Zhang S, Liu J, Fang B, Yao J and Cheng B: Matrine inhibits the invasive and migratory properties of human hepatocellular carcinoma by regulating epithelial‑mesenchymal transition. Mol Med Rep 18: 911-919, 2018.
APA
Wang, Y., Zhang, S., Liu, J., Fang, B., Yao, J., & Cheng, B. (2018). Matrine inhibits the invasive and migratory properties of human hepatocellular carcinoma by regulating epithelial‑mesenchymal transition. Molecular Medicine Reports, 18, 911-919. https://doi.org/10.3892/mmr.2018.9023
MLA
Wang, Y., Zhang, S., Liu, J., Fang, B., Yao, J., Cheng, B."Matrine inhibits the invasive and migratory properties of human hepatocellular carcinoma by regulating epithelial‑mesenchymal transition". Molecular Medicine Reports 18.1 (2018): 911-919.
Chicago
Wang, Y., Zhang, S., Liu, J., Fang, B., Yao, J., Cheng, B."Matrine inhibits the invasive and migratory properties of human hepatocellular carcinoma by regulating epithelial‑mesenchymal transition". Molecular Medicine Reports 18, no. 1 (2018): 911-919. https://doi.org/10.3892/mmr.2018.9023
Copy and paste a formatted citation
x
Spandidos Publications style
Wang Y, Zhang S, Liu J, Fang B, Yao J and Cheng B: Matrine inhibits the invasive and migratory properties of human hepatocellular carcinoma by regulating epithelial‑mesenchymal transition. Mol Med Rep 18: 911-919, 2018.
APA
Wang, Y., Zhang, S., Liu, J., Fang, B., Yao, J., & Cheng, B. (2018). Matrine inhibits the invasive and migratory properties of human hepatocellular carcinoma by regulating epithelial‑mesenchymal transition. Molecular Medicine Reports, 18, 911-919. https://doi.org/10.3892/mmr.2018.9023
MLA
Wang, Y., Zhang, S., Liu, J., Fang, B., Yao, J., Cheng, B."Matrine inhibits the invasive and migratory properties of human hepatocellular carcinoma by regulating epithelial‑mesenchymal transition". Molecular Medicine Reports 18.1 (2018): 911-919.
Chicago
Wang, Y., Zhang, S., Liu, J., Fang, B., Yao, J., Cheng, B."Matrine inhibits the invasive and migratory properties of human hepatocellular carcinoma by regulating epithelial‑mesenchymal transition". Molecular Medicine Reports 18, no. 1 (2018): 911-919. https://doi.org/10.3892/mmr.2018.9023
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