Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Molecular Medicine Reports
Join Editorial Board Propose a Special Issue
Print ISSN: 1791-2997 Online ISSN: 1791-3004
Journal Cover
July-2018 Volume 18 Issue 1

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
July-2018 Volume 18 Issue 1

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Review

Molecular mechanisms of autophagy in cardiac ischemia/reperfusion injury (Review)

  • Authors:
    • Xiao‑Long Lin
    • Wei‑Jin Xiao
    • Le‑Le Xiao
    • Mi‑Hua Liu
  • View Affiliations / Copyright

    Affiliations: Department of Pathology, Hui Zhou Third People's Hospital, Guangzhou Medical University, Huizhou, Guangdong 516002, P.R. China, Department of Pathology, The Central Hospital of Shaoyang, Hunan 422000, P.R. China, School of Medicine, Huzhou University, Huzhou, Zhejiang 313000, P.R. China, Department of Infectious Diseases, Centre for Lipid Research and Key Laboratory of Molecular Biology for Infectious Diseases (Ministry of Education), Institute for Viral Hepatitis, The Second Affiliated Hospital, Chongqing Medical University, Chongqing 400016, P.R. China
  • Pages: 675-683
    |
    Published online on: May 16, 2018
       https://doi.org/10.3892/mmr.2018.9028
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Autophagy is a maintenance process for recycling long-lived proteins and cytoplasmic organelles. The level of this process is enhanced during ischemia/reperfusion (I/R) injury. Autophagy can trigger survival signaling in myocardial ischemia, whereas defective autophagy during reperfusion is detrimental. Autophagy can be regulated through multiple signaling pathways in I/R, including Beclin‑1/class III phosphatidylinositol‑3 kinase (PI‑3K), adenosine monophosphate activated protein kinase/mammalian target of rapamycin (mTOR), and PI‑3K/protein kinase B/mTOR pathways, which consequently lead to different functions. Thus, autophagy has both protective and detrimental functions, which are determined by different signaling pathways and conditions. Targeting the activation of autophagy can be a promising new therapeutic strategy for treating cardiovascular disease.
View Figures

Figure 1

Figure 2

Figure 3

View References

1 

Yang K, Xu C, Li X and Jiang H: Combination of D942 with curcumin protects cardiomyocytes from ischemic damage through promoting autophagy. J Cardiovasc Pharmacol Therap. 18:570–581. 2013. View Article : Google Scholar

2 

Han Z, Cao J, Song D, Tian L, Chen K, Wang Y, Gao L, Yin Z, Fan Y and Wang C: Autophagy is involved in the cardioprotection effect of remote limb ischemic postconditioning on myocardial ischemia/reperfusion injury in normal mice, but not diabetic mice. PLoS One. 9:e868382014. View Article : Google Scholar : PubMed/NCBI

3 

Murphy E and Steenbergen C: Mechanisms underlying acute protection from cardiac ischemia-reperfusion injury. Physiol Rev. 88:581–609. 2008. View Article : Google Scholar : PubMed/NCBI

4 

Das DK and Maulik N: Preconditioning potentiates redox signaling and converts death signal into survival signal. Arch Biochem Biophys. 420:305–311. 2003. View Article : Google Scholar : PubMed/NCBI

5 

Aoyagi T, Kusakari Y, Xiao CY, Inouye BT, Takahashi M, Scherrer-Crosbie M, Rosenzweig A, Hara K and Matsui T: Cardiac mTOR protects the heart against ischemia-reperfusion injury. Am J Physiol Heart Circ Physiol. 303:H75–H85. 2012. View Article : Google Scholar : PubMed/NCBI

6 

Li Y, Xiang Y, Zhang S, Wang Y, Yang J, Liu W and Xue F: Intramyocardial injection of thioredoxin 2-expressing lentivirus alleviates myocardial ischemia-reperfusion injury in rats. Am J Transl Res. 9:4428–4439. 2017.PubMed/NCBI

7 

Sasaki Y, Ikeda Y, Iwabayashi M, Akasaki Y and Ohishi M: The impact of autophagy on cardiovascular senescence and diseases. Int Heart J. 58:666–673. 2017. View Article : Google Scholar : PubMed/NCBI

8 

Yang L, Wang H, Shen Q, Feng L and Jin H: Long non-coding RNAs involved in autophagy regulation. Cell Death Dis. 8:e30732017. View Article : Google Scholar : PubMed/NCBI

9 

Green DR, Galluzzi L and Kroemer G: Mitochondria and the autophagy-inflammation-cell death axis in organismal aging. Science. 333:1109–1112. 2011. View Article : Google Scholar : PubMed/NCBI

10 

Sica V, Galluzzi L, Pedro Bravo-San JM, Izzo V, Maiuri MC and Kroemer G: Organelle-specific initiation of autophagy. Mol Cell. 59:522–539. 2015. View Article : Google Scholar : PubMed/NCBI

11 

Mowers EE, Sharifi MN and MacLeod KF: Functions of autophagy in the tumor microenvironment and cancer metastasis. FEBS J. 2018.doi: 10.1111/febs.14388. View Article : Google Scholar : PubMed/NCBI

12 

Pellacani C and Costa LG: Role of autophagy in environmental neurotoxicity. Environ Pollut. 235:791–805. 2018. View Article : Google Scholar : PubMed/NCBI

13 

Yang X, Cohen MV and Downey JM: Mechanism of cardioprotection by early ischemic preconditioning. Cardiovasc Drugs Ther. 24:225–234. 2010. View Article : Google Scholar : PubMed/NCBI

14 

Levine B and Klionsky DJ: Development by self-digestion: Molecular mechanisms and biological functions of autophagy. Dev Cell. 6:463–477. 2004. View Article : Google Scholar : PubMed/NCBI

15 

Ma H, Guo R, Yu L, Zhang Y and Ren J: Aldehyde dehydrogenase 2 (ALDH2) rescues myocardial ischaemia/reperfusion injury: Role of autophagy paradox and toxic aldehyde. Eur Heart J. 32:1025–1038. 2011. View Article : Google Scholar : PubMed/NCBI

16 

Huang C, Yitzhaki S, Perry CN, Liu W, Giricz Z, Mentzer RM Jr and Gottlieb RA: Autophagy induced by ischemic preconditioning is essential for cardioprotection. J Cardiovasc Transl Res. 3:365–373. 2010. View Article : Google Scholar : PubMed/NCBI

17 

Shintani T and Klionsky DJ: Autophagy in health and disease: A double-edged sword. Science. 306:990–995. 2004. View Article : Google Scholar : PubMed/NCBI

18 

Rubinsztein DC, Gestwicki JE, Murphy LO and Klionsky DJ: Potential therapeutic applications of autophagy. Nat Rev Drug Discov. 6:304–312. 2007. View Article : Google Scholar : PubMed/NCBI

19 

Sciarretta S, Hariharan N, Monden Y, Zablocki D and Sadoshima J: Is autophagy in response to ischemia and reperfusion protective or detrimental for the heart? Pediatr Cardiol. 32:275–281. 2011. View Article : Google Scholar : PubMed/NCBI

20 

Go AS, Mozaffarian D, Roger VL, Benjamin EJ, Berry JD, Blaha MJ, Dai S, Ford ES, Fox CS, Franco S, et al: Executive summary: Heart disease and stroke statistics-2014 update: A report from the American Heart Association. Circulation. 129:399–410. 2014. View Article : Google Scholar : PubMed/NCBI

21 

Bulluck H, Yellon DM and Hausenloy DJ: Reducing myocardial infarct size: Challenges and future opportunities. Heart. 102:341–348. 2016. View Article : Google Scholar : PubMed/NCBI

22 

Hamacher-Brady A, Brady NR, Logue SE, Sayen MR, Jinno M, Kirshenbaum LA, Gottlieb RA and Gustafsson AB: Response to myocardial ischemia/reperfusion injury involves Bnip3 and autophagy. Cell Death Differ. 14:146–157. 2007. View Article : Google Scholar : PubMed/NCBI

23 

Decker RS and Wildenthal K: Lysosomal alterations in hypoxic and reoxygenated hearts. I. Ultrastructural and cytochemical changes. Am J Pathol. 98:425–444. 1980.PubMed/NCBI

24 

Matsui Y, Takagi H, Qu X, Abdellatif M, Sakoda H, Asano T, Levine B and Sadoshima J: Distinct roles of autophagy in the heart during ischemia and reperfusion: Roles of AMP-activated protein kinase and Beclin 1 in mediating autophagy. Circ Res. 100:914–922. 2007. View Article : Google Scholar : PubMed/NCBI

25 

Kassiotis C, Ballal K, Wellnitz K, Vela D, Gong M, Salazar R, Frazier OH and Taegtmeyer H: Markers of autophagy are downregulated in failing human heart after mechanical unloading. Circulation. 120 11 Suppl:S191–S197. 2009. View Article : Google Scholar : PubMed/NCBI

26 

Jahania SM, Sengstock D, Vaitkevicius P, Andres A, Ito BR, Gottlieb RA and Mentzer RM Jr: Activation of the homeostatic intracellular repair response during cardiac surgery. J Am Coll Surg. 216:719–729. 2013. View Article : Google Scholar : PubMed/NCBI

27 

Schiattarella GG and Hill JA: Therapeutic targeting of autophagy in cardiovascular disease. J Mol Cell Cardiol. 95:86–93. 2016. View Article : Google Scholar : PubMed/NCBI

28 

Hu Y, Sun Q, Li Z, Chen J, Shen C, Song Y and Zhong Q: High basal level of autophagy in high-altitude residents attenuates myocardial ischemia-reperfusion injury. J Thorac Cardiovasc Surg. 148:1674–1680. 2014. View Article : Google Scholar : PubMed/NCBI

29 

Hamacher-Brady A, Brady NR and Gottlieb RA: The interplay between pro-death and pro-survival signaling pathways in myocardial ischemia/reperfusion injury: Apoptosis meets autophagy. Cardiovasc Drugs Ther. 20:445–462. 2006. View Article : Google Scholar : PubMed/NCBI

30 

Gustafsson AB and Gottlieb RA: Eat your heart out: Role of autophagy in myocardial ischemia/reperfusion. Autophagy. 4:416–421. 2008. View Article : Google Scholar : PubMed/NCBI

31 

Song X, Kusakari Y, Xiao CY, Kinsella SD, Rosenberg MA, Scherrer-Crosbie M, Hara K, Rosenzweig A and Matsui T: mTOR attenuates the inflammatory response in cardiomyocytes and prevents cardiac dysfunction in pathological hypertrophy. Am J Physiol Cell Physiol. 299:C1256–C1266. 2010. View Article : Google Scholar : PubMed/NCBI

32 

McCormick J, Suleman N, Scarabelli TM, Knight RA, Latchman DS and Stephanou A: STAT1 deficiency in the heart protects against myocardial infarction by enhancing autophagy. J Cell Mol Med. 16:386–393. 2012. View Article : Google Scholar : PubMed/NCBI

33 

Gustafsson AB and Gottlieb RA: Autophagy in ischemic heart disease. Circ Res. 104:150–158. 2009. View Article : Google Scholar : PubMed/NCBI

34 

House SL, Branch K, Newman G, Doetschman T and Jel Schultz J: Cardioprotection induced by cardiac-specific overexpression of fibroblast growth factor-2 is mediated by the MAPK cascade. Am J Physiol Heart Circ Physiol. 289:H2167–H2175. 2005. View Article : Google Scholar : PubMed/NCBI

35 

Baehrecke EH: Autophagy: Dual roles in life and death? Nat Rev Mol Cell Biol. 6:505–510. 2005. View Article : Google Scholar : PubMed/NCBI

36 

Qian J, Ren X, Wang X, Zhang P, Jones WK, Molkentin JD, Fan GC and Kranias EG: Blockade of Hsp20 phosphorylation exacerbates cardiac ischemia/reperfusion injury by suppressed autophagy and increased cell death. Circ Res. 105:1223–1231. 2009. View Article : Google Scholar : PubMed/NCBI

37 

Tsujimoto Y and Shimizu S: Another way to die: Autophagic programmed cell death. Cell Death Differ. 12 Suppl 2:S1528–S1534. 2005. View Article : Google Scholar

38 

Galluzzi L, Maiuri MC, Vitale I, Zischka H, Castedo M, Zitvogel L and Kroemer G: Cell death modalities: Classification and pathophysiological implications. Cell Death Differ. 14:1237–1243. 2007. View Article : Google Scholar : PubMed/NCBI

39 

Huang C, Liu W, Perry CN, Yitzhaki S, Lee Y, Yuan H, Tsukada YT, Hamacher-Brady A, Mentzer RM Jr and Gottlieb RA: Autophagy and protein kinase C are required for cardioprotection by sulfaphenazole. Am J Physiol Heart Circ Physiol. 298:H570–H579. 2010. View Article : Google Scholar : PubMed/NCBI

40 

Hamacher-Brady A, Brady NR and Gottlieb RA: Enhancing macroautophagy protects against ischemia/reperfusion injury in cardiac myocytes. J Biol Chem. 281:29776–29787. 2006. View Article : Google Scholar : PubMed/NCBI

41 

Huber SM, Misovic M, Mayer C, Rodemann HP and Dittmann K: EGFR-mediated stimulation of sodium/glucose cotransport promotes survival of irradiated human A549 lung adenocarcinoma cells. Radiother Oncol. 103:373–379. 2012. View Article : Google Scholar : PubMed/NCBI

42 

Gottlieb RA and Mentzer RM: Autophagy during cardiac stress: Joys and frustrations of autophagy. Annu Rev Physiol. 72:45–59. 2010. View Article : Google Scholar : PubMed/NCBI

43 

Sciarretta S, Zhai P, Shao D, Zablocki D, Nagarajan N, Terada LS, Volpe M and Sadoshima J: Activation of NADPH oxidase 4 in the endoplasmic reticulum promotes cardiomyocyte autophagy and survival during energy stress through the protein kinase RNA-activated-like endoplasmic reticulum kinase/eukaryotic initiation factor 2α/activating transcription factor 4 pathway. Circ Res. 113:1253–1264. 2013. View Article : Google Scholar : PubMed/NCBI

44 

Wei L, Wu RB, Yang CM, Zheng SY and Yu XY: Cardioprotective effect of a hemoglobin-based oxygen carrier on cold ischemia/reperfusion injury. Cardiology. 120:73–83. 2011. View Article : Google Scholar : PubMed/NCBI

45 

Boya P and Kroemer G: Beclin 1: A BH3-only protein that fails to induce apoptosis. Oncogene. 28:2125–2127. 2009. View Article : Google Scholar : PubMed/NCBI

46 

Zalckvar E, Berissi H, Eisenstein M and Kimchi A: Phosphorylation of Beclin 1 by DAP-kinase promotes autophagy by weakening its interactions with Bcl-2 and Bcl-XL. Autophagy. 5:720–722. 2009. View Article : Google Scholar : PubMed/NCBI

47 

Pattingre S, Tassa A, Qu X, Garuti R, Liang XH, Mizushima N, Packer M, Schneider MD and Levine B: Bcl-2 antiapoptotic proteins inhibit Beclin 1-dependent autophagy. Cell. 122:927–939. 2005. View Article : Google Scholar : PubMed/NCBI

48 

Itakura E, Kishi C, Inoue K and Mizushima N: Beclin 1 forms two distinct phosphatidylinositol 3-kinase complexes with mammalian Atg14 and UVRAG. Mol Biol Cell. 19:5360–5372. 2008. View Article : Google Scholar : PubMed/NCBI

49 

Martinet W, Knaapen MW, Kockx MM and De Meyer GR: Autophagy in cardiovascular disease. Trends Mol Med. 13:482–491. 2007. View Article : Google Scholar : PubMed/NCBI

50 

Furuya N, Yu J, Byfield M, Pattingre S and Levine B: The evolutionarily conserved domain of Beclin 1 is required for Vps34 binding, autophagy and tumor suppressor function. Autophagy. 1:46–52. 2005. View Article : Google Scholar : PubMed/NCBI

51 

Valentim L, Laurence KM, Townsend PA, Carroll CJ, Soond S, Scarabelli TM, Knight RA, Latchman DS and Stephanou A: Urocortin inhibits Beclin1-mediated autophagic cell death in cardiac myocytes exposed to ischaemia/reperfusion injury. J Mol Cell Cardiol. 40:846–852. 2006. View Article : Google Scholar : PubMed/NCBI

52 

Xie H, Liu Q, Qiao S, Jiang X and Wang C: Delayed cardioprotection by sevoflurane preconditioning: A novel mechanism via inhibiting Beclin 1-mediated autophagic cell death in cardiac myocytes exposed to hypoxia/reoxygenation injury. Int J Clin Exp Pathol. 8:217–226. 2015.PubMed/NCBI

53 

Peng W, Liu Y, Xu WJ and Xia QH: Role of Beclin 1-dependent autophagy in cardioprotection of ischemic preconditioning. J Huazhong Univ Sci Technolog Med Sci. 33:51–56. 2013. View Article : Google Scholar : PubMed/NCBI

54 

Levine B, Sinha S and Kroemer G: Bcl-2 family members: Dual regulators of apoptosis and autophagy. Autophagy. 4:600–606. 2008. View Article : Google Scholar :

55 

Shimizu S, Kanaseki T, Mizushima N, Mizuta T, Arakawa-Kobayashi S, Thompson CB and Tsujimoto Y: Role of Bcl-2 family proteins in a non-apoptotic programmed cell death dependent on autophagy genes. Nat Cell Biol. 6:1221–1228. 2004. View Article : Google Scholar : PubMed/NCBI

56 

Brocheriou V, Hagege AA, Oubenaissa A, Lambert M, Mallet VO, Duriez M, Wassef M, Kahn A, Menasché P and Gilgenkrantz H: Cardiac functional improvement by a human Bcl-2 transgene in a mouse model of ischemia/reperfusion injury. J Gene Med. 2:326–333. 2000. View Article : Google Scholar : PubMed/NCBI

57 

Imahashi K, Schneider MD, Steenbergen C and Murphy E: Transgenic expression of Bcl-2 modulates energy metabolism, prevents cytosolic acidification during ischemia and reduces ischemia/reperfusion injury. Circ Res. 95:734–741. 2004. View Article : Google Scholar : PubMed/NCBI

58 

Liang XH, Kleeman LK, Jiang HH, Gordon G, Goldman JE, Berry G, Herman B and Levine B: Protection against fatal Sindbis virus encephalitis by beclin, a novel Bcl-2-interacting protein. J Virol. 72:8586–8596. 1998.PubMed/NCBI

59 

Ke J, Yao B, Li T, Cui S and Ding H: A2 Adenosine receptor-mediated cardioprotection against reperfusion injury in rat hearts is associated with autophagy downregulation. J Cardiovasc Pharmacol. 66:25–34. 2015. View Article : Google Scholar : PubMed/NCBI

60 

Maiuri MC, Le Toumelin G, Criollo A, Rain JC, Gautier F, Juin P, Tasdemir E, Pierron G, Troulinaki K, Tavernarakis N, et al: Functional and physical interaction between Bcl-X(L) and a BH3-like domain in Beclin-1. EMBO J. 26:2527–2539. 2007. View Article : Google Scholar : PubMed/NCBI

61 

Weston CR and Davis RJ: The JNK signal transduction pathway. Curr Opin Cell Biol. 19:142–149. 2007. View Article : Google Scholar : PubMed/NCBI

62 

Zhao Y and Herdegen T: Cerebral ischemia provokes a profound exchange of activated JNK isoforms in brain mitochondria. Mol Cell Neurosci. 41:186–195. 2009. View Article : Google Scholar : PubMed/NCBI

63 

Xu J, Qin X, Cai X, Yang L, Xing Y, Li J, Zhang L, Tang Y, Liu J, Zhang X and Gao F: Mitochondrial JNK activation triggers autophagy and apoptosis and aggravates myocardial injury following ischemia/reperfusion. Biochim Biophys Acta. 1852:262–270. 2015. View Article : Google Scholar : PubMed/NCBI

64 

Madesh M, Antonsson B, Srinivasula SM, Alnemri ES and Hajnoczky G: Rapid kinetics of tBid-induced cytochrome c and Smac/DIABLO release and mitochondrial depolarization. J Biol Chem. 277:5651–5659. 2002. View Article : Google Scholar : PubMed/NCBI

65 

Yang J, Liu X, Bhalla K, Kim CN, Ibrado AM, Cai J, Peng TI, Jones DP and Wang X: Prevention of apoptosis by Bcl-2: Release of cytochrome c from mitochondria blocked. Science. 275:1129–1132. 1997. View Article : Google Scholar : PubMed/NCBI

66 

Chu G, Egnaczyk GF, Zhao W, Jo SH, Fan GC, Maggio JE, Xiao RP and Kranias EG: Phosphoproteome analysis of cardiomyocytes subjected to beta-adrenergic stimulation: Identification and characterization of a cardiac heat shock protein p20. Circ Res. 94:184–193. 2004. View Article : Google Scholar : PubMed/NCBI

67 

Gurusamy N, Lekli I, Gorbunov NV, Gherghiceanu M, Popescu LM and Das DK: Cardioprotection by adaptation to ischaemia augments autophagy in association with BAG-1 protein. J Cell Mol Med. 13:373–387. 2009. View Article : Google Scholar : PubMed/NCBI

68 

Overbye A, Fengsrud M and Seglen PO: Proteomic analysis of membrane-associated proteins from rat liver autophagosomes. Autophagy. 3:300–322. 2007. View Article : Google Scholar : PubMed/NCBI

69 

Townsend PA, Stephanou A, Packham G and Latchman DS: BAG-1: A multi-functional pro-survival molecule. Int J Biochem Cell Biol. 37:251–259. 2005. View Article : Google Scholar : PubMed/NCBI

70 

Petiot A, Ogier-Denis E, Blommaart EF, Meijer AJ and Codogno P: Distinct classes of phosphatidylinositol 3′-kinases are involved in signaling pathways that control macroautophagy in HT-29 cells. J Biol Chem. 275:992–998. 2000. View Article : Google Scholar : PubMed/NCBI

71 

Gutierrez MG, Master SS, Singh SB, Taylor GA, Colombo MI and Deretic V: Autophagy is a defense mechanism inhibiting BCG and Mycobacterium tuberculosis survival in infected macrophages. Cell. 119:753–766. 2004. View Article : Google Scholar : PubMed/NCBI

72 

Zheng Y, Gu S, Li X, Tan J, Liu S, Jiang Y, Zhang C, Gao L and Yang HT: Berbamine postconditioning protects the heart from ischemia/reperfusion injury through modulation of autophagy. Cell Death Dis. 8:e25772017. View Article : Google Scholar : PubMed/NCBI

73 

Herzig S and Shaw RJ: AMPK: Guardian of metabolism and mitochondrial homeostasis. Nat Rev Mol Cell Biol. 19:121–135. 2018. View Article : Google Scholar : PubMed/NCBI

74 

Hardie DG and Sakamoto K: AMPK: A key sensor of fuel and energy status in skeletal muscle. Physiology (Bethesda). 21:48–60. 2006.PubMed/NCBI

75 

Meley D, Bauvy C, Houben-Weerts JH, Dubbelhuis PF, Helmond MT, Codogno P and Meijer AJ: AMP-activated protein kinase and the regulation of autophagic proteolysis. J Biol Chem. 281:34870–34879. 2006. View Article : Google Scholar : PubMed/NCBI

76 

Samari HR and Seglen PO: Inhibition of hepatocytic autophagy by adenosine, aminoimidazole-4-carboxamide riboside and N6-mercaptopurine riboside. Evidence for involvement of amp-activated protein kinase. J Biol Chem. 273:23758–23763. 1998. View Article : Google Scholar : PubMed/NCBI

77 

Rohailla S, Clarizia N, Sourour M, Sourour W, Gelber N, Wei C, Li J and Redington AN: Acute, delayed and chronic remote ischemic conditioning is associated with downregulation of mTOR and enhanced autophagy signaling. PLoS One. 9:e1112912014. View Article : Google Scholar : PubMed/NCBI

78 

Kandadi MR, Hu N and Ren J: ULK1 plays a critical role in AMPK-mediated myocardial autophagy and contractile dysfunction following acute alcohol challenge. Curr Pharm Des. 19:4874–4887. 2013. View Article : Google Scholar : PubMed/NCBI

79 

Park CW, Hong SM, Kim ES, Kwon JH, Kim KT, Nam HG and Choi KY: BNIP3 is degraded by ULK1-dependent autophagy via MTORC1 and AMPK. Autophagy. 9:345–360. 2013. View Article : Google Scholar : PubMed/NCBI

80 

Przyklenk K, Undyala VV, Wider J, Sala-Mercado JA, Gottlieb RA and Mentzer RM Jr: Acute induction of autophagy as a novel strategy for cardioprotection: Getting to the heart of the matter. Autophagy. 7:432–433. 2011. View Article : Google Scholar : PubMed/NCBI

81 

Dunlop EA, Hunt DK, Acosta-Jaquez HA, Fingar DC and Tee AR: ULK1 inhibits mTORC1 signaling, promotes multisite Raptor phosphorylation and hinders substrate binding. Autophagy. 7:737–747. 2011. View Article : Google Scholar : PubMed/NCBI

82 

Kim J, Kundu M, Viollet B and Guan KL: AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1. Nat Cell Biol. 13:132–141. 2011. View Article : Google Scholar : PubMed/NCBI

83 

Fiordaliso F, Li B, Latini R, Sonnenblick EH, Anversa P, Leri A and Kajstura J: Myocyte death in streptozotocin-induced diabetes in rats in angiotensin II-dependent. Lab Invest. 80:513–527. 2000. View Article : Google Scholar : PubMed/NCBI

84 

Lekli I, Ray D, Mukherjee S, Gurusamy N, Ahsan MK, Juhasz B, Bak I, Tosaki A, Gherghiceanu M, Popescu LM and Das DK: Co-ordinated autophagy with resveratrol and gamma-tocotrienol confers synergetic cardioprotection. J Cell Mol Med. 14:2506–2518. 2010. View Article : Google Scholar : PubMed/NCBI

85 

Li Y, Wang Y, Kim E, Beemiller P, Wang CY, Swanson J, You M and Guan KL: Bnip3 mediates the hypoxia-induced inhibition on mammalian target of rapamycin by interacting with Rheb. J Biol Chem. 282:35803–35813. 2007. View Article : Google Scholar : PubMed/NCBI

86 

Hamacher-Brady A, Brady NR, Gottlieb RA and Gustafsson AB: Autophagy as a protective response to Bnip3-mediated apoptotic signaling in the heart. Autophagy. 2:307–309. 2006. View Article : Google Scholar : PubMed/NCBI

87 

Xu W, Jiang H, Hu X and Fu W: Effects of high-mobility group box 1 on the expression of Beclin-1 and LC3 proteins following hypoxia and reoxygenation injury in rat cardiomyocytes. Int J Clin Exp Med. 7:5353–5357. 2014.PubMed/NCBI

88 

Ouyang F, Huang H, Zhang M, Chen M, Huang F and Zhou S: HMGB1 induces apoptosis and EMT in association with increased autophagy following H/R injury in cardiomyocytes. Int J Mol Med. 37:679–689. 2016. View Article : Google Scholar : PubMed/NCBI

89 

Sciarretta S, Zhai P, Shao D, Maejima Y, Robbins J, Volpe M, Condorelli G and Sadoshima J: Rheb is a critical regulator of autophagy during myocardial ischemia: Pathophysiological implications in obesity and metabolic syndrome. Circulation. 125:1134–1146. 2012. View Article : Google Scholar : PubMed/NCBI

90 

Shi WY, Xiao D, Wang L, Dong LH, Yan ZX, Shen ZX, Chen SJ, Chen Y and Zhao WL: Therapeutic metformin/AMPK activation blocked lymphoma cell growth via inhibition of mTOR pathway and induction of autophagy. Cell Death Dis. 3:e2752012. View Article : Google Scholar : PubMed/NCBI

91 

Gurusamy N, Lekli I, Mukherjee S, Ray D, Ahsan MK, Gherghiceanu M, Popescu LM and Das DK: Cardioprotection by resveratrol: A novel mechanism via autophagy involving the mTORC2 pathway. Cardiovasc Res. 86:103–112. 2010. View Article : Google Scholar : PubMed/NCBI

92 

Zhao M, Sun L, Yu XJ, Miao Y, Liu JJ, Wang H, Ren J and Zang WJ: Acetylcholine mediates AMPK-dependent autophagic cytoprotection in H9c2 cells during hypoxia/reoxygenation injury. Cell Physiol Biochem. 32:601–613. 2013. View Article : Google Scholar : PubMed/NCBI

93 

Xie H, Xu Q, Jia J, Ao G, Sun Y, Hu L, Alkayed NJ, Wang C and Cheng J: Hydrogen sulfide protects against myocardial ischemia and reperfusion injury by activating AMP-activated protein kinase to restore autophagic flux. Biochem Biophys Res Commun. 458:632–638. 2015. View Article : Google Scholar : PubMed/NCBI

94 

Takagi H, Matsui Y, Hirotani S, Sakoda H, Asano T and Sadoshima J: AMPK mediates autophagy during myocardial ischemia in vivo. Autophagy. 3:405–407. 2007. View Article : Google Scholar : PubMed/NCBI

95 

Yang Y, Wang H, Wang S, Xu M, Liu M, Liao M, Frank JA, Adhikari S, Bower KA, Shi X, et al: GSK3β signaling is involved in ultraviolet B-induced activation of autophagy in epidermal cells. Int J Oncol. 41:1782–1788. 2012. View Article : Google Scholar : PubMed/NCBI

96 

Onishi A, Miyamae M, Kaneda K, Kotani J and Figueredo VM: Direct evidence for inhibition of mitochondrial permeability transition pore opening by sevoflurane preconditioning in cardiomyocytes: Comparison with cyclosporine A. Eur J Pharmacol. 675:40–46. 2012. View Article : Google Scholar : PubMed/NCBI

97 

Shiomi M, Miyamae M, Takemura G, Kaneda K, Inamura Y, Onishi A, Koshinuma S, Momota Y, Minami T and Figueredo VM: Sevoflurane induces cardioprotection through reactive oxygen species-mediated upregulation of autophagy in isolated guinea pig hearts. J Anesth. 28:593–600. 2014. View Article : Google Scholar : PubMed/NCBI

98 

Hariharan N, Zhai P and Sadoshima J: Oxidative stress stimulates autophagic flux during ischemia/reperfusion. Antioxid Redox Signal. 14:2179–2190. 2011. View Article : Google Scholar : PubMed/NCBI

99 

Zhong Y, Zhong P, He S, Zhang Y, Tang L, Ling Y, Fu S, Tang Y, Yang P, Luo T, et al: Trimetazidine protects cardiomyocytes against hypoxia/reoxygenation injury by promoting AMP-activated protein kinase-dependent autophagic flux. J Cardiovasc Pharmacol. 69:389–397. 2017. View Article : Google Scholar : PubMed/NCBI

100 

Li YY, Xiang Y, Zhang S, Wang Y, Yang J, Liu W and Xue FT: Thioredoxin-2 protects against oxygen-glucose deprivation/reperfusion injury by inhibiting autophagy and apoptosis in H9c2 cardiomyocytes. Am J Transl Res. 9:1471–1482. 2017.PubMed/NCBI

101 

Shiomi M, Miyamae M, Takemura G, Kaneda K, Inamura Y, Onishi A, Koshinuma S, Momota Y, Minami T and Figueredo VM: Induction of autophagy restores the loss of sevoflurane cardiac preconditioning seen with prolonged ischemic insult. Eur J Pharmacol. 724:58–66. 2014. View Article : Google Scholar : PubMed/NCBI

102 

He C and Klionsky DJ: Regulation mechanisms and signaling pathways of autophagy. Annu Rev Genet. 43:67–93. 2009. View Article : Google Scholar : PubMed/NCBI

103 

Wang LQ, Cheng XS, Huang CH, Huang B and Liang Q: Rapamycin protects cardiomyocytes against anoxia/reoxygenation injury by inducing autophagy through the PI3k/Akt pathway. J Huazhong Univ Sci Technolog Med Sci. 35:10–15. 2015. View Article : Google Scholar : PubMed/NCBI

104 

Zhai P, Sciarretta S, Galeotti J, Volpe M and Sadoshima J: Differential roles of GSK-3β during myocardial ischemia and ischemia/reperfusion. Circ Res. 109:502–511. 2011. View Article : Google Scholar : PubMed/NCBI

105 

Horn HF and Vousden KH: Coping with stress: Multiple ways to activate p53. Oncogene. 26:1306–1316. 2007. View Article : Google Scholar : PubMed/NCBI

106 

Hoshino A, Matoba S, Iwai-Kanai E, Nakamura H, Kimata M, Nakaoka M, Katamura M, Okawa Y, Ariyoshi M, Mita Y, et al: p53-TIGAR axis attenuates mitophagy to exacerbate cardiac damage after ischemia. J Mol Cell Cardiol. 52:175–184. 2012. View Article : Google Scholar : PubMed/NCBI

107 

Townsend PA, Scarabelli TM, Davidson SM, Knight RA, Latchman DS and Stephanou A: STAT-1 interacts with p53 to enhance DNA damage-induced apoptosis. J Biol Chem. 279:5811–5820. 2004. View Article : Google Scholar : PubMed/NCBI

108 

Halestrap AP, Clarke SJ and Javadov SA: Mitochondrial permeability transition pore opening during myocardial reperfusion-a target for cardioprotection. Cardiovasc Res. 61:372–385. 2004. View Article : Google Scholar : PubMed/NCBI

109 

Hausenloy D, Wynne A, Duchen M and Yellon D: Transient mitochondrial permeability transition pore opening mediates preconditioning-induced protection. Circulation. 109:1714–1717. 2004. View Article : Google Scholar : PubMed/NCBI

110 

Saotome M, Katoh H, Yaguchi Y, Tanaka T, Urushida T, Satoh H and Hayashi H: Transient opening of mitochondrial permeability transition pore by reactive oxygen species protects myocardium from ischemia-reperfusion injury. Am J Physiol Heart Circ Physiol. 296:H1125–H1132. 2009. View Article : Google Scholar : PubMed/NCBI

111 

Nanda A, Gukovskaya A, Tseng J and Grinstein S: Activation of vacuolar-type proton pumps by protein kinase C. Role in neutrophil pH regulation. J Biol Chem. 267:22740–22746. 1992.PubMed/NCBI

112 

Nordstrom T, Grinstein S, Brisseau GF, Manolson MF and Rotstein OD: Protein kinase C activation accelerates proton extrusion by vacuolar-type H(+)-ATPases in murine peritoneal macrophages. FEBS Lett. 350:82–86. 1994. View Article : Google Scholar : PubMed/NCBI

113 

Voss M, Vitavska O, Walz B, Wieczorek H and Baumann O: Stimulus-induced phosphorylation of vacuolar H (+)-ATPase by protein kinase A. J Biol Chem. 282:33735–33742. 2007. View Article : Google Scholar : PubMed/NCBI

114 

Shen YT, Depre C, Yan L, Park JY, Tian B, Jain K, Chen L, Zhang Y, Kudej RK, Zhao X, et al: Repetitive ischemia by coronary stenosis induces a novel window of ischemic preconditioning. Circulation. 118:1961–1969. 2008. View Article : Google Scholar : PubMed/NCBI

115 

Depre C, Park JY, Shen YT, Zhao X, Qiu H, Yan L, Tian B, Vatner SF and Vatner DE: Molecular mechanisms mediating preconditioning following chronic ischemia differ from those in classical second window. Am J Physiol Heart Circ Physiol. 299:H752–H762. 2010. View Article : Google Scholar : PubMed/NCBI

116 

Khan S, Salloum F, Das A, Xi L, Vetrovec GW and Kukreja RC: Rapamycin confers preconditioning-like protection against ischemia-reperfusion injury in isolated mouse heart and cardiomyocytes. J Mol Cell Cardiol. 41:256–264. 2006. View Article : Google Scholar : PubMed/NCBI

117 

Marzetti E, Wohlgemuth SE, Anton SD, Bernabei R, Carter CS and Leeuwenburgh C: Cellular mechanisms of cardioprotection by calorie restriction: State of the science and future perspectives. Clin Geriatr Med. 25:715–732. 2009. View Article : Google Scholar : PubMed/NCBI

118 

Kavazis AN, Alvarez S, Talbert E, Lee Y and Powers SK: Exercise training induces a cardioprotective phenotype and alterations in cardiac subsarcolemmal and intermyofibrillar mitochondrial proteins. Am J Physiol Heart Circ Physiol. 297:H144–H152. 2009. View Article : Google Scholar : PubMed/NCBI

119 

Jones SP and Bolli R: The ubiquitous role of nitric oxide in cardioprotection. J Mol Cell Cardiol. 40:16–23. 2006. View Article : Google Scholar : PubMed/NCBI

120 

Ha T, Hua F, Liu X, Ma J, McMullen JR, Shioi T, Izumo S, Kelley J, Gao X, Browder W, et al: Lipopolysaccharide-induced myocardial protection against ischaemia/reperfusion injury is mediated through a PI3K/Akt-dependent mechanism. Cardiovasc Res. 78:546–553. 2008. View Article : Google Scholar : PubMed/NCBI

121 

Sala-Mercado JA, Wider J, Undyala VV, Jahania S, Yoo W, Mentzer RM Jr, Gottlieb RA and Przyklenk K: Profound cardioprotection with chloramphenicol succinate in the swine model of myocardial ischemia-reperfusion injury. Circulation. 122:S179–S184. 2010. View Article : Google Scholar : PubMed/NCBI

122 

Shirakabe A, Ikeda Y, Sciarretta S, Zablocki DK and Sadoshima J: Aging and autophagy in the heart. Circ Res. 118:1563–1576. 2016. View Article : Google Scholar : PubMed/NCBI

123 

Gottlieb RA and Mentzer RM Jr: Cardioprotection through autophagy: Ready for clinical trial? Autophagy. 7:434–435. 2011. View Article : Google Scholar : PubMed/NCBI

124 

Kanamori H, Takemura G, Goto K, Maruyama R, Tsujimoto A, Ogino A, Takeyama T, Kawaguchi T, Watanabe T, Fujiwara T, et al: The role of autophagy emerging in postinfarction cardiac remodelling. Cardiovasc Res. 91:330–339. 2011. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Lin XL, Xiao WJ, Xiao LL and Liu MH: Molecular mechanisms of autophagy in cardiac ischemia/reperfusion injury (Review). Mol Med Rep 18: 675-683, 2018.
APA
Lin, X., Xiao, W., Xiao, L., & Liu, M. (2018). Molecular mechanisms of autophagy in cardiac ischemia/reperfusion injury (Review). Molecular Medicine Reports, 18, 675-683. https://doi.org/10.3892/mmr.2018.9028
MLA
Lin, X., Xiao, W., Xiao, L., Liu, M."Molecular mechanisms of autophagy in cardiac ischemia/reperfusion injury (Review)". Molecular Medicine Reports 18.1 (2018): 675-683.
Chicago
Lin, X., Xiao, W., Xiao, L., Liu, M."Molecular mechanisms of autophagy in cardiac ischemia/reperfusion injury (Review)". Molecular Medicine Reports 18, no. 1 (2018): 675-683. https://doi.org/10.3892/mmr.2018.9028
Copy and paste a formatted citation
x
Spandidos Publications style
Lin XL, Xiao WJ, Xiao LL and Liu MH: Molecular mechanisms of autophagy in cardiac ischemia/reperfusion injury (Review). Mol Med Rep 18: 675-683, 2018.
APA
Lin, X., Xiao, W., Xiao, L., & Liu, M. (2018). Molecular mechanisms of autophagy in cardiac ischemia/reperfusion injury (Review). Molecular Medicine Reports, 18, 675-683. https://doi.org/10.3892/mmr.2018.9028
MLA
Lin, X., Xiao, W., Xiao, L., Liu, M."Molecular mechanisms of autophagy in cardiac ischemia/reperfusion injury (Review)". Molecular Medicine Reports 18.1 (2018): 675-683.
Chicago
Lin, X., Xiao, W., Xiao, L., Liu, M."Molecular mechanisms of autophagy in cardiac ischemia/reperfusion injury (Review)". Molecular Medicine Reports 18, no. 1 (2018): 675-683. https://doi.org/10.3892/mmr.2018.9028
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team