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Article

Upregulation of microRNA‑24 causes vasospasm following subarachnoid hemorrhage by suppressing the expression of endothelial nitric oxide synthase

  • Authors:
    • Huan‑Ting Li
    • Jing Wang
    • Shi‑Fang Li
    • Lei Cheng
    • Wan‑Zhong Tang
    • Yu‑Gong Feng
  • View Affiliations / Copyright

    Affiliations: Department of Neurosurgery, The Affiliated Hospital of Qingdao University, Qingdao, Shandong 266003, P.R. China, Department of Oncology, The Affiliated Hospital of Qingdao University, Qingdao, Shandong 266003, P.R. China
  • Pages: 1181-1187
    |
    Published online on: May 22, 2018
       https://doi.org/10.3892/mmr.2018.9050
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Abstract

MicroRNA (miR)‑24 has been reported to associate with various diseases by acting on different signaling pathways. The present study aimed to elucidate the association between miR‑24 expression levels and vasospasm following subarachnoid hemorrhage (SAH), and its underlying mechanism. An miR online database was searched, identifying endothelial nitric oxide synthase (NOS3) as a potential target gene of miR‑24. A luciferase reporter assay performed to investigate the regulatory association between miR‑24 and NOS3 revealed that miR‑24 bound to the NOS3 3' untranslated region and inhibited NOS3 expression. Reverse transcription‑quantitative polymerase chain reaction and western blot analysis were performed to investigate the miR‑24 and NOS3 expression levels in samples from patients with SAH, and demonstrated a negative correlation between the two. In addition, miR‑24 expression levels were increased in SAH patients with vasospasm compared with those without, whereas the opposite results were observed for NOS3. Vascular smooth muscle cells (VSMCs) transfected with an miR‑24 inhibitor exhibited increased expression levels of NOS3, whereas those transfected with an miR‑24 mimic or NOS3 small interfering RNA exhibited reduced expression levels of NOS3, compared with the control. These results indicated a negative regulatory association between miR‑24 and NOS3. Downregulation of NOS3 may induce vasospasm following SAH, which may be due to the upregualtion of miR‑24 in VSMCs.
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1 

Connolly ES Jr, Rabinstein AA, Carhuapoma JR, Derdeyn CP, Dion J, Higashida RT, Hoh BL, Kirkness CJ, Naidech AM, Ogilvy CS, et al: Guidelines for the management of aneurysmal subarachnoid hemorrhage: A guideline for healthcare professionals from the American Heart Association/american Stroke Association. Stroke. 43:1711–1737. 2012. View Article : Google Scholar : PubMed/NCBI

2 

Suarez JI, Tarr RW and Selman WR: Aneurysmal subarachnoid hemorrhage. N Engl J Med. 354:387–396. 2006. View Article : Google Scholar : PubMed/NCBI

3 

Sarrafzadeh A, Haux D, Sakowitz O, Benndorf G, Herzog H, Kuechler I and Unterberg A: Acute focal neurological deficits in aneurysmal subarachnoid hemorrhage: Relation of clinical course, CT findings, and metabolite abnormalities monitored with bedside microdialysis. Stroke. 34:1382–1388. 2003. View Article : Google Scholar : PubMed/NCBI

4 

Quyyumi AA, Dakak N, Andrews NP, Gilligan DM, Panza JA and Cannon RO III: Contribution of nitric oxide to metabolic coronary vasodilation in the human heart. Circulation. 92:320–326. 1995. View Article : Google Scholar : PubMed/NCBI

5 

Weir B and MacDonald L: Cerebral vasospasm. Clin Neurosurg. 40:40–55. 1993.PubMed/NCBI

6 

Khurana VG, Smith LA, Baker TA, Eguchi D, O'Brien T and Katusic ZS: Protective vasomotor effects of in vivo recombinant endothelial nitric oxide synthase gene expression in a canine model of cerebral vasospasm. Stroke. 33:782–789. 2002. View Article : Google Scholar : PubMed/NCBI

7 

Woszczyk A, Deinsberger W and Böker DK: Nitric oxide metabolites in cisternal CSF correlate with cerebral vasospasm in patients with a subarachnoid haemorrhage. Acta Neurochir (Wien). 145:257–263; discussion 263–644. 2003. View Article : Google Scholar : PubMed/NCBI

8 

Sadamitsu D, Kuroda Y, Nagamitsu T, Tsuruta R, Inoue T, Ueda T, Nakashima K, Ito H and Maekawa T: Cerebrospinal fluid and plasma concentrations of nitric oxide metabolites in postoperative patients with subarachnoid hemorrhage. Crit Care Med. 29:77–79. 2001. View Article : Google Scholar : PubMed/NCBI

9 

Khurana VG, Smith LA, Weiler DA, Springett MJ, Parisi JE, Meyer FB, Marsh WR, O'Brien T and Katusic ZS: Adenovirus-mediated gene transfer to human cerebral arteries. J Cereb Blood Flow Metab. 20:1360–1371. 2000. View Article : Google Scholar : PubMed/NCBI

10 

Moncada S, Palmer RM and Higgs EA: Nitric oxide: Physiology, pathophysiology, and pharmacology. Pharmacol Rev. 43:109–142. 1991.PubMed/NCBI

11 

Dumont AS, Dumont RJ, Chow MM, Lin CL, Calisaneller T, Ley KF, Kassell NF and Lee KS: Cerebral vasospasm after subarachnoid hemorrhage: Putative role of inflammation. Neurosurgery. 53:123–133; discussion 133–135. 2003. View Article : Google Scholar : PubMed/NCBI

12 

Khurana VG, Sohni YR, Mangrum WI, McClelland RL, O'Kane DJ, Meyer FB and Meissner I: Endothelial nitric oxide synthase gene polymorphisms predict susceptibility to aneurysmal subarachnoid hemorrhage and cerebral vasospasm. J Cereb Blood Flow Metab. 24:291–297. 2004. View Article : Google Scholar : PubMed/NCBI

13 

Yoshimura M, Nakayama M, Shimasaki Y, Ogawa H, Kugiyama K, Nakamura S, Ito T, Mizuno Y, Harada E, Yasue H, et al: A T-786->C mutation in the 5′-flanking region of the endothelial nitric oxide synthase gene and coronary arterial vasomotility. Am J Cardiol. 85:710–714. 2000. View Article : Google Scholar : PubMed/NCBI

14 

Saugstad JA: MicroRNAs as effectors of brain function with roles in ischemia and injury, neuroprotection, and neurodegeneration. J Cereb Blood Flow Metab. 30:1564–1576. 2010. View Article : Google Scholar : PubMed/NCBI

15 

Cordes KR, Sheehy NT, White MP, Berry EC, Morton SU, Muth AN, Lee TH, Miano JM, Ivey KN and Srivastava D: miR-145 and miR-143 regulate smooth muscle cell fate and plasticity. Nature. 460:705–710. 2009.PubMed/NCBI

16 

Vikman P, Ansar S, Henriksson M, Stenman E and Edvinsson L: Cerebral ischemia induces transcription of inflammatory and extracellular-matrix-related genes in rat cerebral arteries. Exp Brain Res. 183:499–510. 2007. View Article : Google Scholar : PubMed/NCBI

17 

Vikman P, Beg S, Khurana TS, Hansen-Schwartz J and Edvinsson L: Gene expression and molecular changes in cerebral arteries following subarachnoid hemorrhage in the rat. J Neurosurg. 105:438–444. 2006. View Article : Google Scholar : PubMed/NCBI

18 

Johansson S, Povlsen GK and Edvinsson L: Expressional changes in cerebrovascular receptors after experimental transient forebrain ischemia. PLoS One. 7:e418522012. View Article : Google Scholar : PubMed/NCBI

19 

Edvinsson LI and Povlsen GK: Vascular plasticity in cerebrovascular disorders. J Cereb Blood Flow Metab. 31:1554–1571. 2011. View Article : Google Scholar : PubMed/NCBI

20 

Liu D, Han L, Wu X, Yang X, Zhang Q and Jiang F: Genome-wide microRNA changes in human intracranial aneurysms. BMC Neurol. 14:1882014. View Article : Google Scholar : PubMed/NCBI

21 

Starke RM, Kim GH, Komotar RJ, Hickman ZL, Black EM, Rosales MB, Kellner CP, Hahn DK, Otten ML, Edwards J, et al: Endothelial nitric oxide synthase gene single-nucleotide polymorphism predicts cerebral vasospasm after aneurysmal subarachnoid hemorrhage. J Cereb Blood Flow Metab. 28:1204–1211. 2008. View Article : Google Scholar : PubMed/NCBI

22 

Khurana VG, Sohni YR, Mangrum WI, McClelland RL, O'Kane DJ, Meyer FB and Meissner I: Section on cerebrovascular surgery: Galbraith Award: Endothelial nitric oxide synthase (eNOS) and heme oxygenase-1 (HO-1) gene polymorphisms predict susceptibility to aneurysmal subarachnoid hemorrhage (SAH) and post-SAH cerebral vasospasm. Clin Neurosurg. 51:343–350. 2004.PubMed/NCBI

23 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

24 

Lang B, Shang C and Meng L: Targeted Silencing of S100A8 Gene by miR-24 to Increase Chemotherapy Sensitivity of Endometrial Carcinoma Cells to Paclitaxel. Med Sci Monit. 22:1953–1958. 2016. View Article : Google Scholar : PubMed/NCBI

25 

Small EM and Olson EN: Pervasive roles of microRNAs in cardiovascular biology. Nature. 469:336–342. 2011. View Article : Google Scholar : PubMed/NCBI

26 

Garofalo M and Croce CM: microRNAs: Master regulators as potential therapeutics in cancer. Annu Rev Pharmacol Toxicol. 51:25–43. 2011. View Article : Google Scholar : PubMed/NCBI

27 

Wang S and Olson EN: AngiomiRs-key regulators of angiogenesis. Curr Opin Genet Dev. 19:205–211. 2009. View Article : Google Scholar : PubMed/NCBI

28 

Zhou Q, Gallagher R, Ufret-Vincenty R, Li X, Olson EN and Wang S: Regulation of angiogenesis and choroidal neovascularization by members of microRNA-23~27~24 clusters. Proc Natl Acad Sci USA. 108:8287–8292. 2011. View Article : Google Scholar : PubMed/NCBI

29 

Urbich C, Kaluza D, Frömel T, Knau A, Bennewitz K, Boon RA, Bonauer A, Doebele C, Boeckel JN, Hergenreider E, et al: MicroRNA-27a/b controls endothelial cell repulsion and angiogenesis by targeting semaphorin 6A. Blood. 119:1607–1616. 2012. View Article : Google Scholar : PubMed/NCBI

30 

Zhou Q, Anderson C, Zhang H, Li X, Inglis F, Jayagopal A and Wang S: Repression of choroidal neovascularization through actin cytoskeleton pathways by microRNA-24. Mol Ther. 22:378–389. 2014. View Article : Google Scholar : PubMed/NCBI

31 

Siuta M, Zuckerman SL and Mocco J: Nitric oxide in cerebral vasospasm: Theories, measurement, and treatment. Neurol Res Int. 2013:9724172013. View Article : Google Scholar : PubMed/NCBI

32 

Jung CS, Iuliano BA, Harvey-White J, Espey MG, Oldfield EH and Pluta RM: Association between cerebrospinal fluid levels of asymmetric dimethyl-L-arginine, an endogenous inhibitor of endothelial nitric oxide synthase, and cerebral vasospasm in a primate model of subarachnoid hemorrhage. J Neurosurg. 101:836–842. 2004. View Article : Google Scholar : PubMed/NCBI

33 

Kim P, Schini VB, Sundt TM Jr and Vanhoutte PM: Reduced production of cGMP underlies the loss of endothelium-dependent relaxations in the canine basilar artery after subarachnoid hemorrhage. Circ Res. 70:248–256. 1992. View Article : Google Scholar : PubMed/NCBI

34 

Hino A, Tokuyama Y, Weir B, Takeda J, Yano H, Bell GI and Macdonald RL: Changes in endothelial nitric oxide synthase mRNA during vasospasm after subarachnoid hemorrhage in monkeys. Neurosurgery. 39:562–567; discussion 567–568. 1996. View Article : Google Scholar : PubMed/NCBI

35 

Afshar JK, Pluta RM, Boock RJ, Thompson BG and Oldfield EH: Effect of intracarotid nitric oxide on primate cerebral vasospasm after subarachnoid hemorrhage. J Neurosurg. 83:118–122. 1995. View Article : Google Scholar : PubMed/NCBI

36 

van Faassen EE, Bahrami S, Feelisch M, Hogg N, Kelm M, Kim-Shapiro DB, Kozlov AV, Li H, Lundberg JO, Mason R, et al: Nitrite as regulator of hypoxic signaling in mammalian physiology. Med Res Rev. 29:683–741. 2009. View Article : Google Scholar : PubMed/NCBI

37 

Förstermann U and Münzel T: Endothelial nitric oxide synthase in vascular disease: From marvel to menace. Circulation. 113:1708–1714. 2006. View Article : Google Scholar : PubMed/NCBI

38 

Sabri M, Ai J, Knight B, Tariq A, Jeon H, Shang X, Marsden PA and Macdonald Loch R: Uncoupling of endothelial nitric oxide synthase after experimental subarachnoid hemorrhage. J Cereb Blood Flow Metab. 31:190–199. 2011. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Li HT, Wang J, Li SF, Cheng L, Tang WZ and Feng YG: Upregulation of microRNA‑24 causes vasospasm following subarachnoid hemorrhage by suppressing the expression of endothelial nitric oxide synthase. Mol Med Rep 18: 1181-1187, 2018.
APA
Li, H., Wang, J., Li, S., Cheng, L., Tang, W., & Feng, Y. (2018). Upregulation of microRNA‑24 causes vasospasm following subarachnoid hemorrhage by suppressing the expression of endothelial nitric oxide synthase. Molecular Medicine Reports, 18, 1181-1187. https://doi.org/10.3892/mmr.2018.9050
MLA
Li, H., Wang, J., Li, S., Cheng, L., Tang, W., Feng, Y."Upregulation of microRNA‑24 causes vasospasm following subarachnoid hemorrhage by suppressing the expression of endothelial nitric oxide synthase". Molecular Medicine Reports 18.1 (2018): 1181-1187.
Chicago
Li, H., Wang, J., Li, S., Cheng, L., Tang, W., Feng, Y."Upregulation of microRNA‑24 causes vasospasm following subarachnoid hemorrhage by suppressing the expression of endothelial nitric oxide synthase". Molecular Medicine Reports 18, no. 1 (2018): 1181-1187. https://doi.org/10.3892/mmr.2018.9050
Copy and paste a formatted citation
x
Spandidos Publications style
Li HT, Wang J, Li SF, Cheng L, Tang WZ and Feng YG: Upregulation of microRNA‑24 causes vasospasm following subarachnoid hemorrhage by suppressing the expression of endothelial nitric oxide synthase. Mol Med Rep 18: 1181-1187, 2018.
APA
Li, H., Wang, J., Li, S., Cheng, L., Tang, W., & Feng, Y. (2018). Upregulation of microRNA‑24 causes vasospasm following subarachnoid hemorrhage by suppressing the expression of endothelial nitric oxide synthase. Molecular Medicine Reports, 18, 1181-1187. https://doi.org/10.3892/mmr.2018.9050
MLA
Li, H., Wang, J., Li, S., Cheng, L., Tang, W., Feng, Y."Upregulation of microRNA‑24 causes vasospasm following subarachnoid hemorrhage by suppressing the expression of endothelial nitric oxide synthase". Molecular Medicine Reports 18.1 (2018): 1181-1187.
Chicago
Li, H., Wang, J., Li, S., Cheng, L., Tang, W., Feng, Y."Upregulation of microRNA‑24 causes vasospasm following subarachnoid hemorrhage by suppressing the expression of endothelial nitric oxide synthase". Molecular Medicine Reports 18, no. 1 (2018): 1181-1187. https://doi.org/10.3892/mmr.2018.9050
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