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Article

Cyclin‑dependent kinase 10 prevents glioma metastasis via modulation of Snail expression

  • Authors:
    • Hui Li
    • Yanjie You
    • Jianfeng Liu
  • View Affiliations / Copyright

    Affiliations: Department of Neurosurgery, The First Hospital of Hebei Medical University, Shijiazhuang, Hebei 050000, P.R. China, Department of Gastroenterology, Ningxia Hui Autonomous Region People's Hospital, Yinchuan, Ningxia Hui Autonomous Region 750021, P.R. China
  • Pages: 1165-1170
    |
    Published online on: May 23, 2018
       https://doi.org/10.3892/mmr.2018.9059
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Abstract

Cyclin‑dependent kinase 10 (CDK10) has been indicated to be a candidate tumor suppressor in multiple cancer types. However, to the best of the authors' knowledge, its biological and regulatory functions in glioma have not been previously reported. In the present study, it was demonstrated that overexpression of CDK10 inhibited glioma cell proliferation and metastasis. By contrast, knockdown of CDK10 expression promoted these malignant phenotypes. It was additionally indicated that dysregulated CDK10 expression was associated with epithelial‑mesenchymal transition (EMT) and that it regulated the expression of zinc finger protein SNAI1 (Snail). Furthermore, silencing Snail expression rescued EMT phenotypes induced by CDK10 knockdown, suggesting that Snail may be involved in the mechanistic association between CDK10 and EMT. The present study illustrated that downregulation of CDK10 expression activated Snail‑driven EMT and consequently promoted glioma metastasis, suggesting that CDK10 may serve as a potential molecular target for glioma therapy.
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Copy and paste a formatted citation
Spandidos Publications style
Li H, You Y and Liu J: Cyclin‑dependent kinase 10 prevents glioma metastasis via modulation of Snail expression. Mol Med Rep 18: 1165-1170, 2018.
APA
Li, H., You, Y., & Liu, J. (2018). Cyclin‑dependent kinase 10 prevents glioma metastasis via modulation of Snail expression. Molecular Medicine Reports, 18, 1165-1170. https://doi.org/10.3892/mmr.2018.9059
MLA
Li, H., You, Y., Liu, J."Cyclin‑dependent kinase 10 prevents glioma metastasis via modulation of Snail expression". Molecular Medicine Reports 18.1 (2018): 1165-1170.
Chicago
Li, H., You, Y., Liu, J."Cyclin‑dependent kinase 10 prevents glioma metastasis via modulation of Snail expression". Molecular Medicine Reports 18, no. 1 (2018): 1165-1170. https://doi.org/10.3892/mmr.2018.9059
Copy and paste a formatted citation
x
Spandidos Publications style
Li H, You Y and Liu J: Cyclin‑dependent kinase 10 prevents glioma metastasis via modulation of Snail expression. Mol Med Rep 18: 1165-1170, 2018.
APA
Li, H., You, Y., & Liu, J. (2018). Cyclin‑dependent kinase 10 prevents glioma metastasis via modulation of Snail expression. Molecular Medicine Reports, 18, 1165-1170. https://doi.org/10.3892/mmr.2018.9059
MLA
Li, H., You, Y., Liu, J."Cyclin‑dependent kinase 10 prevents glioma metastasis via modulation of Snail expression". Molecular Medicine Reports 18.1 (2018): 1165-1170.
Chicago
Li, H., You, Y., Liu, J."Cyclin‑dependent kinase 10 prevents glioma metastasis via modulation of Snail expression". Molecular Medicine Reports 18, no. 1 (2018): 1165-1170. https://doi.org/10.3892/mmr.2018.9059
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