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Molecular Medicine Reports
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July-2018 Volume 18 Issue 1

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Article

Acid fibroblast growth factor facilitates the progression of atherosclerotic plaques regardless of alterations in serum lipid expression levels in HFD‑fed ApoE‑/‑ mice

  • Authors:
    • Jibo Han
    • Yao Du
    • Lintao Wang
    • Xiong Chen
    • Liqin Jiang
    • Jianjiang Xu
  • View Affiliations / Copyright

    Affiliations: Department of Cardiology, The Second Affiliated Hospital of Jiaxing University, Jiaxing, Zhejiang 314000, P.R. China, Medication Department, Nanjing Drum Tower Hospital Affiliated to Medical College of Nanjing University, Nanjing, Jiangsu 210000, P.R. China, Chemical Biology Research Center, School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang 325000, P.R. China
  • Pages: 1025-1030
    |
    Published online on: May 23, 2018
       https://doi.org/10.3892/mmr.2018.9060
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Abstract

Atherosclerosis is recognized at present as a chronic metabolic disease of the arteries that leads to multifocal plaque development. Previous studies have reported that acid fibroblast growth factor (aFGF) is a critical therapeutic regulator in numerous chronic metabolic disorders. However, there is currently no direct evidence indicating whether aFGF serves a therapeutic role in atherosclerosis. In the present study, the role of aFGF in atherosclerotic lesion development was investigated by examining high‑fat diet (HFD)‑fed apolipoprotein E (ApoE)‑/‑ mice and parenteral administration of aFGF. Increased expression of aFGF and peroxisome proliferator‑activated receptor α (PPARα) was observed during atherosclerotic lesion development. The parenteral delivery of aFGF facilitated the progression of atherosclerosis without altering serum lipid expression levels in HFD‑fed ApoE‑/‑ mice. Furthermore, it was demonstrated that aFGF increased the expression of PPARα and inflammatory cytokines. The present results provided evidence that aFGF accelerates the progression of atherosclerosis and suggested that aFGF may be a potential therapeutic target for the prevention of atherosclerosis development.
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Copy and paste a formatted citation
Spandidos Publications style
Han J, Du Y, Wang L, Chen X, Jiang L and Xu J: Acid fibroblast growth factor facilitates the progression of atherosclerotic plaques regardless of alterations in serum lipid expression levels in HFD‑fed ApoE‑/‑ mice. Mol Med Rep 18: 1025-1030, 2018.
APA
Han, J., Du, Y., Wang, L., Chen, X., Jiang, L., & Xu, J. (2018). Acid fibroblast growth factor facilitates the progression of atherosclerotic plaques regardless of alterations in serum lipid expression levels in HFD‑fed ApoE‑/‑ mice. Molecular Medicine Reports, 18, 1025-1030. https://doi.org/10.3892/mmr.2018.9060
MLA
Han, J., Du, Y., Wang, L., Chen, X., Jiang, L., Xu, J."Acid fibroblast growth factor facilitates the progression of atherosclerotic plaques regardless of alterations in serum lipid expression levels in HFD‑fed ApoE‑/‑ mice". Molecular Medicine Reports 18.1 (2018): 1025-1030.
Chicago
Han, J., Du, Y., Wang, L., Chen, X., Jiang, L., Xu, J."Acid fibroblast growth factor facilitates the progression of atherosclerotic plaques regardless of alterations in serum lipid expression levels in HFD‑fed ApoE‑/‑ mice". Molecular Medicine Reports 18, no. 1 (2018): 1025-1030. https://doi.org/10.3892/mmr.2018.9060
Copy and paste a formatted citation
x
Spandidos Publications style
Han J, Du Y, Wang L, Chen X, Jiang L and Xu J: Acid fibroblast growth factor facilitates the progression of atherosclerotic plaques regardless of alterations in serum lipid expression levels in HFD‑fed ApoE‑/‑ mice. Mol Med Rep 18: 1025-1030, 2018.
APA
Han, J., Du, Y., Wang, L., Chen, X., Jiang, L., & Xu, J. (2018). Acid fibroblast growth factor facilitates the progression of atherosclerotic plaques regardless of alterations in serum lipid expression levels in HFD‑fed ApoE‑/‑ mice. Molecular Medicine Reports, 18, 1025-1030. https://doi.org/10.3892/mmr.2018.9060
MLA
Han, J., Du, Y., Wang, L., Chen, X., Jiang, L., Xu, J."Acid fibroblast growth factor facilitates the progression of atherosclerotic plaques regardless of alterations in serum lipid expression levels in HFD‑fed ApoE‑/‑ mice". Molecular Medicine Reports 18.1 (2018): 1025-1030.
Chicago
Han, J., Du, Y., Wang, L., Chen, X., Jiang, L., Xu, J."Acid fibroblast growth factor facilitates the progression of atherosclerotic plaques regardless of alterations in serum lipid expression levels in HFD‑fed ApoE‑/‑ mice". Molecular Medicine Reports 18, no. 1 (2018): 1025-1030. https://doi.org/10.3892/mmr.2018.9060
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