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Article Open Access

Downregulation of CUEDC2 prevents doxorubicin‑induced cardiotoxicity in H9c2 cells

  • Authors:
    • Xianpu Zhang
    • Jiaojiao Li
    • Yongbo Cheng
    • Jianguang Yi
    • Xin Liu
    • Wei Cheng
  • View Affiliations / Copyright

    Affiliations: Department of Cardio‑Thoracic Surgery, Southwest Hospital, The First Affiliated Hospital of Third Military Medical University (Army Medical University), Chongqing 400038, P.R. China
    Copyright: © Zhang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 855-863
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    Published online on: May 23, 2018
       https://doi.org/10.3892/mmr.2018.9072
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Abstract

Treatment with doxorubicin (DOX), which is an effective anticancer agent, is limited by cardiotoxicity. CUE domain‑containing 2 (CUEDC2) serves a role in numerous cellular processes. The present study aimed to elucidate the potential function of CUEDC2 in DOX‑induced cardiotoxicity. Cell Counting kit‑8 assay demonstrated that DOX induced cytotoxicity of H9c2 cells in a dose‑dependent manner. Flow cytometry demonstrated that downregulation of CUEDC2 reduced the levels of DOX‑induced reactive oxygen species. Furthermore, compared with in the DOX‑treated group, the activity of superoxide dismutase was increased in the DOX + small interfering RNA (si)CUEDC2 group; whereas, the malondialdehyde content was reduced in the DOX + siCUEDC2 group. In addition, flow cytometric analysis indicated that mitochondrial membrane potential was maintained following the depletion of CUEDC2. Furthermore, CUEDC2 downregulation significantly inhibited DOX‑induced apoptosis. The expression levels of proapoptotic genes, including B‑cell lymphoma 2 (Bcl‑2)‑associated X protein, cleaved caspase‑3 and cytochrome c were inhibited by the depletion of CUEDC2. Conversely, the expression levels of the anti‑apoptotic gene Bcl‑2 were elevated in the CUEDC2 knockdown group. Downregulation of CUEDC2 also increased phosphorylation of protein kinase B and forkhead box O3a, and decreased the expression of Bcl‑2‑like protein 11 according to western blot analysis. Taken together, the present study demonstrated that CUEDC2 downregulation prevented DOX‑induced cardiotoxicity in H9c2 cells. Therefore, CUEDC2 may be a promising target for the prevention of DOX‑induced cardiotoxicity.
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1 

Capranico G, Kohn KW and Pommier Y: Local sequence requirements for DNA cleavage by mammalian topoisomerase II in the presence of doxorubicin. Nucleic Acids Res. 18:6611–6619. 1990. View Article : Google Scholar : PubMed/NCBI

2 

Young RC, Ozols RF and Myers CE: The anthracycline neoplastic drugs. N Engl J Med. 305:139–153. 1981. View Article : Google Scholar : PubMed/NCBI

3 

Thorn CF, Oshiro C, Marsh S, Hernandez-Boussard T, McLeod H, Klein TE and Altman RB: Doxorubicin pathways: Pharmacodynamics and adverse effects. Pharmacogenet Genomics. 21:440–446. 2011. View Article : Google Scholar : PubMed/NCBI

4 

Orhan B: Doxorubicin cardiotoxicity: Growing importance. J Clin Oncol. 17:2294–2296. 1999. View Article : Google Scholar : PubMed/NCBI

5 

Samuel L: Doxorubicin-induced cardiotoxicity. Postgrad Med J. 71:3181995. View Article : Google Scholar : PubMed/NCBI

6 

Pereira GC, Pereira SP, Pereira CV, Lumini JA, Magalhães J, Ascensão A, Santos MS, Bjork JA, Moreno AJ, Wallace KB, et al: Doxorubicin-induced cardiac, hepatic and renal mitochondrial toxicity in an acute versus sub-chronic treatment model. Biochim Biophys Acta. 1797 Supple:S812010. View Article : Google Scholar

7 

Skladanowski A and Konopa J: Adriamycin and daunomycin induce programmed cell death (apoptosis) in tumour cells. Biochem Pharmacol. 46:375–382. 1993. View Article : Google Scholar : PubMed/NCBI

8 

Carter ME and Brunet A: FOXO transcription factors. Curr Biol. 17:R113–R114. 2007. View Article : Google Scholar : PubMed/NCBI

9 

Li M, Chiu JF, Mossman BT and Fukagawa NK: Down-regulation of manganese-superoxide dismutase through phosphorylation of FOXO3a by Akt in explanted vascular smooth muscle cells from old rats. J Biol Chem. 281:40429–40439. 2006. View Article : Google Scholar : PubMed/NCBI

10 

Yang Y, Zhao Y, Liao W, Yang J, Wu L, Zheng Z, Yu Y, Zhou W, Li L, Feng J, et al: Acetylation of FoxO1 activates Bim expression to induce apoptosis in response to histone deacetylase inhibitor depsipeptide treatment. Neoplasia. 11:313–324. 2009. View Article : Google Scholar : PubMed/NCBI

11 

Lin CH, Lin CC, Ting WJ, Pai PY, Kuo CH, Ho TJ, Kuo WW, Chang CH, Huang CY and Lin WT: Resveratrol enhanced FOXO3 phosphorylation via synergetic activation of SIRT1 and PI3K/Akt signaling to improve the effects of exercise in elderly rat hearts. Age (Dordr). 36:97052014. View Article : Google Scholar : PubMed/NCBI

12 

Sharma G, Kar S, Palit S and Das PK: 18β-glycyrrhetinic acid induces apoptosis through modulation of Akt/FOXO3a/Bim pathway in human breast cancer MCF-7 cells. J Cell Physiol. 227:1923–1931. 2012. View Article : Google Scholar : PubMed/NCBI

13 

Zhang PJ, Zhao J, Li HY, Man JH, He K, Zhou T, Pan X, Li AL, Gong WL, Jin BF, et al: CUE domain containing 2 regulates degradation of progesterone receptor by ubiquitin-proteasome. Embo J. 26:1831–1842. 2007. View Article : Google Scholar : PubMed/NCBI

14 

Man J and Zhang X: CUEDC2: An emerging key player in inflammation and tumorigenesis. Protein Cell. 2:699–703. 2011. View Article : Google Scholar : PubMed/NCBI

15 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

16 

Kotamraju S, Konorev EA, Joseph J and Kalyanaraman B: Doxorubicin-induced apoptosis in endothelial cells and cardiomyocytes is ameliorated by nitrone spin traps and ebselen. Role of reactive oxygen and nitrogen species. J Biol Chem. 275:33585–33592. 2000. View Article : Google Scholar : PubMed/NCBI

17 

Jian Z, Liang B, Pan X, Xu G, Guo SS, Li T, Zhou T, Xiao YB and Li AL: CUEDC2 modulates cardiomyocyte oxidative capacity by regulating GPX1 stability. EMBO Mol Med. 8:813–829. 2016. View Article : Google Scholar : PubMed/NCBI

18 

Morakinyo A, Iranloye B and Adegoke O: Calcium antagonists modulate oxidative stress and acrosomal reaction in rat spermatozoa. Arch Med Sci. 7:613–618. 2011. View Article : Google Scholar : PubMed/NCBI

19 

Kalivendi SV, Konorev EA, Cunningham S, Vanamala SK, Kaji EH, Joseph J and Kalyanaraman B: Doxorubicin activates nuclear factor of activated T-lymphocytes and Fas ligand transcription: Role of mitochondrial reactive oxygen species and calcium. Biochem J. 389:527–539. 2005. View Article : Google Scholar : PubMed/NCBI

20 

Konorev EA, Kennedy MC and Kalyanaraman B: Cell-permeable superoxide dismutase and glutathione peroxidase mimetics afford superior protection against doxorubicin-induced cardiotoxicity: The role of reactive oxygen and nitrogen intermediates. Arch Biochem Biophys. 368:421–428. 1999. View Article : Google Scholar : PubMed/NCBI

21 

Gomez-Cabrera MC, Sanchis-Gomar F, Garcia-Valles R, Pareja-Galeano H, Gambini J, Borras C and Vina J: Mitochondria as sources and targets of damage in cellular aging. Clin Chem Lab Med. 50:1287–1295. 2012. View Article : Google Scholar : PubMed/NCBI

22 

Takasaki A, Hanyu H, Iwamoto T, Shirato K, Izumi R, Toyota H, Mizuguchi J, Miyazawa K and Tomoda A: Mitochondrial depolarization and apoptosis associated with sustained activation of c-jun-N-terminal kinasein the human multiple myeloma cell line U266 induced by 2-aminophenoxazine-3-one. Mol Med Rep. 2:199–203. 2009.PubMed/NCBI

23 

Luo H, Yang Y, Duan J, Wu P, Jiang Q and Xu C: PTEN-regulated AKT/FoxO3a/Bim signaling contributes to reactive oxygen species-mediated apoptosis in selenite-treated colorectal cancer cells. Cell Death Dis. 4:e4812013. View Article : Google Scholar : PubMed/NCBI

24 

Xiong H, Wang J, Guan H, Wu J, Xu R, Wang M, Rong X, Huang K, Huang J, Liao Q, et al: SphK1 confers resistance to apoptosis in gastric cancer cells by downregulating Bim via stimulating Akt/FoxO3a signaling. Oncol Rep. 32:1369–1373. 2014. View Article : Google Scholar : PubMed/NCBI

25 

Arola OJ, Saraste A, Pulkki K, Kallajoki M, Parvinen M and Voipio-Pulkki LM: Acute doxorubicin cardiotoxicity involves cardiomyocyte apoptosis. Cancer Res. 60:1789–1792. 2000.PubMed/NCBI

26 

Kimes BW and Brandt BL: Properties of a clonal muscle cell line from rat heart. Exp Cell Res. 98:367–381. 1976. View Article : Google Scholar : PubMed/NCBI

27 

Hescheler J, Meyer R, Plant S, Krautwurst D, Rosenthal W and Schultz G: Morphological, biochemical, and electrophysiological characterization of a clonal cell (H9c2) line from rat heart. Circ Res. 69:1476–1486. 1991. View Article : Google Scholar : PubMed/NCBI

28 

Sipido KR and Marban E: L-type calcium channels, potassium channels, and novel nonspecific cation channels in a clonal muscle cell line derived from embryonic rat ventricle. Circ Res. 69:1487–1499. 1991. View Article : Google Scholar : PubMed/NCBI

29 

Watkins SJ, Borthwick GM and Arthur HM: The H9C2 cell line and primary neonatal cardiomyocyte cells show similar hypertrophic responses in vitro. In vitro Cell Dev Biol Anim. 47:125–131. 2011. View Article : Google Scholar : PubMed/NCBI

30 

Arstall MA, Sawyer DB, Fukazawa R and Kelly RA: Cytokine-mediated apoptosis in cardiac myocytes: The role of inducible nitric oxide synthase induction and peroxynitrite generation. Circ Res. 85:829–840. 1999. View Article : Google Scholar : PubMed/NCBI

31 

Ly JD, Grubb DR and Lawen A: The mitochondrial membrane potential (deltapsi(m)) in apoptosis; an update. Apoptosis. 8:115–128. 2003. View Article : Google Scholar : PubMed/NCBI

32 

Sharifi AM, Mousavi SH and Jorjani M: Effect of chronic lead exposure on pro-apoptotic Bax and anti-apoptotic Bcl-2 protein expression in rat hippocampus in vivo. Cell Mol Neurobiol. 30:769–774. 2010. View Article : Google Scholar : PubMed/NCBI

33 

Zhai D, Jin C, Huang Z, Satterthwait AC and Reed JC: Differential regulation of Bax and Bak by anti-apoptotic Bcl-2 family proteins Bcl-B and Mcl-1. J Biol Chem. 283:9580–9586. 2008. View Article : Google Scholar : PubMed/NCBI

34 

Salvesen GS: Caspases: Opening the boxes and interpreting the arrows. Cell Death Differ. 9:3–5. 2002. View Article : Google Scholar : PubMed/NCBI

35 

Ghavami S, Hashemi M, Ande SR, Yeganeh B, Xiao W, Eshraghi M, Bus CJ, Kadkhoda K, Wiechec E, Halayko AJ and Los M: Apoptosis and cancer: Mutations within caspase genes. J Med Genet. 46:497–510. 2009. View Article : Google Scholar : PubMed/NCBI

36 

Yang J, Liu X, Bhalla K, Kim CN, Ibrado AM, Cai J, Peng TI, Jones DP and Wang X: Prevention of apoptosis by Bcl-2: Release of cytochrome c from mitochondria blocked. Science. 275:1129–1132. 1997. View Article : Google Scholar : PubMed/NCBI

37 

Lam EW, Francis RE and Petkovic M: FOXO transcription factors: Key regulators of cell fate. Biochem Soc Trans. 34:722–726. 2006. View Article : Google Scholar : PubMed/NCBI

38 

Sunters A, de Mattos Fernández S, Stahl M, Brosens JJ, Zoumpoulidou G, Saunders CA, Coffer PJ, Medema RH, Coombes RC and Lam EW: FoxO3a transcriptional regulation of Bim controls apoptosis in paclitaxel-treated breast cancer cell lines. J Biol Chem. 278:49795–49805. 2003. View Article : Google Scholar : PubMed/NCBI

39 

Sunters A, Madureira PA, Pomeranz KM, Aubert M, Brosens JJ, Cook SJ, Burgering BM, Coombes RC and Lam EW: Paclitaxel-induced nuclear translocation of FOXO3a in breast cancer cells is mediated by c-Jun NH2-terminal kinase and Akt. Cancer Res. 66:212–220. 2006. View Article : Google Scholar : PubMed/NCBI

40 

Concannon CG, Tuffy LP, Weisová P, Bonner HP, Davila D, Bonner C, Devocelle MC, Strasser A, Ward MW and Prehn JH: AMP kinase-mediated activation of the BH3-only protein Bim couples energy depletion to stress-induced apoptosis. J Cell Biol. 189:83–94. 2010. View Article : Google Scholar : PubMed/NCBI

41 

Samuel SM, Thirunavukkarasu M, Penumathsa SV, Paul D and Maulik N: Akt/FOXO3a/SIRT1-mediated cardioprotection by n-tyrosol against ischemic stress in rat in vivo model of myocardial infarction: Switching gears toward survival and longevity. J Agric Food Chem. 56:9692–9698. 2008. View Article : Google Scholar : PubMed/NCBI

42 

Wang A, Guo C, Sun Y, Lu L, Wang Y, Wang Q, Zhang Y, Zhang H, Wang L, Gu Y, et al: Overexpression of CUEDC2 predicts poor prognosis in ovarian serous carcinomas. J Cancer. 6:542–547. 2015. View Article : Google Scholar : PubMed/NCBI

43 

Sun L, Bai L, Lin G, Wang R, Liu Y, Cai J, Guo Y, Zhu Z and Xie C: CUEDC2 down-regulation is associated with tumor growth and poor prognosis in lung adenocarcinoma. Oncotarget. 6:20685–20696. 2015. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Zhang X, Li J, Cheng Y, Yi J, Liu X and Cheng W: Downregulation of CUEDC2 prevents doxorubicin‑induced cardiotoxicity in H9c2 cells. Mol Med Rep 18: 855-863, 2018.
APA
Zhang, X., Li, J., Cheng, Y., Yi, J., Liu, X., & Cheng, W. (2018). Downregulation of CUEDC2 prevents doxorubicin‑induced cardiotoxicity in H9c2 cells. Molecular Medicine Reports, 18, 855-863. https://doi.org/10.3892/mmr.2018.9072
MLA
Zhang, X., Li, J., Cheng, Y., Yi, J., Liu, X., Cheng, W."Downregulation of CUEDC2 prevents doxorubicin‑induced cardiotoxicity in H9c2 cells". Molecular Medicine Reports 18.1 (2018): 855-863.
Chicago
Zhang, X., Li, J., Cheng, Y., Yi, J., Liu, X., Cheng, W."Downregulation of CUEDC2 prevents doxorubicin‑induced cardiotoxicity in H9c2 cells". Molecular Medicine Reports 18, no. 1 (2018): 855-863. https://doi.org/10.3892/mmr.2018.9072
Copy and paste a formatted citation
x
Spandidos Publications style
Zhang X, Li J, Cheng Y, Yi J, Liu X and Cheng W: Downregulation of CUEDC2 prevents doxorubicin‑induced cardiotoxicity in H9c2 cells. Mol Med Rep 18: 855-863, 2018.
APA
Zhang, X., Li, J., Cheng, Y., Yi, J., Liu, X., & Cheng, W. (2018). Downregulation of CUEDC2 prevents doxorubicin‑induced cardiotoxicity in H9c2 cells. Molecular Medicine Reports, 18, 855-863. https://doi.org/10.3892/mmr.2018.9072
MLA
Zhang, X., Li, J., Cheng, Y., Yi, J., Liu, X., Cheng, W."Downregulation of CUEDC2 prevents doxorubicin‑induced cardiotoxicity in H9c2 cells". Molecular Medicine Reports 18.1 (2018): 855-863.
Chicago
Zhang, X., Li, J., Cheng, Y., Yi, J., Liu, X., Cheng, W."Downregulation of CUEDC2 prevents doxorubicin‑induced cardiotoxicity in H9c2 cells". Molecular Medicine Reports 18, no. 1 (2018): 855-863. https://doi.org/10.3892/mmr.2018.9072
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