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Article

TROP2 promotes cell proliferation and migration in osteosarcoma through PI3K/AKT signaling

  • Authors:
    • Qing‑Zhi Gu
    • Abulimiti Nijiati
    • Xing Gao
    • Kai‑Liang Tao
    • Cheng‑Duo Li
    • Xue‑Peng Fan
    • Zheng Tian
  • View Affiliations / Copyright

    Affiliations: Department of Bone Tumor, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang 830054, P.R. China
  • Pages: 1782-1788
    |
    Published online on: May 29, 2018
       https://doi.org/10.3892/mmr.2018.9083
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Abstract

Human trophoblast cell surface antigen 2 (TROP2) has been noted to serve an important role in the proliferation and migration of various types of human cancers. However, the potential role and the molecular mechanisms of TROP2 in osteosarcoma (OS) remain largely unclear. In the present study, high expression of TROP2 in human OS tissues and cell lines was observed. Overexpression of TROP2 promoted the proliferation and migration of OS cell lines, while TROP2 knockdown markedly decreased cell growth and migration. Furthermore, it was revealed that TROP2 overexpression significantly activated the phosphoinositide 3‑kinase/protein kinase B (PI3K/AKT) signaling pathway. Collectively, these results suggested that TROP2 may promote OS cell proliferation and migration via PI3K/AKT signaling and may serve as a novel treatment target for OS.
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1 

Zambo I and Vesely K: WHO classification of tumours of soft tissue and bone 2013: The main changes compared to the 3rd edition. Cesk Patol. 50:64–70. 2014.(In Czech). PubMed/NCBI

2 

Hu K, Wang Z, Lin P, Wen Z, Ren H, Sun L, Li H, Li B, Wang S, Zhou X, et al: Three hematological indexes that may serve as prognostic indicators in patients with primary, high-grade, appendicular osteosarcoma. Oncotarget. 8:43130–43139. 2017.PubMed/NCBI

3 

Li GL, Wu YX, Li YM and Li J: High expression of long non-coding RNA XIST in osteosarcoma is associated with cell proliferation and poor prognosis. Eur Rev Med Pharmacol Sci. 21:2829–2834. 2017.PubMed/NCBI

4 

Wu Y, Wu J, Dong QR and Guo NZ: Association between expression of nuclear receptor co-activator 5 protein and prognosis in postoperative patients with osteosarcoma. Oncol Lett. 15:1888–1892. 2018.PubMed/NCBI

5 

Tao Y, Xin M, Cheng H, Huang Z, Hu T, Zhang T and Wang J: TRIM37 promotes tumor cell proliferation and drug resistance in pediatric osteosarcoma. Oncol Lett. 14:6365–6372. 2017.PubMed/NCBI

6 

Lu J, Song G, Tang Q, Yin J, Zou C, Zhao Z, Xie X, Xu H, Huang G, Wang J, et al: MiR-26a inhibits stem cell-like phenotype and tumor growth of osteosarcoma by targeting Jagged1. Oncogene. 36:231–241. 2017. View Article : Google Scholar : PubMed/NCBI

7 

Liu X, Zhou X, Xu H, He Z, Shi X and Wu S: SLC34A2 regulates the proliferation, migration, and invasion of human osteosarcoma cells through PTEN/PI3K/AKT signaling. DNA Cell Biol. 36:775–780. 2017.PubMed/NCBI

8 

Cao J, Han X, Qi X, Jin X and Li X: TUG1 promotes osteosarcoma tumorigenesis by upregulating EZH2 expression via miR-144-3p. Int J Oncol. 51:1115–1123. 2017. View Article : Google Scholar : PubMed/NCBI

9 

Zhao YX, Wang YS, Cai QQ, Wang JQ and Yao WT: Up-regulation of HDAC9 promotes cell proliferation through suppressing p53 transcription in osteosarcoma. Int J Clin Exp Med. 8:11818–11823. 2015.PubMed/NCBI

10 

Kong JS, Kim HJ, Kim MJ, Kim A, Lee D, Han K, Park S, Koh JS and Myung JK: The significance of TROP2 expression in predicting braf mutations in papillary thyroid carcinoma. J Pathol Transl Med. 52:14–20. 2018. View Article : Google Scholar : PubMed/NCBI

11 

Zhao W, Zhu H, Zhang S, Yong H, Wang W, Zhou Y, Wang B, Wen J, Qiu Z, Ding G, et al: Trop2 is overexpressed in gastric cancer and predicts poor prognosis. Oncotarget. 7:6136–6145. 2016.PubMed/NCBI

12 

Shvartsur A and Bonavida B: Trop2 and its overexpression in cancers: Regulation and clinical/therapeutic implications. Genes Cancer. 6:84–105. 2015.PubMed/NCBI

13 

Lin H, Zhang H, Wang J, Lu M, Zheng F, Wang C, Tang X, Xu N, Chen R, Zhang D, et al: A novel human Fab antibody for Trop2 inhibits breast cancer growth in vitro and in vivo. Int J Cancer. 134:1239–1249. 2014. View Article : Google Scholar : PubMed/NCBI

14 

Mao Y, Wang X, Zheng F, Wang C, Tang Q, Tang X, Xu N, Zhang H, Zhang D, Xiong L, et al: The tumor-inhibitory effectiveness of a novel anti-Trop2 Fab conjugate in pancreatic cancer. Oncotarget. 7:24810–24823. 2016. View Article : Google Scholar : PubMed/NCBI

15 

Fong D, Moser P, Krammel C, Gostner JM, Margreiter R, Mitterer M, Gastl G and Spizzo G: High expression of TROP2 correlates with poor prognosis in pancreatic cancer. Br J Cancer. 99:1290–1295. 2008. View Article : Google Scholar : PubMed/NCBI

16 

Mühlmann G, Spizzo G, Gostner J, Zitt M, Maier H, Moser P, Gastl G, Zitt M, Müller HM, Margreiter R, et al: TROP2 expression as prognostic marker for gastric carcinoma. J Clin Pathol. 62:152–158. 2009. View Article : Google Scholar : PubMed/NCBI

17 

Inamura K, Yokouchi Y, Kobayashi M, Ninomiya H, Sakakibara R, Subat S, Nagano H, Nomura K, Okumura S, Shibutani T and Ishikawa Y: Association of tumor TROP2 expression with prognosis varies among lung cancer subtypes. Oncotarget. 8:28725–28735. 2017. View Article : Google Scholar : PubMed/NCBI

18 

Pak MG, Shin DH, Lee CH and Lee MK: Significance of EpCAM and TROP2 expression in non-small cell lung cancer. World J Surg Oncol. 10:532012. View Article : Google Scholar : PubMed/NCBI

19 

Wu B, Yu C, Zhou B, Huang T, Gao L, Liu T and Yang X: Overexpression of TROP2 promotes proliferation and invasion of ovarian cancer cells. Exp Ther Med. 14:1947–1952. 2017. View Article : Google Scholar : PubMed/NCBI

20 

Ohmachi T, Tanaka F, Mimori K, Inoue H, Yanaga K and Mori M: Clinical significance of TROP2 expression in colorectal cancer. Clin Cancer Res. 12:3057–3063. 2006. View Article : Google Scholar : PubMed/NCBI

21 

Sukhthankar M, Alberti S and Baek SJ: (−)-Epigallocatechin-3-gallate (EGCG) post-transcriptionally and post-translationally suppresses the cell proliferative protein TROP2 in human colorectal cancer cells. Anticancer Res. 30:2497–2503. 2010.PubMed/NCBI

22 

Cubas R, Zhang S, Li M, Chen C and Yao Q: Trop2 expression contributes to tumor pathogenesis by activating the ERK MAPK pathway. Mol Cancer. 9:2532010. View Article : Google Scholar : PubMed/NCBI

23 

Fang YJ, Lu ZH, Wang GQ, Pan ZZ, Zhou ZW, Yun JP, Zhang MF and Wan DS: Elevated expressions of MMP7, TROP2, and survivin are associated with survival, disease recurrence, and liver metastasis of colon cancer. Int J Colorectal Dis. 24:875–884. 2009. View Article : Google Scholar : PubMed/NCBI

24 

Guan H, Guo Z, Liang W, Li H, Wei G, Xu L, Xiao H and Li Y: Trop2 enhances invasion of thyroid cancer by inducing MMP2 through ERK and JNK pathways. BMC Cancer. 17:4862017. View Article : Google Scholar : PubMed/NCBI

25 

Chiang SF, Kan CY, Hsiao YC, Tang R, Hsieh LL, Chiang JM, Tsai WS, Yeh CY, Hsieh PS, Liang Y, et al: Bone marrow stromal antigen 2 is a novel plasma biomarker and prognosticator for colorectal carcinoma: A secretome-based verification study. Dis Markers. 2015:8740542015. View Article : Google Scholar : PubMed/NCBI

26 

Yang J, Zhu Z, Wang H, Li F, Du X and Ma RZ: Trop2 regulates the proliferation and differentiation of murine compact-bone derived MSCs. Int J Oncol. 43:859–867. 2013. View Article : Google Scholar : PubMed/NCBI

27 

Eisenwort G, Jurkin J, Yasmin N, Bauer T, Gesslbauer B and Strobl H: Identification of TROP2 (TACSTD2), an EpCAM-like molecule, as a specific marker for TGF-β1-dependent human epidermal Langerhans cells. J Invest Dermatol. 131:2049–2057. 2011. View Article : Google Scholar : PubMed/NCBI

28 

Wen ZQ, Li XG, Zhang YJ, Ling ZH and Lin XJ: Osteosarcoma cell-intrinsic colony stimulating factor-1 receptor functions to promote tumor cell metastasis through JAG1 signaling. Am J Cancer Res. 7:801–815. 2017.PubMed/NCBI

29 

Gong C, Liao H, Wang J, Lin Y, Qi J, Qin L, Tian LQ and Guo FJ: LY294002 induces G0/G1 cell cycle arrest and apoptosis of cancer stem-like cells from human osteosarcoma via down-regulation of PI3K activity. Asian Pac J Cancer Prev. 13:3103–3107. 2012. View Article : Google Scholar : PubMed/NCBI

30 

Han G, Wang Y and Bi W: C-Myc overexpression promotes osteosarcoma cell invasion via activation of MEK-ERK pathway. Oncol Res. 20:149–156. 2012. View Article : Google Scholar : PubMed/NCBI

31 

Liu Y, Cheng Z, Pan F and Yan W: MicroRNA-373 promotes growth and cellular invasion in osteosarcoma cells by activation of the PI3K/AKT-Rac1-JNK pathway: The potential role in spinal osteosarcoma. Oncol Res. 25:989–999. 2017. View Article : Google Scholar : PubMed/NCBI

32 

Son S, Shin S, Rao NV, Um W, Jeon J, Ko H, Deepagan VG, Kwon S, Lee JY and Park JH: Anti-Trop2 antibody-conjugated bioreducible nanoparticles for targeted triple negative breast cancer therapy. Int J Biol Macromol. 110:406–415. 2018. View Article : Google Scholar : PubMed/NCBI

33 

Chen MB, Wu HF, Zhan Y, Fu XL, Wang AK, Wang LS and Lei HM: Prognostic value of TROP2 expression in patients with gallbladder cancer. Tumour Biol. 35:11565–11569. 2014. View Article : Google Scholar : PubMed/NCBI

34 

Guan GF, Zhang DJ, Wen LJ, Yu DJ, Zhao Y, Zhu L, Guo YY and Zheng Y: Prognostic value of TROP2 in human nasopharyngeal carcinoma. Int J Clin Exp Pathol. 8:10995–11004. 2015.PubMed/NCBI

35 

Liu X, Li S and Yi F: Trop2 gene: A novel target for cervical cancer treatment. J Cancer Res Clin Oncol. 140:1331–1341. 2014. View Article : Google Scholar : PubMed/NCBI

36 

Ma J, Huang H, Han Z, Zhu C and Yue B: RLN2 Is a positive regulator of AKT-2-induced gene expression required for osteosarcoma cells invasion and chemoresistance. Biomed Res Int. 2015:1474682015. View Article : Google Scholar : PubMed/NCBI

37 

Wang H, Luo QF, Peng AF, Long XH, Wang TF, Liu ZL, Zhang GM, Zhou RP, Gao S, Zhou Y and Chen WZ: Positive feedback regulation between Akt phosphorylation and fatty acid synthase expression in osteosarcoma. Int J Mol Med. 33:633–639. 2014. View Article : Google Scholar : PubMed/NCBI

38 

Graziano AC, Cardile V, Avola R, Vicario N, Parenti C, Salvatorelli L, Magro G and Parenti R: Wilms' tumor gene 1 silencing inhibits proliferation of human osteosarcoma MG-63 cell line by cell cycle arrest and apoptosis activation. Oncotarget. 8:13917–13931. 2017. View Article : Google Scholar : PubMed/NCBI

39 

Huang S and Jin A: ZIC2 promotes viability and invasion of human osteosarcoma cells by suppressing SHIP2 expression and activating PI3K/AKT pathways. J Cell Biochem. 119:2248–2257. 2018. View Article : Google Scholar : PubMed/NCBI

40 

Li X, Teng S, Zhang Y, Zhang W, Zhang X, Xu K, Yao H, Yao J, Wang H, Liang X and Hu Z: TROP2 promotes proliferation, migration and metastasis of gallbladder cancer cells by regulating PI3K/AKT pathway and inducing EMT. Oncotarget. 8:47052–47063. 2017.PubMed/NCBI

41 

Lin JC, Wu YY, Wu JY, Lin TC, Wu CT, Chang YL, Jou YS, Hong TM and Yang PC: TROP2 is epigenetically inactivated and modulates IGF-1R signalling in lung adenocarcinoma. EMBO Mol Med. 4:472–485. 2012. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Gu QZ, Nijiati A, Gao X, Tao KL, Li CD, Fan XP and Tian Z: TROP2 promotes cell proliferation and migration in osteosarcoma through PI3K/AKT signaling. Mol Med Rep 18: 1782-1788, 2018.
APA
Gu, Q., Nijiati, A., Gao, X., Tao, K., Li, C., Fan, X., & Tian, Z. (2018). TROP2 promotes cell proliferation and migration in osteosarcoma through PI3K/AKT signaling. Molecular Medicine Reports, 18, 1782-1788. https://doi.org/10.3892/mmr.2018.9083
MLA
Gu, Q., Nijiati, A., Gao, X., Tao, K., Li, C., Fan, X., Tian, Z."TROP2 promotes cell proliferation and migration in osteosarcoma through PI3K/AKT signaling". Molecular Medicine Reports 18.2 (2018): 1782-1788.
Chicago
Gu, Q., Nijiati, A., Gao, X., Tao, K., Li, C., Fan, X., Tian, Z."TROP2 promotes cell proliferation and migration in osteosarcoma through PI3K/AKT signaling". Molecular Medicine Reports 18, no. 2 (2018): 1782-1788. https://doi.org/10.3892/mmr.2018.9083
Copy and paste a formatted citation
x
Spandidos Publications style
Gu QZ, Nijiati A, Gao X, Tao KL, Li CD, Fan XP and Tian Z: TROP2 promotes cell proliferation and migration in osteosarcoma through PI3K/AKT signaling. Mol Med Rep 18: 1782-1788, 2018.
APA
Gu, Q., Nijiati, A., Gao, X., Tao, K., Li, C., Fan, X., & Tian, Z. (2018). TROP2 promotes cell proliferation and migration in osteosarcoma through PI3K/AKT signaling. Molecular Medicine Reports, 18, 1782-1788. https://doi.org/10.3892/mmr.2018.9083
MLA
Gu, Q., Nijiati, A., Gao, X., Tao, K., Li, C., Fan, X., Tian, Z."TROP2 promotes cell proliferation and migration in osteosarcoma through PI3K/AKT signaling". Molecular Medicine Reports 18.2 (2018): 1782-1788.
Chicago
Gu, Q., Nijiati, A., Gao, X., Tao, K., Li, C., Fan, X., Tian, Z."TROP2 promotes cell proliferation and migration in osteosarcoma through PI3K/AKT signaling". Molecular Medicine Reports 18, no. 2 (2018): 1782-1788. https://doi.org/10.3892/mmr.2018.9083
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