TROP2 promotes cell proliferation and migration in osteosarcoma through PI3K/AKT signaling

  • Authors:
    • Qing‑Zhi Gu
    • Abulimiti Nijiati
    • Xing Gao
    • Kai‑Liang Tao
    • Cheng‑Duo Li
    • Xue‑Peng Fan
    • Zheng Tian
  • View Affiliations

  • Published online on: May 29, 2018     https://doi.org/10.3892/mmr.2018.9083
  • Pages: 1782-1788
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Abstract

Human trophoblast cell surface antigen 2 (TROP2) has been noted to serve an important role in the proliferation and migration of various types of human cancers. However, the potential role and the molecular mechanisms of TROP2 in osteosarcoma (OS) remain largely unclear. In the present study, high expression of TROP2 in human OS tissues and cell lines was observed. Overexpression of TROP2 promoted the proliferation and migration of OS cell lines, while TROP2 knockdown markedly decreased cell growth and migration. Furthermore, it was revealed that TROP2 overexpression significantly activated the phosphoinositide 3‑kinase/protein kinase B (PI3K/AKT) signaling pathway. Collectively, these results suggested that TROP2 may promote OS cell proliferation and migration via PI3K/AKT signaling and may serve as a novel treatment target for OS.
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August-2018
Volume 18 Issue 2

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Spandidos Publications style
Gu QZ, Nijiati A, Gao X, Tao KL, Li CD, Fan XP and Tian Z: TROP2 promotes cell proliferation and migration in osteosarcoma through PI3K/AKT signaling. Mol Med Rep 18: 1782-1788, 2018
APA
Gu, Q., Nijiati, A., Gao, X., Tao, K., Li, C., Fan, X., & Tian, Z. (2018). TROP2 promotes cell proliferation and migration in osteosarcoma through PI3K/AKT signaling. Molecular Medicine Reports, 18, 1782-1788. https://doi.org/10.3892/mmr.2018.9083
MLA
Gu, Q., Nijiati, A., Gao, X., Tao, K., Li, C., Fan, X., Tian, Z."TROP2 promotes cell proliferation and migration in osteosarcoma through PI3K/AKT signaling". Molecular Medicine Reports 18.2 (2018): 1782-1788.
Chicago
Gu, Q., Nijiati, A., Gao, X., Tao, K., Li, C., Fan, X., Tian, Z."TROP2 promotes cell proliferation and migration in osteosarcoma through PI3K/AKT signaling". Molecular Medicine Reports 18, no. 2 (2018): 1782-1788. https://doi.org/10.3892/mmr.2018.9083