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Long non‑coding RNA SENCR alleviates the inhibitory effects of rapamycin on human umbilical vein endothelial cells

  • Authors:
    • Hongtao Sun
    • Shuiyun Wang
    • Min Song
  • View Affiliations / Copyright

    Affiliations: Department of Cardiac Surgery, Cardiovascular Institute and Fu Wai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100037, P.R. China
    Copyright: © Sun et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 1405-1414
    |
    Published online on: May 29, 2018
       https://doi.org/10.3892/mmr.2018.9094
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Abstract

Rapamycin (RPM) is frequently used as the drug coating in drug‑eluting stents (DESs) as it can inhibit the growth of smooth muscle cells. However, RPM also inhibits the proliferation and migration of vascular endothelial cells, and impairs reendothelialization in DES implantation. Therefore, the development of a strategy to protect vascular endothelial cells after DES implantation is of great importance. Long non‑coding RNAs (lncRNAs) metastasis‑associated lung adenocarcinoma transcript 1 (MALAT1) and smooth muscle and endothelial cell‑enriched migration/differentiation‑associated lncRNA (SENCR) are able to enhance the proliferation, migration and angiogenesis of endothelial cells, which suggests that they may have potential as antagonists of the adverse effects of RPM in DES. However, the relationship between RPM and lncRNAs in endothelial cells during the intervention is not fully understood at present. The current study investigated the role and potential mechanism of the lncRNA SENCR on the activity of human umbilical vein endothelial cells (HUVECs) after RPM treatment. The proliferation, migration, angiogenic capacity and cell cycle progression of lncRNA SENCR‑overexpressing HUVECs following RPM treatment was examined. The proliferation‑related proteins of lncRNA SENCR‑modified HUVECs were evaluated to understand the mechanism of action. LncRNA SENCR significantly alleviated the inhibition of proliferation, migration, angiogenesis and cell cycle progression of HUVECs caused by RPM by activating extracellular signal‑regulated kinase 1/2 and mammalian target of RPM. The lncRNA SENCR could alleviate the inhibitory effects of RPM on HUVECs and may be useful as a new combinative agent to avoid the disadvantages of RPM in DES implantation.
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Copy and paste a formatted citation
Spandidos Publications style
Sun H, Wang S and Song M: Long non‑coding RNA SENCR alleviates the inhibitory effects of rapamycin on human umbilical vein endothelial cells. Mol Med Rep 18: 1405-1414, 2018.
APA
Sun, H., Wang, S., & Song, M. (2018). Long non‑coding RNA SENCR alleviates the inhibitory effects of rapamycin on human umbilical vein endothelial cells. Molecular Medicine Reports, 18, 1405-1414. https://doi.org/10.3892/mmr.2018.9094
MLA
Sun, H., Wang, S., Song, M."Long non‑coding RNA SENCR alleviates the inhibitory effects of rapamycin on human umbilical vein endothelial cells". Molecular Medicine Reports 18.2 (2018): 1405-1414.
Chicago
Sun, H., Wang, S., Song, M."Long non‑coding RNA SENCR alleviates the inhibitory effects of rapamycin on human umbilical vein endothelial cells". Molecular Medicine Reports 18, no. 2 (2018): 1405-1414. https://doi.org/10.3892/mmr.2018.9094
Copy and paste a formatted citation
x
Spandidos Publications style
Sun H, Wang S and Song M: Long non‑coding RNA SENCR alleviates the inhibitory effects of rapamycin on human umbilical vein endothelial cells. Mol Med Rep 18: 1405-1414, 2018.
APA
Sun, H., Wang, S., & Song, M. (2018). Long non‑coding RNA SENCR alleviates the inhibitory effects of rapamycin on human umbilical vein endothelial cells. Molecular Medicine Reports, 18, 1405-1414. https://doi.org/10.3892/mmr.2018.9094
MLA
Sun, H., Wang, S., Song, M."Long non‑coding RNA SENCR alleviates the inhibitory effects of rapamycin on human umbilical vein endothelial cells". Molecular Medicine Reports 18.2 (2018): 1405-1414.
Chicago
Sun, H., Wang, S., Song, M."Long non‑coding RNA SENCR alleviates the inhibitory effects of rapamycin on human umbilical vein endothelial cells". Molecular Medicine Reports 18, no. 2 (2018): 1405-1414. https://doi.org/10.3892/mmr.2018.9094
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