Open Access

Downregulation of miR‑637 promotes proliferation and metastasis by targeting Smad3 in keloids

Corrigendum in: /10.3892/mmr.2023.13083

  • Authors:
    • Ye Zhang
    • Bingyu Guo
    • Qiang Hui
    • Wei Li
    • Peng Chang
    • Kai Tao
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  • Published online on: May 29, 2018     https://doi.org/10.3892/mmr.2018.9099
  • Pages: 1628-1636
  • Copyright: © Zhang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Keloids are a type of abnormal scar tissue. MicroRNAs (miRNAs) exhibit a pivotal role in the regulation of cell proliferation and metastasis of keloids. miRNA microarray revealed that miR‑637 was one of the most frequently altered miRNAs in keloids. Furthermore, up­regulation of miR‑637 inhibited cell proliferation and metastasis by targeting mothers against decapentaplegic homolog (Smad)3, one of the important proteins that affects the formation of keloids. Further studies demonstrated that miR‑637 regulated the proliferation and metastasis of human keloid fibroblast (HKF) cells by mediating the Smad3 signaling pathway. Overall, the present findings suggest that miR‑637 may be a promising therapeutic target in keloids.
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August-2018
Volume 18 Issue 2

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Spandidos Publications style
Zhang Y, Guo B, Hui Q, Li W, Chang P and Tao K: Downregulation of miR‑637 promotes proliferation and metastasis by targeting Smad3 in keloids Corrigendum in /10.3892/mmr.2023.13083. Mol Med Rep 18: 1628-1636, 2018
APA
Zhang, Y., Guo, B., Hui, Q., Li, W., Chang, P., & Tao, K. (2018). Downregulation of miR‑637 promotes proliferation and metastasis by targeting Smad3 in keloids Corrigendum in /10.3892/mmr.2023.13083. Molecular Medicine Reports, 18, 1628-1636. https://doi.org/10.3892/mmr.2018.9099
MLA
Zhang, Y., Guo, B., Hui, Q., Li, W., Chang, P., Tao, K."Downregulation of miR‑637 promotes proliferation and metastasis by targeting Smad3 in keloids Corrigendum in /10.3892/mmr.2023.13083". Molecular Medicine Reports 18.2 (2018): 1628-1636.
Chicago
Zhang, Y., Guo, B., Hui, Q., Li, W., Chang, P., Tao, K."Downregulation of miR‑637 promotes proliferation and metastasis by targeting Smad3 in keloids Corrigendum in /10.3892/mmr.2023.13083". Molecular Medicine Reports 18, no. 2 (2018): 1628-1636. https://doi.org/10.3892/mmr.2018.9099