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Article Open Access

Low expression of KCNN3 may affect drug resistance in ovarian cancer

  • Authors:
    • Xia Liu
    • Luwei Wei
    • Bingbing Zhao
    • Xiangxue Cai
    • Caihua Dong
    • Fuqiang Yin
  • View Affiliations / Copyright

    Affiliations: Key Laboratory of Longevity and Ageing‑Related Disease of Chinese Ministry of Education, Centre for Translational Medicine and School of Preclinical Medicine, Guangxi Medical University, Nanning, Guangxi 530021, P.R. China, Department of Gynecologic Oncology, The Affiliated Tumor Hospital, Guangxi Medical University, Nanning, Guangxi 530021, P.R. China, Life Sciences Institute, Guangxi Medical University, Nanning, Guangxi 530021, P.R. China
    Copyright: © Liu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 1377-1386
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    Published online on: May 31, 2018
       https://doi.org/10.3892/mmr.2018.9107
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Abstract

Drug resistance is a principal contributor to the poor prognosis of ovarian cancer (OC). Therefore, identifying factors that affect drug resistance in OC is critical. In the present study, 51 OC specimens from lab collections were immunohistochemically tested, public data for 489 samples from The Cancer Genome Atlas cohort and 1,656 samples from the Kaplan‑Meier Plotter were downloaded, and data were retrieved from Oncomine. It was identified that the mRNA and protein expression of the potassium calcium‑activated channel subfamily N member 3 (KCNN3) was markedly lower in OC tissues compared with normal tissues, and in drug‑resistant OC tissues compared with sensitive OC tissues. Low KCNN3 expression consistently predicted shorter disease‑free and overall survival (OS). Specifically, low KCNN3 expression predicted shorter OS in 395 patients with low expression levels of mucin‑16. There was additional evidence that KCNN3 expression is mediated by microRNA‑892b. Furthermore, text mining and analyses of protein and gene interactions indicated that KCNN3 affects drug resistance. To the best of the authors' knowledge, this is the first report to associate KCNN3 with poor prognosis and drug resistance in OC. The present findings indicated that KCNN3 is a potential prognostic marker and therapeutic target for OC.
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Copy and paste a formatted citation
Spandidos Publications style
Liu X, Wei L, Zhao B, Cai X, Dong C and Yin F: Low expression of KCNN3 may affect drug resistance in ovarian cancer. Mol Med Rep 18: 1377-1386, 2018.
APA
Liu, X., Wei, L., Zhao, B., Cai, X., Dong, C., & Yin, F. (2018). Low expression of KCNN3 may affect drug resistance in ovarian cancer. Molecular Medicine Reports, 18, 1377-1386. https://doi.org/10.3892/mmr.2018.9107
MLA
Liu, X., Wei, L., Zhao, B., Cai, X., Dong, C., Yin, F."Low expression of KCNN3 may affect drug resistance in ovarian cancer". Molecular Medicine Reports 18.2 (2018): 1377-1386.
Chicago
Liu, X., Wei, L., Zhao, B., Cai, X., Dong, C., Yin, F."Low expression of KCNN3 may affect drug resistance in ovarian cancer". Molecular Medicine Reports 18, no. 2 (2018): 1377-1386. https://doi.org/10.3892/mmr.2018.9107
Copy and paste a formatted citation
x
Spandidos Publications style
Liu X, Wei L, Zhao B, Cai X, Dong C and Yin F: Low expression of KCNN3 may affect drug resistance in ovarian cancer. Mol Med Rep 18: 1377-1386, 2018.
APA
Liu, X., Wei, L., Zhao, B., Cai, X., Dong, C., & Yin, F. (2018). Low expression of KCNN3 may affect drug resistance in ovarian cancer. Molecular Medicine Reports, 18, 1377-1386. https://doi.org/10.3892/mmr.2018.9107
MLA
Liu, X., Wei, L., Zhao, B., Cai, X., Dong, C., Yin, F."Low expression of KCNN3 may affect drug resistance in ovarian cancer". Molecular Medicine Reports 18.2 (2018): 1377-1386.
Chicago
Liu, X., Wei, L., Zhao, B., Cai, X., Dong, C., Yin, F."Low expression of KCNN3 may affect drug resistance in ovarian cancer". Molecular Medicine Reports 18, no. 2 (2018): 1377-1386. https://doi.org/10.3892/mmr.2018.9107
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