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Article

MicroRNA‑539 inhibits cell proliferation, colony formation and invasion in pancreatic ductal adenocarcinoma by directly targeting IGF‑1R

  • Authors:
    • Yongquan Lin
    • Lihua Rong
    • Jingrong Zhao
    • Ronghui Lin
    • Shuhua Li
  • View Affiliations / Copyright

    Affiliations: Department of Emergency, Yidu Central Hospital of Weifang, Weifang, Shandong 262500, P.R. China, Department of General Surgery, The 89th Hospital of Chinese People's Liberation Army, Weifang, Shandong 262500, P.R. China, Health clinics, Qingzhou Yanghe River Authority, Qingzhou, Shandong 261021, P.R. China, Department of Emergency, Weifang People's Hospital, Weifang, Shandong 261000, P.R. China
  • Pages: 1804-1811
    |
    Published online on: May 31, 2018
       https://doi.org/10.3892/mmr.2018.9109
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Abstract

MicroRNAs (miRNAs) possess oncogenic and tumour‑suppressive roles in the carcinogenesis and progression of pancreatic ductal adenocarcinoma (PDAC) by regulating the expression of numerous cancer‑related genes. Thus, the investigation on the expression and roles of miRNAs in PDAC may facilitate the identification of novel and effective targets for the clinical diagnosis and treatment of patients with PDAC. miRNA‑539 (miR‑539) has been studied in multiple types of human cancer. However, its expression and potential biological function in PDAC remain unclear. In the current study, the expression level, clinical significance, roles and underlying molecular mechanism of miR‑539 in PDAC. The present results demonstrated that miR‑539 expression was downregulated in PDAC tissues and cell lines. A low miR‑539 level was associated with TNM stage and lymph node metastasis of patients with PDAC. miR‑539 overexpression induced a significant reduction in the proliferation, colony formation and invasion of PDAC cells. Insulin‑like growth factor 1 receptor (IGF‑1R) was confirmed as a direct target gene of miR‑539 in PDAC. Further analysis indicated that IGF‑1R was overexpressed in PDAC tissues. Notably, the mRNA expression of IGF‑1R was negatively correlated with miR‑539 levels in PDAC tissues. In addition, the recovered IGF‑1R expression also partially counteracted the suppressive roles of miR‑539 overexpression in PDAC cells. Overall, miR‑539 may inhibit the aggressive behaviour of PDAC by directly targeting IGF‑1R and may serve as a novel therapeutic target for patients with this disease.
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Copy and paste a formatted citation
Spandidos Publications style
Lin Y, Rong L, Zhao J, Lin R and Li S: MicroRNA‑539 inhibits cell proliferation, colony formation and invasion in pancreatic ductal adenocarcinoma by directly targeting IGF‑1R. Mol Med Rep 18: 1804-1811, 2018.
APA
Lin, Y., Rong, L., Zhao, J., Lin, R., & Li, S. (2018). MicroRNA‑539 inhibits cell proliferation, colony formation and invasion in pancreatic ductal adenocarcinoma by directly targeting IGF‑1R. Molecular Medicine Reports, 18, 1804-1811. https://doi.org/10.3892/mmr.2018.9109
MLA
Lin, Y., Rong, L., Zhao, J., Lin, R., Li, S."MicroRNA‑539 inhibits cell proliferation, colony formation and invasion in pancreatic ductal adenocarcinoma by directly targeting IGF‑1R". Molecular Medicine Reports 18.2 (2018): 1804-1811.
Chicago
Lin, Y., Rong, L., Zhao, J., Lin, R., Li, S."MicroRNA‑539 inhibits cell proliferation, colony formation and invasion in pancreatic ductal adenocarcinoma by directly targeting IGF‑1R". Molecular Medicine Reports 18, no. 2 (2018): 1804-1811. https://doi.org/10.3892/mmr.2018.9109
Copy and paste a formatted citation
x
Spandidos Publications style
Lin Y, Rong L, Zhao J, Lin R and Li S: MicroRNA‑539 inhibits cell proliferation, colony formation and invasion in pancreatic ductal adenocarcinoma by directly targeting IGF‑1R. Mol Med Rep 18: 1804-1811, 2018.
APA
Lin, Y., Rong, L., Zhao, J., Lin, R., & Li, S. (2018). MicroRNA‑539 inhibits cell proliferation, colony formation and invasion in pancreatic ductal adenocarcinoma by directly targeting IGF‑1R. Molecular Medicine Reports, 18, 1804-1811. https://doi.org/10.3892/mmr.2018.9109
MLA
Lin, Y., Rong, L., Zhao, J., Lin, R., Li, S."MicroRNA‑539 inhibits cell proliferation, colony formation and invasion in pancreatic ductal adenocarcinoma by directly targeting IGF‑1R". Molecular Medicine Reports 18.2 (2018): 1804-1811.
Chicago
Lin, Y., Rong, L., Zhao, J., Lin, R., Li, S."MicroRNA‑539 inhibits cell proliferation, colony formation and invasion in pancreatic ductal adenocarcinoma by directly targeting IGF‑1R". Molecular Medicine Reports 18, no. 2 (2018): 1804-1811. https://doi.org/10.3892/mmr.2018.9109
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