Open Access

Lipid raft‑associated β‑adducin participates in neutrophil migration

  • Authors:
    • Chen Yang
    • Zhefeng Sui
    • Tingshuang Xu
    • Wenai Liu
    • Xiaoguang Wang
    • Xianlu Zeng
  • View Affiliations

  • Published online on: May 31, 2018     https://doi.org/10.3892/mmr.2018.9113
  • Pages: 1353-1360
  • Copyright: © Yang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Previous studies have demonstrated that lipid rafts and β‑adducin serve an important role in leukocyte rolling. In the present study the migratory ability and behavior of neutrophils was demonstrated to rely on the integrity of the lipid raft structure. β‑adducin was demonstrated to have a critical role in neutrophil migration. Knockdown of β‑adducin attenuated the migratory ability of dHL‑60 cells and the distribution of β‑adducin in lipid raft structures was changed by N‑formylmethionyl‑leucyl‑phenyl‑alanine treatment. Furthermore, the findings demonstrated that the tyrosine phosphorylation of β‑adducin was required for its relocation. The results of the present study suggested that the lipid raft‑associated protein β‑adducin may be a novel control point for the excessive infiltration of neutrophils during inflammation.
View Figures
View References

Related Articles

Journal Cover

August-2018
Volume 18 Issue 2

Print ISSN: 1791-2997
Online ISSN:1791-3004

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Yang C, Sui Z, Xu T, Liu W, Wang X and Zeng X: Lipid raft‑associated β‑adducin participates in neutrophil migration. Mol Med Rep 18: 1353-1360, 2018
APA
Yang, C., Sui, Z., Xu, T., Liu, W., Wang, X., & Zeng, X. (2018). Lipid raft‑associated β‑adducin participates in neutrophil migration. Molecular Medicine Reports, 18, 1353-1360. https://doi.org/10.3892/mmr.2018.9113
MLA
Yang, C., Sui, Z., Xu, T., Liu, W., Wang, X., Zeng, X."Lipid raft‑associated β‑adducin participates in neutrophil migration". Molecular Medicine Reports 18.2 (2018): 1353-1360.
Chicago
Yang, C., Sui, Z., Xu, T., Liu, W., Wang, X., Zeng, X."Lipid raft‑associated β‑adducin participates in neutrophil migration". Molecular Medicine Reports 18, no. 2 (2018): 1353-1360. https://doi.org/10.3892/mmr.2018.9113