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Article

CXCL8 and CXCL11 chemokine secretion in dermal fibroblasts is differentially modulated by vanadium pentoxide

  • Authors:
    • P. Fallahi
    • R. Foddis
    • G. Elia
    • F. Ragusa
    • A. Patrizio
    • S. Benvenga
    • A. Cristaudo
    • A. Antonelli
    • S. M. Ferrari
  • View Affiliations / Copyright

    Affiliations: Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, I‑56126 Pisa, Italy, Department of Clinical and Experimental Medicine, School of Medicine, University of Pisa, I‑56126 Pisa, Italy, Department of Clinical and Experimental Medicine, University of Messina, I‑98125 Messina, Italy
  • Pages: 1798-1803
    |
    Published online on: June 1, 2018
       https://doi.org/10.3892/mmr.2018.9121
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Abstract

An increase in skin rashes or atopic dermatitis has been observed in individuals working with vanadium. However, to the best of our knowledge no in vivo or in vitro studies have evaluated the effect of exposure to vanadium in dermal fibroblasts. Cells viability and proliferation were assessed by WST‑1 assay, cells were treated with increasing concentrations of V2O5 (1, 10 and 100 nM). CXCL8 and CXCL11 concentrations were measured in the supernatants using an ELISA assay. V2O5 was not observed as having a significant effect on dermal fibroblast's viability and proliferation. However, it was revealed that V2O5 was able to induce the secretion of CXCL8 and CXCL11 chemokines into dermal fibroblasts. V2O5 synergistically increased the effect of interferon (IFN)γ on CXCL11 secretion. In addition, V2O5 synergistically increased the effect of the tumor necrosis factor α on CXCL8 secretion and abolished the inhibitory effect of IFNγ. V2O5 induction of CXCL8 and CXCL11 chemokines may lead to the appearance and perpetuation of an inflammatory reaction into the dermal tissue. Further studies are required to evaluate dermal integrity and manifestations in subjects occupationally exposed, or living in polluted areas.
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Copy and paste a formatted citation
Spandidos Publications style
Fallahi P, Foddis R, Elia G, Ragusa F, Patrizio A, Benvenga S, Cristaudo A, Antonelli A and Ferrari SM: CXCL8 and CXCL11 chemokine secretion in dermal fibroblasts is differentially modulated by vanadium pentoxide. Mol Med Rep 18: 1798-1803, 2018.
APA
Fallahi, P., Foddis, R., Elia, G., Ragusa, F., Patrizio, A., Benvenga, S. ... Ferrari, S.M. (2018). CXCL8 and CXCL11 chemokine secretion in dermal fibroblasts is differentially modulated by vanadium pentoxide. Molecular Medicine Reports, 18, 1798-1803. https://doi.org/10.3892/mmr.2018.9121
MLA
Fallahi, P., Foddis, R., Elia, G., Ragusa, F., Patrizio, A., Benvenga, S., Cristaudo, A., Antonelli, A., Ferrari, S. M."CXCL8 and CXCL11 chemokine secretion in dermal fibroblasts is differentially modulated by vanadium pentoxide". Molecular Medicine Reports 18.2 (2018): 1798-1803.
Chicago
Fallahi, P., Foddis, R., Elia, G., Ragusa, F., Patrizio, A., Benvenga, S., Cristaudo, A., Antonelli, A., Ferrari, S. M."CXCL8 and CXCL11 chemokine secretion in dermal fibroblasts is differentially modulated by vanadium pentoxide". Molecular Medicine Reports 18, no. 2 (2018): 1798-1803. https://doi.org/10.3892/mmr.2018.9121
Copy and paste a formatted citation
x
Spandidos Publications style
Fallahi P, Foddis R, Elia G, Ragusa F, Patrizio A, Benvenga S, Cristaudo A, Antonelli A and Ferrari SM: CXCL8 and CXCL11 chemokine secretion in dermal fibroblasts is differentially modulated by vanadium pentoxide. Mol Med Rep 18: 1798-1803, 2018.
APA
Fallahi, P., Foddis, R., Elia, G., Ragusa, F., Patrizio, A., Benvenga, S. ... Ferrari, S.M. (2018). CXCL8 and CXCL11 chemokine secretion in dermal fibroblasts is differentially modulated by vanadium pentoxide. Molecular Medicine Reports, 18, 1798-1803. https://doi.org/10.3892/mmr.2018.9121
MLA
Fallahi, P., Foddis, R., Elia, G., Ragusa, F., Patrizio, A., Benvenga, S., Cristaudo, A., Antonelli, A., Ferrari, S. M."CXCL8 and CXCL11 chemokine secretion in dermal fibroblasts is differentially modulated by vanadium pentoxide". Molecular Medicine Reports 18.2 (2018): 1798-1803.
Chicago
Fallahi, P., Foddis, R., Elia, G., Ragusa, F., Patrizio, A., Benvenga, S., Cristaudo, A., Antonelli, A., Ferrari, S. M."CXCL8 and CXCL11 chemokine secretion in dermal fibroblasts is differentially modulated by vanadium pentoxide". Molecular Medicine Reports 18, no. 2 (2018): 1798-1803. https://doi.org/10.3892/mmr.2018.9121
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