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A novel APC mutation identified in a large Chinese family with familial adenomatous polyposis and a brief literature review

  • Authors:
    • Minghui Pang
    • Yijun Liu
    • Xiaolin Hou
    • Jialiang Yang
    • Xuelai He
    • Nengyi Hou
    • Peixi Liu
    • Luo Liang
    • Junwen Fu
    • Kang Wang
    • Zimeng Ye
    • Bo Gong
  • View Affiliations / Copyright

    Affiliations: Department of Gastrointestinal Surgery, Sichuan Academy of Medical Sciences and Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, Sichuan 610072, P.R. China, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Department of Clinical Laboratory Medicine, Sun Yat‑Sen University Cancer Center, Guangzhou, Guangdong 510000, P.R. China, Sichuan Provincial Key Laboratory for Human Disease Gene Study, Sichuan Academy of Medical Sciences and Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, Sichuan 610072, P.R. China, Department of Gastroenterology, Sichuan Academy of Medical Sciences and Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, Sichuan 610072, P.R. China
    Copyright: © Pang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 1423-1432
    |
    Published online on: June 5, 2018
       https://doi.org/10.3892/mmr.2018.9130
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Abstract

Familial adenomatous polyposis (FAP), an autosomal dominant disease, is a colon cancer predisposition syndrome that manifests as a large number of adenomatous polyps. Mutations in the Adenomatous polyposis coli (APC) gene are responsible for the majority of cases of FAP. The purpose of the present study was to report the clinical features of a Chinese family with FAP and screen for novel mutations using the targeted next‑generation sequencing technology. Among the 29 family members, 12 were diagnosed of FAP. Based on an established filtering strategy and data analyses, along with confirmation by Sanger sequencing and co‑segregation, a novel frameshift mutation c.1317delA (p.Ala440LeufsTer14) in exon 10 of the APC gene was identified. To the best of our knowledge, this mutation has not been reported prior to the present study. In addition, it was correlated with extra‑colonic phenotypes featuring duodenal polyposis and sebaceous cysts in this family. This novel frameshift mutation causing FAP not only expands the germline mutation spectrum of the APC gene in the Chinese population, but it also increases the understanding of the phenotypic and genotypic correlations of FAP, and may potentially lead to improved genetic counseling and specific treatment for families with FAP in the future.
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1 

Half E, Bercovich D and Rozen P: Familial adenomatous polyposis. Orphanet J Rare Dis. 4:222009. View Article : Google Scholar : PubMed/NCBI

2 

Galiatsatos P and Foulkes WD: Familial adenomatous polyposis. Am J Gastroenterol. 101:385–398. 2006. View Article : Google Scholar : PubMed/NCBI

3 

Jiang SS, Li JJ, Li Y, He LJ, Wang QJ, Weng DS, Pan K, Liu Q, Zhao JJ, Pan QZ, et al: A novel pathogenic germline mutation in the adenomatous polyposis coli gene in a Chinese family with familial adenomatous coli. Oncotarget. 6:27267–27274. 2015. View Article : Google Scholar : PubMed/NCBI

4 

Sung JJ, Lau JY, Goh KL and Leung WK: Asia Pacific Working Group on Colorectal Cancer: Increasing incidence of colorectal cancer in Asia: Implications for screening. Lancet Oncol. 6:871–876. 2005. View Article : Google Scholar : PubMed/NCBI

5 

Jang YH, Lim SB, Kim MJ, Chung HJ, Yoo HW, Byeon JS, Myung SJ, Lee W, Chun S and Min WK: Three novel mutations of the APC gene in Korean patients with familial adenomatous polyposis. Cancer Genet Cytogenet. 200:34–39. 2010. View Article : Google Scholar : PubMed/NCBI

6 

Burt RW, DiSario JA and Cannon-Albright L: Genetics of colon cancer: Impact of inheritance on colon cancer risk. Annu Rev Med. 46:371–379. 1995. View Article : Google Scholar : PubMed/NCBI

7 

Stenson PD, Ball EV, Mort M, Phillips AD, Shiel JA, Thomas NS, Abeysinghe S, Krawczak M and Cooper DN: Human gene mutation database (HGMD): 2003 update. Hum Mutat. 21:577–581. 2003. View Article : Google Scholar : PubMed/NCBI

8 

Fearnhead NS, Britton MP and Bodmer WF: The ABC of APC. Hum Mol Genet. 10:721–733. 2001. View Article : Google Scholar : PubMed/NCBI

9 

Korinek V, Barker N, Morin PJ, van Wichen D, de Weger R, Kinzler KW, Vogelstein B and Clevers H: Constitutive transcriptional activation by a beta-catenin-Tcf complex in APC-/- colon carcinoma. Science. 275:1784–1787. 1997. View Article : Google Scholar : PubMed/NCBI

10 

Leoz ML, Carballal S, Moreira L, Ocaña T and Balaguer F: The genetic basis of familial adenomatous polyposis and its implications for clinical practice and risk management. Appl Clin Genet. 8:95–107. 2015.PubMed/NCBI

11 

Ibrahim A, Barnes DR, Dunlop J, Barrowdale D, Antoniou AC and Berg JN: Attenuated familial adenomatous polyposis manifests as autosomal dominant late-onset colorectal cancer. Eur J Hum Genet. 22:1330–1333. 2014. View Article : Google Scholar : PubMed/NCBI

12 

Aihara H, Kumar N and Thompson CC: Diagnosis, surveillance, and treatment strategies for familial adenomatous polyposis: Rationale and update. Eur J Gastroenterol Hepatol. 26:255–262. 2014. View Article : Google Scholar : PubMed/NCBI

13 

Van de Wetering M, Sancho E, Verweij C, de Lau W, Oving I, Hurlstone A, van der Horn K, Batlle E, Coudreuse D, Haramis AP, et al: The beta-catenin/TCF-4 complex imposes a crypt progenitor phenotype on colorectal cancer cells. Cell. 111:241–250. 2002. View Article : Google Scholar : PubMed/NCBI

14 

Sieber OM, Tomlinson IP and Lamlum H: The adenomatous polyposis coli (APC) tumour suppressor-genetics, function and disease. Mol MedToday. 6:462–469. 2000.

15 

Moon RT, Kohn AD, De Ferrari GV and Kaykas A: WNT and beta-catenin signalling: Diseases and therapies. Nat Rev Genet. 5:691–701. 2004. View Article : Google Scholar : PubMed/NCBI

16 

Tang Y, Simoneau AR, Liao WX, Yi G, Hope C, Liu F, Li S, Xie J, Holcombe RF, Jurnak FA, et al: WIF1, a Wnt pathway inhibitor, regulates SKP2 and c-myc expression leading to G1 arrest and growth inhibition of human invasive urinary bladder cancer cells. Mol Cancer Ther. 8:458–468. 2009. View Article : Google Scholar : PubMed/NCBI

17 

Sulekova Z, Reina-Sanchez J and Ballhausen WG: Multiple APC messenger RNA isoforms encoding exon 15 short open reading frames are expressed in the context of a novel exon 10A-derived sequence. Int J Cancer. 63:435–441. 1995. View Article : Google Scholar : PubMed/NCBI

18 

Zumbrunn J, Kinoshita K, Hyman AA and Nathke IS: Binding of the adenomatous polyposis coli protein to microtubules increases microtubule stability and is regulated by GSK3 beta phosphorylation. Curr Biol. 11:44–49. 2001. View Article : Google Scholar : PubMed/NCBI

19 

Adamcikova Z, Wachsmannova L, Hainova K, Stevurkova V, Holec V, Ciernikova S, Cierna Z, Janega P, Babal P, Mego M, et al: Study of the APC gene function in the mouse APC+/APC1638N model. Neuro Endocrinol Lett. 33:26–33. 2012.PubMed/NCBI

20 

Liu XR, Shan XN, Friedl W, Uhlhaas S, Propping P and Wang YP: Analysis of germline mutations in the APC gene in familial adenomatous polyposis patients. Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 22:261–264. 2005.PubMed/NCBI

21 

Pang CP, Fan DS, Keung JW, Baum L, Tang NL, Lau JW and Lam DS: Congenital hypertrophy of the retinal pigment epithelium and APC mutations in Chinese with familial adenomatous polyposis. Ophthalmologica. 215:408–411. 2001. View Article : Google Scholar : PubMed/NCBI

22 

Cai SR, Zhang SZ and Zheng S: Detection of adenomatous polyposis coli gene mutations in 31 familial adenomatous polyposis families by using denaturing high performance liquid chromatography. Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 25:164–167. 2008.(In Chinese). PubMed/NCBI

23 

Zhang S, Qin H, Lv W, Luo S, Wang J, Fu C, Ma R, Shen Y, Chen S and Wu L: Novel and reported APC germline mutations in Chinese patients with familial adenomatous polyposis. Gene. 577:187–192. 2016. View Article : Google Scholar : PubMed/NCBI

24 

Sheng JQ, Cui WJ, Fu L, Jin P, Han Y, Li SJ, Fan RY, Li AQ, Zhang MZ and Li SR: APC gene mutations in Chinese familial adenomatous polyposis patients. World J Gastroenterol. 16:1522–1526. 2010. View Article : Google Scholar : PubMed/NCBI

25 

Jang YH, Lim SB, Kim MJ, Chung HJ, Yoo HW, Byeon JS, Myung SJ, Lee W, Chun S and Min WK: Three novel mutations of APC gene in Chinese patients with familial adenomatous polyposis. Cancer Genet Cytogenet. 200:34–39. 2010. View Article : Google Scholar : PubMed/NCBI

26 

Song G, Yuan Y, Zheng F and Yang N: Novel insertion mutation p. Asp610GlyfsX23 in APC gene causes familial adenomatous polyposis in Chinese families. Gene. 516:204–208. 2013. View Article : Google Scholar : PubMed/NCBI

27 

Chen S, Zhou J, Zhang X, Zhou X, Zhu M, Zhang Y, Ma G and Li J: Mutation analysis of the APC Gene in a Chinese FAP Pedigree with unusual Phenotype. ISRN Gastroenterol. 2011:9091212011.PubMed/NCBI

28 

Li H, Zhang L, Jiang Q, Shi Z and Tong H: Identification a nonsense mutation of APC gene in Chinese patients with familial adenomatous polyposis. Exp Ther Med. 13:1495–1499. 2017. View Article : Google Scholar : PubMed/NCBI

29 

Wang TT, Chen SQ and Zhang XM: Germline mutation of adenomatous polyposis coli gene in Chinese patients with familial adenomatous polyposis. Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 25:199–202. 2008.PubMed/NCBI

30 

Chen Q, Liu S, Feng J, Zhang X, Chen S, Ma G, Zhu M, Zhang Y and Yu J: Analysis of C.3925_3929 deletional mutations of APC gene in pedigrees with familial adenomatous polyposis. Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 32:524–528. 2015.(In Chinese). PubMed/NCBI

31 

Chen QW, Zhang XM, Zhou JN, Zhou X, Ma GJ, Zhu M, Zhang YY, Yu J, Feng JF and Chen S: Analysis of small fragment deletions of the APC gene in chinese patients with familial adenomatous polyposis, a precancerous condition. Asian Pac J Cancer Prev. 16:4915–4920. 2015. View Article : Google Scholar : PubMed/NCBI

32 

Zhang Z, Liang S, Wang D, Liang S, Li Y, Wang B, Jiang T, Zhao G, Zhang X and Banerjee S: A novel pathogenic single nucleotide germline deletion in APC gene in a four generation Chinese family with familial adenomatous polyposis. Sci Rep. 7:123572017. View Article : Google Scholar : PubMed/NCBI

33 

Zhu Z, Huang J, Dong J, et al: Analysis of APC mutation in five kindreds of familial adenomatous polyposis. Med J West China. 24:1654–1657. 2012.

34 

Liao DX, Li B, Du XM, Yu JH, Chang H, Wu ZQ, Hao HJ, Wang YX, Han WD, Cheng SJ and Luo CH: Two Chinese pedigrees for adenomatous polyposis coli: New mutations at codon 1309 and predisposition to phenotypic variations. Fam Cancer. 13:361–368. 2014. View Article : Google Scholar : PubMed/NCBI

35 

Zhang J, Li Z, Huang X and Ye J: Clinical and molecular characteristics of a child with familial adenomatous polyposis. Zhonghua Er Ke Za Zhi. 54:205–208. 2016.PubMed/NCBI

36 

Pan H, Gao HL, Wu QY, et al: Diagnosis of APC gene mutation in a patient with familial adenomatous polyposis. Mil Med J Southeast China. 16:566–168. 2014.

37 

Gan YB, Zheng S and Cai XH: Detection of a gene mutation in familial adenomatous polyposis families by PCR-RFLP method. Zhonghua Yi Xue Za Zhi. 74:352–354, 390–391. 1994.(In Chinese). PubMed/NCBI

38 

Zhang Z, Liang S, Huang H, Wang D, Zhang X, Wu J, Chen H, Wang Y, Rong T, Zhou Y and Banerjee S: A novel pathogenic large germline deletion in adenomatous polyposis coli gene in a Chinese family with familial adenomatous polyposis. Oncotarget. 7:50392–50400. 2016.PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Pang M, Liu Y, Hou X, Yang J, He X, Hou N, Liu P, Liang L, Fu J, Wang K, Wang K, et al: A novel APC mutation identified in a large Chinese family with familial adenomatous polyposis and a brief literature review. Mol Med Rep 18: 1423-1432, 2018.
APA
Pang, M., Liu, Y., Hou, X., Yang, J., He, X., Hou, N. ... Gong, B. (2018). A novel APC mutation identified in a large Chinese family with familial adenomatous polyposis and a brief literature review. Molecular Medicine Reports, 18, 1423-1432. https://doi.org/10.3892/mmr.2018.9130
MLA
Pang, M., Liu, Y., Hou, X., Yang, J., He, X., Hou, N., Liu, P., Liang, L., Fu, J., Wang, K., Ye, Z., Gong, B."A novel APC mutation identified in a large Chinese family with familial adenomatous polyposis and a brief literature review". Molecular Medicine Reports 18.2 (2018): 1423-1432.
Chicago
Pang, M., Liu, Y., Hou, X., Yang, J., He, X., Hou, N., Liu, P., Liang, L., Fu, J., Wang, K., Ye, Z., Gong, B."A novel APC mutation identified in a large Chinese family with familial adenomatous polyposis and a brief literature review". Molecular Medicine Reports 18, no. 2 (2018): 1423-1432. https://doi.org/10.3892/mmr.2018.9130
Copy and paste a formatted citation
x
Spandidos Publications style
Pang M, Liu Y, Hou X, Yang J, He X, Hou N, Liu P, Liang L, Fu J, Wang K, Wang K, et al: A novel APC mutation identified in a large Chinese family with familial adenomatous polyposis and a brief literature review. Mol Med Rep 18: 1423-1432, 2018.
APA
Pang, M., Liu, Y., Hou, X., Yang, J., He, X., Hou, N. ... Gong, B. (2018). A novel APC mutation identified in a large Chinese family with familial adenomatous polyposis and a brief literature review. Molecular Medicine Reports, 18, 1423-1432. https://doi.org/10.3892/mmr.2018.9130
MLA
Pang, M., Liu, Y., Hou, X., Yang, J., He, X., Hou, N., Liu, P., Liang, L., Fu, J., Wang, K., Ye, Z., Gong, B."A novel APC mutation identified in a large Chinese family with familial adenomatous polyposis and a brief literature review". Molecular Medicine Reports 18.2 (2018): 1423-1432.
Chicago
Pang, M., Liu, Y., Hou, X., Yang, J., He, X., Hou, N., Liu, P., Liang, L., Fu, J., Wang, K., Ye, Z., Gong, B."A novel APC mutation identified in a large Chinese family with familial adenomatous polyposis and a brief literature review". Molecular Medicine Reports 18, no. 2 (2018): 1423-1432. https://doi.org/10.3892/mmr.2018.9130
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