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Article

Effects of strontium ranelate on wear particle‑induced aseptic loosening in female ovariectomized mice

  • Authors:
    • Tianxiang Geng
    • Xi Chen
    • Mengxue Zheng
    • Haochen Yu
    • Shuai Zhang
    • Shouxuan Sun
    • Haohui Guo
    • Qunhua Jin
  • View Affiliations / Copyright

    Affiliations: Department of Orthopedic Surgery, Ningxia Medical University, Yinchuan, Ningxia Hui Autonomous Region 750004, P.R. China, Department of Orthopedic Surgery, General Hospital of Ningxia Medical University, Yinchuan, Ningxia Hui Autonomous Region 750004, P.R. China
  • Pages: 1849-1857
    |
    Published online on: June 5, 2018
       https://doi.org/10.3892/mmr.2018.9133
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Abstract

Aseptic loosening and menopause‑induced osteoporosis are caused by an imbalance between bone formation and osteolysis. With an aging population, the probability of simultaneous occurrence of such conditions in an elderly individual is increasing. Strontium ranelate (SR) is an anti‑osteoporosis drug that promotes bone formation and inhibits osteolysis. The present study compared the effects of SR with those of the traditional anti‑osteoporosis drug alendronate (ALN) using an ovariectomized mouse model of osteolysis. The degree of firmness of the prosthesis and the surrounding tissue was examined, a micro‑CT scan of the prosthesis and the surrounding tissue was performed, and the levels of inflammatory and osteogenic and osteoclast factors were examined. It was observed that treatment with SR and ALN improved the bond between the prosthesis and the surrounding bone tissue by reducing the degree of osteolysis, thus improving the quality of bone around the prosthesis. SR increased the secretion of osteocalcin, runt‑related transcription factor 2 and osteoprotegerin (OPG). It additionally decreased the expression of the receptor activator of nuclear factor‑κB ligand (RANKL) and consequently increased the protein ratio OPG/RANKL, whereas ALN exhibited the opposite effect. Furthermore, SR and ALN suppressed tumor necrosis factor‑α and interleukin‑1β production, with SR exerting a more marked effect. The present results demonstrate that SR and ALN may stimulate bone formation and inhibit bone resorption in the ovariectomized mouse model of wear particle‑mediated osteolysis, with SR demonstrating better effects compared with ALN.
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View References

1 

Wang ML, Sharkey PF and Tuan RS: Particle bioreactivity and wear-mediated osteolysis. J Arthroplasty. 19:1028–1038. 2004. View Article : Google Scholar : PubMed/NCBI

2 

Pioletti DP and Kottelat A: The influence of wear particles in the expression of osteoclastogenesis factors by osteoblasts. Biomaterials. 25:5803–5808. 2004. View Article : Google Scholar : PubMed/NCBI

3 

Shao H, Shen J, Wang M, Cui J, Wang Y, Zhu S, Zhang W, Yang H, Xu Y and Geng D: Icariin protects against titanium particle-induced osteolysis and inflammatory response in a mouse calvarial model. Biomaterials. 60:92–99. 2015. View Article : Google Scholar : PubMed/NCBI

4 

Flecher X, Rolland C, Rixrath E, Argenson J, Robert P, Bongrand P, Wendling S and Vitte J: Local and systemic activation of the mononuclear phagocyte system in aseptic loosening of total hip arthroplasty. J Clin Immunol. 29:681–690. 2009. View Article : Google Scholar : PubMed/NCBI

5 

Pajarinen J, Lin T, Nabeshima A, Jämsen E, Lu L, Nathan K, Yao Z and Goodman SB: Mesenchymal stem cells in the aseptic loosening of total joint replacements. J Biomed Mater Res A. 105:1195–1207. 2017. View Article : Google Scholar : PubMed/NCBI

6 

Haleem-Smith H, Argintar E, Bush C, Hampton D, Postma WF, Chen FH, Rimington T, Lamb J and Tuan RS: Biological responses of human mesenchymal stem cells to titanium wear debris particles. J Orthop Res. 30:853–863. 2012. View Article : Google Scholar : PubMed/NCBI

7 

Huang C, Li L, Yu X, Gu Z and Zhang X: The inhibitory effect of strontium-doped calcium polyphosphate particles on cytokines from macrophages and osteoblasts leading to aseptic loosening in vitro. Biomed Mater. 9:0250102014. View Article : Google Scholar : PubMed/NCBI

8 

Ferreira E, Bortolin RH, Freire-Neto FP, Souza K, Bezerra JF, Ururahy M, Ramos AMO, Himelfarb ST, Abreu BJ, Didone TVN, et al: Zinc supplementation reduces rankl/opg ratio and prevents bone architecture alterations in ovariectomized and type 1 diabetic rats. Nutr Res. 40:48–56. 2017. View Article : Google Scholar : PubMed/NCBI

9 

Szwarc MM, Kommagani R, Jacob AP, Dougall WC, Ittmann MM and Lydon JP: Aberrant activation of the rank signaling receptor induces murine salivary gland tumors. PLoS One. 10:e1284672015. View Article : Google Scholar

10 

Neuerburg C, Wedemeyer C, Goedel J, Schlepper R, Hilken G, Schwindenhammer B, Schilling AF, Jager M and Kauther MD: The role of calcitonin receptor signalling in polyethylene particle-induced osteolysis. Acta Biomater. 14:125–132. 2015. View Article : Google Scholar : PubMed/NCBI

11 

Armas LA and Recker RR: Pathophysiology of osteoporosis: New mechanistic insights. Endocrinol Metab Clin North Am. 41:475–486. 2012. View Article : Google Scholar : PubMed/NCBI

12 

Riggs BL: The mechanisms of estrogen regulation of bone resorption. J Clin Invest. 106:1203–1204. 2000. View Article : Google Scholar : PubMed/NCBI

13 

Syed F and Khosla S: Mechanisms of sex steroid effects on bone. Biochem Biophys Res Commun. 328:688–696. 2005. View Article : Google Scholar : PubMed/NCBI

14 

Frenkel B, Hong A, Baniwal SK, Coetzee GA, Ohlsson C, Khalid O and Gabet Y: Regulation of adult bone turnover by sex steroids. J Cell Physiol. 224:305–310. 2010. View Article : Google Scholar : PubMed/NCBI

15 

Gilbert L, He X, Farmer P, Boden S, Kozlowski M, Rubin J and Nanes MS: Inhibition of osteoblast differentiation by tumor necrosis factor-alpha. Endocrinology. 141:3956–3964. 2000. View Article : Google Scholar : PubMed/NCBI

16 

Manolagas SC: Birth and death of bone cells: Basic regulatory mechanisms and implications for the pathogenesis and treatment of osteoporosis. Endocr Rev. 21:115–137. 2000. View Article : Google Scholar : PubMed/NCBI

17 

Raehtz S, Bierhalter H, Schoenherr D, Parameswaran N and McCabe LR: Estrogen deficiency exacerbates type 1 diabetes induced bone TNFα expression and osteoporosis in female mice. Endocrinology. 158:2086–2101. 2017. View Article : Google Scholar : PubMed/NCBI

18 

Dorr LD, Faugere MC, Mackel AM, Gruen TA, Bognar B and Malluche HH: Structural and cellular assessment of bone quality of proximal femur. Bone. 14:231–242. 1993. View Article : Google Scholar : PubMed/NCBI

19 

Dorr LD, Faugere MC, Mackel AM, Gruen TA, Bognar B and Malluche HH: Structural and cellular assessment of bone quality of proximal femur. Bone. 14:231–242. 1993. View Article : Google Scholar : PubMed/NCBI

20 

Bottai V, Dell'Osso G, Celli F, Bugelli G, Cazzella N, Cei E, Guido G and Giannotti S: Total hip replacement in osteoarthritis: The role of bone metabolism and its complications. Clin Cases Miner Bone Metab. 12:247–250. 2015.PubMed/NCBI

21 

Stepan JJ, Alenfeld F, Boivin G, Feyen JH and Lakatos P: Mechanisms of action of antiresorptive therapies of postmenopausal osteoporosis. Endocr Regul. 37:225–238. 2003.PubMed/NCBI

22 

Chen BL, Xie DH, Zheng ZM, Lu W, Ning CY, Li YQ, Li FB and Liao WM: Comparison of the effects of alendronate sodium and calcitonin on bone-prosthesis osseointegration in osteoporotic rats. Osteoporos Int. 22:265–270. 2011. View Article : Google Scholar : PubMed/NCBI

23 

O'Hara LJ, Nivbrant B and Rohrl S: Cross-linked polyethylene and bisphosphonate therapy for osteolysis in total hip arthroplasty: A case report. J Orthop Surg (Hong Kong). 12:114–121. 2004. View Article : Google Scholar : PubMed/NCBI

24 

Reginster JY, Brandi ML, Cannata-Andia J, Cooper C, Cortet B, Feron JM, Genant H, Palacios S, Ringe JD and Rizzoli R: The position of strontium ranelate in today's management of osteoporosis. Osteoporos Int. 26:1667–1671. 2015. View Article : Google Scholar : PubMed/NCBI

25 

Karakan NC, Akpinar A, Goze F and Poyraz O: Investigating the effects of systemically administered strontium ranelate on alveolar bone loss histomorphometrically and histopathologically on experimental periodontitis in rats. J Periodontol. 88:e24–e31. 2017. View Article : Google Scholar : PubMed/NCBI

26 

Marie PJ: Optimizing bone metabolism in osteoporosis: Insight into the pharmacologic profile of strontium ranelate. Osteoporos Int. 14 Suppl 3:S9–S12. 2003. View Article : Google Scholar : PubMed/NCBI

27 

Sun S, Guo H, Zhang J, Yu B, Sun K and Jin Q: Adenovirus-mediated expression of bone morphogenetic protein-2 activates titanium particle-induced osteoclastogenesis and this effect occurs in spite of the suppression of tnf-alpha expression by sirna. Int J Mol Med. 32:403–409. 2013. View Article : Google Scholar : PubMed/NCBI

28 

National Research Council (US) Committee for the Update of the Guide for the Care and Use of Laboratory Animals: Guide for the Care and Use of Laboratory Animals. 8th edition. National Academies Press (US); Washington, D.C: 2011

29 

Yang S, Yu H, Gong W, Wu B, Mayton L, Costello R and Wooley PH: Murine model of prosthesis failure for the long-term study of aseptic loosening. J Orthop Res. 25:603–611. 2007. View Article : Google Scholar : PubMed/NCBI

30 

Huang RC, Khan SN, Sandhu HS, Metzl JA, Cammisa FJ, Zheng F, Sama AA and Lane JM: Alendronate inhibits spine fusion in a rat model. Spine (Phila Pa 1976). 30:2516–2522. 2005. View Article : Google Scholar : PubMed/NCBI

31 

Geng T, Sun S, Chen X, Wang B, Guo H, Zhang S and Jin Q: Strontium ranelate reduces the progression of titanium particle-induced osteolysis by increasing the ratio of osteoprotegerin to receptor activator of nuclear factor-κB ligand in vivo. Mol Med Rep. 17:3829–3836. 2018.PubMed/NCBI

32 

Bouxsein ML, Boyd SK, Christiansen BA, Guldberg RE, Jepsen KJ and Müller R: Guidelines for assessment of bone microstructure in rodents using micro-computed tomography. J Bone Miner Res. 25:1468–1486. 2010. View Article : Google Scholar : PubMed/NCBI

33 

Chen B, Li Y, Yang X, Xu H and Xie D: Zoledronic acid enhances bone-implant osseointegration more than alendronate and strontium ranelate in ovariectomized rats. Osteoporos Int. 24:2115–2121. 2013. View Article : Google Scholar : PubMed/NCBI

34 

Ucer S, Iyer S, Kim H, Han L, Rutlen C, Allison K, Thostenson JD, de Cabo R, Jilka RL, O'Brien C, et al: The effects of aging and sex steroid deficiency on the murine skeleton are independent and mechanistically distinct. J Bone Miner Res. 32:560–574. 2017. View Article : Google Scholar : PubMed/NCBI

35 

Bouxsein ML, Boyd SK, Christiansen BA, Guldberg RE, Jepsen KJ and Muller R: Guidelines for assessment of bone microstructure in rodents using micro-computed tomography. J Bone Miner Res. 25:1468–1486. 2010. View Article : Google Scholar : PubMed/NCBI

36 

Bonnelye E, Chabadel A, Saltel F and Jurdic P: Dual effect of strontium ranelate: Stimulation of osteoblast differentiation and inhibition of osteoclast formation and resorption in vitro. Bone. 42:129–138. 2008. View Article : Google Scholar : PubMed/NCBI

37 

Faverani LP, Polo TO, Ramalho-Ferreira G, Momesso GAC, Hassumi JS, Rossi AC, Freire AR, Prado FB, Luvizuto ER, Gruber R and Okamoto R: Raloxifene but not alendronate can compensate the impaired osseointegration in osteoporotic rats. Clin Oral Invest. 22:255–265. 2018. View Article : Google Scholar

38 

Stuss M, Sewerynek E, Król I, Stępień-Kłos W and Jędrzejczyk S: Assessment of OPG, RANKL, bone turnover markers serum levels and BMD after treatment with strontium ranelate and ibandronate in patients with postmenopausal osteoporosis. Endokrynol Pol. 67:174–184. 2016. View Article : Google Scholar : PubMed/NCBI

39 

Komrakova M, Weidemann A, Dullin C, Ebert J, Tezval M, Stuermer KM and Sehmisch S: The impact of strontium ranelate on metaphyseal bone healing in ovariectomized rats. Calcif Tissue Int. 97:391–401. 2015. View Article : Google Scholar : PubMed/NCBI

40 

Gur A, Denli A, Cevik R, Nas K, Karakoc M and Sarac AJ: The effects of alendronate and calcitonin on cytokines in postmenopausal osteoporosis: A 6-month randomized and controlled study. Yonsei Med J. 44:99–109. 2003. View Article : Google Scholar : PubMed/NCBI

41 

Liu X, Zhu S, Cui J, Shao H, Zhang W, Yang H, Xu Y, Geng D and Yu L: Strontium ranelate inhibits titanium-particle-induced osteolysis by restraining inflammatory osteoclastogenesis in vivo. Acta Biomater. 10:4912–4918. 2014. View Article : Google Scholar : PubMed/NCBI

42 

Bakker AD, Zandieh-Doulabi B and Klein-Nulend J: Strontium ranelate affects signaling from mechanically-stimulated osteocytes towards osteoclasts and osteoblasts. Bone. 53:112–119. 2013. View Article : Google Scholar : PubMed/NCBI

43 

Guo X, Wei S, Lu M, Shao Z, Lu J, Xia L, Lin K and Zou D: Dose-dependent effects of strontium ranelate on ovariectomy rat bone marrow mesenchymal stem cells and human umbilical vein endothelial cells. Int J Biol Sci. 12:1511–1522. 2016. View Article : Google Scholar : PubMed/NCBI

44 

Muise ES, Podtelezhnikov AA, Pickarski M, Loboda A, Tan Y, Hu G, Thomspon JR and Duong T: Effects of long-term odanacatib treatment on bone gene expression in ovariectomized adult rhesus monkeys: Differentiation from alendronate. J Bone Miner Res. 31:839–851. 2016. View Article : Google Scholar : PubMed/NCBI

45 

Kang AR, Oh YR, Kim HY, Park MJ, Joo BS, Choi WJ, Lee JY, Jung MH, Ji YI and Choi JS: Up-regulation of inhibitors of dna binding/differentiation gene during alendronate-induced osteoblast differentiation. Arch Gynecol Obstet. 285:1331–1338. 2012. View Article : Google Scholar : PubMed/NCBI

46 

Shimizu E, Tamasi J and Partridge NC: Alendronate affects osteoblast functions by crosstalk through ephrinb1-ephb. J Dent Res. 91:268–274. 2012. View Article : Google Scholar : PubMed/NCBI

47 

Rossini M, Adami G, Adami S, Viapiana O and Gatti D: Safety issues and adverse reactions with osteoporosis management. Exp Opin Drug Saf. 15:321–332. 2015. View Article : Google Scholar

48 

Guo X, Wei S, Lu M, Shao Z, Lu J, Xia L, Lin K and Zou D: Dose-dependent effects of strontium ranelate on ovariectomy rat bone marrow mesenchymal stem cells and human umbilical vein endothelial cells. Int J Biol Sci. 12:1511–1522. 2016. View Article : Google Scholar : PubMed/NCBI

49 

Gu Z, Huang B, Li Y, Tian M, Li L and Yu X: Strontium-doped calcium polyphosphate/ultrahigh molecular weight polyethylene composites: A new class of artificial joint components with enhanced biological efficacy to aseptic loosening. Mater Sci Eng C Mater Biol Appl. 61:526–533. 2016. View Article : Google Scholar : PubMed/NCBI

50 

Tian A, Zhai JJ, Peng Y, Zhang L, Teng MH, Liao J, Sun X and Liang X: Osteoblast response to titanium surfaces coated with strontium ranelate-loaded chitosan film. Int J Oral Maxillofac Implants. 29:1446–1453. 2014. View Article : Google Scholar : PubMed/NCBI

51 

Newman SD, Lotfibakhshaiesh N, O'Donnell M, Walboomers XF, Horwood N, Jansen JA, Amis AA, Cobb JP and Stevens MM: Enhanced osseous implant fixation with strontium-substituted bioactive glass coating. Tissue Eng Part A. 20:1850–1857. 2014. View Article : Google Scholar : PubMed/NCBI

52 

Wornham DP, Hajjawi MO, Orriss IR and Arnett TR: Strontium potently inhibits mineralisation in bone-forming primary rat osteoblast cultures and reduces numbers of osteoclasts in mouse marrow cultures. Osteoporos Int. 25:2477–2484. 2014. View Article : Google Scholar : PubMed/NCBI

53 

Rossini M, Adami G, Adami S, Viapiana O and Gatti D: Safety issues and adverse reactions with osteoporosis management. Exp Opin Drug Saf. 15:321–332. 2015. View Article : Google Scholar

54 

Lee HY, Shen MX, Lim YL, Tay YK, Chan MM, Pang SM, Xiao ZW, Ang SB and Ren EC: Increased risk of strontium ranelate-related sjs/ten is associated with hla. Osteoporos Int. 27:2577–2583. 2016. View Article : Google Scholar : PubMed/NCBI

55 

Tian A, Zhai JJ, Peng Y, Zhang L, Teng MH, Liao J, Sun X and Liang X: Osteoblast response to titanium surfaces coated with strontium ranelate-loaded chitosan film. Int J Oral Maxillofac Implants. 29:1446–1453. 2014. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Geng T, Chen X, Zheng M, Yu H, Zhang S, Sun S, Guo H and Jin Q: Effects of strontium ranelate on wear particle‑induced aseptic loosening in female ovariectomized mice. Mol Med Rep 18: 1849-1857, 2018.
APA
Geng, T., Chen, X., Zheng, M., Yu, H., Zhang, S., Sun, S. ... Jin, Q. (2018). Effects of strontium ranelate on wear particle‑induced aseptic loosening in female ovariectomized mice. Molecular Medicine Reports, 18, 1849-1857. https://doi.org/10.3892/mmr.2018.9133
MLA
Geng, T., Chen, X., Zheng, M., Yu, H., Zhang, S., Sun, S., Guo, H., Jin, Q."Effects of strontium ranelate on wear particle‑induced aseptic loosening in female ovariectomized mice". Molecular Medicine Reports 18.2 (2018): 1849-1857.
Chicago
Geng, T., Chen, X., Zheng, M., Yu, H., Zhang, S., Sun, S., Guo, H., Jin, Q."Effects of strontium ranelate on wear particle‑induced aseptic loosening in female ovariectomized mice". Molecular Medicine Reports 18, no. 2 (2018): 1849-1857. https://doi.org/10.3892/mmr.2018.9133
Copy and paste a formatted citation
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Spandidos Publications style
Geng T, Chen X, Zheng M, Yu H, Zhang S, Sun S, Guo H and Jin Q: Effects of strontium ranelate on wear particle‑induced aseptic loosening in female ovariectomized mice. Mol Med Rep 18: 1849-1857, 2018.
APA
Geng, T., Chen, X., Zheng, M., Yu, H., Zhang, S., Sun, S. ... Jin, Q. (2018). Effects of strontium ranelate on wear particle‑induced aseptic loosening in female ovariectomized mice. Molecular Medicine Reports, 18, 1849-1857. https://doi.org/10.3892/mmr.2018.9133
MLA
Geng, T., Chen, X., Zheng, M., Yu, H., Zhang, S., Sun, S., Guo, H., Jin, Q."Effects of strontium ranelate on wear particle‑induced aseptic loosening in female ovariectomized mice". Molecular Medicine Reports 18.2 (2018): 1849-1857.
Chicago
Geng, T., Chen, X., Zheng, M., Yu, H., Zhang, S., Sun, S., Guo, H., Jin, Q."Effects of strontium ranelate on wear particle‑induced aseptic loosening in female ovariectomized mice". Molecular Medicine Reports 18, no. 2 (2018): 1849-1857. https://doi.org/10.3892/mmr.2018.9133
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