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Review

Efficacy prediction of targeted therapy for gastric cancer: The current status (Review)

  • Authors:
    • Wanjing Feng
    • Xiaodong Zhu
  • View Affiliations / Copyright

    Affiliations: Department of Medical Oncology, Fudan University Shanghai Cancer Center, Shanghai 200032, P.R. China
  • Pages: 1238-1246
    |
    Published online on: June 6, 2018
       https://doi.org/10.3892/mmr.2018.9145
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Abstract

Despite significant progress in the treatment of gastric cancer (GC), the prognosis remains poor and the mortality is high. Targeted drugs have been incorporated into routine treatment to improve treatment efficacy. However, the therapy response is still below 50%. Therefore, there is a need to identify predictive factors for patient response to a specific drug in order to improve the efficacy of drug therapy. The present article reviewed the predictive factors for target therapy in GC, including epidermal growth factor receptor, human epidermal receptor 2, vascular endothelial growth factor family, molecules in the mesenchymal‑epithelial transition pathway and the mammalian target of rapamycin. Additionally, the present review described the interactions between these molecules and signaling pathways.
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Copy and paste a formatted citation
Spandidos Publications style
Feng W and Zhu X: Efficacy prediction of targeted therapy for gastric cancer: The current status (Review). Mol Med Rep 18: 1238-1246, 2018.
APA
Feng, W., & Zhu, X. (2018). Efficacy prediction of targeted therapy for gastric cancer: The current status (Review). Molecular Medicine Reports, 18, 1238-1246. https://doi.org/10.3892/mmr.2018.9145
MLA
Feng, W., Zhu, X."Efficacy prediction of targeted therapy for gastric cancer: The current status (Review)". Molecular Medicine Reports 18.2 (2018): 1238-1246.
Chicago
Feng, W., Zhu, X."Efficacy prediction of targeted therapy for gastric cancer: The current status (Review)". Molecular Medicine Reports 18, no. 2 (2018): 1238-1246. https://doi.org/10.3892/mmr.2018.9145
Copy and paste a formatted citation
x
Spandidos Publications style
Feng W and Zhu X: Efficacy prediction of targeted therapy for gastric cancer: The current status (Review). Mol Med Rep 18: 1238-1246, 2018.
APA
Feng, W., & Zhu, X. (2018). Efficacy prediction of targeted therapy for gastric cancer: The current status (Review). Molecular Medicine Reports, 18, 1238-1246. https://doi.org/10.3892/mmr.2018.9145
MLA
Feng, W., Zhu, X."Efficacy prediction of targeted therapy for gastric cancer: The current status (Review)". Molecular Medicine Reports 18.2 (2018): 1238-1246.
Chicago
Feng, W., Zhu, X."Efficacy prediction of targeted therapy for gastric cancer: The current status (Review)". Molecular Medicine Reports 18, no. 2 (2018): 1238-1246. https://doi.org/10.3892/mmr.2018.9145
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