Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Molecular Medicine Reports
Join Editorial Board Propose a Special Issue
Print ISSN: 1791-2997 Online ISSN: 1791-3004
Journal Cover
August-2018 Volume 18 Issue 2

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
August-2018 Volume 18 Issue 2

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

Organ‑specific expression of the divalent ion channel proteins NCKX3, TRPV2, CTR1, ATP7A, IREG1 and HEPH in various canine organs

  • Authors:
    • Changhwan Ahn
    • Jong‑Sam Choi
    • Eui‑Bae Jeung
  • View Affiliations / Copyright

    Affiliations: Laboratory of Veterinary Biochemistry and Molecular Biology, College of Veterinary Medicine, Chungbuk National University, Cheongju, Chungbuk 28644, Republic of Korea
  • Pages: 1773-1781
    |
    Published online on: June 7, 2018
       https://doi.org/10.3892/mmr.2018.9148
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Transmembrane cation channels include those for calcium, copper and iron ion transport. Each channel has physiological significance, and all have been associated with disease. However, the comparative study of transcriptional‑translational levels in canine organs has not been previously reported. In the present study, organ‑specific expression of calcium channels, including sodium/potassium/calcium exchanger 3 (NCKX3) and transient receptor potential cation channel subfamily V member 2 (TRPV2), copper channels, including high affinity copper uptake protein 1 (CTR1) and copper‑transporting ATPase 1 (ATP7A), and iron channels, including iron‑regulated transporter 1 (IREG1) and hephaestin (HEPH) proteins and their mRNAs were examined in the canine duodenum, kidney, spleen and liver. NCKX3 protein expression was highest in the kidney, moderate in the duodenum, and lowest in the spleen and liver, whereas TRPV2 protein was highly expressed in the kidney, duodenum and liver, and was low in the spleen. The CTR1 protein expression level was highest in the liver, followed (in descending order) by the duodenum, kidney and spleen. The ATP7A protein expression level was highest in the duodenum and lowest in the spleen. The IREG1 protein expression level was highest in the liver, followed (in descending order) by the kidney, duodenum and spleen. The HEPH protein level was high in liver, moderate in the duodenum and kidney, and low in the spleen. The results of the immunohistochemistry analysis demonstrated ion channel protein localizations. These results suggested that cation channel proteins are differentially expressed among canine organs, and they may be involved in organ‑specific functions associated with the maintenance of physiological homeostasis.
View Figures

Figure 1

Figure 2

Figure 3

View References

1 

Argüello JM, Raimunda D and González-Guerrero M: Metal transport across biomembranes: Emerging models for a distinct chemistry. J Biol Chem. 287:13510–13517. 2012. View Article : Google Scholar : PubMed/NCBI

2 

Turner RW, Anderson D and Zamponi GW: Signaling complexes of voltage-gated calcium channels. Channels (Austin). 5:440–448. 2011. View Article : Google Scholar : PubMed/NCBI

3 

Maryon EB, Molloy SA, Ivy K, Yu H and Kaplan JH: Rate and regulation of copper transport by human copper transporter 1 (hCTR1). J Biol Chem. 288:18035–18046. 2013. View Article : Google Scholar : PubMed/NCBI

4 

Anderson ER and Shah YM: Iron homeostasis in the liver. Compr Physiol. 3:315–330. 2013.PubMed/NCBI

5 

Jalloul AH, Szerencsei RT and Schnetkamp PP: Cation dependencies and turnover rates of the human K+-dependent Na+-Ca2+ exchangers NCKX1, NCKX2, NCKX3 and NCKX4. Cell Calcium. 59:1–11. 2016. View Article : Google Scholar : PubMed/NCBI

6 

Yang H, Lee GS, Yoo YM, Choi KC and Jeung EB: Sodium/potassium/calcium exchanger 3 is regulated by the steroid hormones estrogen and progesterone in the uterus of mice during the estrous cycle. Biochem Biophys Res Commun. 385:279–283. 2009. View Article : Google Scholar : PubMed/NCBI

7 

Kraev A, Quednau BD, Leach S, Li XF, Dong H, Winkfein R, Perizzolo M, Cai X, Yang R, Philipson KD and Lytton J: Molecular cloning of a third member of the potassium-dependent sodium-calcium exchanger gene family, NCKX3. J Biol Chem. 276:23161–23172. 2001. View Article : Google Scholar : PubMed/NCBI

8 

Nilius B and Owsianik G: The transient receptor potential family of ion channels. Genome Biol. 12:2182011. View Article : Google Scholar : PubMed/NCBI

9 

Park DJ, Kim SH, Nah SS, Lee JH, Kim SK, Lee YA, Hong SJ, Kim HS, Lee HS, Kim HA, et al: Polymorphisms of the TRPV2 and TRPV3 genes associated with fibromyalgia in a Korean population. Rheumatology (Oxford). 55:1518–1527. 2016. View Article : Google Scholar : PubMed/NCBI

10 

Kunert-Keil C, Bisping F, Kruger J and Brinkmeier H: Tissue-specific expression of TRP channel genes in the mouse and its variation in three different mouse strains. BMC Genomics. 7:1592006. View Article : Google Scholar : PubMed/NCBI

11 

Perálvarez-Marín A, Doñate-Macian P and Gaudet R: What do we know about the transient receptor potential vanilloid 2 (TRPV2) ion channel? FEBS J. 280:5471–5487. 2013. View Article : Google Scholar : PubMed/NCBI

12 

Tsai CY, Liebig JK, Tsigelny IF and Howell SB: The copper transporter 1 (CTR1) is required to maintain the stability of copper transporter 2 (CTR2). Metallomics. 7:1477–1487. 2015. View Article : Google Scholar : PubMed/NCBI

13 

Landon CD, Benjamin SE, Ashcraft KA and Dewhirst MW: A role for the copper transporter Ctr1 in the synergistic interaction between hyperthermia and cisplatin treatment. Int J Hyperthermia. 29:528–538. 2013. View Article : Google Scholar : PubMed/NCBI

14 

Yi L and Kaler SG: Direct interactions of adaptor protein complexes 1 and 2 with the copper transporter ATP7A mediate its anterograde and retrograde trafficking. Hum Mol Genet. 24:2411–2425. 2015. View Article : Google Scholar : PubMed/NCBI

15 

La Fontaine S and Mercer JF: Trafficking of the copper-ATPases, ATP7A and ATP7B: Role in copper homeostasis. Arch Biochem Biophys. 463:149–167. 2007. View Article : Google Scholar : PubMed/NCBI

16 

Holloway ZG, Velayos-Baeza A, Howell GJ, Levecque C, Ponnambalam S, Sztul E and Monaco AP: Trafficking of the Menkes copper transporter ATP7A is regulated by clathrin-, AP-2-, AP-1-, and Rab22-dependent steps. Mol Biol Cell. 24:1735–1748, S1-S8. 2013. View Article : Google Scholar : PubMed/NCBI

17 

McKie AT and Barlow DJ: The SLC40 basolateral iron transporter family (IREG1/ferroportin/MTP1). Pflugers Arch. 447:801–806. 2004. View Article : Google Scholar : PubMed/NCBI

18 

Miret S, Simpson RJ and McKie AT: Physiology and molecular biology of dietary iron absorption. Annu Rev Nutr. 23:283–301. 2003. View Article : Google Scholar : PubMed/NCBI

19 

Aguirre P, Mena N, Tapia V, Arredondo M and Núñez MT: Iron homeostasis in neuronal cells: A role for IREG1. BMC Neurosci. 6:32005. View Article : Google Scholar : PubMed/NCBI

20 

Kelleher T, Ryan E, Barrett S, Sweeney M, Byrnes V, O'Keane C and Crowe J: Increased DMT1 but not IREG1 or HFE mRNA following iron depletion therapy in hereditary haemochromatosis. Gut. 53:1174–1179. 2004. View Article : Google Scholar : PubMed/NCBI

21 

Yeh KY, Yeh M, Mims L and Glass J: Iron feeding induces ferroportin 1 and hephaestin migration and interaction in rat duodenal epithelium. Am J Physiol Gastrointest Liver Physiol. 296:G55–G65. 2009. View Article : Google Scholar : PubMed/NCBI

22 

Lee SM, Attieh ZK, Son HS, Chen H, Bacouri-Haidar M and Vulpe CD: Iron repletion relocalizes hephaestin to a proximal basolateral compartment in polarized MDCK and Caco2 cells. Biochem Biophys Res Commun. 421:449–455. 2012. View Article : Google Scholar : PubMed/NCBI

23 

Fuqua BK, Lu Y, Darshan D, Frazer DM, Wilkins SJ, Wolkow N, Bell AG, Hsu J, Yu CC, Chen H, et al: The multicopper ferroxidase hephaestin enhances intestinal iron absorption in mice. PLoS One. 9:e987922014. View Article : Google Scholar : PubMed/NCBI

24 

Gaggelli E, Kozlowski H, Valensin D and Valensin G: Copper homeostasis and neurodegenerative disorders (Alzheimer's, prion, and Parkinson's diseases and amyotrophic lateral sclerosis). Chem Rev. 106:1995–2044. 2006. View Article : Google Scholar : PubMed/NCBI

25 

Hubner CA and Jentsch TJ: Ion channel diseases. Hum Mol Genet. 11:2435–2445. 2002. View Article : Google Scholar : PubMed/NCBI

26 

Hudson DM, Curtis SB, Smith VC, Griffiths TA, Wong AY, Scudamore CH, Buchan AM and MacGillivray RT: Human hephaestin expression is not limited to enterocytes of the gastrointestinal tract but is also found in the antrum, the enteric nervous system, and pancreatic {beta}-cells. Am J Physiol Gastrointest Liver Physiol. 298:G425–G432. 2010. View Article : Google Scholar : PubMed/NCBI

27 

Lee GS, Choi KC and Jeung EB: K+-dependent Na+/Ca2+ exchanger 3 is involved in renal active calcium transport and is differentially expressed in the mouse kidney. Am J Physiol Renal Physiol. 297:F371–F379. 2009. View Article : Google Scholar : PubMed/NCBI

28 

Nose Y, Wood LK, Kim BE, Prohaska JR, Fry RS, Spears JW and Thiele DJ: Ctr1 is an apical copper transporter in mammalian intestinal epithelial cells in vivo that is controlled at the level of protein stability. J Biol Chem. 285:32385–32392. 2010. View Article : Google Scholar : PubMed/NCBI

29 

White C, Lee J, Kambe T, Fritsche K and Petris MJ: A role for the ATP7A copper-transporting ATPase in macrophage bactericidal activity. J Biol Chem. 284:33949–33956. 2009. View Article : Google Scholar : PubMed/NCBI

30 

Kuo YM, Gybina AA, Pyatskowit JW, Gitschier J and Prohaska JR: Copper transport protein (Ctr1) levels in mice are tissue specific and dependent on copper status. J Nutr. 136:21–26. 2006. View Article : Google Scholar : PubMed/NCBI

31 

Vennekens R, Owsianik G and Nilius B: Vanilloid transient receptor potential cation channels: An overview. Curr Pharm Des. 14:18–31. 2008. View Article : Google Scholar : PubMed/NCBI

32 

Wolff NA, Liu W, Fenton RA, Lee WK, Thévenod F and Smith CP: Ferroportin 1 is expressed basolaterally in rat kidney proximal tubule cells and iron excess increases its membrane trafficking. J Cell Mol Med. 15:209–219. 2011. View Article : Google Scholar : PubMed/NCBI

33 

Tanner MR and Beeton C: Differences in ion channel phenotype and function between humans and animal models. Front Biosci (Landmark Ed). 23:43–64. 2018. View Article : Google Scholar : PubMed/NCBI

34 

Lin JH: Species similarities and differences in pharmacokinetics. Drug Metab Dispos. 23:1008–1021. 1995.PubMed/NCBI

35 

Chandler K: Canine epilepsy: What can we learn from human seizure disorders? Vet J. 172:207–217. 2006. View Article : Google Scholar : PubMed/NCBI

36 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

37 

Entin-Meer M, Levy R, Goryainov P, Landa N, Barshack I, Avivi C, Semo J and Keren G: The transient receptor potential vanilloid 2 cation channel is abundant in macrophages accumulating at the peri-infarct zone and may enhance their migration capacity towards injured cardiomyocytes following myocardial infarction. PLoS One. 9:e1050552014. View Article : Google Scholar : PubMed/NCBI

38 

Kiela PR and Ghishan FK: Physiology of intestinal absorption and secretion. Best Pract Res Clin Gastroenterol. 30:145–159. 2016. View Article : Google Scholar : PubMed/NCBI

39 

Kulbacka J, Choromańska A, Rossowska J, Weżgowiec J, Saczko J and Rols MP: Cell membrane transport mechanisms: Ion channels and electrical properties of cell membranes. Adv Anat Embryol Cell Biol. 227:39–58. 2017. View Article : Google Scholar : PubMed/NCBI

40 

Santoni G, Farfariello V, Liberati S, Morelli MB, Nabissi M, Santoni M and Amantini C: The role of transient receptor potential vanilloid type-2 ion channels in innate and adaptive immune responses. Front Immunol. 4:342013. View Article : Google Scholar : PubMed/NCBI

41 

Yang H, An BS, Choi KC and Jeung EB: Change of genes in calcium transport channels caused by hypoxic stress in the placenta, duodenum, and kidney of pregnant rats. Biol Reprod. 88:302013. View Article : Google Scholar : PubMed/NCBI

42 

Kruger MC and Wolber FM: Osteoporosis: Modern paradigms for last century's bones. Nutrients. 8:pii: E376. 2016. View Article : Google Scholar

43 

Entin-Meer M, Cohen L, Hertzberg-Bigelman E, Levy R, Ben-Shoshan J and Keren G: TRPV2 knockout mice demonstrate an improved cardiac performance following myocardial infarction due to attenuated activity of peri-infarct macrophages. PLoS One. 12:e01771322017. View Article : Google Scholar : PubMed/NCBI

44 

Hassan S, Eldeeb K, Millns PJ, Bennett AJ, Alexander SP and Kendall DA: Cannabidiol enhances microglial phagocytosis via transient receptor potential (TRP) channel activation. Br J Pharmacol. 171:2426–2439. 2014. View Article : Google Scholar : PubMed/NCBI

45 

Link TM, Park U, Vonakis BM, Raben DM, Soloski MJ and Caterina MJ: TRPV2 has a pivotal role in macrophage particle binding and phagocytosis. Nat Immunol. 11:232–239. 2010. View Article : Google Scholar : PubMed/NCBI

46 

Yamashiro K, Sasano T, Tojo K, Namekata I, Kurokawa J, Sawada N, Suganami T, Kamei Y, Tanaka H, Tajima N, et al: Role of transient receptor potential vanilloid 2 in LPS-induced cytokine production in macrophages. Biochem Biophys Res Commun. 398:284–289. 2010. View Article : Google Scholar : PubMed/NCBI

47 

Holzer P: TRP channels in the digestive system. Curr Pharm Biotechnol. 12:24–34. 2011. View Article : Google Scholar : PubMed/NCBI

48 

Sulk M, Seeliger S, Aubert J, Schwab VD, Cevikbas F, Rivier M, Nowak P, Voegel JJ, Buddenkotte J and Steinhoff M: Distribution and expression of non-neuronal transient receptor potential (TRPV) ion channels in rosacea. J Invest Dermatol. 132:1253–1262. 2012. View Article : Google Scholar : PubMed/NCBI

49 

Ohrvik H and Thiele DJ: How copper traverses cellular membranes through the mammalian copper transporter 1, Ctr1. Ann N Y Acad Sci. 1314:32–41. 2014. View Article : Google Scholar : PubMed/NCBI

50 

Collins JF, Hua P, Lu Y and Ranganathan PN: Alternative splicing of the Menkes copper Atpase (Atp7a) transcript in the rat intestinal epithelium. Am J Physiol Gastrointest Liver Physiol. 297:G695–G707. 2009. View Article : Google Scholar : PubMed/NCBI

51 

Linz R, Barnes NL, Zimnicka AM, Kaplan JH, Eipper B and Lutsenko S: Intracellular targeting of copper-transporting ATPase ATP7A in a normal and Atp7b-/-kidney. Am J Physiol Renal Physiol. 294:F53–F61. 2008. View Article : Google Scholar : PubMed/NCBI

52 

Vonk WI, de Bie P, Wichers CG, van den Berghe PV, van der Plaats R, Berger R, Wijmenga C, Klomp LW and van de Sluis B: The copper-transporting capacity of ATP7A mutants associated with Menkes disease is ameliorated by COMMD1 as a result of improved protein expression. Cell Mol Life Sci. 69:149–163. 2012. View Article : Google Scholar : PubMed/NCBI

53 

Pinnix ZK, Miller LD, Wang W, D'Agostino R Jr, Kute T, Willingham MC, Hatcher H, Tesfay L, Sui G, Di X, et al: Ferroportin and iron regulation in breast cancer progression and prognosis. Sci Transl Med. 2:43ra562010. View Article : Google Scholar : PubMed/NCBI

54 

Kong WN, Chang YZ, Wang SM, Zhai XL, Shang JX, Li LX and Duan XL: Effect of erythropoietin on hepcidin, DMT1 with IRE, and hephaestin gene expression in duodenum of rats. J Gastroenterol. 43:136–143. 2008. View Article : Google Scholar : PubMed/NCBI

55 

Petrak J and Vyoral D: Hephaestin-a ferroxidase of cellular iron export. Int J Biochem Cell Biol. 37:1173–1178. 2005. View Article : Google Scholar : PubMed/NCBI

56 

Malik IA, Naz N, Sheikh N, Khan S, Moriconi F, Blaschke M and Ramadori G: Comparison of changes in gene expression of transferrin receptor-1 and other iron-regulatory proteins in rat liver and brain during acute-phase response. Cell Tissue Res. 344:299–312. 2011. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Ahn C, Choi JS and Jeung EB: Organ‑specific expression of the divalent ion channel proteins NCKX3, TRPV2, CTR1, ATP7A, IREG1 and HEPH in various canine organs. Mol Med Rep 18: 1773-1781, 2018.
APA
Ahn, C., Choi, J., & Jeung, E. (2018). Organ‑specific expression of the divalent ion channel proteins NCKX3, TRPV2, CTR1, ATP7A, IREG1 and HEPH in various canine organs. Molecular Medicine Reports, 18, 1773-1781. https://doi.org/10.3892/mmr.2018.9148
MLA
Ahn, C., Choi, J., Jeung, E."Organ‑specific expression of the divalent ion channel proteins NCKX3, TRPV2, CTR1, ATP7A, IREG1 and HEPH in various canine organs". Molecular Medicine Reports 18.2 (2018): 1773-1781.
Chicago
Ahn, C., Choi, J., Jeung, E."Organ‑specific expression of the divalent ion channel proteins NCKX3, TRPV2, CTR1, ATP7A, IREG1 and HEPH in various canine organs". Molecular Medicine Reports 18, no. 2 (2018): 1773-1781. https://doi.org/10.3892/mmr.2018.9148
Copy and paste a formatted citation
x
Spandidos Publications style
Ahn C, Choi JS and Jeung EB: Organ‑specific expression of the divalent ion channel proteins NCKX3, TRPV2, CTR1, ATP7A, IREG1 and HEPH in various canine organs. Mol Med Rep 18: 1773-1781, 2018.
APA
Ahn, C., Choi, J., & Jeung, E. (2018). Organ‑specific expression of the divalent ion channel proteins NCKX3, TRPV2, CTR1, ATP7A, IREG1 and HEPH in various canine organs. Molecular Medicine Reports, 18, 1773-1781. https://doi.org/10.3892/mmr.2018.9148
MLA
Ahn, C., Choi, J., Jeung, E."Organ‑specific expression of the divalent ion channel proteins NCKX3, TRPV2, CTR1, ATP7A, IREG1 and HEPH in various canine organs". Molecular Medicine Reports 18.2 (2018): 1773-1781.
Chicago
Ahn, C., Choi, J., Jeung, E."Organ‑specific expression of the divalent ion channel proteins NCKX3, TRPV2, CTR1, ATP7A, IREG1 and HEPH in various canine organs". Molecular Medicine Reports 18, no. 2 (2018): 1773-1781. https://doi.org/10.3892/mmr.2018.9148
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team