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Fennel main constituent, trans‑anethole treatment against LPS‑induced acute lung injury by regulation of Th17/Treg function

  • Authors:
    • Sichao Zhang
    • Xi Chen
    • Ichinkhorloo Devshilt
    • Qi Yun
    • Cong Huang
    • Lijun An
    • Sosorburam Dorjbat
    • Xin He
  • View Affiliations / Copyright

    Affiliations: School of Chinese Materia Medica, Tianjin University Traditional Chinese Medicine, Tianjin 300193, P.R. China, Xinjiang Tefeng Pharmaceutical Co., Ltd., Urumqi, Xinjiang 830054, P.R. China
    Copyright: © Zhang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 1369-1376
    |
    Published online on: June 7, 2018
       https://doi.org/10.3892/mmr.2018.9149
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Abstract

Fennel, commonly used in traditional Chinese medicine, is known as Foeniculum vulgare Mill. And its clinical application has been shown to target many biological systems including gastroenterology, endocrinology, gynecology and respiratory. The main constituent of the fennel essential oil is trans‑anethole, which has been described to have anti‑inflammatory and antibacterial activities. The aim of the present study was to define the anti‑inflammatory influence in acute lung injury (ALI)‑bearing mice. For 3 days, ALI‑bearing mice were induced by lipopolysaccharide (LPS) suspension in normal saline (24 mg/kg). On the fourth day, the trans‑anethole was administrated (36.4, 72.8 or 145.6 mg/kg) as well as dexamethasone (5 mg/kg) once per day for 7 consecutive days in mice. Following the completion of drug administration mice were sacrificed. Hematoxylin and eosin staining was performed in the lung paraffin section, for comparisons between monocyte and eosinophil cells in bronchoalveolar lavage fluid. The relative gene expression of interleukin (IL)‑10 and IL‑17 was determined by reverse transcription‑quantitative polymerase chain reaction. These two cytokines and the proportion of T helper 17 (Th17) cells and T regulatory (Treg) cells were determined by flow cytometry. The main constituent of fennel, trans‑anethole, eliminated LPS‑induced histopathological changes, decreased the number of inflammatory cells and resulted in a notable reduction in IL‑17 mRNA expression. In addition, trans‑anethole increased IL‑10 mRNA expression in isolated lung tissues and resulted in a marked elevation in Treg cells and reduction in Th17 cells in spleen tissues. The results of the present study indicated that the main constituent of fennel, trans‑anethole may be an anti‑inflammation component, which influenced the regulation of Th17/Treg responses. Therefore, this medicinal herb may support a healing effect on diseases of inflammatory.
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1 

Badgujar SB, Patel VV and Bandivdekar AH: Foeniculum vulgare Mill: A review of its botany, phytochemistry, pharmacology, contemporary application, and toxicology. Biomed Res Int. 2014:8426742014. View Article : Google Scholar : PubMed/NCBI

2 

Garg C, Khan SA, Ansari SH, Suman A and Garg M: Chemical composition, therapeutic potential and perspectives of Foeniculum vulgare. Pharmacogn Rev. 3:346–352. 2009.

3 

Muckensturm B, Foechterlen D, Reduron JP, Danton P and Hildenbrand M: Phytochemical and chemotaxonomic studies of Foeniculum vulgare. Biochem Syst Ecol. 25:353–358. 1997. View Article : Google Scholar

4 

Ostad SN, Soodi M, Shariffzadeh M, Khorshidi N and Marzban H: The effect of fennel essential oil on uterine contraction as a model for dysmenorrhea, pharmacology and toxicology study. J Ethnopharmacol. 76:299–304. 2001. View Article : Google Scholar : PubMed/NCBI

5 

Malini T, Vanithakumari G, Megala N, Anusya S, Devi K and Elango V: Effect of Foeniculum vulgare Mill. seed extract on the genital organs of male and female rats. Indian J Physiol Pharmacol. 29:21–26. 1985.PubMed/NCBI

6 

Ghodsi Z and Asltoghiri M: The effect of fennel on pain quality, symptoms and menstrual duration in primary dysmenorrhea. J Pediatr Adol Gynec. 27:283–286. 2014. View Article : Google Scholar

7 

Piras A, Falconieri D, Porcedda S, Marongiu B, Gonçalves MJ, Cavaleiro C and Salgueiro L: Supercritical CO2 extraction of volatile oils from Sardinian Foeniculum vulgare ssp. vulgare (Apiaceae): Chemical composition and biological activity. Nat Prod Res. 28:1819–1825. 2014. View Article : Google Scholar : PubMed/NCBI

8 

Damjanović B, Lepojević Ž, Živković V and Tolić A: Extraction of fennel (Foeniculum vulgare Mill.) seeds with supercritical CO2: Comparison with hydrodistillation. Food Chem. 92:143–149. 2005. View Article : Google Scholar

9 

Fang L, Qi M, Li T, Shao Q and Fu R: Headspace solvent microextraction-gas chromatography-mass spectrometry for the analysis of volatile compounds from Foeniculum vulgare Mill. J Pharm Biomed Anal. 41:791–797. 2006. View Article : Google Scholar : PubMed/NCBI

10 

Pacifico S, Galasso S, Piccolella S, Kretschmer N, Pan SP, Nocera P, Lettieri A, Bauer R and Monaco P: Winter wild fennel leaves as a source of anti-inflammatory and antioxidant polyphenols. Arab J Chem. (In press).

11 

Kaur GJ and Arora DS: Antibacterial and phytochemical screening of Anethum graveolens, Foeniculum vulgare and Trachyspermum ammi. BMC Complement Altern Med. 9:302009. View Article : Google Scholar : PubMed/NCBI

12 

Kang P, Kim KY, Lee HS, Min SS and Seol GH: Anti-inflammatory effects of anethole in lipopolysaccharide-induced acute lung injury in mice. Life Sci. 93:955–961. 2013. View Article : Google Scholar : PubMed/NCBI

13 

Jahromi Namavar B, Tartifizadeh A and Khabnadideh S: Comparison of fennel and mefenamic acid for the treatment of primary dysmenorrhea. Int J Gynaecol Obstet. 80:153–157. 2003. View Article : Google Scholar : PubMed/NCBI

14 

Elsoud N, Ellaithy N, Elsaeed G, Wahby M, Khalil M, Morsy F and Shaffie N: Antidiabetic activities of Foeniculum vulgare Mill. essential oil in streptozotocin-induced diabetic rats. Maced J Med Sci. 4:139–146. 2011.

15 

Koppula S and Kumar H: Foeniculum vulgare Mill (Umbelliferae) attenuates stress and improves memory in wister rats. Trop J Pharm Res. 12:553–558. 2013.

16 

Ferguson ND, Fan E, Camporota L, Antonelli M, Anzueto A, Beale R, Brochard L, Brower R, Esteban A, Gattinoni L, et al: The Berlin definition of ARDS: An expanded rationale, justification, and supplementary material. Intensive Care Med. 38:1573–1582. 2012. View Article : Google Scholar : PubMed/NCBI

17 

Matthay MA, Ware LB and Zimmerman GA: The acute respiratory distress syndrome. J Clin Invest. 122:2731–2740. 2012. View Article : Google Scholar : PubMed/NCBI

18 

Mizgerd JP: Respiratory infection and the impact of pulmonary immunity on lung health and disease. Am J Respir Crit Care Med. 186:824–829. 2012. View Article : Google Scholar : PubMed/NCBI

19 

Bhattacharya J and Matthay MA: Regulation and repair of the alveolar-capillary barrier in acute lung injury. Ann Rev Physiol. 75:593–615. 2013. View Article : Google Scholar

20 

Kim MR, Hong SW, Choi EB, Lee WH, Kim YS, Jeon SG, Jang MH, Gho YS and Kim YK: Staphylococcus aureus-derived extracellular vesicles induce neutrophilic pulmonary inflammation via both Th1 and Th17 cell responses. Allergy. 67:1271–1281. 2012. View Article : Google Scholar : PubMed/NCBI

21 

Iwakura Y, Ishigame H, Saijo S and Nakae S: Functional specialization of interleukin-17 family members. Immunity. 34:149–162. 2011. View Article : Google Scholar : PubMed/NCBI

22 

Risso K, Kumar G, Ticchioni M, Sanfiorenzo C, Dellamonica J, Guillouet-de Salvador F, Bernardin G, Marquette CH and Roger PM: Early infectious acute respiratory distress syndrome is characterized by activation and proliferation of alveolar T-cells. Eur J Clin Microbiol Infect Dis. 34:1111–1118. 2015. View Article : Google Scholar : PubMed/NCBI

23 

Noack M and Miossec P: Th17 and regulatory T cell balance in autoimmune and inflammatory diseases. Autoimmun Rev. 13:668–677. 2014. View Article : Google Scholar : PubMed/NCBI

24 

Costantino CM, Baecher-Allan CM and Hafler DA: Human regulatory T cells and autoimmunity. Eur J Immunol. 38:921–924. 2008. View Article : Google Scholar : PubMed/NCBI

25 

Guo Z, Wen Z, Qin A, Zhou Y, Liao Z, Liu Z, Liang Y, Ren T and Xu L: Antisense oligonucleotide treatment enhances the recovery of acute lung injury through IL-10-secreting M2-like macrophage-induced expansion of CD4+ regulatory T cells. J Immunol. 190:4337–4348. 2013. View Article : Google Scholar : PubMed/NCBI

26 

Mills KH: Regulatory T cells: Friend or foe in immunity to infection? Nat Rev Immunol. 4:841–855. 2004. View Article : Google Scholar : PubMed/NCBI

27 

Miossec P, Korn T and Kuchroo VK: Interleukin-17 and type 17 helper T cells. New Engl J Med. 361:888–898. 2009. View Article : Google Scholar : PubMed/NCBI

28 

Nistala K, Moncrieffe H, Newton KR, Varsani H, Hunter P and Wedderburn LR: Interleukin-17-producing T cells are enriched in the joints of children with arthritis, but have a reciprocal relationship to regulatory T cell numbers. Arthritis Rheum. 58:875–887. 2008. View Article : Google Scholar : PubMed/NCBI

29 

Tzartos JS, Friese MA, Craner MJ, Palace J, Newcombe J, Esiri MM and Fugger L: Interleukin-17 production in central nervous system-infiltrating T cells and glial cells is associated with active disease in multiple sclerosis. Am J Pathol. 172:146–155. 2008. View Article : Google Scholar : PubMed/NCBI

30 

Hirota K, Yoshitomi H, Hashimoto M, Maeda S, Teradaira S, Sugimoto N, Yamaguchi T, Nomura T, Ito H, Nakamura T, et al: Preferential recruitment of CCR6-expressing Th17 cells to inflamed joints via CCL20 in rheumatoid arthritis and its animal model. J Exp Med. 204:2803–2812. 2007. View Article : Google Scholar : PubMed/NCBI

31 

Halwani R, Al-Muhsen S and Hamid Q: T helper 17 cells in airway diseases: From laboratory bench to bedside. Chest. 143:494–501. 2013. View Article : Google Scholar : PubMed/NCBI

32 

Hartigan-O'Connor DJ, Hirao LA, McCune JM and Dandekar S: Th17 cells and regulatory T cells in elite control over HIV and SIV. Curr Opin HIV AIDS. 6:221–227. 2011. View Article : Google Scholar : PubMed/NCBI

33 

You QH, Zhang D, Niu CC, Zhu ZM, Wang N, Yue Y and Sun GY: Expression of IL-17A and IL-17F in lipopolysaccharide-induced acute lung injury and the counteraction of anisodamine or methylprednisolone. Cytokine. 66:78–86. 2014. View Article : Google Scholar : PubMed/NCBI

34 

Li C, Yang P, Sun Y, Li T, Wang C, Wang Z, Zou Z, Yan Y, Wang W, Wang C, et al: IL-17 response mediates acute lung injury induced by the 2009 pandemic influenza A (H1N1) virus. Cell Res. 22:528–538. 2012. View Article : Google Scholar : PubMed/NCBI

35 

Fedele G, Spensieri F, Palazzo R, Nasso M, Cheung GY, Coote JG and Ausiello CM: Bordetella pertussis commits human dendritic cells to promote a Th1/Th17 response through the activity of adenylate cyclase toxin and MAPK-pathways. PLoS One. 5:e87342010. View Article : Google Scholar : PubMed/NCBI

36 

Liu J, Zhang PS, Yu Q, Liu L, Yang Y, Guo FM and Qiu HB: Losartan inhibits conventional dendritic cell maturation and Th1 and Th17 polarization responses: Νovel mechanisms of preventive effects on lipopolysaccharide-induced acute lung injury. Int J Mol Med. 29:269–276. 2012.PubMed/NCBI

37 

Choi EM and Hwang JK: Antiinflammatory, analgesic and antioxidant activities of the fruit of Foeniculum vulgare. Fitoterapia. 75:557–565. 2004. View Article : Google Scholar : PubMed/NCBI

38 

Taylor A, Verhagen J, Blaser K, Akdis M and Akdis CA: Mechanisms of immune suppression by interleukin-10 and transforming growth factor-beta: The role of T regulatory cells. Immunology. 117:433–442. 2006. View Article : Google Scholar : PubMed/NCBI

39 

De M, De AK, Sen P and Banerjee AB: Antimicrobial properties of star anise (Illicium verum Hook f). Phytother Res. 16:94–95. 2002. View Article : Google Scholar : PubMed/NCBI

40 

Wang H, Peng W, Weng Y, Ying H, Li H, Xia D and Yu W: Imbalance of Th17/Treg cells in mice with chronic cigarette smoke exposure. Int Immunopharmacol. 14:504–512. 2012. View Article : Google Scholar : PubMed/NCBI

41 

Scheffold A, Murphy KM and Höfer T: Competition for cytokines: T(reg) cells take all. Nat Immunol. 8:1285–1287. 2007. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Zhang S, Chen X, Devshilt I, Yun Q, Huang C, An L, Dorjbat S and He X: Fennel main constituent, trans‑anethole treatment against LPS‑induced acute lung injury by regulation of Th17/Treg function. Mol Med Rep 18: 1369-1376, 2018.
APA
Zhang, S., Chen, X., Devshilt, I., Yun, Q., Huang, C., An, L. ... He, X. (2018). Fennel main constituent, trans‑anethole treatment against LPS‑induced acute lung injury by regulation of Th17/Treg function. Molecular Medicine Reports, 18, 1369-1376. https://doi.org/10.3892/mmr.2018.9149
MLA
Zhang, S., Chen, X., Devshilt, I., Yun, Q., Huang, C., An, L., Dorjbat, S., He, X."Fennel main constituent, trans‑anethole treatment against LPS‑induced acute lung injury by regulation of Th17/Treg function". Molecular Medicine Reports 18.2 (2018): 1369-1376.
Chicago
Zhang, S., Chen, X., Devshilt, I., Yun, Q., Huang, C., An, L., Dorjbat, S., He, X."Fennel main constituent, trans‑anethole treatment against LPS‑induced acute lung injury by regulation of Th17/Treg function". Molecular Medicine Reports 18, no. 2 (2018): 1369-1376. https://doi.org/10.3892/mmr.2018.9149
Copy and paste a formatted citation
x
Spandidos Publications style
Zhang S, Chen X, Devshilt I, Yun Q, Huang C, An L, Dorjbat S and He X: Fennel main constituent, trans‑anethole treatment against LPS‑induced acute lung injury by regulation of Th17/Treg function. Mol Med Rep 18: 1369-1376, 2018.
APA
Zhang, S., Chen, X., Devshilt, I., Yun, Q., Huang, C., An, L. ... He, X. (2018). Fennel main constituent, trans‑anethole treatment against LPS‑induced acute lung injury by regulation of Th17/Treg function. Molecular Medicine Reports, 18, 1369-1376. https://doi.org/10.3892/mmr.2018.9149
MLA
Zhang, S., Chen, X., Devshilt, I., Yun, Q., Huang, C., An, L., Dorjbat, S., He, X."Fennel main constituent, trans‑anethole treatment against LPS‑induced acute lung injury by regulation of Th17/Treg function". Molecular Medicine Reports 18.2 (2018): 1369-1376.
Chicago
Zhang, S., Chen, X., Devshilt, I., Yun, Q., Huang, C., An, L., Dorjbat, S., He, X."Fennel main constituent, trans‑anethole treatment against LPS‑induced acute lung injury by regulation of Th17/Treg function". Molecular Medicine Reports 18, no. 2 (2018): 1369-1376. https://doi.org/10.3892/mmr.2018.9149
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