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miR‑23b inhibits proliferation of SMMC‑7721 cells by directly targeting IL‑11

  • Authors:
    • Tianpeng Jiang
    • Zhi Huang
    • Shuai Zhang
    • Weijie Zou
    • Lei Xiang
    • Xiaowen Wu
    • Yaping Shen
    • Weixin Liu
    • Zhu Zeng
    • Ansu Zhao
    • Shi Zhou
    • Qingfan Zeng
  • View Affiliations / Copyright

    Affiliations: Department of Interventional Radiology, The Affiliated Hospital of Guizhou Medical University, Guizhou 550002, P.R. China, Department of Interventional Radiology, The Affiliated Cancer Hospital of Guizhou Medical University, Guiyang, Guizhou 550001, P.R. China, Department of Interventional Radiology, The Affiliated Baiyun Hospital of Guizhou Medical University, Guiyang, Guizhou 550001, P.R. China, School of Biology and Engineering, Guizhou Medical University, Guiyang, Guizhou 550001, P.R. China
    Copyright: © Jiang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 1591-1599
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    Published online on: June 11, 2018
       https://doi.org/10.3892/mmr.2018.9151
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Abstract

Hepatocellular carcinoma (HCC) is the third leading cause of cancer‑associated mortality in the 21st century. microRNA (miR)‑23b has been shown to be involved in the pathogenesis of many cancers, including breast and prostate cancer. However, the role of miR‑23b in HCC remains unclear. The present study revealed a negative correlation between miR‑23b expression in HCC tissues and progression of carcinomas. Compared to normal tissues, miR‑23b expression was significantly downregulated in HCC tissues, whereas the expression of interleukin (IL)‑11 and IL‑11 receptor α (IL‑11Rα) was significantly upregulated, indicating that miR‑23b expression is negatively correlated with IL‑11 and IL‑11Rα expression. In addition, miR‑23b inhibited proliferation and promoted apoptosis of SMMC‑7721 cells. This effect was mediated by IL‑11, which was found to be the direct target of miR‑23b in this study. These results indicated that miR‑23b regulates IL‑11 and IL‑11Rα expression, and might act as an anti‑oncogenic agent in the progression of HCC by directly downregulating IL‑11 expression.
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Copy and paste a formatted citation
Spandidos Publications style
Jiang T, Huang Z, Zhang S, Zou W, Xiang L, Wu X, Shen Y, Liu W, Zeng Z, Zhao A, Zhao A, et al: miR‑23b inhibits proliferation of SMMC‑7721 cells by directly targeting IL‑11. Mol Med Rep 18: 1591-1599, 2018.
APA
Jiang, T., Huang, Z., Zhang, S., Zou, W., Xiang, L., Wu, X. ... Zeng, Q. (2018). miR‑23b inhibits proliferation of SMMC‑7721 cells by directly targeting IL‑11. Molecular Medicine Reports, 18, 1591-1599. https://doi.org/10.3892/mmr.2018.9151
MLA
Jiang, T., Huang, Z., Zhang, S., Zou, W., Xiang, L., Wu, X., Shen, Y., Liu, W., Zeng, Z., Zhao, A., Zhou, S., Zeng, Q."miR‑23b inhibits proliferation of SMMC‑7721 cells by directly targeting IL‑11". Molecular Medicine Reports 18.2 (2018): 1591-1599.
Chicago
Jiang, T., Huang, Z., Zhang, S., Zou, W., Xiang, L., Wu, X., Shen, Y., Liu, W., Zeng, Z., Zhao, A., Zhou, S., Zeng, Q."miR‑23b inhibits proliferation of SMMC‑7721 cells by directly targeting IL‑11". Molecular Medicine Reports 18, no. 2 (2018): 1591-1599. https://doi.org/10.3892/mmr.2018.9151
Copy and paste a formatted citation
x
Spandidos Publications style
Jiang T, Huang Z, Zhang S, Zou W, Xiang L, Wu X, Shen Y, Liu W, Zeng Z, Zhao A, Zhao A, et al: miR‑23b inhibits proliferation of SMMC‑7721 cells by directly targeting IL‑11. Mol Med Rep 18: 1591-1599, 2018.
APA
Jiang, T., Huang, Z., Zhang, S., Zou, W., Xiang, L., Wu, X. ... Zeng, Q. (2018). miR‑23b inhibits proliferation of SMMC‑7721 cells by directly targeting IL‑11. Molecular Medicine Reports, 18, 1591-1599. https://doi.org/10.3892/mmr.2018.9151
MLA
Jiang, T., Huang, Z., Zhang, S., Zou, W., Xiang, L., Wu, X., Shen, Y., Liu, W., Zeng, Z., Zhao, A., Zhou, S., Zeng, Q."miR‑23b inhibits proliferation of SMMC‑7721 cells by directly targeting IL‑11". Molecular Medicine Reports 18.2 (2018): 1591-1599.
Chicago
Jiang, T., Huang, Z., Zhang, S., Zou, W., Xiang, L., Wu, X., Shen, Y., Liu, W., Zeng, Z., Zhao, A., Zhou, S., Zeng, Q."miR‑23b inhibits proliferation of SMMC‑7721 cells by directly targeting IL‑11". Molecular Medicine Reports 18, no. 2 (2018): 1591-1599. https://doi.org/10.3892/mmr.2018.9151
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