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Article Open Access

Anti-angiogenic activity of Middle East medicinal plants of the Lamiaceae family

  • Authors:
    • Qasem Abdallah
    • Ibrahim Al‑Deeb
    • Ammar Bader
    • Fayez  Hamam
    • Kamel Saleh
    • Amin Abdulmajid
  • View Affiliations / Copyright

    Affiliations: Department of Pharmacology and Toxicology, College of Pharmacy, Taif University, Taif, Makkah 21974, Saudi Arabia, Department of Pharmacology, School of Pharmaceutical Sciences, University Sains Malaysia, Minden, Penang 11800, Malaysia, Department of Pharmacognosy, College of Pharmacy, Umm Al‑Qura University, Makkah 21955, Saudi Arabia, Department of Biology, Science College, King Khalid University, Abha, Asir 61413, Saudi Arabia
    Copyright: © Abdallah et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 2441-2448
    |
    Published online on: June 12, 2018
       https://doi.org/10.3892/mmr.2018.9155
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Abstract

Angiogenesis plays a crucial role in malignant tumor progression and development. The present study aimed to identify lead plants with selective anti-angiogenic properties. A total of 26 methanolic extracts obtained from 18 plants growing in Saudi Arabia and Jordan that belong to the Lamiaceae family were screened for their cytotoxic and anti-angiogenic activities using MTT and rat aortic ring assays, respectively. Four novel extracts of Thymbra capitata (L.) Cav., Phlomis viscosa Poir, Salvia samuelssonii Rech.f., and Premna resinosa (Hochst.) Schauer were identified for their selective anti-angiogenic effects. These extracts did not exhibit cytotoxic effects on human endothelial cells (EA.hy926) indicating the involvement of indirect anti-angiogenic mechanisms. The active extracts are potential candidates for further phytochemical and mechanistic studies.
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Copy and paste a formatted citation
Spandidos Publications style
Abdallah Q, Al‑Deeb I, Bader A, Hamam F, Saleh K and Abdulmajid A: Anti-angiogenic activity of Middle East medicinal plants of the Lamiaceae family. Mol Med Rep 18: 2441-2448, 2018.
APA
Abdallah, Q., Al‑Deeb, I., Bader, A., Hamam, F., Saleh, K., & Abdulmajid, A. (2018). Anti-angiogenic activity of Middle East medicinal plants of the Lamiaceae family. Molecular Medicine Reports, 18, 2441-2448. https://doi.org/10.3892/mmr.2018.9155
MLA
Abdallah, Q., Al‑Deeb, I., Bader, A., Hamam, F., Saleh, K., Abdulmajid, A."Anti-angiogenic activity of Middle East medicinal plants of the Lamiaceae family". Molecular Medicine Reports 18.2 (2018): 2441-2448.
Chicago
Abdallah, Q., Al‑Deeb, I., Bader, A., Hamam, F., Saleh, K., Abdulmajid, A."Anti-angiogenic activity of Middle East medicinal plants of the Lamiaceae family". Molecular Medicine Reports 18, no. 2 (2018): 2441-2448. https://doi.org/10.3892/mmr.2018.9155
Copy and paste a formatted citation
x
Spandidos Publications style
Abdallah Q, Al‑Deeb I, Bader A, Hamam F, Saleh K and Abdulmajid A: Anti-angiogenic activity of Middle East medicinal plants of the Lamiaceae family. Mol Med Rep 18: 2441-2448, 2018.
APA
Abdallah, Q., Al‑Deeb, I., Bader, A., Hamam, F., Saleh, K., & Abdulmajid, A. (2018). Anti-angiogenic activity of Middle East medicinal plants of the Lamiaceae family. Molecular Medicine Reports, 18, 2441-2448. https://doi.org/10.3892/mmr.2018.9155
MLA
Abdallah, Q., Al‑Deeb, I., Bader, A., Hamam, F., Saleh, K., Abdulmajid, A."Anti-angiogenic activity of Middle East medicinal plants of the Lamiaceae family". Molecular Medicine Reports 18.2 (2018): 2441-2448.
Chicago
Abdallah, Q., Al‑Deeb, I., Bader, A., Hamam, F., Saleh, K., Abdulmajid, A."Anti-angiogenic activity of Middle East medicinal plants of the Lamiaceae family". Molecular Medicine Reports 18, no. 2 (2018): 2441-2448. https://doi.org/10.3892/mmr.2018.9155
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