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Article

MicroRNA‑125b regulates Alzheimer's disease through SphK1 regulation

  • Authors:
    • Yan Jin
    • Qiuyun Tu
    • Min Liu
  • View Affiliations / Copyright

    Affiliations: Department of Operation Center, The Third Xiangya Hospital of Central South University, Changsha, Hunan 410013, P.R. China
  • Pages: 2373-2380
    |
    Published online on: June 13, 2018
       https://doi.org/10.3892/mmr.2018.9156
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Abstract

The present study aimed to investigate the expression of microRNA (miR)‑125b in patients with Alzheimer's disease (AD) and to determine its potential role in AD. Mouse neuroblastoma Neuro2a APPSwe/Δ9 cells were used to generate an in vitro AD model. The results demonstrated that the expression levels of miR‑125b were markedly increased in patients with AD compared with in the normal group. In addition, overexpression of miR‑125b significantly inhibited cell proliferation, induced apoptosis, and enhanced inflammation and oxidative stress in an in vitro model of AD model. Furthermore, overexpression of miR‑125b significantly promoted amyloid precursor protein and β‑secretase 1 expression and β‑amyloid peptide production, and suppressed sphingosine kinase 1 (SphK1) protein expression in vitro. These findings suggested that miR‑125b may regulate AD, and neuronal cell growth and apoptosis, via the regulation of inflammatory factors and oxidative stress by SphK1; therefore, miR‑125b may be involved in the development of AD.
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Copy and paste a formatted citation
Spandidos Publications style
Jin Y, Tu Q and Liu M: MicroRNA‑125b regulates Alzheimer's disease through SphK1 regulation. Mol Med Rep 18: 2373-2380, 2018.
APA
Jin, Y., Tu, Q., & Liu, M. (2018). MicroRNA‑125b regulates Alzheimer's disease through SphK1 regulation. Molecular Medicine Reports, 18, 2373-2380. https://doi.org/10.3892/mmr.2018.9156
MLA
Jin, Y., Tu, Q., Liu, M."MicroRNA‑125b regulates Alzheimer's disease through SphK1 regulation". Molecular Medicine Reports 18.2 (2018): 2373-2380.
Chicago
Jin, Y., Tu, Q., Liu, M."MicroRNA‑125b regulates Alzheimer's disease through SphK1 regulation". Molecular Medicine Reports 18, no. 2 (2018): 2373-2380. https://doi.org/10.3892/mmr.2018.9156
Copy and paste a formatted citation
x
Spandidos Publications style
Jin Y, Tu Q and Liu M: MicroRNA‑125b regulates Alzheimer's disease through SphK1 regulation. Mol Med Rep 18: 2373-2380, 2018.
APA
Jin, Y., Tu, Q., & Liu, M. (2018). MicroRNA‑125b regulates Alzheimer's disease through SphK1 regulation. Molecular Medicine Reports, 18, 2373-2380. https://doi.org/10.3892/mmr.2018.9156
MLA
Jin, Y., Tu, Q., Liu, M."MicroRNA‑125b regulates Alzheimer's disease through SphK1 regulation". Molecular Medicine Reports 18.2 (2018): 2373-2380.
Chicago
Jin, Y., Tu, Q., Liu, M."MicroRNA‑125b regulates Alzheimer's disease through SphK1 regulation". Molecular Medicine Reports 18, no. 2 (2018): 2373-2380. https://doi.org/10.3892/mmr.2018.9156
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