|
1
|
Neubauer S: The failing heart-an engine
out of fuel. N Engl J Med. 356:1140–1151. 2007. View Article : Google Scholar : PubMed/NCBI
|
|
2
|
Kong X, Banks A, Liu T, Kazak L, Rao RR,
Cohen P, Wang X, Yu S, Lo JC, Tseng YH, et al: IRF4 is a key
thermogenic transcriptional partner of PGC-1alpha. Cell. 158:69–83.
2014. View Article : Google Scholar : PubMed/NCBI
|
|
3
|
Huang TY, Zheng D, Houmard JA, Brault JJ,
Hickner RC and Cortright RN: Overexpression of PGC-1alpha increases
peroxisomal and mitochondrial fatty acid oxidation in human primary
myotubes. Am J Physiol Endocrinol Metab. 331–2016. 2017.
|
|
4
|
Wu Z, Puigserver P, Andersson U, Zhang C,
Adelmant G, Mootha V, Troy A, Cinti S, Lowell B, Scarpulla RC and
Spiegelman BM: Mechanisms controlling mitochondrial biogenesis and
respiration through the thermogenic coactivator PGC-1. Cell.
98:115–124. 1999. View Article : Google Scholar : PubMed/NCBI
|
|
5
|
Depre C, Vanoverschelde JL and Taegtmeyer
H: Glucose for the heart. Circulation. 99:578–588. 1999. View Article : Google Scholar : PubMed/NCBI
|
|
6
|
Arumugam S, Sreedhar R, Thandavarayan RA,
Karuppagounder V and Watanabe K: Targeting fatty acid metabolism in
heart failure: Is it a suitable therapeutic approach? Drug Discov
Today. 21:1003–1008. 2016. View Article : Google Scholar : PubMed/NCBI
|
|
7
|
Lin J, Wu PH, Tarr PT, Lindenberg KS,
St-Pierre J, Zhang CY, Mootha VK, Jager S, Vianna CR, Reznick RM,
et al: Defects in adaptive energy metabolism with CNS-linked
hyperactivity in PGC-1alpha null mice. Cell. 119:121–135. 2004.
View Article : Google Scholar : PubMed/NCBI
|
|
8
|
Leone TC, Lehman JJ, Finck BN, Schaeffer
PJ, Wende AR, Boudina S, Courtois M, Wozniak DF, Sambandam N,
Bernal-Mizrachi C, et al: PGC-1alpha deficiency causes multi-system
energy metabolic derangements: Muscle dysfunction, abnormal weight
control and hepatic steatosis. PLoS Biol. 3:e1012005. View Article : Google Scholar : PubMed/NCBI
|
|
9
|
Karamanlidis G, Garcia-Menendez L, Kolwicz
SJ, Lee CF and Tian R: Promoting PGC-1alpha-driven mitochondrial
biogenesis is detrimental in pressure-overloaded mouse hearts. Am J
Physiol Heart Circ Physiol. 307:H1307–H1316. 2014. View Article : Google Scholar : PubMed/NCBI
|
|
10
|
LeBleu VS, O'Connell JT, Gonzalez HK,
Wikman H, Pantel K, Haigis MC, de Carvalho FM, Damascena A,
Domingos CL, Rocha RM, et al: PGC-1alpha mediates mitochondrial
biogenesis and oxidative phosphorylation in cancer cells to promote
metastasis. Nat Cell Biol. 16:992–1003, 1–15. 2014. View Article : Google Scholar : PubMed/NCBI
|
|
11
|
Russell LK, Mansfield CM, Lehman JJ,
Kovacs A, Courtois M, Saffitz JE, Medeiros DM, Valencik ML,
McDonald JA and Kelly DP: Cardiac-specific induction of the
transcriptional coactivator peroxisome proliferator-activated
receptor gamma coactivator-1alpha promotes mitochondrial biogenesis
and reversible cardiomyopathy in a developmental stage-dependent
manner. Circ Res. 94:525–533. 2004. View Article : Google Scholar : PubMed/NCBI
|
|
12
|
Pereira RO, Wende AR, Crum A, Hunter D,
Olsen CD, Rawlings T, Riehle C, Ward WF and Abel ED: Maintaining
PGC-1alpha expression following pressure overload-induced cardiac
hypertrophy preserves angiogenesis but not contractile or
mitochondrial function. FASEB J. 28:3691–3702. 2014. View Article : Google Scholar : PubMed/NCBI
|
|
13
|
Xie J, Cui K, Hao H, Zhang Y, Lin H, Chen
Z, Huang X, Cao S, Liao W, Bin J, et al: Acute hyperglycemia
suppresses left ventricular diastolic function and inhibits
autophagic flux in mice under prohypertrophic stimulation.
Cardiovasc Diabetol. 15:1362016. View Article : Google Scholar : PubMed/NCBI
|
|
14
|
Li Y, Li J, Hou Z, Yu Y and Yu B: KLF5
overexpression attenuates cardiomyocyte inflammation induced by
oxygen-glucose deprivation/reperfusion through the
PPARgamma/PGC-1alpha/TNF-alpha signaling pathway. Biomed
Pharmacother. 84:940–946. 2016. View Article : Google Scholar : PubMed/NCBI
|
|
15
|
Gundewar S, Calvert JW, Jha S,
Toedt-Pingel I, Ji SY, Nunez D, Ramachandran A, Anaya-Cisneros M,
Tian R and Lefer DJ: Activation of AMP-activated protein kinase by
metformin improves left ventricular function and survival in heart
failure. Circ Res. 104:403–411. 2009. View Article : Google Scholar : PubMed/NCBI
|
|
16
|
Patten IS and Arany Z: PGC-1 coactivators
in the cardiovascular system. Trends Endocrinol Metab. 23:90–97.
2012. View Article : Google Scholar : PubMed/NCBI
|
|
17
|
Zhang Y, Huypens P, Adamson AW, Chang JS,
Henagan TM, Boudreau A, Lenard NR, Burk D, Klein J, Perwitz N, et
al: Alternative mRNA splicing produces a novel biologically active
short isoform of PGC-1alpha. J Biol Chem. 284:32813–32826. 2009.
View Article : Google Scholar : PubMed/NCBI
|
|
18
|
Trausch-Azar J, Leone TC, Kelly DP and
Schwartz AL: Ubiquitin proteasome-dependent degradation of the
transcriptional coactivator PGC-1{alpha} via the N-terminal
pathway. J Biol Chem. 285:40192–40200. 2010. View Article : Google Scholar : PubMed/NCBI
|
|
19
|
Chang JS, Huypens P, Zhang Y, Black C,
Kralli A and Gettys TW: Regulation of NT-PGC-1alpha subcellular
localization and function by protein kinase A-dependent modulation
of nuclear export by CRM1. J Biol Chem. 285:18039–18050. 2010.
View Article : Google Scholar : PubMed/NCBI
|
|
20
|
Choi J, Ravipati A, Nimmagadda V, Schubert
M, Castellani RJ and Russell JW: Potential roles of PINK1 for
increased PGC-1alpha-mediated mitochondrial fatty acid oxidation
and their associations with Alzheimer disease and diabetes.
Mitochondrion. 18:41–48. 2014. View Article : Google Scholar : PubMed/NCBI
|
|
21
|
Guide for the Care and Use of Laboratory
Animals (8th Edition). 2011.https://grants.nih.gov/grants/olaw/Guide-for-the-Care-and-Use-of-Laboratory-Animals.pdfPubMed/NCBI
|
|
22
|
Livak KJ and Schmittgen TD: Analysis of
relative gene expression data using real-time quantitative PCR and
the 2(-Delta Delta C(T)) Method. Methods. 25:402–408. 2001.
View Article : Google Scholar : PubMed/NCBI
|
|
23
|
Kim J, Fernand VE, Henagan TM, Shin J,
Huypens P, Newman S, Gettys TW and Chang JS: Regulation of brown
and white adipocyte transcriptome by the transcriptional
coactivator NT-PGC-1alpha. PLoS One. 11:e1599902016.
|
|
24
|
Jun HJ, Joshi Y, Patil Y, Noland RC and
Chang JS: NT-PGC-1alpha activation attenuates high-fat diet-induced
obesity by enhancing brown fat thermogenesis and adipose tissue
oxidative metabolism. Diabetes. 63:3615–3625. 2014. View Article : Google Scholar : PubMed/NCBI
|
|
25
|
Popov DV, Bachinin AV, Lysenko EA, Miller
TF and Vinogradova OL: Exercise-induced expression of peroxisome
proliferator-activated receptor γ coactivator-1α isoforms in
skeletal muscle of endurance-trained males. J Physiol Sci.
64:317–323. 2014. View Article : Google Scholar : PubMed/NCBI
|
|
26
|
Keys JR, Zhou RH, Harris DM, Druckman CA
and Eckhart AD: Vascular smooth muscle overexpression of G
protein-coupled receptor kinase 5 elevates blood pressure, which
segregates with sex and is dependent on Gi-mediated signaling.
Circulation. 112:1145–1153. 2005. View Article : Google Scholar : PubMed/NCBI
|
|
27
|
Schlegel P, Reinkober J, Meinhardt E,
Tscheschner H, Gao E, Schumacher SM, Yuan A, Backs J, Most P,
Wieland T, et al: G protein-coupled receptor kinase 2 promotes
cardiac hypertrophy. PLoS One. 12:e1821102017. View Article : Google Scholar
|
|
28
|
Huang Q, Huang J, Zeng Z, Luo J, Liu P,
Chen S, Liu B, Pan X, Zang L and Zhou S: Effects of
ERK1/2/PPARalpha/SCAD signal pathways on cardiomyocyte hypertrophy
induced by insulin-like growth factor 1 and phenylephrine. Life
Sci. 124:41–49. 2015. View Article : Google Scholar : PubMed/NCBI
|
|
29
|
Geng T, Li P, Yin X and Yan Z: PGC-1alpha
promotes nitric oxide antioxidant defenses and inhibits FOXO
signaling against cardiac cachexia in mice. Am J Pathol.
178:1738–1748. 2011. View Article : Google Scholar : PubMed/NCBI
|
|
30
|
Choi J, Batchu VV, Schubert M, Castellani
RJ and Russell JW: A novel PGC-1alpha isoform in brain localizes to
mitochondria and associates with PINK1 and VDAC. Biochem Biophys
Res Commun. 435:671–677. 2013. View Article : Google Scholar : PubMed/NCBI
|
|
31
|
Kehrer JP, Biswal SS, La E, Thuillier P,
Datta K, Fischer SM and Vanden HJ: Inhibition of
peroxisome-proliferator-activated receptor (PPAR)alpha by MK886.
Biochem J. 356:899–906. 2001. View Article : Google Scholar : PubMed/NCBI
|
|
32
|
Pascual F and Coleman RA: Fuel
availability and fate in cardiac metabolism: A tale of two
substrates. Biochim Biophys Acta. 1861:1425–1433. 2016. View Article : Google Scholar : PubMed/NCBI
|
|
33
|
Beca S, Ahmad F, Shen W, Liu J, Makary S,
Polidovitch N, Sun J, Hockman S, Chung YW, Movsesian M, et al:
Phosphodiesterase type 3A regulates basal myocardial contractility
through interacting with sarcoplasmic reticulum calcium ATPase type
2a signaling complexes in mouse heart. Circ Res. 112:289–297. 2013.
View Article : Google Scholar : PubMed/NCBI
|
|
34
|
Chang JS and Ha K: An unexpected role for
the transcriptional coactivator isoform NT-PGC-1alpha in the
regulation of mitochondrial respiration in brown adipocytes. J Biol
Chem. 292:9958–9966. 2017. View Article : Google Scholar : PubMed/NCBI
|
|
35
|
Villena JA: New insights into PGC-1
coactivators: Redefining their role in the regulation of
mitochondrial function and beyond. FEBS J. 282:647–672. 2015.
View Article : Google Scholar : PubMed/NCBI
|
