The effects of hyperoxia liquid regulate cardiopulmonary bypass‑induced myocardial damage through the Nrf2‑ARE signaling pathway

  • Authors:
    • Xiaochun Ma
    • Bin Hu
    • Chengwei Zou
    • Aiguo Han
    • Zhenqiang Xu
    • Tao Zhang
    • Wancheng Yu
  • View Affiliations

  • Published online on: June 14, 2018     https://doi.org/10.3892/mmr.2018.9162
  • Pages: 2342-2348
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Abstract

The aim of the present study was to investigate the protective role of hyperoxia liquid in regulating cardiopulmonary bypass (CPB)‑induced myocardial damage and its possible underlying mechanism. In the CPB‑induced rat model, hyperoxia liquid enhanced left ventricular ejection fraction (LVEF), reduced the left ventricular internal dimension systole (LVIDs) level, inhibited malondialdehyde levels, increased superoxide dismutase, glutathione (GSH) and GSH peroxidase levels, suppressed heart cell apoptosis, and induced the nuclear factor erythroid 2‑related factor 2 (Nrf2) and heme oxygenase‑1 (HO‑1) signaling pathway. Then, ML385, a Nrf2 inhibitor, was used to attenuate the effect of hyperoxia liquid on LVEF and LVIDs levels, oxidative stress and heart cell apoptosis in the CPB‑induced rat model. Collectively, the results of the present study demonstrated that the protective role of hyperoxia liquid may regulate oxidative stress in a CPB‑induced rat model through the Nrf2‑antioxidant response element signaling pathway.
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August-2018
Volume 18 Issue 2

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Spandidos Publications style
Ma X, Hu B, Zou C, Han A, Xu Z, Zhang T and Yu W: The effects of hyperoxia liquid regulate cardiopulmonary bypass‑induced myocardial damage through the Nrf2‑ARE signaling pathway. Mol Med Rep 18: 2342-2348, 2018
APA
Ma, X., Hu, B., Zou, C., Han, A., Xu, Z., Zhang, T., & Yu, W. (2018). The effects of hyperoxia liquid regulate cardiopulmonary bypass‑induced myocardial damage through the Nrf2‑ARE signaling pathway. Molecular Medicine Reports, 18, 2342-2348. https://doi.org/10.3892/mmr.2018.9162
MLA
Ma, X., Hu, B., Zou, C., Han, A., Xu, Z., Zhang, T., Yu, W."The effects of hyperoxia liquid regulate cardiopulmonary bypass‑induced myocardial damage through the Nrf2‑ARE signaling pathway". Molecular Medicine Reports 18.2 (2018): 2342-2348.
Chicago
Ma, X., Hu, B., Zou, C., Han, A., Xu, Z., Zhang, T., Yu, W."The effects of hyperoxia liquid regulate cardiopulmonary bypass‑induced myocardial damage through the Nrf2‑ARE signaling pathway". Molecular Medicine Reports 18, no. 2 (2018): 2342-2348. https://doi.org/10.3892/mmr.2018.9162