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Spleen tyrosine kinase promotes NLR family pyrin domain containing 3 inflammasome‑mediated IL‑1β secretion via c‑Jun N‑terminal kinase activation and cell apoptosis during diabetic nephropathy

  • Authors:
    • Yingchun Qiao
    • Xixi Tian
    • Li Men
    • Shengyu Li
    • Yufeng Chen
    • Meiting Xue
    • Yahui Hu
    • Pengfei Zhou
    • Guangfeng Long
    • Yue Shi
    • Ruiqing Liu
    • Yunde Liu
    • Zhi Qi
    • Yujie Cui
    • Yanna Shen
  • View Affiliations / Copyright

    Affiliations: School of Medical Laboratory, Tianjin Medical University, Tianjin 300203, P.R. China, Department of Histology and Embryology, School of Medicine, Nankai University, Tianjin 300071, P.R. China
    Copyright: © Qiao et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 1995-2008
    |
    Published online on: June 14, 2018
       https://doi.org/10.3892/mmr.2018.9164
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Abstract

Diabetic nephropathy (DN) is a serious complication of diabetes and can cause an increased mortality risk. It was previously reported that NLR family pyrin domain containing 3 (NLRP3) inflammasome is involved in the pathogenesis of diabetes. However, the underlying mechanism is not clearly understood. In the present study, the effects of spleen tyrosine kinase (Syk) and c‑Jun N‑terminal kinase (JNK) on the NLRP3 inflammasome were examined in vivo and in vitro. Sprague‑Dawley rats were injected intraperitoneally with streptozotocin (65 mg/kg) to induce diabetes. HK2 cells and rat glomerular mesangial cells (RGMCs) were examined to detect the expression of JNK and NLRP3 inflammasome‑associated proteins following treatment with a Syk inhibitor or Syk‑small interfering (si)RNA in a high glucose condition. In the present study, it was revealed that the protein and mRNA expression levels of NLRP3 inflammasome‑associated molecules and the downstream mature interleukin (IL)‑1β were upregulated in vivo and in vitro. The Syk inhibitor and Syk‑siRNA suppressed high glucose‑induced JNK activation, and subsequently downregulated the activation of the NLRP3 inflammasome and mature IL‑1β in HK2 cells and RGMCs. Furthermore, high glucose‑induced apoptosis of HK2 cells was reduced by the Syk inhibitor BAY61‑3606. Therefore, the present results determined that high glucose‑induced activation of the NLRP3 inflammasome is mediated by Syk/JNK activation, which subsequently increased the protein expression level of IL‑1β and mature IL‑1β. The present study identified that the Syk/JNK/NLRP3 signaling pathway may serve a vital role in the pathogenesis of DN.
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View References

1 

Wang YW, Wang YG, Luo MY, Wu H, Kong LL, Xin Y, Cui WP, Zhao YJ, Wang JY, Liang G, et al: Novel curcumin analog C66 prevents diabetic nephropathy via JNK pathway with the involvement of p300/CBP-mediated histone acetylation. Biochim Biophys Acta. 1852:34–46. 2015. View Article : Google Scholar : PubMed/NCBI

2 

Sun XY, Qin HJ, Zhang Z, Xu Y, Yang XC, Zhao DM, Li XN and Sun LK: Valproate attenuates diabetic nephropathy through inhibition of endoplasmic reticulum stress-induced apoptosis. Mol Med Rep. 13:661–668. 2016. View Article : Google Scholar : PubMed/NCBI

3 

Gao C, Huang W, Kanasaki K and Xu Y: The role of ubiquitination and sumoylation in diabetic nephropathy. Biomed Res Int. 2014:1606922014. View Article : Google Scholar : PubMed/NCBI

4 

Prasad N, Gupta P, Jain M, Bhadauria D, Gupta A, Sharma RK and Kaul A: Outcomes of De Novo allograft diabetic nephropathy in renal allograft recipients. Exp Clin Transplant. 11:215–221. 2013. View Article : Google Scholar : PubMed/NCBI

5 

Samra YA, Said HS, Elsherbiny NM, Liou GI, El-Shishtawy MM and Eissa LA: Cepharanthine and Piperine ameliorate diabetic nephropathy inrats:role of NF-κB and NLRP3 inflammasome. Life Sciences. 157:187–199. 2016. View Article : Google Scholar : PubMed/NCBI

6 

Stryker LS: Modifying risk factors: Strategies that work diabetes mellitus. J Arthroplasty. 31:1625–1627. 2016. View Article : Google Scholar : PubMed/NCBI

7 

Hara H, Kohsuke Tsuchiya, Kawamura I, Fang RD, Cuellar EH, Shen YN, Mizuguchi J, Schweighoffer E, Tybulewicz V and Masao Mitsuyama: Phosphorylation of ASC acts as a molecular switch controlling the formation of speck-like aggregates and inflammasome activity. Nat Immunol. 14:1247–1255. 2013. View Article : Google Scholar : PubMed/NCBI

8 

Wada J and Makino H: Inflammation and the pathogenesis of diabetic nephropathy. Clin Sci (Lond). 124:139–152. 2013. View Article : Google Scholar : PubMed/NCBI

9 

Wang C, Pan Y, Zhang QY, Wang FM and Kong LD: Quercetin and allopurinol ameliorate kidney injury in STZ-treated rats with regulation of renal NLRP3 inflammasome activation and lipid accumulation. PLoS One. 7:e382852012. View Article : Google Scholar : PubMed/NCBI

10 

Keller M, Rüegg A, Werner S and Beer HD: Active caspase-1 is a regulator of unconventional protein secretion. Cell. 132:818–831. 2007. View Article : Google Scholar

11 

Okada M, Matsuzawa A, Yoshimura A and Ichijo H: The lysosome rupture-activated TAK1-JNK pathway regulates NLRP3 inflammasome activation. J Biol Chem. 289:32926–32936. 2014. View Article : Google Scholar : PubMed/NCBI

12 

Yang WS, Chang JW, Han NJ, Lee SK and Park SK: Spleen tyrosine kinase mediates high glucose-induced transforming growth factor-β1 up-regulation in proximal tubular epithelial cells. Exp Cell Res. 318:1867–1876. 2012. View Article : Google Scholar : PubMed/NCBI

13 

Ryan MJ, Johnson G, Kirk J, Fuerstenberg SM, Zager RA and Torok-Seorb B: HK-2: An immortalized proximal tubule epithelial cell line from normal adult human kidney. Kidney Int. 45:48–57. 1994. View Article : Google Scholar : PubMed/NCBI

14 

Gennero I, Fauvel J, Nieto M, Cariven C, Gaits F, Briand-Mésange F, Chap H and Salles JP: Apoptotic effect of sphingosine 1-phosphate and increased sphingosine 1-phosphate hydrolysis on mesangial cells cultured at low cell density. J Biol Chem. 277:12724–12734. 2002. View Article : Google Scholar : PubMed/NCBI

15 

Elsherbiny NM and Al-Gayyar MM: The role of IL-18 in type 1 diabetic nephropathy: The problem and future treatment. Cytokine. 81:15–22. 2016. View Article : Google Scholar : PubMed/NCBI

16 

Qian X, Li XH, Ma FF, Luo SS, Ge RW and Zhu YZ: Novel hydrogen sulfide-releasing compound, S-propargyl-cysteine, prevents STZ-induced diabetic nephropathy. Biochem Biophys Res Commun. 473:931–938. 2016. View Article : Google Scholar : PubMed/NCBI

17 

Pan Y, Zhang XH, Wang Y, Cai L, Ren LQ, Tang LG, Wang JY, Zhao YJ, Wang YG, Liu Q, et al: Targeting JNK by a new curcumin analog to inhibit NF-κB-mediated expression of cell adhesion molecules attenuates renal macrophage infiltration and injury in diabetic mice. PLoS ONE. 8:e790842013. View Article : Google Scholar : PubMed/NCBI

18 

Jun W and Hirofumi M: Inflammation and the pathogenesis of diabetic Nephropathy. Clin Sci (Lond). 124:139–152. 2013. View Article : Google Scholar : PubMed/NCBI

19 

Kim SM, Lee SH, Kim YG, Kim SY, Seo JW, Choi YW, Kim DJ, Jeong KH, Lee TW, Ihm CG, et al: Hyperuricemia-induced NLRP3 activation of macrophages contributes to the progression of diabetic nephropathy. Am J Physiol Renal Physiol. 308:F993–F1003. 2015. View Article : Google Scholar : PubMed/NCBI

20 

Kanellis J, Ma FY, Kandane-Rathnayake R, Dowling JP, Polkinghorne KR, Bennett BL, Friedman GC and Nikolic-Paterson DJ: JNK signaling in human and experimental renal ischaemia/reperfusion injury. Nephrol Dial Transplant. 25:2898–2908. 2010. View Article : Google Scholar : PubMed/NCBI

21 

Feng H, Gu JL, Gou F, Huang W, Gao CL, Chen G, Long Y, Zhou XQ, Yang MJ, Liu S, et al: High glucose and lipopolysaccharide prime NLRP3 inflammasome via ROS/TXNIP pathway in mesangial cells. J Diabetes Res. 2016:69731752016. View Article : Google Scholar : PubMed/NCBI

22 

Ryan J, Ma FY, Kanellis J, Delgado M, Blease K and Nikolic-Paterson DJ: Spleen tyrosine kinase promotes acute neutrophil-mediated glomerular injury via activation of JNK and p38 MAPK in rat nephrotoxic serum nephritis. Lab Invest. 91:1727–1738. 2011. View Article : Google Scholar : PubMed/NCBI

23 

Lee CK, Yang Y, Chen C and Liu J: Syk-mediated tyrosine phosphorylation of Mule promotes TNF-induced JNK activation and cell death. Oncogene. 35:1988–1995. 2016. View Article : Google Scholar : PubMed/NCBI

24 

Wu HM, Fang L, Shen QY and Liu RY: SP600125 promotes resolution of allergic airway inflammation via TLR9 in an OVA-induced murine acute asthma model. Mol Immunol. 67:311–316. 2015. View Article : Google Scholar : PubMed/NCBI

25 

Shen H, Wu N, Wang Y, Han X, Zheng Q, Cai X, Zhang H and Zhao M: JNK inhibitor SP600125 attenuates paraquat-induced acute lung injury: An in vivo and in vitro study. Inflammation. 40:1319–1330. 2017. View Article : Google Scholar : PubMed/NCBI

26 

Long AJ, Sampson E, McCarthy RW, Harris CM, Barnard M, Shi D, Conlon D, Caldwell R, Honor D, Wishart N, et al: Syk Inhibition induces platelet dependent peri-islet hemorrhage in the rat pancreas. Toxicol Pathol. 44:998–1012. 2016. View Article : Google Scholar : PubMed/NCBI

27 

Llop-Guevara A, Porras M, Cendón C, Di Ceglie I, Siracusa F, Madarena F, Rinotas V, Gómez L, van Lent PL, Douni E, et al: Simultaneous inhibition of JAK and SYK kinases ameliorates chronic and destructive arthritis in mice. Arthritis Res Ther. 17:3562015. View Article : Google Scholar : PubMed/NCBI

28 

Fu Y, Wang C, Zhang D, Xin Y, Li J, Zhang Y and Chu X: Increased TRPC6 expression is associated with tubular epithelial cell proliferation and inflammation in diabetic nephropathy. Mol Immunol. 94:75–81. 2018. View Article : Google Scholar : PubMed/NCBI

29 

Chen P, Yuan Y, Zhang Ty, Xu B, Gao Q and Guan TJ: Pentosan polysulfate ameliorates apoptosis and inflammation by suppressing activation of the p38 MAPK pathway in high glucose-treated HK2 cells. Int J Mol Med. 41:908–914. 2018.PubMed/NCBI

30 

Li J, Bao L, Zha D, Zhang L, Gao P, Zhang J and Wu X: Oridonin protects against the inflammatory response in diabetic nephropathy by inhibiting the TLR4/p38-MAPK and TLR4/NF-κB signaling pathways. Int Immunopharmacol. 55:9–19. 2018. View Article : Google Scholar : PubMed/NCBI

31 

Yang J, Kan M and Wu GY: Bergenin ameliorates diabetic nephropathy in rats via suppressing renal inflammation and TGF-β1-Smads pathway. Immunopharmacol Immunotoxicol. 38:145–152. 2016. View Article : Google Scholar : PubMed/NCBI

32 

Yang WS, Kim JS, Han NJ, Lee MJ and Park SK: Toll-like receptor 4/spleen tyrosine kinase complex in high glucose signal transduction of proximal tubular epithelial cells. Cell Physiol Biochem. 35:2309–2319. 2015. View Article : Google Scholar : PubMed/NCBI

33 

Wang S, Yang Z, Xiong F, Chen C, Chao X, Huang J and Huang H: Betulinic acid ameliorates experimental diabetic-induced renal inflammation and fibrosis via inhibiting the activation of NF-κB signaling pathway. Mol Cell Endocrinol. 434:135–143. 2016. View Article : Google Scholar : PubMed/NCBI

34 

Yang WS, Seo JW, Han NJ, Choi J, Lee KU, Ahn H, Lee SK and Park SK: High glucose-induced NF-kappaB activation occurs via tyrosine phosphorylation of IkappaBaplha in human glomerular endothelial cells: Involvement of Syk tyrosine kinase. Am J Physiol Renal Physio. 1294:F1065–F1075. 2008. View Article : Google Scholar

35 

Qi W, Niu J, Qin Q, Qiao Z and Gu Y: Glycated albumin triggers fibrosis and apoptosis via an NADPH oxidase/Nox4-MAPK pathway-dependent mechanism in renal proximal tubular cells. Mol Cell Endocrinol. 405:74–83. 2015. View Article : Google Scholar : PubMed/NCBI

36 

Wei MM, Li ZG, Xiao L and Yang Z: Effects of ROS-relative NF-κB signaling on high glucose-induced TLR4 and MCP-1 expression in podocyte injury. Mol Immunol. 68:261–271. 2015. View Article : Google Scholar : PubMed/NCBI

37 

Zhang LY, Pang SS, Deng B, Qian LH, Chen J, Zou JJ, Zheng JY, Yang LH, Zhang CY, Chen XF, et al: High glucose induces renal mesangial cell proliferation and fibronectin expression through JNK/NF-NF-κB/NADPH oxidase/ROS pathway, which is inhibited by resveratrol. Int J Biochem Cell Biol. 44:629–638. 2012. View Article : Google Scholar : PubMed/NCBI

38 

Devi TS, Lee I, Hüttemann M, Kumar A, Nantwi KD and Singh LP: TXNIP links innate host defense mechanisms to oxidative stress and inflammation in retinal muller glia under chronic hyperglycemia: Implications for diabetic retinopathy. Exp Diabetes Res. 2012:4382382012. View Article : Google Scholar : PubMed/NCBI

39 

Tan SM, Zhang Y, Cox AJ, Kelly DJ and Qi WE: Tranilast attenuates the up-regulation of thioredoxin-interacting protein and oxidative stress in an experimental model of diabetic nephropathy. Nephrol Dial Transpl. 26:100–110. 2011. View Article : Google Scholar

40 

Shi JJ, Zhao Y, Wang K, Shi XY, Wang Y, Huang HW, Zhuang YH, Cai T, Wang FC and Shao F: Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death. Nature. 526:660–676. 2015. View Article : Google Scholar : PubMed/NCBI

41 

Liu ZJ, Lu Gan, Xu YT, Luo D, Ren Q, Song Wu S and Sun C: Melatonin alleviates inflammasome-induced pyroptosis through inhibiting NF-κB/GSDMD signal in mice adipose tissue. J Pineal Res. 63:2017. View Article : Google Scholar

42 

Pal PB, Sinha K and Sil PC: Mangiferin attenuates diabetic nephropathy by inhibiting oxidative stress mediated signaling cascade, TNFα related and mitochondrial dependent apoptotic pathways in streptozotocin-induced diabetic rats. PLoS One. 9:e1072202014. View Article : Google Scholar : PubMed/NCBI

43 

Yao F, Li Z, Ehara T, Yang L, Wang D, Feng L, Zhang Y, Wang K, Shi Y, Duan H and Zhang L: Fatty acid-binding protein 4 mediates apoptosis via endoplasmic reticulum stress in mesangial cells of diabetic nephropathy. Mol Cell Endocrinol. 411:232–242. 2015. View Article : Google Scholar : PubMed/NCBI

44 

Wilcox RA, Sun DX, Novak A, Dogan A, Ansell SM and Feldman AL: Inhibition of Syk protein tyrosine kinase induces apoptosis and blocks proliferation in T-cell non-Hodgkin lymphoma cell lines. Leukemia. 24:229–232. 2010. View Article : Google Scholar : PubMed/NCBI

45 

Qiu Q, Yang C, Xiong W, Tahiri H, Payeur M, Superstein R, Carret AS, Hamel P, Ellezam B, Martin B, et al: SYK is a target of lymphocyte-derived microparticles in the induction of apoptosis of human retinoblastoma cells. Apoptosis. 20:1613–1622. 2015. View Article : Google Scholar : PubMed/NCBI

46 

Wang WH, Childress MO and Geahlen RL: Syk interacts with and phosphorylates nucleolin to stabilize Bcl-x(L) mRNA and promote cell survival. Mol Cell Biol. 34:3788–3799. 2014. View Article : Google Scholar : PubMed/NCBI

47 

Gobessi S, Laurenti L, Longo PG, Carsetti L, Berno V, Sica S, Leone G and Efremov DG: Inhibition of constitutive and BCR-induced Syk activation downregulates Mcl-1 and induces apoptosis in chronic lymphocytic leukemia B cells. Leukemia. 23:686–697. 2009. View Article : Google Scholar : PubMed/NCBI

48 

Scheib JL, Sullivan CS and Carter BD: Jedi-1 and MEGF10 signal engulfment of apoptotic neurons through the tyrosine kinase Syk. J Neurosci. 32:13022–13031. 2012. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Qiao Y, Tian X, Men L, Li S, Chen Y, Xue M, Hu Y, Zhou P, Long G, Shi Y, Shi Y, et al: Spleen tyrosine kinase promotes NLR family pyrin domain containing 3 inflammasome‑mediated IL‑1β secretion via c‑Jun N‑terminal kinase activation and cell apoptosis during diabetic nephropathy. Mol Med Rep 18: 1995-2008, 2018.
APA
Qiao, Y., Tian, X., Men, L., Li, S., Chen, Y., Xue, M. ... Shen, Y. (2018). Spleen tyrosine kinase promotes NLR family pyrin domain containing 3 inflammasome‑mediated IL‑1β secretion via c‑Jun N‑terminal kinase activation and cell apoptosis during diabetic nephropathy. Molecular Medicine Reports, 18, 1995-2008. https://doi.org/10.3892/mmr.2018.9164
MLA
Qiao, Y., Tian, X., Men, L., Li, S., Chen, Y., Xue, M., Hu, Y., Zhou, P., Long, G., Shi, Y., Liu, R., Liu, Y., Qi, Z., Cui, Y., Shen, Y."Spleen tyrosine kinase promotes NLR family pyrin domain containing 3 inflammasome‑mediated IL‑1β secretion via c‑Jun N‑terminal kinase activation and cell apoptosis during diabetic nephropathy". Molecular Medicine Reports 18.2 (2018): 1995-2008.
Chicago
Qiao, Y., Tian, X., Men, L., Li, S., Chen, Y., Xue, M., Hu, Y., Zhou, P., Long, G., Shi, Y., Liu, R., Liu, Y., Qi, Z., Cui, Y., Shen, Y."Spleen tyrosine kinase promotes NLR family pyrin domain containing 3 inflammasome‑mediated IL‑1β secretion via c‑Jun N‑terminal kinase activation and cell apoptosis during diabetic nephropathy". Molecular Medicine Reports 18, no. 2 (2018): 1995-2008. https://doi.org/10.3892/mmr.2018.9164
Copy and paste a formatted citation
x
Spandidos Publications style
Qiao Y, Tian X, Men L, Li S, Chen Y, Xue M, Hu Y, Zhou P, Long G, Shi Y, Shi Y, et al: Spleen tyrosine kinase promotes NLR family pyrin domain containing 3 inflammasome‑mediated IL‑1β secretion via c‑Jun N‑terminal kinase activation and cell apoptosis during diabetic nephropathy. Mol Med Rep 18: 1995-2008, 2018.
APA
Qiao, Y., Tian, X., Men, L., Li, S., Chen, Y., Xue, M. ... Shen, Y. (2018). Spleen tyrosine kinase promotes NLR family pyrin domain containing 3 inflammasome‑mediated IL‑1β secretion via c‑Jun N‑terminal kinase activation and cell apoptosis during diabetic nephropathy. Molecular Medicine Reports, 18, 1995-2008. https://doi.org/10.3892/mmr.2018.9164
MLA
Qiao, Y., Tian, X., Men, L., Li, S., Chen, Y., Xue, M., Hu, Y., Zhou, P., Long, G., Shi, Y., Liu, R., Liu, Y., Qi, Z., Cui, Y., Shen, Y."Spleen tyrosine kinase promotes NLR family pyrin domain containing 3 inflammasome‑mediated IL‑1β secretion via c‑Jun N‑terminal kinase activation and cell apoptosis during diabetic nephropathy". Molecular Medicine Reports 18.2 (2018): 1995-2008.
Chicago
Qiao, Y., Tian, X., Men, L., Li, S., Chen, Y., Xue, M., Hu, Y., Zhou, P., Long, G., Shi, Y., Liu, R., Liu, Y., Qi, Z., Cui, Y., Shen, Y."Spleen tyrosine kinase promotes NLR family pyrin domain containing 3 inflammasome‑mediated IL‑1β secretion via c‑Jun N‑terminal kinase activation and cell apoptosis during diabetic nephropathy". Molecular Medicine Reports 18, no. 2 (2018): 1995-2008. https://doi.org/10.3892/mmr.2018.9164
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