Peroxiredoxin I deficiency increases LPS‑induced lethal shock in mice

  • Authors:
    • Hu‑Nan Sun
    • Li Feng
    • Ai‑Guo Wang
    • Jing‑Yu Wang
    • Lei Liu
    • Mei‑Hua Jin
    • Gui‑Nan Shen
    • Cheng‑Hao Jin
    • Dong‑Soek Lee
    • Tae‑Ho Kwon
    • Yu‑Dong Cui
    • Dae‑Yeul Yu
    • Ying‑Hao Han
  • View Affiliations

  • Published online on: June 14, 2018     https://doi.org/10.3892/mmr.2018.9170
  • Pages: 2427-2432
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Abstract

Peroxiredoxin I (Prx I) plays a role in regulating macrophage proinflammatory cytokine production and gene expression and participates in immune regulation. However, the possible protective role of Prx I in endotoxin‑induced lethal shock is poorly understood. In the present study, western blot analysis, ELISA and haematoxylin and eosin staining were performed to examine the protein expression of cytoines and analyses the levels of cytokines in the serum and tissue to evaluate the tissue damage. The present study revealed that lipopolysaccharide (LPS)‑induced lethality in Prx I‑/‑ mice was is accelerated via the observed decreased serum IL‑10 levels. Results also demonstrated rapid immune cell infiltration and oxidative stress in the Prx I‑/‑mice liver after LPS injections. These phenomena increased liver apoptosis through increasing cleaved caspase‑3 protein expression in Prx I‑/‑ mice after LPS injections, resulting in high lethality after LPS challenges. These findings provide a new insight for understanding the function of Prx I against endotoxin‑induced injury.
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August-2018
Volume 18 Issue 2

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Spandidos Publications style
Sun HN, Feng L, Wang AG, Wang JY, Liu L, Jin MH, Shen GN, Jin CH, Lee DS, Kwon TH, Kwon TH, et al: Peroxiredoxin I deficiency increases LPS‑induced lethal shock in mice. Mol Med Rep 18: 2427-2432, 2018
APA
Sun, H., Feng, L., Wang, A., Wang, J., Liu, L., Jin, M. ... Han, Y. (2018). Peroxiredoxin I deficiency increases LPS‑induced lethal shock in mice. Molecular Medicine Reports, 18, 2427-2432. https://doi.org/10.3892/mmr.2018.9170
MLA
Sun, H., Feng, L., Wang, A., Wang, J., Liu, L., Jin, M., Shen, G., Jin, C., Lee, D., Kwon, T., Cui, Y., Yu, D., Han, Y."Peroxiredoxin I deficiency increases LPS‑induced lethal shock in mice". Molecular Medicine Reports 18.2 (2018): 2427-2432.
Chicago
Sun, H., Feng, L., Wang, A., Wang, J., Liu, L., Jin, M., Shen, G., Jin, C., Lee, D., Kwon, T., Cui, Y., Yu, D., Han, Y."Peroxiredoxin I deficiency increases LPS‑induced lethal shock in mice". Molecular Medicine Reports 18, no. 2 (2018): 2427-2432. https://doi.org/10.3892/mmr.2018.9170