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Article

Peroxiredoxin I deficiency increases LPS‑induced lethal shock in mice

  • Authors:
    • Hu‑Nan Sun
    • Li Feng
    • Ai‑Guo Wang
    • Jing‑Yu Wang
    • Lei Liu
    • Mei‑Hua Jin
    • Gui‑Nan Shen
    • Cheng‑Hao Jin
    • Dong‑Soek Lee
    • Tae‑Ho Kwon
    • Yu‑Dong Cui
    • Dae‑Yeul Yu
    • Ying‑Hao Han
  • View Affiliations / Copyright

    Affiliations: College of Life Science and Technology, Heilongjiang Bayi Agricultural University, Daqing, Heilongjiang 163319, P.R. China, Laboratory Animal Center, Dalian Medical University, Dalian, Liaoning 116044, P.R. China, Phamaron Beijing Co., Ltd., Beijing 100176, P.R. China, School of Life Sciences, KNU Creative BioResearch Group (BK21 Plus Project), Kyungpook National University, Daegu 702‑701, Republic of Korea, Laboratory of Animal Genetic Engineering and Stem Cell Biology, Department of Animal Biotechnology, Faculty of Biotechnology, Jeju National University, Jeju 63243, Republic of Korea, Aging Intervention Research Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon, Chungcheongnam 34141, Republic of Korea
  • Pages: 2427-2432
    |
    Published online on: June 14, 2018
       https://doi.org/10.3892/mmr.2018.9170
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Abstract

Peroxiredoxin I (Prx I) plays a role in regulating macrophage proinflammatory cytokine production and gene expression and participates in immune regulation. However, the possible protective role of Prx I in endotoxin‑induced lethal shock is poorly understood. In the present study, western blot analysis, ELISA and haematoxylin and eosin staining were performed to examine the protein expression of cytoines and analyses the levels of cytokines in the serum and tissue to evaluate the tissue damage. The present study revealed that lipopolysaccharide (LPS)‑induced lethality in Prx I‑/‑ mice was is accelerated via the observed decreased serum IL‑10 levels. Results also demonstrated rapid immune cell infiltration and oxidative stress in the Prx I‑/‑mice liver after LPS injections. These phenomena increased liver apoptosis through increasing cleaved caspase‑3 protein expression in Prx I‑/‑ mice after LPS injections, resulting in high lethality after LPS challenges. These findings provide a new insight for understanding the function of Prx I against endotoxin‑induced injury.
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Copy and paste a formatted citation
Spandidos Publications style
Sun HN, Feng L, Wang AG, Wang JY, Liu L, Jin MH, Shen GN, Jin CH, Lee DS, Kwon TH, Kwon TH, et al: Peroxiredoxin I deficiency increases LPS‑induced lethal shock in mice. Mol Med Rep 18: 2427-2432, 2018.
APA
Sun, H., Feng, L., Wang, A., Wang, J., Liu, L., Jin, M. ... Han, Y. (2018). Peroxiredoxin I deficiency increases LPS‑induced lethal shock in mice. Molecular Medicine Reports, 18, 2427-2432. https://doi.org/10.3892/mmr.2018.9170
MLA
Sun, H., Feng, L., Wang, A., Wang, J., Liu, L., Jin, M., Shen, G., Jin, C., Lee, D., Kwon, T., Cui, Y., Yu, D., Han, Y."Peroxiredoxin I deficiency increases LPS‑induced lethal shock in mice". Molecular Medicine Reports 18.2 (2018): 2427-2432.
Chicago
Sun, H., Feng, L., Wang, A., Wang, J., Liu, L., Jin, M., Shen, G., Jin, C., Lee, D., Kwon, T., Cui, Y., Yu, D., Han, Y."Peroxiredoxin I deficiency increases LPS‑induced lethal shock in mice". Molecular Medicine Reports 18, no. 2 (2018): 2427-2432. https://doi.org/10.3892/mmr.2018.9170
Copy and paste a formatted citation
x
Spandidos Publications style
Sun HN, Feng L, Wang AG, Wang JY, Liu L, Jin MH, Shen GN, Jin CH, Lee DS, Kwon TH, Kwon TH, et al: Peroxiredoxin I deficiency increases LPS‑induced lethal shock in mice. Mol Med Rep 18: 2427-2432, 2018.
APA
Sun, H., Feng, L., Wang, A., Wang, J., Liu, L., Jin, M. ... Han, Y. (2018). Peroxiredoxin I deficiency increases LPS‑induced lethal shock in mice. Molecular Medicine Reports, 18, 2427-2432. https://doi.org/10.3892/mmr.2018.9170
MLA
Sun, H., Feng, L., Wang, A., Wang, J., Liu, L., Jin, M., Shen, G., Jin, C., Lee, D., Kwon, T., Cui, Y., Yu, D., Han, Y."Peroxiredoxin I deficiency increases LPS‑induced lethal shock in mice". Molecular Medicine Reports 18.2 (2018): 2427-2432.
Chicago
Sun, H., Feng, L., Wang, A., Wang, J., Liu, L., Jin, M., Shen, G., Jin, C., Lee, D., Kwon, T., Cui, Y., Yu, D., Han, Y."Peroxiredoxin I deficiency increases LPS‑induced lethal shock in mice". Molecular Medicine Reports 18, no. 2 (2018): 2427-2432. https://doi.org/10.3892/mmr.2018.9170
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