miR‑590‑5p suppresses osteosarcoma cell proliferation and invasion via targeting KLF5

  • Authors:
    • Wei Cai
    • Yong Xu
    • Jian Yin
    • Wenshan Zuo
    • Zhen Su
  • View Affiliations

  • Published online on: June 15, 2018     https://doi.org/10.3892/mmr.2018.9173
  • Pages: 2328-2334
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Abstract

Recently, microRNA (miR)‑590‑5p has been shown to inhibit tumorigenesis in colorectal and breast cancer; however, its function in osteosarcoma (OS) requires further investigation. In the present study miR‑590‑5p expression was poorly expressed in OS samples and cell lines when compared with that observed in normal cells. In addition, overexpression of miR‑590‑5p significantly reduced the proliferation, migration and invasion of SAOS2 and U2OS cells in vitro, as well as inhibiting tumor sizes in vivo. The results revealed that miR‑590‑5p directly targeted Kruppel‑like factor 5 (KLF5) in SAOS2 and U2OS cells. Their expression was inversely correlated with OS tissues. Finally, it was demonstrated that overexpression of KLF5 rescued the inhibitory effects of miR‑590‑5p on cell proliferation, migration and invasion. Overall, the results of the present study suggested that the miR‑590‑5p/KLF5 axis may regulate OS progression and thus, may be a novel therapeutic target for the treatment of patients with OS.

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August 2018
Volume 18 Issue 2

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APA
Cai, W., Xu, Y., Yin, J., Zuo, W., & Su, Z. (2018). miR‑590‑5p suppresses osteosarcoma cell proliferation and invasion via targeting KLF5. Molecular Medicine Reports, 18, 2328-2334. https://doi.org/10.3892/mmr.2018.9173
MLA
Cai, W., Xu, Y., Yin, J., Zuo, W., Su, Z."miR‑590‑5p suppresses osteosarcoma cell proliferation and invasion via targeting KLF5". Molecular Medicine Reports 18.2 (2018): 2328-2334.
Chicago
Cai, W., Xu, Y., Yin, J., Zuo, W., Su, Z."miR‑590‑5p suppresses osteosarcoma cell proliferation and invasion via targeting KLF5". Molecular Medicine Reports 18, no. 2 (2018): 2328-2334. https://doi.org/10.3892/mmr.2018.9173