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Hydrogen‑rich solution against myocardial injury and aquaporin expression via the PI3K/Akt signaling pathway during cardiopulmonary bypass in rats

  • Authors:
    • Dandan Song
    • Xuelei Liu
    • Yugang Diao
    • Yingjie Sun
    • Guangjie Gao
    • Tiezheng Zhang
    • Keyan Chen
    • Ling Pei
  • View Affiliations / Copyright

    Affiliations: Department of Anesthesiology, The First Affiliated Hospital of China Medical University, Shenyang, Liaoning 110016, P.R. China, Department of Clinical Laboratory, General Hospital of Shenyang Military Area Command, Shenyang, Liaoning 110016, P.R. China, Department of Anesthesiology, General Hospital of Shenyang Military Area Command, Shenyang, Liaoning 110016, P.R. China, Department of Anesthesiology, The 463rd Hospital of People's Liberation Army China, Shenyang, Liaoning 110012, P.R. China, Department of Laboratory Animal Science, China Medical University, Shenyang, Liaoning 110122, P.R. China
    Copyright: © Song et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 1925-1938
    |
    Published online on: June 20, 2018
       https://doi.org/10.3892/mmr.2018.9198
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Abstract

Myocardial ischemia, hypoxia and reperfusion injury are induced by aortic occlusion, cardiac arrest and resuscitation during cardiopulmonary bypass (CPB), which can severely affect cardiac function. The aim of the present study was to investigate the effects of hydrogen‑rich solution (HRS) and aquaporin (AQP) on cardiopulmonary bypass (CPB)‑induced myocardial injury, and determine the mechanism of the phosphatidylinositol 3‑kinase (PI3K)/protein kinase B (Akt) signaling pathway. Sprague Dawley rats were divided into a sham operation group, a CPB surgery group and a HRS group. A CPB model was established, and the hemodynamic parameters were determined at the termination of CPB. The myocardial tissues were observed by hematoxylin and eosin, and Masson staining. The levels of myocardial injury markers [adult cardiac troponin I (cTnI), lactate dehydrogenase (LDH), creatine kinase MB (CK‑MB) and brain natriuretic peptide (BNP)], inflammatory factors [interleukin (IL)‑1β, IL‑6 and tumor necrosis factor‑α (TNF‑α)] and oxidative stress indicators [superoxide dismutase (SOD), malondialdehyde (MDA) and myeloperoxidase (MPO)] were determined by ELISA. Furthermore, H9C2 cells were treated with HRS following hypoxia/reoxygenation. Cell viability and cell apoptosis were investigated. The expression of apoptosis regulator Bcl‑2 (Bcl‑2), apoptosis regulator Bax (Bax), caspase 3, AQP‑1, AQP‑4, phosphorylated (p)‑Akt, heme oxygenase 1 (HO‑1) and nuclear factor erythroid 2‑related factor 2 (Nrf2) were investigated using western blotting and quantitative‑polymerase chain reaction of tissues and cells. Following CPB, myocardial cell arrangement was disordered, myocardial injury markers (cTnI, LDH, CK‑MB and BNP), inflammatory cytokines (IL‑1β, IL‑6 and TNF‑α) and MDA levels were significantly increased compared with the sham group; whereas the SOD levels were significantly downregulated following CPB compared with the sham group. HRS attenuated myocardial injury, reduced the expression levels of cTnI, LDH, CK‑MB, BNP, IL‑1β, IL‑6, TNF‑α, MDA and MPO, and increased SOD release. Levels of Bcl‑2, AQP‑1, AQP‑4, p‑Akt, HO‑1 and Nrf2 were significantly increased following HRS; whereas Bax and caspase‑3 expression levels were significantly reduced following CPB. HRS treatment significantly increased the viability of myocardial cells, reduced the rate of myocardial cell apoptosis and the release of MDA and LDH compared with the CPB group. A PI3K inhibitor (LY294002) was revealed to reverse the protective effect of HRS treatment. HRS was demonstrated to attenuate CPB‑induced myocardial injury, suppress AQP‑1 and AQP‑4 expression following CPB treatment and protect myocardial cells via the PI3K/Akt signaling pathway.
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View References

1 

Suleiman MS, Zacharowski K and Angelini GD: Inflammatory response and cardioprotection during open-heart surgery: The importance of anaesthetics. Br J Pharmacol. 153:21–33. 2008. View Article : Google Scholar : PubMed/NCBI

2 

Steuer J, Granath F, de Faire U, Ekbom A and Stahle E: Increased risk of heart failure as a consequence of perioperative myocardial injury after coronary artery bypass grafting. Heart. 91:754–758. 2005. View Article : Google Scholar : PubMed/NCBI

3 

De Hert S and Moerman A: Myocardial injury and protection related to cardiopulmonary bypass. Best Pract Res Clin Anaesthesiol. 29:137–149. 2015. View Article : Google Scholar : PubMed/NCBI

4 

Ohsawa I, Ishikawa M, Takahashi K, Watanabe M, Nishimaki K, Yamagata K, Katsura K, Katayama Y, Asoh S and Ohta S: Hydrogen acts as a therapeutic antioxidant by selectively reducing cytotoxic oxygen radicals. Nat Med. 13:688–694. 2007. View Article : Google Scholar : PubMed/NCBI

5 

Qian L, Li B, Cai J and Gao F: The hypothesis of an effective safe and novel radioprotective agent: Hydrogen-rich solution. West Indian Med J. 59:122–124. 2010.PubMed/NCBI

6 

Noda K, Shigemura N, Tanaka Y, Kawamura T, Lim Hyun S, Kokubo K, Billiar TR, Bermudez CA, Kobayashi H and Nakao A: A novel method of preserving cardiac grafts using a hydrogen-rich water bath. J Heart Lung Transplant. 32:241–250. 2013. View Article : Google Scholar : PubMed/NCBI

7 

Nagaraju GP, Basha R, Rajitha B, Alese OB, Alam A, Pattnaik S and El-Rayes B: Aquaporins: Their role in gastrointestinal malignancies. Cancer Lett. 373:12–18. 2016. View Article : Google Scholar : PubMed/NCBI

8 

Jonker S, Davis LE, van der Bilt JD, Hadder B, Hohimer AR, Giraud GD and Thornburg KL: Anaemia stimulates aquaporin 1 expression in the fetal sheep heart. Exp Physiol. 88:691–698. 2003. View Article : Google Scholar : PubMed/NCBI

9 

Ding FB, Yan YM, Huang JB, Mei J, Zhu JQ and Liu H: The involvement of AQP1 in heart oedema induced by global myocardial ischemia. Cell Biochem Funct. 31:60–64. 2013. View Article : Google Scholar : PubMed/NCBI

10 

Butler TL, Au CG, Yang B, Egan JR, Tan YM, Hardeman EC, North KN, Verkman AS and Winlaw DS: Cardiac aquaporin expression in humans, rats, and mice. Am J Physiol Heart Circ Physiol. 291:H705–H713. 2006. View Article : Google Scholar : PubMed/NCBI

11 

Rutkovskiy A, Stenslokken KO, Mariero LH, Skrbic B, Amiry-Moghaddam M, Hillestad V, Valen G, Perreault MC, Ottersen OP, Gullestad L, et al: Aquaporin-4 in the heart: Expression, regulation and functional role in ischemia. Basic Res Cardiol. 107:2802012. View Article : Google Scholar : PubMed/NCBI

12 

Chaudhuri S, Singh MK, Bhattacharya D, Datta A, Hazra I, Mondal S, Faruk Sk, Md O, Ronsard L, Ghosh TK and Chaudhuri S: T11TS immunotherapy repairs PI3K-AKT signaling in T-cells: Clues toward enhanced T-cell survival in rat glioma model. J Cell Physiol. 233:759–770. 2018. View Article : Google Scholar : PubMed/NCBI

13 

Zhu X, Huang H, Zhang J, Liu H, Ao R, Xiao M and Wu Y: The anticancer effects of Cucurbitacin I inhibited cell growth of human non-small cell lung cancer through PI3K/AKT/p70S6K pathway. Mol Med Rep. 17:2750–2756. 2018.PubMed/NCBI

14 

Zhang B, Liu Y, Li Y, Zhe X, Zhang S and Zhang L: Neuroglobin promotes the proliferation and suppresses the apoptosis of glioma cells by activating the PI3K/AKT pathway. Mol Med Rep. 17:2757–2763. 2018.PubMed/NCBI

15 

Wu MP, Zhang YS, Zhou QM, Xiong J, Dong YR and Yan C: Higenamine protects ischemia/reperfusion induced cardiac injury and myocyte apoptosis through activation of β2-AR/PI3K/AKT signaling pathway. Pharmacol Res. 104:115–123. 2016. View Article : Google Scholar : PubMed/NCBI

16 

Hu S, Zhang Y, Zhang M, Guo Y, Yang P, Zhang S, Simsekyilmaz S, Xu JF, Li J, Xiang X, et al: Aloperine protects mice against ischemia reperfusion (IR)-induced renal injury by regulating PI3K/AKT/mTOR signaling and AP-1 activity. Mol Med. Nov 3–2015.(Epub ahead of print). View Article : Google Scholar

17 

Yang C, Cao Y, Zhang Y, Li L, Xu M, Long Y, Rong R and Zhu T: Cyclic helix B peptide inhibits ischemia reperfusion-induced renal fibrosis via the PI3K/Akt/FoxO3a pathway. J Transl Med. 13:3552015. View Article : Google Scholar : PubMed/NCBI

18 

Sun Y, Jiang C, Jiang J and Qiu L: Dexmedetomidine protects mice against myocardium ischaemic/reperfusion injury by activating an AMPK/PI3K/Akt/eNOS pathway. Clin Exp Pharmacol Physiol. 44:946–953. 2017. View Article : Google Scholar : PubMed/NCBI

19 

Zhang J, Wu Q, Song S, Wan Y, Zhang R, Tai M and Liu C: Effect of hydrogen-rich water on acute peritonitis of rat models. Int Immunopharmacol. 21:94–101. 2014. View Article : Google Scholar : PubMed/NCBI

20 

Stark RA, Nahrwold ML and Cohen PJ: Blind oral tracheal intubation of rats. J Appl Physiol Respir Environ Exerc Physiol. 51:1355–1356. 1981.PubMed/NCBI

21 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

22 

Xu F, Yu H, Liu J and Cheng L: αB-crystallin regulates oxidative stress-induced apoptosis in cardiac H9c2 cells via the PI3K/AKT pathway. Mol Biol Rep. 40:2517–2526. 2013. View Article : Google Scholar : PubMed/NCBI

23 

Su D, Zhou Y, Hu S, Guan L, Shi C, Wang Q, Chen Y, Lu C, Li Q and Ma X: Role of GAB1/PI3K/AKT signaling high glucose-induced cardiomyocyte apoptosis. Biomed Pharmacother. 93:1197–1204. 2017. View Article : Google Scholar : PubMed/NCBI

24 

Chen K, Wang N, Diao Y, Dong W, Sun Y, Liu L and Wu X: Hydrogen-rich saline attenuates brain injury induced by cardiopulmonary bypass and inhibits microvascular endothelial cell apoptosis via the PI3K/Akt/GSK3β signaling pathway in rats. Cell Physiol Biochem. 43:1634–1647. 2017. View Article : Google Scholar : PubMed/NCBI

25 

Li J, Hong Z, Liu H, Zhou J, Cui L, Yuan S, Chu X and Yu P: Hydrogen-rich saline promotes the recovery of renal function after ischemia/reperfusion injury in rats via anti-apoptosis and anti-inflammation. Front Pharmacol. 7:1062016. View Article : Google Scholar : PubMed/NCBI

26 

Shigeta T, Sakamoto S, Li XK, Cai S, Liu C, Kurokawa R, Nakazawa A, Kasahara M and Uemoto S: Luminal injection of hydrogen-rich solution attenuates intestinal ischemia-reperfusion injury in rats. Transplantation. 99:500–507. 2015. View Article : Google Scholar : PubMed/NCBI

27 

Li T, Luo N, Du L, Zhou J, Zhang J, Gong L and Jiang N: Tumor necrosis factor-α plays an initiating role in extracorporeal circulation-induced acute lung injury. Lung. 191:207–214. 2013. View Article : Google Scholar : PubMed/NCBI

28 

Kim J, Yin T, Shinozaki K, Lampe JW and Becker LB: DHA-supplemented diet increases the survival of rats following asphyxia-induced cardiac arrest and cardiopulmonary bypass resuscitation. Sci Rep. 6:365452016. View Article : Google Scholar : PubMed/NCBI

29 

Cai DS, Jin BB, Pei L and Jin Z: Protective effects of penehyclidine hydrochloride on liver injury in a rat cardiopulmonary bypass model. Eur J Anaesthesiol. 27:824–828. 2010. View Article : Google Scholar : PubMed/NCBI

30 

Aregger F, Pilop C, Uehlinger DE, Brunisholz R, Carrel TP, Frey FJ and Frey BM: Urinary proteomics before and after extracorporeal circulation in patients with and without acute kidney injury. J Thorac Cardiovasc Surg. 139:692–700. 2010. View Article : Google Scholar : PubMed/NCBI

31 

Zhou J, Zhou N, Wu XN, Cao HJ, Sun YJ, Zhang TZ, Chen KY and Yu DM: Role of the Tolllike receptor 3 signaling pathway in the neuroprotective effect of sevoflurane pre-conditioning during cardiopulmonary bypass in rats. Mol Med Rep. 12:7859–7868. 2015. View Article : Google Scholar : PubMed/NCBI

32 

Peterss S, Guenther S, Kellermann K, Jungwirth B, Lichtinghagen R, Haverich A, Hagl C and Khaladj N: An experimental model of myocardial infarction and controlled reperfusion using a miniaturized cardiopulmonary bypass in rats. Interact Cardiovasc Thorac Surg. 19:561–566. 2014. View Article : Google Scholar : PubMed/NCBI

33 

Baehner T, Boehm O, Probst C, Poetzsch B, Hoeft A, Baumgarten G and Knuefermann P: Cardiopulmonary bypass in cardiac surgery. Anaesthesist. 61:846–856. 2012. View Article : Google Scholar : PubMed/NCBI

34 

Prondzinsky R, Knupfer A, Loppnow H, Redling F, Lehmann DW, Stabenow I, Witthaut R, Unverzagt S, Radke J, Zerkowski HR and Werdan K: Surgical trauma affects the proinflammatory status after cardiac surgery to a higher degree than cardiopulmonary bypass. J Thorac Cardiovasc Surg. 129:760–766. 2005. View Article : Google Scholar : PubMed/NCBI

35 

Balogh AL, Petak F, Fodor GH, Sudy R and Babik B: Sevoflurane relieves lung function deterioration after cardiopulmonary bypass. J Cardiothorac Vasc Anesth. 31:2017–2026. 2017. View Article : Google Scholar : PubMed/NCBI

36 

Tavener SA, Long EM, Robbins SM, McRae KM, Van Remmen H and Kubes P: Immune cell Toll-like receptor 4 is required for cardiac myocyte impairment during endotoxemia. Circ Res. 95:700–707. 2004. View Article : Google Scholar : PubMed/NCBI

37 

Liu WB, Han XH, Guo YY, Zhang DM, Tang FJ, Zhao L, Ji LL and Guo FM: Effects of tumor necrosis factor and E-selectin on coronary artery flow. Eur Rev Med Pharmacol Sci. 21:1843–1849. 2017.PubMed/NCBI

38 

Sadeghzadeh J, Vakili A, Bandegi AR, Sameni HR, Khorasani Zahedi M and Darabian M: Lavandula reduces heart injury via attenuating tumor necrosis factor-alpha and oxidative stress in a rat model of infarct-like myocardial injury. Cell J. 19:84–93. 2017.PubMed/NCBI

39 

Sonnino C, Christopher S, Oddi C, Toldo S, Falcao RA, Melchior RD, Mueller GH, Abouzaki NA, Varma A, Gambill ML, et al: Leukocyte activity in patients with ST-segment elevation acute myocardial infarction treated with anakinra. Mol Med. 20:486–489. 2014. View Article : Google Scholar : PubMed/NCBI

40 

Ikonomidis I, Athanassopoulos G, Lekakis J, Venetsanou K, Marinou M, Stamatelopoulos K, Cokkinos DV and Nihoyannopoulos P: Myocardial ischemia induces interleukin-6 and tissue factor production in patients with coronary artery disease: A dobutamine stress echocardiography study. Circulation. 112:3272–3279. 2005. View Article : Google Scholar : PubMed/NCBI

41 

Cui W, Gao C, Fang P, Lin G and Shen W: Alleviation of cadmium toxicity in Medicago sativa by hydrogen-rich water. J Hazard Mater. 260:715–724. 2013. View Article : Google Scholar : PubMed/NCBI

42 

Aoki K, Nakao A, Adachi T, Matsui Y and Miyakawa S: Pilot study: Effects of drinking hydrogen-rich water on muscle fatigue caused by acute exercise in elite athletes. Med Gas Res. 2:122012. View Article : Google Scholar : PubMed/NCBI

43 

Zhao S, Yang Y, Liu W, Xuan Z, Wu S, Yu S, Mei K, Huang Y, Zhang P, Cai J, et al: Protective effect of hydrogen-rich saline against radiation-induced immune dysfunction. J Cell Mol Med. 18:938–946. 2014. View Article : Google Scholar : PubMed/NCBI

44 

Takahashi M, Chen-Yoshikawa TF, Saito M, Tanaka S, Miyamoto E, Ohata K, Kondo T, Motoyama H, Hijiya K, Aoyama A and Date H: Immersing lungs in hydrogen-rich saline attenuates lung ischaemia-reperfusion injury. Eur J Cardiothorac Surg. 51:442–448. 2017.PubMed/NCBI

45 

Schulz-Menger J: Myocardial edema in acute ischemic injury. JACC Cardiovasc Imaging. 4:279–281. 2011. View Article : Google Scholar : PubMed/NCBI

46 

Rutkovskiy A, Valen G and Vaage J: Cardiac aquaporins. Basic Res Cardiol. 108:3932013. View Article : Google Scholar : PubMed/NCBI

47 

Netti VA, Vatrella MC, Chamorro MF, Rosón MI, Zotta E, Fellet AL and Balaszczuk AM: Comparison of cardiovascular aquaporin-1 changes during water restriction between 25- and 50-day-old rats. Eur J Nutr. 53:287–295. 2014. View Article : Google Scholar : PubMed/NCBI

48 

Rutkovskiy A, Bliksoen M, Hillestad V, Amin M, Czibik G, Valen G, Vaage J, Amiry-Moghaddam M and Stensløkken KO: Aquaporin-1 in cardiac endothelial cells is downregulated in ischemia, hypoxia and cardioplegia. J Mol Cell Cardiol. 56:22–33. 2013. View Article : Google Scholar : PubMed/NCBI

49 

Wu Y, Pan CY, Guo CZ, Dong ZJ, Wu Q, Dong HM and Zhang W: Expression of aquaporin 1 and 4 in rats with acute hypoxic lung injury and its significance. Genet Mol Res. 14:12756–12764. 2015. View Article : Google Scholar : PubMed/NCBI

50 

Tie L, Wang D, Shi Y and Li X: Aquaporins in cardiovascular system. Adv Exp Med Biol. 969:105–113. 2017. View Article : Google Scholar : PubMed/NCBI

51 

Zhang HZ, Kim MH, Lim JH and Bae HR: Time-dependent expression patterns of cardiac aquaporins following myocardial infarction. J Korean Med Sci. 28:402–408. 2013. View Article : Google Scholar : PubMed/NCBI

52 

Warth A, Eckle T, Kohler D, Faigle M, Zug S, Klingel K, Eltzschig HK and Wolburg H: Upregulation of the water channel aquaporin-4 as a potential cause of postischemic cell swelling in a murine model of myocardial infarction. Cardiology. 107:402–410. 2007. View Article : Google Scholar : PubMed/NCBI

53 

Tang Y, Li S, Zhang P, Zhu J, Meng G, Xie L, Yu Y, Ji Y and Han Y: Soy isoflavone protects myocardial ischemia/reperfusion injury through increasing endothelial nitric oxide synthase and decreasing oxidative stress in ovariectomized rats. Oxid Med Cell Longev. 2016:50574052016. View Article : Google Scholar : PubMed/NCBI

54 

Hong Y, Shao A, Wang J, Chen S, Wu H, McBride DW, Wu Q, Sun X and Zhang J: Neuroprotective effect of hydrogen-rich saline against neurologic damage and apoptosis in early brain injury following subarachnoid hemorrhage: Possible role of the Akt/GSK3β signaling pathway. PLoS One. 9:e962122014. View Article : Google Scholar : PubMed/NCBI

55 

Wu D, Liang M, Dang H, Fang F, Xu F and Liu C: Hydrogen protects against hyperoxia-induced apoptosis in type II alveolar epithelial cells via activation of PI3K/Akt/Foxo3a signaling pathway. Biochem Biophys Res Commun. 495:1620–1627. 2018. View Article : Google Scholar : PubMed/NCBI

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Song D, Liu X, Diao Y, Sun Y, Gao G, Zhang T, Chen K and Pei L: Hydrogen‑rich solution against myocardial injury and aquaporin expression via the PI3K/Akt signaling pathway during cardiopulmonary bypass in rats. Mol Med Rep 18: 1925-1938, 2018.
APA
Song, D., Liu, X., Diao, Y., Sun, Y., Gao, G., Zhang, T. ... Pei, L. (2018). Hydrogen‑rich solution against myocardial injury and aquaporin expression via the PI3K/Akt signaling pathway during cardiopulmonary bypass in rats. Molecular Medicine Reports, 18, 1925-1938. https://doi.org/10.3892/mmr.2018.9198
MLA
Song, D., Liu, X., Diao, Y., Sun, Y., Gao, G., Zhang, T., Chen, K., Pei, L."Hydrogen‑rich solution against myocardial injury and aquaporin expression via the PI3K/Akt signaling pathway during cardiopulmonary bypass in rats". Molecular Medicine Reports 18.2 (2018): 1925-1938.
Chicago
Song, D., Liu, X., Diao, Y., Sun, Y., Gao, G., Zhang, T., Chen, K., Pei, L."Hydrogen‑rich solution against myocardial injury and aquaporin expression via the PI3K/Akt signaling pathway during cardiopulmonary bypass in rats". Molecular Medicine Reports 18, no. 2 (2018): 1925-1938. https://doi.org/10.3892/mmr.2018.9198
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Spandidos Publications style
Song D, Liu X, Diao Y, Sun Y, Gao G, Zhang T, Chen K and Pei L: Hydrogen‑rich solution against myocardial injury and aquaporin expression via the PI3K/Akt signaling pathway during cardiopulmonary bypass in rats. Mol Med Rep 18: 1925-1938, 2018.
APA
Song, D., Liu, X., Diao, Y., Sun, Y., Gao, G., Zhang, T. ... Pei, L. (2018). Hydrogen‑rich solution against myocardial injury and aquaporin expression via the PI3K/Akt signaling pathway during cardiopulmonary bypass in rats. Molecular Medicine Reports, 18, 1925-1938. https://doi.org/10.3892/mmr.2018.9198
MLA
Song, D., Liu, X., Diao, Y., Sun, Y., Gao, G., Zhang, T., Chen, K., Pei, L."Hydrogen‑rich solution against myocardial injury and aquaporin expression via the PI3K/Akt signaling pathway during cardiopulmonary bypass in rats". Molecular Medicine Reports 18.2 (2018): 1925-1938.
Chicago
Song, D., Liu, X., Diao, Y., Sun, Y., Gao, G., Zhang, T., Chen, K., Pei, L."Hydrogen‑rich solution against myocardial injury and aquaporin expression via the PI3K/Akt signaling pathway during cardiopulmonary bypass in rats". Molecular Medicine Reports 18, no. 2 (2018): 1925-1938. https://doi.org/10.3892/mmr.2018.9198
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