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Article

BM‑MSCs protect against liver ischemia/reperfusion injury via HO‑1 mediated autophagy

  • Authors:
    • Xun Wang
    • Shuai Wang
    • Yuan Zhou
    • Halmurat Obulkasim
    • Zhi‑Heng Zhang
    • Bo Dai
    • Wei Zhu
    • Xiao‑Lei Shi
  • View Affiliations / Copyright

    Affiliations: Department of Hepatobiliary Surgery, The Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, Jiangsu 210008, P.R. China, Department of Hepatobiliary Surgery, Drum Tower Clinical Medical College of Nanjing Medical University, Nanjing, Jiangsu 210008, P.R. China, Department of Anesthesiology, The Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, Jiangsu 210008, P.R. China
  • Pages: 2253-2262
    |
    Published online on: June 22, 2018
       https://doi.org/10.3892/mmr.2018.9207
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Abstract

Ischemia/reperfusion (I/R) injury is considered to be a contributing factor in liver injury following major hepatic resection or liver transplantation. Bone marrow mesenchymal stem cells (BM‑MSCs) have the potential to protect against liver I/R injury; however, the precise mechanisms have not been completely elucidated. Autophagy serves an important role in protecting against various injuries, including I/R injury. The present study aimed to determine the role of autophagy and its potential regulatory mechanism in BM‑MSC‑mediated protection against liver I/R injury in rats. The results demonstrated that BM‑MSCs mitigated I/R injury and enhanced autophagy in vivo. In addition, inhibition of autophagy by 3‑methyladenine reversed the positive effects of BM‑MSCs. Furthermore, heme oxygenase‑1 (HO‑1) expression was promoted by BM‑MSCs. Using zinc protoporphyrin IX to inhibit HO‑1 demonstrated that HO‑1 was important for the promotion of autophagy. In conclusion, the present study revealed that BM‑MSCs protected against liver I/R injury via the promotion of HO‑1‑mediated autophagy.
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View References

1 

de Groot H and Rauen U: Ischemia-reperfusion injury: Processes in pathogenetic networks: A review. Transplant Proc. 39:481–484. 2007. View Article : Google Scholar : PubMed/NCBI

2 

Ke B, Lipshutz GS and Kupiec-Weglinski JW: Gene therapy in liver ischemia and reperfusion injury. Curr Pharm Des. 12:2969–2975. 2006. View Article : Google Scholar : PubMed/NCBI

3 

Kim YI: Ischemia-reperfusion injury of the human liver during hepatic resection. J Hepatobiliary Pancreat Surg. 10:195–199. 2003. View Article : Google Scholar : PubMed/NCBI

4 

Selzner N, Rudiger H, Graf R and Clavien PA: Protective strategies against ischemic injury of the liver. Gastroenterology. 125:917–936. 2003. View Article : Google Scholar : PubMed/NCBI

5 

Liu A, Huang L, Guo E, Li R, Yang J, Li A, Yang Y, Liu S, Hu J, Jiang X, et al: Baicalein pretreatment reduces liver ischemia/reperfusion injury via induction of autophagy in rats. Sci Rep. 6:250422016. View Article : Google Scholar : PubMed/NCBI

6 

Bahde R and Spiegel HU: Hepatic ischaemia-reperfusion injury from bench to bedside. Br J Surg. 97:1461–1475. 2010. View Article : Google Scholar : PubMed/NCBI

7 

Sun CK, Chang CL, Lin YC, Kao YH, Chang LT, Yen CH, Shao PL, Chen CH, Leu S and Yip HK: Systemic administration of autologous adipose-derived mesenchymal stem cells alleviates hepatic ischemia-reperfusion injury in rats. Crit Care Med. 40:1279–1290. 2012. View Article : Google Scholar : PubMed/NCBI

8 

Zhang H, Xiang M, Meng D, Sun N and Chen S: Inhibition of myocardial ischemia/reperfusion injury by exosomes secreted from mesenchymal stem cells. Stem Cells Int. 2016:43283622016. View Article : Google Scholar : PubMed/NCBI

9 

Sheashaa H, Lotfy A, Elhusseini F, Aziz AA, Baiomy A, Awad S, Alsayed A, El-Gilany AH, Saad MA, Mahmoud K, et al: Protective effect of adipose-derived mesenchymal stem cells against acute kidney injury induced by ischemia-reperfusion in Sprague-Dawley rats. Exp Ther Med. 11:1573–1580. 2016. View Article : Google Scholar : PubMed/NCBI

10 

Chang CL, Sung PH, Sun CK, Chen CH, Chiang HJ, Huang TH, Chen YL, Zhen YY, Chai HT, Chung SY, et al: Protective effect of melatonin-supported adipose-derived mesenchymal stem cells against small bowel ischemia-reperfusion injury in rat. J Pineal Res. 59:206–220. 2015. View Article : Google Scholar : PubMed/NCBI

11 

Lin YC, Ko TL, Shih YH, Lin MY, Fu TW, Hsiao HS, Hsu JY and Fu YS: Human umbilical mesenchymal stem cells promote recovery after ischemic stroke. Stroke. 42:2045–2053. 2011. View Article : Google Scholar : PubMed/NCBI

12 

Semedo P, Palasio CG, Oliveira CD, Feitoza CQ, Gonçalves GM, Cenedeze MA, Wang PM, Teixeira VP, Reis MA, Pacheco-Silva A and Câmara NO: Early modulation of inflammation by mesenchymal stem cell after acute kidney injury. Int Immunopharmacol. 9:677–682. 2009. View Article : Google Scholar : PubMed/NCBI

13 

Li J, Zhou J, Zhang D, Song Y, She J and Bai C: Bone marrow-derived mesenchymal stem cells enhance autophagy via PI3K/AKT signalling to reduce the severity of ischaemia/reperfusion-induced lung injury. J Cell Mol Med. 19:2341–2351. 2015. View Article : Google Scholar : PubMed/NCBI

14 

Rautou PE, Mansouri A, Lebrec D, Durand F, Valla D and Moreau R: Autophagy in liver diseases. J Hepatol. 53:1123–1134. 2010. View Article : Google Scholar : PubMed/NCBI

15 

Denaes T, Lodder J, Chobert MN, Ruiz I, Pawlotsky JM, Lotersztajn S and Teixeira-Clerc F: The cannabinoid receptor 2 protects against alcoholic liver disease via a macrophage autophagy-dependent pathway. Sci Rep. 6:288062016. View Article : Google Scholar : PubMed/NCBI

16 

Zhu S, Wu Y, Ye X, Ma L, Qi J, Yu D, Wei Y, Lin G, Ren G and Li D: FGF21 ameliorates nonalcoholic fatty liver disease by inducing autophagy. Mol Cell Biochem. 420:107–119. 2016. View Article : Google Scholar : PubMed/NCBI

17 

Wang D, Ma Y, Li Z, Kang K, Sun X, Pan S, Wang J, Pan H, Liu L, Liang D and Jiang H: The role of AKT1 and autophagy in the protective effect of hydrogen sulphide against hepatic ischemia/reperfusion injury in mice. Autophagy. 8:954–962. 2012. View Article : Google Scholar : PubMed/NCBI

18 

Jung J, Choi JH, Lee Y, Park JW, Oh IH, Hwang SG, Kim KS and Kim GJ: Human placenta-derived mesenchymal stem cells promote hepatic regeneration in CCl4-injured rat liver model via increased autophagic mechanism. Stem Cells. 31:1584–1596. 2013. View Article : Google Scholar : PubMed/NCBI

19 

Yun N, Eum HA and Lee SM: Protective role of heme oxygenase-1 against liver damage caused by hepatic ischemia and reperfusion in rats. Antioxid Redox Signal. 13:1503–1512. 2010. View Article : Google Scholar : PubMed/NCBI

20 

Ke B, Shen XD, Zhang Y, Ji H, Gao F, Yue S, Kamo N, Zhai Y, Yamamoto M, Busuttil RW, et al: KEAP1-NRF2 complex in ischemia-induced hepatocellular damage of mouse liver transplants. J Hepatol. 59:1200–1207. 2013. View Article : Google Scholar : PubMed/NCBI

21 

Ke B, Shen XD, Ji H, Kamo N, Gao F, Freitas MC, Busuttil RW and Kupiec-Weglinski JW: HO-1-STAT3 axis in mouse liver ischemia/reperfusion injury: Regulation of TLR4 innate responses through PI3K/PTEN signaling. J Hepatol. 56:359–366. 2012. View Article : Google Scholar : PubMed/NCBI

22 

Wang Y, Shen J, Xiong X, Xu Y, Zhang H, Huang C, Tian Y, Jiao C, Wang X and Li X: Remote ischemic preconditioning protects against liver ischemia-reperfusion injury via heme oxygenase-1-induced autophagy. PLoS One. 9:e988342014. View Article : Google Scholar : PubMed/NCBI

23 

Xia X, Chen W, Ma T, Xu G, Liu H, Liang C, Bai X, Zhang Y, He Y and Liang T: Mesenchymal stem cells administered after liver transplantation prevent acute graft-versus-host disease in rats. Liver Transpl. 18:696–706. 2012. View Article : Google Scholar : PubMed/NCBI

24 

Zhang X, Li J, Nie J, Jiang K, Zhen Z, Wang J and Shen L: Differentiation character of adult mesenchymal stem cells and transfection of MSCs with lentiviral vectors. J Huazhong Univ Sci Technolog Med Sci. 30:687–693. 2010. View Article : Google Scholar : PubMed/NCBI

25 

Fu J, Zhang H, Zhuang Y, Liu H, Shi Q, Li D and Ju X: The role of N-acetyltransferase 8 in mesenchymal stem cell-based therapy for liver ischemia/reperfusion injury in rats. PLoS One. 9:e1033552014. View Article : Google Scholar : PubMed/NCBI

26 

Saidi RF, Rajeshkumar B, Shariftabrizi A, Bogdanov AA, Zheng S, Dresser K and Walter O: Human adipose-derived mesenchymal stem cells attenuate liver ischemia-reperfusion injury and promote liver regeneration. Surgery. 156:1225–1231. 2014. View Article : Google Scholar : PubMed/NCBI

27 

Wang S, Shi XL, Feng M, Wang X, Zhang ZH, Zhao X, Han B, Ma HC, Dai B and Ding YT: Puerarin protects against CCl4-induced liver fibrosis in mice: Possible role of PARP-1 inhibition. Int Immunopharmacol. 38:238–245. 2016. View Article : Google Scholar : PubMed/NCBI

28 

Huang YH, Yang YL, Tiao MM, Kuo HC, Huang LT and Chuang JH: Hepcidin protects against lipopolysaccharide-induced liver injury in a mouse model of obstructive jaundice. Peptides. 35:212–217. 2012. View Article : Google Scholar : PubMed/NCBI

29 

Schmidt R, Tritschler E, Hoetzel A, Loop T, Humar M, Halverscheid L, Geiger KK and Pannen BH: Heme oxygenase-1 induction by the clinically used anesthetic isoflurane protects rat livers from ischemia/reperfusion injury. Ann Surg. 245:931–942. 2007. View Article : Google Scholar : PubMed/NCBI

30 

Carchman EH, Rao J, Loughran PA, Rosengart MR and Zuckerbraun BS: Heme oxygenase-1-mediated autophagy protects against hepatocyte cell death and hepatic injury from infection/sepsis in mice. Hepatology. 53:2053–2062. 2011. View Article : Google Scholar : PubMed/NCBI

31 

Zhang Y, Cai W, Huang Q, Gu Y, Shi Y, Huang J, Zhao F, Liu Q, Wei X, Jin M, et al: Mesenchymal stem cells alleviate bacteria-induced liver injury in mice by inducing regulatory dendritic cells. Hepatology. 59:671–682. 2014. View Article : Google Scholar : PubMed/NCBI

32 

Lee KC, Lin HC, Huang YH and Hung SC: Allo-transplantation of mesenchymal stem cells attenuates hepatic injury through IL1Ra dependent macrophage switch in a mouse model of liver disease. J Hepatol. 63:1405–1412. 2015. View Article : Google Scholar : PubMed/NCBI

33 

Sun L, Fan X, Zhang L, Shi G, Aili M, Lu X, Jiang T and Zhang Y: Bone mesenchymal stem cell transplantation via four routes for the treatment of acute liver failure in rats. Int J Mol Med. 34:987–996. 2014. View Article : Google Scholar : PubMed/NCBI

34 

van Poll D, Parekkadan B, Cho CH, Berthiaume F, Nahmias Y, Tilles AW and Yarmush ML: Mesenchymal stem cell-derived molecules directly modulate hepatocellular death and regeneration in vitro and in vivo. Hepatology. 47:1634–1643. 2008. View Article : Google Scholar : PubMed/NCBI

35 

Park M, Kim YH, Woo SY, Lee HJ, Yu Y, Kim HS, Park YS, Jo I, Park JW, Jung SC, et al: Tonsil-derived mesenchymal stem cells ameliorate CCl4-induced liver fibrosis in mice via autophagy activation. Sci Rep. 5:86162015. View Article : Google Scholar : PubMed/NCBI

36 

Li X, Zeng Z, Li Q, Xu Q, Xie J, Hao H, Luo G, Liao W, Bin J, Huang X and Liao Y: Inhibition of microRNA-497 ameliorates anoxia/reoxygenation injury in cardiomyocytes by suppressing cell apoptosis and enhancing autophagy. Oncotarget. 6:18829–18844. 2015.PubMed/NCBI

37 

Zhang X, Yan H, Yuan Y, Gao J, Shen Z, Cheng Y, Shen Y, Wang RR, Wang X, Hu WW, et al: Cerebral ischemia-reperfusion-induced autophagy protects against neuronal injury by mitochondrial clearance. Autophagy. 9:1321–1333. 2013. View Article : Google Scholar : PubMed/NCBI

38 

Zou Z, Cai Y and Chen Y, Chen S, Liu L, Shen Z, Zhang S, Xu L and Chen Y: Bone marrow-derived mesenchymal stem cells attenuate acute liver injury and regulate the expression of fibrinogen-like-protein 1 and signal transducer and activator of transcription 3. Mol Med Rep. 12:2089–2097. 2015. View Article : Google Scholar : PubMed/NCBI

39 

Zhao X, Shi X, Zhang Z, Ma H, Yuan X and Ding Y: Combined treatment with MSC transplantation and neutrophil depletion ameliorates D-GalN/LPS-induced acute liver failure in rats. Clin Res Hepatol Gastroenterol. 40:730–738. 2016. View Article : Google Scholar : PubMed/NCBI

40 

Lu W, Si YI, Ding J, Chen X, Zhang X, Dong Z and Fu W: Mesenchymal stem cells attenuate acute ischemia-reperfusion injury in a rat model. Exp Ther Med. 10:2131–2137. 2015. View Article : Google Scholar : PubMed/NCBI

41 

Liu A, Fang H, Wei W, Dirsch O and Dahmen U: Ischemic preconditioning protects against liver ischemia/reperfusion injury via heme oxygenase-1-mediated autophagy. Crit Care Med. 42:e762–e771. 2014. View Article : Google Scholar : PubMed/NCBI

42 

Li SP, He JD, Wang Z, Yu Y, Fu SY, Zhang HM, Zhang JJ and Shen ZY: miR-30b inhibits autophagy to alleviate hepatic ischemia-reperfusion injury via decreasing the Atg12-Atg5 conjugate. World J Gastroenterol. 22:4501–4514. 2016. View Article : Google Scholar : PubMed/NCBI

43 

Jiang YB, Zhang XL, Tang YL, Ma GS, Shen CX, Wei Q, Zhu Q, Yao YY and Liu NF: Effects of heme oxygenase-1 gene modulated mesenchymal stem cells on vasculogenesis in ischemic swine hearts. Chin Med J (Engl). 124:401–407. 2011.PubMed/NCBI

44 

Nong K, Wang W, Niu X, Hu B, Ma C, Bai Y, Wu B, Wang Y and Ai K: Hepatoprotective effect of exosomes from human-induced pluripotent stem cell-derived mesenchymal stromal cells against hepatic ischemia-reperfusion injury in rats. Cytotherapy. 18:1548–1559. 2016. View Article : Google Scholar : PubMed/NCBI

45 

Chen YT, Sun CK, Lin YC, Chang LT, Chen YL, Tsai TH, Chung SY, Chua S, Kao YH, Yen CH, et al: Adipose-derived mesenchymal stem cell protects kidneys against ischemia-reperfusion injury through suppressing oxidative stress and inflammatory reaction. J Transl Med. 9:512011. View Article : Google Scholar : PubMed/NCBI

46 

Zhang B, Adesanya TM, Zhang L, Xie N, Chen Z, Fu M, Zhang J, Zhang J, Tan T, Kilic A, et al: Delivery of placenta-derived mesenchymal stem cells ameliorates ischemia induced limb injury by immunomodulation. Cell Physiol Biochem. 34:1998–2006. 2014. View Article : Google Scholar : PubMed/NCBI

47 

Gracia-Sancho J, Guixé-Muntet S, Hide D and Bosch J: Modulation of autophagy for the treatment of liver diseases. Expert Opin Investig Drugs. 23:965–977. 2014. View Article : Google Scholar : PubMed/NCBI

48 

Awan MU and Deng Y: Role of autophagy and its significance in cellular homeostasis. Appl Microbiol Biotechnol. 98:5319–5328. 2014. View Article : Google Scholar : PubMed/NCBI

49 

Hale AN, Ledbetter DJ, Gawriluk TR and Rucker EB III: Autophagy: Regulation and role in development. Autophagy. 9:951–972. 2013. View Article : Google Scholar : PubMed/NCBI

50 

Mizushima N and Levine B: Autophagy in mammalian development and differentiation. Nat Cell Biol. 12:823–830. 2010. View Article : Google Scholar : PubMed/NCBI

51 

Liu Q, Guan JZ, Sun Y, Le Z, Zhang P, Yu D and Liu Y: Insulin-like growth factor 1 receptor-mediated cell survival in hypoxia depends on the promotion of autophagy via suppression of the PI3K/Akt/mTOR signaling pathway. Mol Med Rep. 15:2136–2142. 2017. View Article : Google Scholar : PubMed/NCBI

52 

Liu S, Hartleben B, Kretz O, Wiech T, Igarashi P, Mizushima N, Walz G and Huber TB: Autophagy plays a critical role in kidney tubule maintenance, aging and ischemia-reperfusion injury. Autophagy. 8:826–837. 2012. View Article : Google Scholar : PubMed/NCBI

53 

Cursio R, Colosetti P and Gugenheim J: Autophagy and liver ischemia-reperfusion injury. Biomed Res Int. 2015:4175902015. View Article : Google Scholar : PubMed/NCBI

54 

Zhao Q, Guo Z, Deng W, Fu S, Zhang C, Chen M, Ju W, Wang D and He X: Calpain 2-mediated autophagy defect increases susceptibility of fatty livers to ischemia-reperfusion injury. Cell Death Dis. 7:e21862016. View Article : Google Scholar : PubMed/NCBI

55 

Wang JH, Ahn IS, Fischer TD, Byeon JI, Dunn WA Jr, Behrns KE, Leeuwenburgh C and Kim JS: Autophagy suppresses age-dependent ischemia and reperfusion injury in livers of mice. Gastroenterology. 141:2188–2199.e6. 2011. View Article : Google Scholar : PubMed/NCBI

56 

Fang H, Liu A, Dahmen U and Dirsch O: Dual role of chloroquine in liver ischemia reperfusion injury: Reduction of liver damage in early phase, but aggravation in late phase. Cell Death Dis. 4:e6942013. View Article : Google Scholar : PubMed/NCBI

57 

Shin JY, Park HJ, Kim HN, Oh SH, Bae JS, Ha HJ and Lee PH: Mesenchymal stem cells enhance autophagy and increase β-amyloid clearance in Alzheimer disease models. Autophagy. 10:32–44. 2014. View Article : Google Scholar : PubMed/NCBI

58 

Zhou Z and You Z: Mesenchymal stem cells alleviate LPS-induced acute lung injury in mice by MiR-142a-5p-Controlled pulmonary endothelial cell autophagy. Cell Physiol Biochem. 38:258–266. 2016. View Article : Google Scholar : PubMed/NCBI

59 

Yin F, Meng C, Lu R, Li L, Zhang Y, Chen H, Qin Y and Guo L: Bone marrow mesenchymal stem cells repair spinal cord ischemia/reperfusion injury by promoting axonal growth and anti-autophagy. Neural Regen Res. 9:1665–1671. 2014. View Article : Google Scholar : PubMed/NCBI

60 

Yun N, Cho HI and Lee SM: Impaired autophagy contributes to hepatocellular damage during ischemia/reperfusion: Heme oxygenase-1 as a possible regulator. Free Radic Biol Med. 68:168–177. 2014. View Article : Google Scholar : PubMed/NCBI

61 

Wang Y, Xiong X, Guo H, Wu M, Li X, Hu Y, Xie G, Shen J and Tian Q: ZnPP reduces autophagy and induces apoptosis, thus aggravating liver ischemia/reperfusion injury in vitro. Int J Mol Med. 34:1555–1564. 2014. View Article : Google Scholar : PubMed/NCBI

62 

Park J, Kang JW and Lee SM: Activation of the cholinergic anti-inflammatory pathway by nicotine attenuates hepatic ischemia/reperfusion injury via heme oxygenase-1 induction. Eur J Pharmacol. 707:61–70. 2013. View Article : Google Scholar : PubMed/NCBI

63 

Rao J, Qian X, Li G, Pan X, Zhang C, Zhang F, Zhai Y, Wang X and Lu L: ATF3-mediated NRF2/HO-1 signaling regulates TLR4 innate immune responses in mouse liver ischemia/reperfusion injury. Am J Transplant. 15:76–87. 2015. View Article : Google Scholar : PubMed/NCBI

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Wang X, Wang S, Zhou Y, Obulkasim H, Zhang ZH, Dai B, Zhu W and Shi XL: BM‑MSCs protect against liver ischemia/reperfusion injury via HO‑1 mediated autophagy. Mol Med Rep 18: 2253-2262, 2018.
APA
Wang, X., Wang, S., Zhou, Y., Obulkasim, H., Zhang, Z., Dai, B. ... Shi, X. (2018). BM‑MSCs protect against liver ischemia/reperfusion injury via HO‑1 mediated autophagy. Molecular Medicine Reports, 18, 2253-2262. https://doi.org/10.3892/mmr.2018.9207
MLA
Wang, X., Wang, S., Zhou, Y., Obulkasim, H., Zhang, Z., Dai, B., Zhu, W., Shi, X."BM‑MSCs protect against liver ischemia/reperfusion injury via HO‑1 mediated autophagy". Molecular Medicine Reports 18.2 (2018): 2253-2262.
Chicago
Wang, X., Wang, S., Zhou, Y., Obulkasim, H., Zhang, Z., Dai, B., Zhu, W., Shi, X."BM‑MSCs protect against liver ischemia/reperfusion injury via HO‑1 mediated autophagy". Molecular Medicine Reports 18, no. 2 (2018): 2253-2262. https://doi.org/10.3892/mmr.2018.9207
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Spandidos Publications style
Wang X, Wang S, Zhou Y, Obulkasim H, Zhang ZH, Dai B, Zhu W and Shi XL: BM‑MSCs protect against liver ischemia/reperfusion injury via HO‑1 mediated autophagy. Mol Med Rep 18: 2253-2262, 2018.
APA
Wang, X., Wang, S., Zhou, Y., Obulkasim, H., Zhang, Z., Dai, B. ... Shi, X. (2018). BM‑MSCs protect against liver ischemia/reperfusion injury via HO‑1 mediated autophagy. Molecular Medicine Reports, 18, 2253-2262. https://doi.org/10.3892/mmr.2018.9207
MLA
Wang, X., Wang, S., Zhou, Y., Obulkasim, H., Zhang, Z., Dai, B., Zhu, W., Shi, X."BM‑MSCs protect against liver ischemia/reperfusion injury via HO‑1 mediated autophagy". Molecular Medicine Reports 18.2 (2018): 2253-2262.
Chicago
Wang, X., Wang, S., Zhou, Y., Obulkasim, H., Zhang, Z., Dai, B., Zhu, W., Shi, X."BM‑MSCs protect against liver ischemia/reperfusion injury via HO‑1 mediated autophagy". Molecular Medicine Reports 18, no. 2 (2018): 2253-2262. https://doi.org/10.3892/mmr.2018.9207
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