BM‑MSCs protect against liver ischemia/reperfusion injury via HO‑1 mediated autophagy

  • Authors:
    • Xun Wang
    • Shuai Wang
    • Yuan Zhou
    • Halmurat Obulkasim
    • Zhi‑Heng Zhang
    • Bo Dai
    • Wei Zhu
    • Xiao‑Lei Shi
  • View Affiliations

  • Published online on: June 22, 2018     https://doi.org/10.3892/mmr.2018.9207
  • Pages: 2253-2262
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Abstract

Ischemia/reperfusion (I/R) injury is considered to be a contributing factor in liver injury following major hepatic resection or liver transplantation. Bone marrow mesenchymal stem cells (BM‑MSCs) have the potential to protect against liver I/R injury; however, the precise mechanisms have not been completely elucidated. Autophagy serves an important role in protecting against various injuries, including I/R injury. The present study aimed to determine the role of autophagy and its potential regulatory mechanism in BM‑MSC‑mediated protection against liver I/R injury in rats. The results demonstrated that BM‑MSCs mitigated I/R injury and enhanced autophagy in vivo. In addition, inhibition of autophagy by 3‑methyladenine reversed the positive effects of BM‑MSCs. Furthermore, heme oxygenase‑1 (HO‑1) expression was promoted by BM‑MSCs. Using zinc protoporphyrin IX to inhibit HO‑1 demonstrated that HO‑1 was important for the promotion of autophagy. In conclusion, the present study revealed that BM‑MSCs protected against liver I/R injury via the promotion of HO‑1‑mediated autophagy.
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August-2018
Volume 18 Issue 2

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Spandidos Publications style
Wang X, Wang S, Zhou Y, Obulkasim H, Zhang ZH, Dai B, Zhu W and Shi XL: BM‑MSCs protect against liver ischemia/reperfusion injury via HO‑1 mediated autophagy. Mol Med Rep 18: 2253-2262, 2018
APA
Wang, X., Wang, S., Zhou, Y., Obulkasim, H., Zhang, Z., Dai, B. ... Shi, X. (2018). BM‑MSCs protect against liver ischemia/reperfusion injury via HO‑1 mediated autophagy. Molecular Medicine Reports, 18, 2253-2262. https://doi.org/10.3892/mmr.2018.9207
MLA
Wang, X., Wang, S., Zhou, Y., Obulkasim, H., Zhang, Z., Dai, B., Zhu, W., Shi, X."BM‑MSCs protect against liver ischemia/reperfusion injury via HO‑1 mediated autophagy". Molecular Medicine Reports 18.2 (2018): 2253-2262.
Chicago
Wang, X., Wang, S., Zhou, Y., Obulkasim, H., Zhang, Z., Dai, B., Zhu, W., Shi, X."BM‑MSCs protect against liver ischemia/reperfusion injury via HO‑1 mediated autophagy". Molecular Medicine Reports 18, no. 2 (2018): 2253-2262. https://doi.org/10.3892/mmr.2018.9207