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Inhibition of autophagy enhanced cobalt chloride‑induced apoptosis in rat alveolar type II epithelial cells

  • Authors:
    • Yan Yu
    • Wanting Li
    • Liqin Ren
    • Chunyan Yang
    • Dongze Li
    • Xin Han
    • Yeying Sun
    • Changjun Lv
    • Fang Han
  • View Affiliations / Copyright

    Affiliations: Medicine and Pharmacy Research Center, Binzhou Medical University, Yantai, Shandong 264003, P.R. China
    Copyright: © Yu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 2124-2132
    |
    Published online on: June 22, 2018
       https://doi.org/10.3892/mmr.2018.9209
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Abstract

Hypoxia is a type of cellular stress that may result in apoptosis and autophagy. The molecular mechanisms underlying the association between autophagy and apoptosis remain unclear, particularly in hypoxic conditions. Transmission electron microscope, AO‑PI staining, flow cytometry and western blot were used to examine the crosstalk between autophagy and apoptosis in hypoxic conditions. Rat alveolar type II epithelial RLE‑6TN cells were cultured in a long‑term hypoxic environment established by cobalt (II) chloride. It was demonstrated that autophagy and apoptosis occurred in RLE‑6TN cells under hypoxic conditions. Treatment of RLE‑6TN cells with the autophagy inhibitor 3‑methyladenine increased the generation of reactive oxygen species, mitochondrial damage and hypoxia‑induced apoptosis. The expression of caspases, particularly caspase‑9, increased and may have participated in these processes. The data indicated that the inhibition of autophagy enhanced apoptosis through the mitochondria‑mediated intrinsic pathway. These findings provide important insight into the molecular mechanism of autophagy and apoptosis crosstalk. This may provide new insights into pulmonary disease surveillance, diagnosis and treatment.
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1 

Jeong JK, Gurunathan S, Kang MH, Han JW, Das J, Choi YJ, Kwon DN, Cho SG, Park C, Seo HG, et al: Hypoxia-mediated autophagic flux inhibits silver nanoparticle-triggered apoptosis in human lung cancer cells. Sci Rep. 6:216882016. View Article : Google Scholar : PubMed/NCBI

2 

Semenza GL: HIF-1, O(2), and the 3 PHDs: How animal cells signal hypoxia to the nucleus. Cell. 107:1–3. 2001. View Article : Google Scholar : PubMed/NCBI

3 

Huang LE and Bunn HF: Hypoxia-inducible factor and its biomedical relevance. J Biol Chem. 278:19575–19578. 2003. View Article : Google Scholar : PubMed/NCBI

4 

Haase VH: The VHL tumor suppressor: Master regulator of HIF. Curr Pharm Des. 15:3895–3903. 2009. View Article : Google Scholar : PubMed/NCBI

5 

Bellot G, Garcia-Medina R, Gounon P, Chiche J, Roux D, Pouysségur J and Mazure NM: Hypoxia-induced autophagy is mediated through hypoxia-inducible factor induction of BNIP3 and BNIP3L via their BH3 domains. Mol Cell Biol. 29:2570–2581. 2009. View Article : Google Scholar : PubMed/NCBI

6 

Ozpolat B and Benbrook DM: Targeting autophagy in cancer management-strategies and developments. Cancer Manag Res. 7:291–299. 2015. View Article : Google Scholar : PubMed/NCBI

7 

Gordy C and He YW: The crosstalk between autophagy and apoptosis: Where does this lead? Protein Cell. 3:17–27. 2012. View Article : Google Scholar : PubMed/NCBI

8 

Volm M and Koomägi R: Hypoxia-inducible factor (HIF-1) and its relationship to apoptosis and proliferation in lung cancer. Anticancer Res. 20:1527–1533. 2000.PubMed/NCBI

9 

Piret J, Lecocl C, Toffoli S, Ninane N, Raes M and Michiels C: Hypoxia and CoCl2 protect HepG2 cells against serum deprivation- and t-BHP-induced apoptosis: A possible anti-apoptotic role for HIF-1. Exp Cell Res. 295:340–349. 2004. View Article : Google Scholar : PubMed/NCBI

10 

Pan T, Rawal P, Wu Y, Xie W, Jankovic J and Le W: Rapamycin protects against rotenone-induced apoptosis through autophagy induction. Neuroscience. 164:541–551. 2009. View Article : Google Scholar : PubMed/NCBI

11 

Ghavami S, Shojaei S, Yeganeh B, Ande SR, Jangamreddy JR, Mehrpour M, Christoffersson J, Chaabane W, Moghadam AR, Kashani HH, et al: Autophagy and apoptosis dysfunction in neurodegenerative disorders. Prog Neurobiol. 112:24–49. 2014. View Article : Google Scholar : PubMed/NCBI

12 

Li T, Jiao YR, Wang LH, Zhou YH and Yao HC: Autophagy in myocardial ischemia reperfusion injury: Friend or foe? Int J Cardiol. 239:102017. View Article : Google Scholar : PubMed/NCBI

13 

Wang G, Hazra TK, Mitra S, Lee HM and Englander EW: Mitochondrial DNA damage and a hypoxic response are induced by CoCl(2) in rat neuronal PC12 cells. Nucleic Acids Res. 28:2135–2140. 2000. View Article : Google Scholar : PubMed/NCBI

14 

Cheng BC, Chen JT, Yang ST, Chio CC, Liu SH and Chen RM: Cobalt chloride treatment induces autophagic apoptosis in human glioma cells via a p53-dependent pathway. Int J Oncol. 50:964–974. 2017. View Article : Google Scholar : PubMed/NCBI

15 

Pouysségur J, Dayan F and Mazure NM: Hypoxia signalling in cancer and approaches to enforce tumour regression. Nature. 441:437–443. 2006. View Article : Google Scholar : PubMed/NCBI

16 

Kim J and Klionsky DJ: Autophagy, cytoplasm-to-vacuole targeting pathway, and pexophagy in yeast and mammalian cells. Annu Rev Biochem. 69:303–342. 2000. View Article : Google Scholar : PubMed/NCBI

17 

Häcker G: The morphology of apoptosis. Cell Tissue Res. 301:5–17. 2000. View Article : Google Scholar : PubMed/NCBI

18 

Ovadje P, Chatterjee S, Griffin C, Tran C, Hamm C and Pandey S: Selective induction of apoptosis through activation of caspase-8 in human leukemia cells (Jurkat) by dandelion root extract. J Ethnopharmacol. 133:86–91. 2011. View Article : Google Scholar : PubMed/NCBI

19 

Rajagopalan V and Yusuf AH: Hannun: Sphingolipid metabolism and signaling as a target for cancer treatmentCell death signaling in cancer biology and treatment. Johnson DE: Humana Press; New York: pp. 205–229. 2013, View Article : Google Scholar

20 

Heo JM and Rutter J: Ubiquitin-dependent mitochondrial protein degradation. Int J Biochem Cell Biol. 43:1422–1426. 2011. View Article : Google Scholar : PubMed/NCBI

21 

Simon HU, Haj-Yehia A and Levi-Schaffer F: Role of reactive oxygen species (ROS) in apoptosis induction. Apoptosis. 5:415–418. 2000. View Article : Google Scholar : PubMed/NCBI

22 

Scherz-Shouval R and Elazar Z: Regulation of autophagy by ROS: Physiology and pathology. Trends Biochem Sci. 36:30–38. 2011. View Article : Google Scholar : PubMed/NCBI

23 

Hasanain M, Bhattacharjee A, Pandey P, Ashraf R, Singh N, Sharma S, Vishwakarma AL, Datta D, Mitra K and Sarkar J: α-Solanine induces ROS-mediated autophagy through activation of endoplasmic reticulum stress and inhibition of Akt/mTOR pathway. Cell Death Dis. 6:e18602015. View Article : Google Scholar : PubMed/NCBI

24 

Wu H, Che X, Zheng Q, Wu A, Pan K, Shao A, Wu Q, Zhang J and Hong Y: Caspases: A molecular switch node in the crosstalk between autophagy and apoptosis. Int J Biol Sci. 10:1072–1083. 2014. View Article : Google Scholar : PubMed/NCBI

25 

Rubinstein AD and Kimchi A: Life in the balance-a mechanistic view of the crosstalk between autophagy and apoptosis. J Cell Sci. 125:5259–5268. 2012. View Article : Google Scholar : PubMed/NCBI

26 

Merelli A, Caltana L, Girimonti P, Ramos AJ, Lazarowski A and Brusco A: Recovery of motor spontaneous activity after intranasal delivery of human recombinant erythropoietin in a focal brain hypoxia model induced by CoCl2 in rats. Neurotox Res. 20:182–192. 2011. View Article : Google Scholar : PubMed/NCBI

27 

Badr GA, Zhang JZ, Tang J, Kern TS and Ismail-Beigi F: Glut1 and glut3 expression, but not capillary density, is increased by cobalt chloride in rat cerebrum and retina. Brain Res Mol Brain Res. 64:24–33. 1999. View Article : Google Scholar : PubMed/NCBI

28 

Zou W, Yan M, Xu W, Huo H, Sun L, Zheng Z and Liu X: Cobalt chloride induces PC12 cells apoptosis through reactive oxygen species and accompanied by AP-1 activation. J Neurosci Res. 64:646–653. 2001. View Article : Google Scholar : PubMed/NCBI

29 

Zhu X, Zhou W, Cui Y, Zhu L, Li J, Feng X, Shao B, Qi H, Zheng J, Wang H and Chen H: Pilocarpine protects cobalt chloride-induced apoptosis of RGC-5 cells: Involvement of muscarinic receptors and HIF-1 alpha pathway. Cell Mol Neurobiol. 30:427–435. 2010. View Article : Google Scholar : PubMed/NCBI

30 

Ouyang L, Shi Z, Zhao S, Wang FT, Zhou TT, Liu B and Bao JK: Programmed cell death pathways in cancer: A review of apoptosis, autophagy and programmed necrosis. Cell Prolif. 45:487–498. 2012. View Article : Google Scholar : PubMed/NCBI

31 

Levine B and Kroemer G: Autophagy in the pathogenesis of disease. Cell. 132:27–42. 2008. View Article : Google Scholar : PubMed/NCBI

32 

Boya P, González-Polo RA, Casares N, Perfettini JL, Dessen P, Larochette N, Métivier D, Meley D, Souquere S, Yoshimori T, et al: Inhibition of macroautophagy triggers apoptosis. Mol Cell Biol. 25:1025–1040. 2005. View Article : Google Scholar : PubMed/NCBI

33 

Zhu H, Tannous P, Johnstone JL, Kong Y, Shelton JM, Richardson JA, Le V, Levine B, Rothermel BA and Hill JA: Cardiac autophagy is a maladaptive response to hemodynamic stress. J Clin Invest. 117:1782–1793. 2007. View Article : Google Scholar : PubMed/NCBI

34 

Zhao Y, Li R, Xia W, Neuzil J, Lu Y, Zhang H, Zhao X, Zhang X, Sun C and Wu K: Bid integrates intrinsic and extrinsic signaling in apoptosis induced by alpha-tocopheryl succinate in human gastric carcinoma cells. Cancer Lett. 288:42–49. 2010. View Article : Google Scholar : PubMed/NCBI

35 

Zhang X, Yan H, Yuan Y, Gao J, Shen Z, Cheng Y, Shen Y, Wang RR, Wang X, Hu WW, et al: Cerebral ischemia-reperfusion-induced autophagy protects against neuronal injury by mitochondrial clearance. Autophagy. 9:1321–1333. 2013. View Article : Google Scholar : PubMed/NCBI

36 

Yan L, Vatner DE, Kim SJ, Ge H, Masurekar M, Massover WH, Yang G, Matsui Y, Sadoshima J and Vatner SF: Autophagy in chronically ischemic myocardium. Proc Natl Acad Sci USA. 102:13807–13812. 2005. View Article : Google Scholar : PubMed/NCBI

37 

Park J, Min JS, Kim B, Yun JW, Choi MS, Kong IK, Chang KT and Lee DS: Mitochondrial ROS govern the LPS-induced pro-inflammatory response in microglia cells by regulating MAPK and NF-κB pathways. Neurosci Lett. 584:191–196. 2015. View Article : Google Scholar : PubMed/NCBI

38 

Hou JT, Li K, Yang J, Yu KK, Liao YX, Ran YZ, Liu YH, Zhou XD and Yu XQ: A ratiometric fluorescent probe for in situ quantification of basal mitochondrial hypochlorite in cancer cells. Chem Commun (Camb). 51:6781–6784. 2015. View Article : Google Scholar : PubMed/NCBI

39 

Ravikumar B, Sarkar S, Davies JE, Futter M, Garcia-Arencibia M, Green-Thompson ZW, Jimenez-Sanchez M, Korolchuk VI, Lichtenberg M, Luo S, et al: Regulation of mammalian autophagy in physiology and pathophysiology. Physiol Rev. 90:1383–1435. 2010. View Article : Google Scholar : PubMed/NCBI

40 

Lemasters JJ, Nieminen AL, Qian T, Trost LC, Elmore SP, Nishimura Y, Crowe RA, Cascio WE, Bradham CA, Brenner DA and Herman B: The mitochondrial permeability transition in cell death: A common mechanism in necrosis, apoptosis and autophagy. Biochim Biophys Acta. 1366:177–196. 1998. View Article : Google Scholar : PubMed/NCBI

41 

Shintani T and Klionsky DJ: Autophagy in health and disease: A double-edged sword. Science. 306:990–995. 2004. View Article : Google Scholar : PubMed/NCBI

42 

Dewaele M, Maes H and Agostinis P: ROS-mediated mechanisms of autophagy stimulation and their relevance in cancer therapy. Autophagy. 6:838–854. 2010. View Article : Google Scholar : PubMed/NCBI

43 

Grishchuk Y, Ginet V, Truttmann AC, Clarke PG and Puyal J: Beclin 1-independent autophagy contributes to apoptosis in cortical neurons. Autophagy. 7:1115–1131. 2011. View Article : Google Scholar : PubMed/NCBI

44 

Li M, Gao P and Zhang J: Crosstalk between autophagy and apoptosis: Potential and emerging therapeutic targets for cardiac diseases. Int J Mol Sci. 17:3322016. View Article : Google Scholar : PubMed/NCBI

45 

Chien CT, Shyue SK and Lai MK: Bcl-xL augmentation potentially reduces ischemia/reperfusion induced proximal and distal tubular apoptosis and autophagy. Transplantation. 84:1183–1190. 2007. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Yu Y, Li W, Ren L, Yang C, Li D, Han X, Sun Y, Lv C and Han F: Inhibition of autophagy enhanced cobalt chloride‑induced apoptosis in rat alveolar type II epithelial cells. Mol Med Rep 18: 2124-2132, 2018.
APA
Yu, Y., Li, W., Ren, L., Yang, C., Li, D., Han, X. ... Han, F. (2018). Inhibition of autophagy enhanced cobalt chloride‑induced apoptosis in rat alveolar type II epithelial cells. Molecular Medicine Reports, 18, 2124-2132. https://doi.org/10.3892/mmr.2018.9209
MLA
Yu, Y., Li, W., Ren, L., Yang, C., Li, D., Han, X., Sun, Y., Lv, C., Han, F."Inhibition of autophagy enhanced cobalt chloride‑induced apoptosis in rat alveolar type II epithelial cells". Molecular Medicine Reports 18.2 (2018): 2124-2132.
Chicago
Yu, Y., Li, W., Ren, L., Yang, C., Li, D., Han, X., Sun, Y., Lv, C., Han, F."Inhibition of autophagy enhanced cobalt chloride‑induced apoptosis in rat alveolar type II epithelial cells". Molecular Medicine Reports 18, no. 2 (2018): 2124-2132. https://doi.org/10.3892/mmr.2018.9209
Copy and paste a formatted citation
x
Spandidos Publications style
Yu Y, Li W, Ren L, Yang C, Li D, Han X, Sun Y, Lv C and Han F: Inhibition of autophagy enhanced cobalt chloride‑induced apoptosis in rat alveolar type II epithelial cells. Mol Med Rep 18: 2124-2132, 2018.
APA
Yu, Y., Li, W., Ren, L., Yang, C., Li, D., Han, X. ... Han, F. (2018). Inhibition of autophagy enhanced cobalt chloride‑induced apoptosis in rat alveolar type II epithelial cells. Molecular Medicine Reports, 18, 2124-2132. https://doi.org/10.3892/mmr.2018.9209
MLA
Yu, Y., Li, W., Ren, L., Yang, C., Li, D., Han, X., Sun, Y., Lv, C., Han, F."Inhibition of autophagy enhanced cobalt chloride‑induced apoptosis in rat alveolar type II epithelial cells". Molecular Medicine Reports 18.2 (2018): 2124-2132.
Chicago
Yu, Y., Li, W., Ren, L., Yang, C., Li, D., Han, X., Sun, Y., Lv, C., Han, F."Inhibition of autophagy enhanced cobalt chloride‑induced apoptosis in rat alveolar type II epithelial cells". Molecular Medicine Reports 18, no. 2 (2018): 2124-2132. https://doi.org/10.3892/mmr.2018.9209
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