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Effects of isomaltulose on insulin resistance and metabolites in patients with non‑alcoholic fatty liver disease: A metabolomic analysis

  • Authors:
    • Takumi Kawaguchi
    • Dan Nakano
    • Tetsuharu Oriishi
    • Takuji Torimura
  • View Affiliations / Copyright

    Affiliations: Division of Gastroenterology, Department of Medicine, Kurume University School of Medicine, Kurume, Fukuoka 830‑0011, Japan
    Copyright: © Kawaguchi et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 2033-2042
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    Published online on: June 26, 2018
       https://doi.org/10.3892/mmr.2018.9223
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Abstract

Insulin resistance is associated with a poor prognosis in non‑alcoholic fatty liver disease (NAFLD) patients. Isomaltulose, a naturally‑occurring disaccharide, is reported to improve glucose and lipid metabolisms in obese patients. The present study aimed to investigate the effects of isomaltulose on insulin resistance and various metabolites in NAFLD patients. Five male patients with NAFLD consumed 20 g isomaltulose or sucrose (control). Changes in insulin resistance and metabolites were evaluated by alterations of serum C‑peptide immunoreactivity (CPR) and metabolomic analysis from baseline to 15 min after the administration, respectively. There was no significant difference in changes of blood glucose level; however, the CPR level was significantly decreased in the Isomaltulose group compared to the control group (0.94±0.89 vs. ‑0.12±0.31, P=0.0216). In a metabolomic analysis, a significant alteration was seen in 52 metabolites between the control and Isomaltulose groups. In particular, the taurodeoxycholic acid level significantly increased approximately 12.5‑fold, and the arachidonic acid level significantly decreased approximately 0.01‑fold. Together, it present study demonstrated that isomaltulose improved insulin resistance in NAFLD patients. It was also revealed that isomaltulose affects taurodeoxycholic acid and arachidonic acid. Thus, isomaltulose may have a beneficial effect on insulin resistance through alterations of bile acid and fatty acid metabolisms in NAFLD patients.
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Copy and paste a formatted citation
Spandidos Publications style
Kawaguchi T, Nakano D, Oriishi T and Torimura T: Effects of isomaltulose on insulin resistance and metabolites in patients with non‑alcoholic fatty liver disease: A metabolomic analysis. Mol Med Rep 18: 2033-2042, 2018.
APA
Kawaguchi, T., Nakano, D., Oriishi, T., & Torimura, T. (2018). Effects of isomaltulose on insulin resistance and metabolites in patients with non‑alcoholic fatty liver disease: A metabolomic analysis. Molecular Medicine Reports, 18, 2033-2042. https://doi.org/10.3892/mmr.2018.9223
MLA
Kawaguchi, T., Nakano, D., Oriishi, T., Torimura, T."Effects of isomaltulose on insulin resistance and metabolites in patients with non‑alcoholic fatty liver disease: A metabolomic analysis". Molecular Medicine Reports 18.2 (2018): 2033-2042.
Chicago
Kawaguchi, T., Nakano, D., Oriishi, T., Torimura, T."Effects of isomaltulose on insulin resistance and metabolites in patients with non‑alcoholic fatty liver disease: A metabolomic analysis". Molecular Medicine Reports 18, no. 2 (2018): 2033-2042. https://doi.org/10.3892/mmr.2018.9223
Copy and paste a formatted citation
x
Spandidos Publications style
Kawaguchi T, Nakano D, Oriishi T and Torimura T: Effects of isomaltulose on insulin resistance and metabolites in patients with non‑alcoholic fatty liver disease: A metabolomic analysis. Mol Med Rep 18: 2033-2042, 2018.
APA
Kawaguchi, T., Nakano, D., Oriishi, T., & Torimura, T. (2018). Effects of isomaltulose on insulin resistance and metabolites in patients with non‑alcoholic fatty liver disease: A metabolomic analysis. Molecular Medicine Reports, 18, 2033-2042. https://doi.org/10.3892/mmr.2018.9223
MLA
Kawaguchi, T., Nakano, D., Oriishi, T., Torimura, T."Effects of isomaltulose on insulin resistance and metabolites in patients with non‑alcoholic fatty liver disease: A metabolomic analysis". Molecular Medicine Reports 18.2 (2018): 2033-2042.
Chicago
Kawaguchi, T., Nakano, D., Oriishi, T., Torimura, T."Effects of isomaltulose on insulin resistance and metabolites in patients with non‑alcoholic fatty liver disease: A metabolomic analysis". Molecular Medicine Reports 18, no. 2 (2018): 2033-2042. https://doi.org/10.3892/mmr.2018.9223
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