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Article

Protection of mouse pancreatic islet function by co‑culture with hypoxia pre‑treated mesenchymal stromal cells

  • Authors:
    • Cheng Xiang
    • Qiu‑Ping Xie
  • View Affiliations / Copyright

    Affiliations: Department of Surgery, The Second Affiliated Hospital of Zhejiang University, Hangzhou, Zhejiang 310009, P.R. China
    Copyright: © Xiang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 2589-2598
    |
    Published online on: June 29, 2018
       https://doi.org/10.3892/mmr.2018.9235
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Abstract

Ectogenic pancreatic islet transplantation has long been discussed as having the potential to reverse diabetes. The aim of the present study was to evaluate the therapeutic efficacy of co‑transplantation with hypoxia pretreated mesenchymal stem cells (MSCs) and islets in a diabetic mouse model. MSCs were isolated from femoral and tibial bone marrow aspirates from female BALB/c donor mice. MSC proliferation rates and the expression levels of vascular endothelial growth factor A (VEGFA), interleukin (IL)‑6, monocyte chemoattractant protein (MCP)‑1 and matrix metalloproteinase (MMP)‑9 were measured in hypoxic conditions. Subsequently, a streptozotocin‑induced diabetic model was established in BALB/c mice. Glucose tolerance and diabetes reversal rate following co‑transplantation of hypoxia pre‑cultured MSCs and islets were demonstrated at different conditions during transplantation. The present study results demonstrated that MSCs increased their proliferation rate and the secretion of growth‑related cytokines, including VEGFA, IL‑6, MCP‑1 and MMP‑9 in a hypoxic environment. In the diabetes animal model, fewer islets (~250) were required to reverse the impaired glucose tolerance condition in Islets + Hypoxia cultured MSCs transplant group compared with the Islets‑only group (~400 islets) and the Islets + Normal cultured MSCs group (~300 islets). Hypoxia‑cultured MSC co‑transplantation accelerated glycemic utilization following glucose intake. In subjects with hyperglycemia control for islet only transplantation group, MSCs pre‑cultured in hypoxic condition prior to co‑transplantation may potentially improve islet tissue regeneration.
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View References

1 

Abdel-Moneim A, Bakery HH and Allam G: The potential pathogenic role of IL-17/Th17 cells in both type 1 and type 2 diabetes mellitus. Biomed Pharmacother. 101:287–292. 2018. View Article : Google Scholar : PubMed/NCBI

2 

Koro CE, Bowlin SJ, Bourgeois N and Fedder DO: Glycemic control from 1988 to 2000 among U.S. adults diagnosed with type 2 diabetes: A preliminary report. Diabetes care. 27:17–20. 2004. View Article : Google Scholar : PubMed/NCBI

3 

El-Badri N and Ghoneim MA: Mesenchymal stem cell therapy in diabetes mellitus: Progress and challenges. J Nucleic Acids. 2013:1948582013. View Article : Google Scholar : PubMed/NCBI

4 

Shapiro AM, Lakey JR, Ryan EA, Korbutt GS, Toth E, Warnock GL, Kneteman NM and Rajotte RV: Islet transplantation in seven patients with type 1 diabetes mellitus using a glucocorticoid-free immunosuppressive regimen. N Engl J Med. 343:230–238. 2000. View Article : Google Scholar : PubMed/NCBI

5 

Barton FB, Rickels MR, Alejandro R, Hering BJ, Wease S, Naziruddin B, Oberholzer J, Odorico JS, Garfinkel MR, Levy M, et al: Improvement in outcomes of clinical islet transplantation: 1999–2010. Diabetes Care. 35:1436–1445. 2012. View Article : Google Scholar : PubMed/NCBI

6 

Ricordi C: Islet transplantation: A brave new world. Diabetes. 52:1595–1603. 2003. View Article : Google Scholar : PubMed/NCBI

7 

Brandhorst H, Asif S, Andersson K, Mönch J, Friedrich O, Rämsch-Günther N, Rämsch C, Steffens M, Lambrecht J, Schräder T, et al: The effect of truncated collagenase class I isomers on human islet isolation outcome. Transplantation. 90:334–335. 2010. View Article : Google Scholar : PubMed/NCBI

8 

Ito T, Itakura S, Todorov I, Rawson J, Asari S, Shintaku J, Nair I, Ferreri K, Kandeel F and Mullen Y: Mesenchymal stem cell and islet co-transplantation promotes graft revascularization and function. Transplantation. 89:1438–1445. 2010. View Article : Google Scholar : PubMed/NCBI

9 

Rackham CL, Chagastelles PC, Nardi NB, Hauge-Evans AC, Jones PM and King AJ: Co-transplantation of mesenchymal stem cells maintains islet organisation and morphology in mice. Diabetologia. 54:1127–1135. 2011. View Article : Google Scholar : PubMed/NCBI

10 

Perez-Basterrechea M, Obaya AJ, Meana A, Otero J and Esteban MM: Cooperation by fibroblasts and bone marrow-mesenchymal stem cells to improve pancreatic rat-to-mouse islet xenotransplantation. PLoS One. 8:e735262013. View Article : Google Scholar : PubMed/NCBI

11 

Berman DM, Willman MA, Han D, Kleiner G, Kenyon NM, Cabrera O, Karl JA, Wiseman RW, O'Connor DH, Bartholomew AM and Kenyon NS: Mesenchymal stem cells enhance allogeneic islet engraftment in nonhuman primates. Diabetes. 59:2558–2568. 2010. View Article : Google Scholar : PubMed/NCBI

12 

Sakata N, Goto M, Yoshimatsu G, Egawa S and Unno M: Utility of co-transplanting mesenchymal stem cells in islet transplantation. World J Gastroenterol. 17:5150–5155. 2011. View Article : Google Scholar : PubMed/NCBI

13 

Sordi V, Melzi R, Mercalli A, Formicola R, Doglioni C, Tiboni F, Ferrari G, Nano R, Chwalek K, Lammert E, et al: Mesenchymal cells appearing in pancreatic tissue culture are bone marrow-derived stem cells with the capacity to improve transplanted islet function. Stem Cells. 28:140–151. 2010. View Article : Google Scholar : PubMed/NCBI

14 

Golocheikine A, Tiriveedhi V, Angaswamy N, Benshoff N, Sabarinathan R and Mohanakumar T: Cooperative signaling for angiogenesis and neovascularization by VEGF and HGF following islet transplantation. Transplantation. 90:725–731. 2010. View Article : Google Scholar : PubMed/NCBI

15 

Ding Y, Xu D, Feng G, Bushell A, Muschel RJ and Wood KJ: Mesenchymal stem cells prevent the rejection of fully allogenic islet grafts by the immunosuppressive activity of matrix metalloproteinase-2 and −9. Diabetes. 58:1797–1806. 2009. View Article : Google Scholar : PubMed/NCBI

16 

Karaoz E, Genc ZS, Demircan PC, Aksoy A and Duruksu G: Protection of rat pancreatic islet function and viability by coculture with rat bone marrow-derived mesenchymal stem cells. Cell Death Dis. 1:e362010. View Article : Google Scholar : PubMed/NCBI

17 

Xie QP, Huang H, Xu B, Dong X, Gao SL, Zhang B and Wu YL: Human bone marrow mesenchymal stem cells differentiate into insulin-producing cells upon microenvironmental manipulation in vitro. Differentiation. 77:483–491. 2009. View Article : Google Scholar : PubMed/NCBI

18 

Grayson WL, Zhao F, Izadpanah R, Bunnell B and Ma T: Effects of hypoxia on human mesenchymal stem cell expansion and plasticity in 3D constructs. J Cell Physiol. 207:331–339. 2006. View Article : Google Scholar : PubMed/NCBI

19 

Rosova I, Dao M, Capoccia B, Link D and Nolta JA: Hypoxic preconditioning results in increased motility and improved therapeutic potential of human mesenchymal stem cells. Stem Cells. 26:2173–2182. 2008. View Article : Google Scholar : PubMed/NCBI

20 

Hung SC, Pochampally RR, Chen SC, Hsu SC and Prockop DJ: Angiogenic effects of human multipotent stromal cell conditioned medium activate the PI3K-Akt pathway in hypoxic endothelial cells to inhibit apoptosis, increase survival and stimulate angiogenesis. Stem Cells. 25:2363–2370. 2007. View Article : Google Scholar : PubMed/NCBI

21 

Dao MA, Pepper KA and Nolta JA: Long-term cytokine production from engineered primary human stromal cells influences human hematopoiesis in an in vivo xenograft model. Stem cells. 15:443–454. 1997. View Article : Google Scholar : PubMed/NCBI

22 

D'Amato F, Noli B, Brancia C, Cocco C, Flore G, Collu M, Nicolussi P and Ferri GL: Differential distribution of VGF-derived peptides in the adrenal medulla and evidence for their selective modulation. J Endocrinol. 197:359–369. 2008. View Article : Google Scholar : PubMed/NCBI

23 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

24 

Ichii H, Wang X, Messinger S, Alvarez A, Fraker C, Khan A, Kuroda Y, Inverardi L, Goss JA, Alejandro R and Ricordi C: Improved human islet isolation using nicotinamide. Am J Transplant. 6:2060–2068. 2006. View Article : Google Scholar : PubMed/NCBI

25 

Pittenger MF, Mackay AM, Beck SC, Jaiswal RK, Douglas R, Mosca JD, Moorman MA, Simonetti DW, Craig S and Marshak DR: Multilineage potential of adult human mesenchymal stem cells. Science. 284:143–147. 1999. View Article : Google Scholar : PubMed/NCBI

26 

Dominici M, Le Blanc K, Mueller I, Slaper-Cortenbach I, Marini F, Krause D, Deans R, Keating A, Prockop Dj and Horwitz E: Minimal criteria for defining multipotent mesenchymal stromal cells. The international society for cellular therapy position statement. Cytotherapy. 8:315–317. 2006. View Article : Google Scholar : PubMed/NCBI

27 

Luo JZ, Xiong F, Al-Homsi AS, Roy T and Luo LG: Human BM stem cells initiate angiogenesis in human islets in vitro. Bone Marrow Transplantat. 46:1128–1137. 2011. View Article : Google Scholar

28 

Hajizadeh-Saffar E, Tahamtani Y, Aghdami N, Azadmanesh K, Habibi-Anbouhi M, Heremans Y, De Leu N, Heimberg H, Ravassard P, Shokrgozar MA and Baharvand H: Inducible VEGF expression by human embryonic stem cell-derived mesenchymal stromal cells reduces the minimal islet mass required to reverse diabetes. Sci Rep. 5:93222015. View Article : Google Scholar : PubMed/NCBI

29 

Sato Y, Endo H, Okuyama H, Takeda T, Iwahashi H, Imagawa A, Yamagata K, Shimomura I and Inoue M: Cellular hypoxia of pancreatic beta-cells due to high levels of oxygen consumption for insulin secretion in vitro. J Biol Chem. 286:12524–12532. 2011. View Article : Google Scholar : PubMed/NCBI

30 

Buchwald P: A local glucose-and oxygen concentration-based insulin secretion model for pancreatic islets. Theor Biol Med Model. 8:202011. View Article : Google Scholar : PubMed/NCBI

31 

Espes D, Lau J, Quach M, Banerjee U, Palmer AF and Carlsson PO: Cotransplantation of Polymerized Hemoglobin Reduces β-Cell Hypoxia and Improves β-Cell Function in Intramuscular Islet Grafts. Transplantation. 99:2077–2082. 2015. View Article : Google Scholar : PubMed/NCBI

32 

Liljeback H, Grapensparr L, Olerud J and Carlsson PO: Extensive loss of islet mass beyond the first day after intraportal human islet transplantation in a mouse model. Cell Transplant. 25:481–489. 2016. View Article : Google Scholar : PubMed/NCBI

33 

Qiao N, Xu C, Zhu YX, Cao Y, Liu DC and Han X: Ets-1 as an early response gene against hypoxia-induced apoptosis in pancreatic β-cells. Cell Death Dis. 6:e16502015. View Article : Google Scholar : PubMed/NCBI

34 

Gerber PA, Bellomo EA, Hodson DJ, Meur G, Solomou A, Mitchell RK, Hollinshead M, Chimienti F, Bosco D, Hughes SJ, et al: Hypoxia lowers SLC30A8/ZnT8 expression and free cytosolic Zn2+ in pancreatic beta cells. Diabetologia. 57:1635–1644. 2014. View Article : Google Scholar : PubMed/NCBI

35 

Sakata N, Chan NK, Chrisler J, Obenaus A and Hathout E: Bone marrow cell cotransplantation with islets improves their vascularization and function. Transplantation. 89:686–693. 2010. View Article : Google Scholar : PubMed/NCBI

36 

Majmundar AJ, Wong WJ and Simon MC: Hypoxia-inducible factors and the response to hypoxic stress. Mol Cell. 40:294–309. 2010. View Article : Google Scholar : PubMed/NCBI

37 

Lampert FM, Kutscher C, Stark GB and Finkenzeller G: Overexpression of Hif-1α in mesenchymal stem cells affects cell-autonomous angiogenic and osteogenic parameters. J Cell Biochem. 117:760–768. 2016. View Article : Google Scholar : PubMed/NCBI

38 

Mao D, Zhu M, Zhang X, Ma R, Yang X, Ke T, Wang L, Li Z, Kong D and Li C: A macroporous heparin-releasing silk fibroin scaffold improves islet transplantation outcome by promoting islet revascularisation and survival. Acta Biomater. 59:210–220. 2017. View Article : Google Scholar : PubMed/NCBI

39 

Linnemann AK, Blumer J, Marasco MR, Battiola TJ, Umhoefer HM, Han JY, Lamming DW and Davis DB: Interleukin 6 protects pancreatic beta cells from apoptosis by stimulation of autophagy. FASEB J. 31:4140–4152. 2017. View Article : Google Scholar : PubMed/NCBI

40 

Melzi R, Mercalli A, Sordi V, Cantarelli E, Nano R, Maffi P, Sitia G, Guidotti LG, Secchi A, Bonifacio E and Piemonti L: Role of CCL2/MCP-1 in islet transplantation. Cell Transplant. 19:1031–1046. 2010. View Article : Google Scholar : PubMed/NCBI

41 

Meier DT, Tu LH, Zraika S, Hogan MF, Templin AT, Hull RL, Raleigh DP and Kahn SE: Matrix metalloproteinase-9 protects islets from amyloid-induced toxicity. J Biol Chem. 290:30475–30485. 2015. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Xiang C and Xie QP: Protection of mouse pancreatic islet function by co‑culture with hypoxia pre‑treated mesenchymal stromal cells. Mol Med Rep 18: 2589-2598, 2018.
APA
Xiang, C., & Xie, Q. (2018). Protection of mouse pancreatic islet function by co‑culture with hypoxia pre‑treated mesenchymal stromal cells. Molecular Medicine Reports, 18, 2589-2598. https://doi.org/10.3892/mmr.2018.9235
MLA
Xiang, C., Xie, Q."Protection of mouse pancreatic islet function by co‑culture with hypoxia pre‑treated mesenchymal stromal cells". Molecular Medicine Reports 18.3 (2018): 2589-2598.
Chicago
Xiang, C., Xie, Q."Protection of mouse pancreatic islet function by co‑culture with hypoxia pre‑treated mesenchymal stromal cells". Molecular Medicine Reports 18, no. 3 (2018): 2589-2598. https://doi.org/10.3892/mmr.2018.9235
Copy and paste a formatted citation
x
Spandidos Publications style
Xiang C and Xie QP: Protection of mouse pancreatic islet function by co‑culture with hypoxia pre‑treated mesenchymal stromal cells. Mol Med Rep 18: 2589-2598, 2018.
APA
Xiang, C., & Xie, Q. (2018). Protection of mouse pancreatic islet function by co‑culture with hypoxia pre‑treated mesenchymal stromal cells. Molecular Medicine Reports, 18, 2589-2598. https://doi.org/10.3892/mmr.2018.9235
MLA
Xiang, C., Xie, Q."Protection of mouse pancreatic islet function by co‑culture with hypoxia pre‑treated mesenchymal stromal cells". Molecular Medicine Reports 18.3 (2018): 2589-2598.
Chicago
Xiang, C., Xie, Q."Protection of mouse pancreatic islet function by co‑culture with hypoxia pre‑treated mesenchymal stromal cells". Molecular Medicine Reports 18, no. 3 (2018): 2589-2598. https://doi.org/10.3892/mmr.2018.9235
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